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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Acta Pharmaceutica Indonesia ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Ilmiah Farmako Bahari
Permana, Benny
Institut Teknologi Bandung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Energy Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Determination of Sugar Content in Fruit Juices Using High Performance Liquid Chromatography Damayanti, Sophi; Permana, Benny; Weng, Choong Chie
Acta Pharmaceutica Indonesia Vol 37, No 4 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.577 KB)

Abstract

Sugar is a sweet, water-soluble, crystallizable material which is obtained commercially from sugarcane or sugar beet. As an important source of dietary carbohydrate, a sweetener, preservative in foods and a cause factor for Diabetic disease, analysis of sugar content is needed. The objective of this study was to verify the suitability and determination of sugar content in fruit juices using HPLC. The fresh fruits except strawberries were peeled, cut and blended using homogenizer. After filtration, 12.5mL of each fresh juices and packed juices were diluted with acetonitrile and distilled water (50:50). The diluted fresh juices and packed juices were loaded onto C18 Sep-Pak cartridge. Fructose, glucose, and sucrose of each fresh juices and packed juices were analyzed in HPLC with Refractive Index detector, NH2 polar bonded phase column, 10μm (250mm ×4.6mm I.D.), temperature of 43.5°C, mobile phase of acetonitrile and 10mM sodium phosphate (monobasic) (78:22) and flow rate of 1.0mL/min. The method validation showed good linearity of equations for fructose, glucose and sucrose were y = 3833208.4806x – 94721.0361, y = 3782886.4708x – 101683.4708, y = 3770593.9638x – 82870.9083 with regression coefficients, r2 of 0.9995, 0.9997 and 0.9996 respectively. The calculated regression function coefficients (Vx0) for fructose, glucose and sucrose were 0.0152, 0.0112 and 0.0132% respectively. The percentage recovery of fructose, glucose, and sucrose was found to be in a range of each 86.681 – 89.888, 86.898 – 90.029, and 94.541 – 97.885%. Sugar contents in fruit juices can be determined using verified HPLC method with Refractive Index Detektor. Fructose, glucose and sucrose of fresh juices contained 0.469 – 1.431, 0.454 – 1.286, 0.544 – 1.861%, whereas that of packed juices contained 0.309 – 1.587, 0.261 – 0.762,0.063 – 0.898%, respectively.Keywords: Fructose, glucose, sucrose, fruit juice, HPLC.Gula merupakan zat yang berasa manis, larut dalam air, berbentuk kristal yang dapat diperoleh dari berbagai sumber antara lain bit gula dan tebu. Sebagai sumber karbohidrat, pemanis dan pengawet dari makanan, dan penyebab diabetes, maka kandungan gula perlu ditentukan. Tujuan dari penelitian ini adalah untuk verifikasi kesesuaian penentuan kadar gula dalam jus buah menggunakan Kromatografi Cair Kinerja Tinggi (KCKT). Buah segar kecuali stroberi dikupas kemudian dipotong dan dicampur dengan menggunakan homogenizer. Setelah disaring, 12.5mL jus segar dan 12.5mL jus kemasan diencerkan dengan asetonitril dan air suling (50:50). Jus segar dan jus kemasan kemudian dilewatkan melalui tabung C18 Sep-Pak. Fruktosa, glukosa dan sukrosa kemudian dianalisis menggunakan KCKT detektor Indeks bias, kolom NH2, 10μm (250μm × ID 4.6mm) dan suhu kolom 43.5ºC, fase gerak asetonitril dan larutan natrium fosfat 10mM (78:22) dan laju aliran adalah 1.0mL/min. Metode validasi menunjukkan linearitas persamaan yang baik untuk fruktosa, glukosa dan sukrosa yaitu y = 3833208,4806x – 94721,0361, y = 3782886,4708x – 101683,4708, y = 3770593,9638x – 82870,9083 dengan koefisien korelasi, r2 adalah 0,9995, 0,9997 and 0,9996 masing-masing. Koefisien fungsi regresi yang dihitung (Vx0) untuk fruktosa, glukosa dan sukrosa adalah 0,0152, 0,0112 dan 0,0132 %. Persentase perolehan kembali untuk fruktose, glukosa dan sukrosa berada dalam rentang masing-masing 86,681 – 89,888, 86,898 – 90,029, dan 94,541 – 97,885%. Kandungan fruktosa, glukosa dan sukrosa dapatditentukan dengan menggunakan kromatografi cair kinerja tinggi dengan detektor indek bias. Fruktosa, glukosa dan sukrosa jus segar mengandung 0,469 – 1,431, 0,454 – 1,286, 0,544 – 1,861% sementara pada jus kemasan mengandung masing-masing 0,309 – 1,587, 0,261 – 0,762, 0,063 – 0,898%.Kata kunci: Fruktosa, glukosa, sukrosa, jus buah, HPLC.
Molecular Docking Study of Anthocyanidin Compounds Against Epidermal Growth Factor Receptor (EGFR) as Anti-Lung Cancer Riska Prasetiawati; Meilia Suherman; Benny Permana; Rahmawati Rahmawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29872

Abstract

It is presumed that antiproliferative activity of anthocyanidin has interaction with Epidermal Growth Factor Receptor (EGFR) which has effect on lung cancer cell growth. This study aimed to observe the interaction between anthocyanidin and EGFR and to find out prediction, absorption, distribution activities as well as anthocyanidin toxicity compared to Gefitinib, an EGFR inhibitor. All test compounds were optimized with Autodock Tools®, then molecular docking simulations and predictions of absorption, distribution and toxicity were carried out. Malvidin was stated to meet the Lipinski's Rule of Five, indicating good bioavailability. Result of molecular docking simulation showed that malvidin had better affinity against EGFR than Gefitinib. Molecular docking visualization result showed that malvidin had interaction with amino acid residue such as Met793, Gln791, Leu718, Thr854, Asp855 and Lys745. Absorption and distribution predictions included percentage scores of Human Intestinal Absorption (HIA), human colon adenocarcinoma (Caco-2), and Plasma Protein Binding. Toxicity test revealed that malvidin was mutagenic compound but not carcinogenic one. The findings indicated that malvidin was potential to be an anti lung cancer candidate through EGFR inhibition.Keywords: Antiproliferative, Anthocyanidin, Epidermal Growth Factor Receptor, Molecular Docking
Determination of Sugar Content in Fruit Juices Using High Performance Liquid Chromatography Sophi Damayanti; Benny Permana; Choong Chie Weng
Acta Pharmaceutica Indonesia Vol. 37 No. 4 (2012)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sugar is a sweet, water-soluble, crystallizable material which is obtained commercially from sugarcane or sugar beet. As an important source of dietary carbohydrate, a sweetener, preservative in foods and a cause factor for Diabetic disease, analysis of sugar content is needed. The objective of this study was to verify the suitability and determination of sugar content in fruit juices using HPLC. The fresh fruits except strawberries were peeled, cut and blended using homogenizer. After filtration, 12.5mL of each fresh juices and packed juices were diluted with acetonitrile and distilled water (50:50). The diluted fresh juices and packed juices were loaded onto C18 Sep-Pak cartridge. Fructose, glucose, and sucrose of each fresh juices and packed juices were analyzed in HPLC with Refractive Index detector, NH2 polar bonded phase column, 10μm (250mm ×4.6mm I.D.), temperature of 43.5°C, mobile phase of acetonitrile and 10mM sodium phosphate (monobasic) (78:22) and flow rate of 1.0mL/min. The method validation showed good linearity of equations for fructose, glucose and sucrose were y = 3833208.4806x "“ 94721.0361, y = 3782886.4708x "“ 101683.4708, y = 3770593.9638x "“ 82870.9083 with regression coefficients, r2 of 0.9995, 0.9997 and 0.9996 respectively. The calculated regression function coefficients (Vx0) for fructose, glucose and sucrose were 0.0152, 0.0112 and 0.0132% respectively. The percentage recovery of fructose, glucose, and sucrose was found to be in a range of each 86.681 "“ 89.888, 86.898 "“ 90.029, and 94.541 "“ 97.885%. Sugar contents in fruit juices can be determined using verified HPLC method with Refractive Index Detektor. Fructose, glucose and sucrose of fresh juices contained 0.469 "“ 1.431, 0.454 "“ 1.286, 0.544 "“ 1.861%, whereas that of packed juices contained 0.309 "“ 1.587, 0.261 "“ 0.762,0.063 "“ 0.898%, respectively.Keywords: Fructose, glucose, sucrose, fruit juice, HPLC.Gula merupakan zat yang berasa manis, larut dalam air, berbentuk kristal yang dapat diperoleh dari berbagai sumber antara lain bit gula dan tebu. Sebagai sumber karbohidrat, pemanis dan pengawet dari makanan, dan penyebab diabetes, maka kandungan gula perlu ditentukan. Tujuan dari penelitian ini adalah untuk verifikasi kesesuaian penentuan kadar gula dalam jus buah menggunakan Kromatografi Cair Kinerja Tinggi (KCKT). Buah segar kecuali stroberi dikupas kemudian dipotong dan dicampur dengan menggunakan homogenizer. Setelah disaring, 12.5mL jus segar dan 12.5mL jus kemasan diencerkan dengan asetonitril dan air suling (50:50). Jus segar dan jus kemasan kemudian dilewatkan melalui tabung C18 Sep-Pak. Fruktosa, glukosa dan sukrosa kemudian dianalisis menggunakan KCKT detektor Indeks bias, kolom NH2, 10μm (250μm × ID 4.6mm) dan suhu kolom 43.5ºC, fase gerak asetonitril dan larutan natrium fosfat 10mM (78:22) dan laju aliran adalah 1.0mL/min. Metode validasi menunjukkan linearitas persamaan yang baik untuk fruktosa, glukosa dan sukrosa yaitu y = 3833208,4806x "“ 94721,0361, y = 3782886,4708x "“ 101683,4708, y = 3770593,9638x "“ 82870,9083 dengan koefisien korelasi, r2 adalah 0,9995, 0,9997 and 0,9996 masing-masing. Koefisien fungsi regresi yang dihitung (Vx0) untuk fruktosa, glukosa dan sukrosa adalah 0,0152, 0,0112 dan 0,0132 %. Persentase perolehan kembali untuk fruktose, glukosa dan sukrosa berada dalam rentang masing-masing 86,681 "“ 89,888, 86,898 "“ 90,029, dan 94,541 "“ 97,885%. Kandungan fruktosa, glukosa dan sukrosa dapatditentukan dengan menggunakan kromatografi cair kinerja tinggi dengan detektor indek bias. Fruktosa, glukosa dan sukrosa jus segar mengandung 0,469 "“ 1,431, 0,454 "“ 1,286, 0,544 "“ 1,861% sementara pada jus kemasan mengandung masing-masing 0,309 "“ 1,587, 0,261 "“ 0,762, 0,063 "“ 0,898%.Kata kunci: Fruktosa, glukosa, sukrosa, jus buah, HPLC.
Development and Validation of Spectrofluorometric Method for the Determination of Ascorbic Acid in Several Dosage Forms by Using Methylene Blue Benny Permana; Debora Ronauli; Ilma Nugrahani
Acta Pharmaceutica Indonesia Vol. 46 No. 1 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ascorbic acid or vitamin C is one of the most widely consumed supplement and available at the market in several preparations such as tablet, sweetlet, effervescent tablet, and ready to drink product. Spectrofluorometric method has been developed in this study for quantitative determination of ascorbic acid in various forms of products based on the reaction between ascorbic acid and methylene blue. Methylene blue concentration decreased along with the addition of ascorbic acid due to a redox reaction which caused the formation of colorless leuco-methylene blue and dehydroascorbic acid. The fluorescence intensity of methylene blue was measured at excitation and emission wavelengths of 664 nm and 686 nm respectively. The proposed method was found to have a good selectivity, linearity, accuracy, and precision. Validation studies demonstrated a good linearity for the method with a correlation coefficient > 0.999 and Vx0 < 2%. The accuracy test also met the requirements with the recoveries were not less than 90.0% and not more than 110.0%. Precision test gave a relative standard deviation (% RSD) not more than 2%. The ascorbic acid content in several marketed products was evaluated by this new spectrofluorometric method and the result was in good agreement for effervescent tablet, isotonic drink and lozenges with the label claim and specification. Due to its simplicity, the method can be used to analyze vitamin C in different product forms.
3D-PHARMACOPHORE MODELING AND MOLECULAR DOCKING TO STUDY THE POTENTIAL ANTI-CANCER AGENT FROM Ficus septica Burm. L Asman Sadino; Benny Permana; Meilia Suherman; Fuji Ayu Noviartika
Pharmacoscript Vol. 5 No. 1 (2022): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v5i1.756

Abstract

In vitro testing showed that awar awar (Ficus septica Burm. L ) leaf had an anticancer activity. Ethanol extract from awar-awar leaves could selectively inhibit cancer cell growth with IC50 values, there were MCF7 breast cancer cells (48 µg/ml), HeLa cervical cancer cells (122.4 µg/mL), and WiDR cancer cells (75.9 µg/mL). However, the active compounds that play a role in inhibiting the three cancer cells are not yet found. Therefore, this research carried out to find out the active compound using in silico. 3D-pharmacophore modeling and Molecular docking were developed for finding out the potential compound that could be acted as an anti-cancer agent. Screening pharmacophore was performed using LigandScout® 4.4 software for searching the matching pharmacophore features against chemical structure databases. Docking was performed using Autodock Tools® and visualized using Discovery Studio Visualizer® software to see the ligand interaction with the active binding site at the receptor and continue with ADMET properties to evaluating the Pharmacodynamic activities of the Hit compounds. Among 17 types of compounds tested, 11 compounds showed anticancer activity and genistin was found promising and showed potential inhibitory characteristics as an anticancer compared to other active compounds of awar-awar leaves. This study suggests that these compound could be used as a lead compound for anticancer agents.
Optimasi Formula Lipid Nanostruktur dengan Pentarget Manosa sebagai Sistem Penghantaran Rifampisin Tri Suciati; Nurani Istiqomah; Benny Permana; Elin Julianti; Marlia Singgih Wibowo; Titah Yudistira; Yani Triyani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1017.477 KB) | DOI: 10.35814/jifi.v17i2.568

Abstract

Limited accumulation of anti-tuberculosis drugs in macrophages become a barrier to the success of latent tuberculosis therapy. The purpose of this study is to develop a D-mannose modified nanoparticle formula as a targeting agent to the mannose receptors to increase the internalization of rifampicin into macrophages. D-mannose was conjugated with chitosan using an amine reducing agent. Chitosan-D-mannose conjugate was characterized using FTIR. Subsequently, the conjugate was adsorbed onto the nanostructured lipid carrier (NLC) electrostatically. The NLC formula consisted of an ethyl acetate solution of solid-liquid lipid blend and rifampicin and an aqueous solution of chitosan-D-mannose conjugate, which were emulsified using polysorbate 80. Solidification of the NLC-chitosan-mannose nanoparticles was carried out by ionotropic gelation and solvent evaporation. The nanoparticle formula was optimized using Box-Behnken design. The formation of chitosan-D-mannose conjugate was shown by the change of the amide band wave number and the Schiff base formation of the FTIR spectra. The optimum formula of nanoparticles had a diameter of 766.1 ± 57.56 nm with a polydispersity index of 0.32 ± 0.02, encapsulation efficiency of 91.54 ± 0.18% and drug loading of 36.62 ± 0.07%. Rifampicin was released from the nanoparticles at pH 5.2 or 7.4 with a similar rate. This D-mannose modified NLC formula has the potential to be further developed as an intracellular antibiotic targeting to macrophages.
In Silico Study on Interaction and Preliminary Toxicity Prediction of Eleutherine americana Components as an Antifungal and Antitoxoplasmosis Candidate Sophi Damayanti; Nadiyah Athifah Salim Martak; Benny Permana; Adi Suwandi; Rika Hartati; Indra Wibowo
Indonesian Journal of Chemistry Vol 20, No 4 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.96 KB) | DOI: 10.22146/ijc.48570

Abstract

Red bulbs of Eleutherine americana (Aubl.) Merr. ex K. Heyne has been known for its high content of naphthoquinones that have antifungal and antiparasitic activities. In this research, in silico interaction study was performed between 31 compounds reported to be found in E. americana with the selected target proteins for antifungal and antitoxoplasmosis activity using the molecular docking method. An ORPs (OSBP-related proteins), Osh4 (PDB ID: 1ZHX), and N-myristoyltransferase (Nmt, PDB ID: 1IYL) were used as the antifungal target proteins. Toxoplasma gondii purine nucleoside phosphorylase (TgPNP, PDB ID: 3MB8) and calcium-dependent protein kinase-1 (TgCDPK1, PDB ID: 4M84) were used as antitoxoplasmosis target proteins. Three-dimensional structures of the test compounds were made and optimized using GaussView 6.0 and Gaussian 09W. The target proteins were prepared using the Discovery Studio 2016 Program. Aquatic toxicity prediction as the preliminary assessment of the safety of the compounds was performed using ECOSAR v2.0. The results suggest that the compound having both the smallest free binding energy compared with positive control and other test compounds and low predicted toxicity is β-sitosterol with a free binding energy of ‒11.55 and ‒11.18 kcal/mol towards Osh4 and Nmt and ‒8.06 and ‒10.29 kcal/mol towards TgPNP and TgCDPK1, respectively.
Simple Method of 9,10-Anthraquinone Assay in Eleutherine americana (Aubl.) Merr. ex K. Heyne using High-Performance Liquid Chromatography Sophi Damayanti; Samuel Gunadi Tanusondjaja; Benny Permana; Rika Hartati; Dian Ayu Eka Pitaloka; Indra Wibowo
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64701

Abstract

Eleutherine americana (E. americana) is a medicinal plant commonly found on the island of Borneo, Indonesia. This plant is known to have several biological activities. However, anthraquinone residues are generally present as contaminants. This study was aimed to develop a method of determining the levels of 9,10-anthraquinone in plant extracts and fractions using High Performance Liquid Chromatography (HPLC). The research aims to optimize the mobile phase, the system suitability test, and the system validation. The optimal mobile phase was acetonitrile:distilled water 1:1 v/v with a flow rate of 1.25 mL/min. The validation result shows that the linearity was obtained with a correlation coefficient (r) of 0.9995 and an r2 coefficient of 0.9991. The estimated limits for detection and quantification values were 0.178 and 0.594 µg/mL, respectively. In the intraday and inter-day accuracy test, the coefficient of variance for reference was 0.627 and 0.774, while the results for the sample were 2.966 and 2.658. The percentage recovery rate for reference was between 98.976–101.452%, and for the sample, the result was 89.191–94.667%. The average 9,10-anthraquinone content in the acetate fraction of E. americana plant was 9.799 µg/g ± 5.243.
STUDI PENAMBATAN MOLEKUL SENYAWA TURUNAN XANTON DARI KULIT BUAH MANGGIS (Garcinia mangostana L.) TERHADAP ER-α (RESEPTOR ESTROGEN ALFA) DAN ER-β (RESEPTOR ESTROGEN BETA) SEBAGAI ANTIKANKER PAYUDARA Riska Prasetiawati; Benny Permana; Dang Soni; Sakti Nunggal Agung
Jurnal Ilmiah Farmako Bahari Vol 9, No 1 (2018): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.567 KB) | DOI: 10.52434/jfb.v9i1.642

Abstract

Secara in silico penelitian senyawa turunan xanton yang berasal dari kulit buah manggis (Garcinia mangostana L.) telah menunjukan berbagai aktivitas farmakologi. Penelitian ini merupakan penelitian eksperimental dengan mengggunakan alat berbantu komputer yaitu perangkat lunak AutoDockTools (versi 1.5.6) dengan tujuan untuk mendapatkan senyawa turunan xanton sebagai kandidat obat antikanker payudara yang terbaik melalui penambatan molekuler. Penambatan 41 senyawa turunan xanton telah dilakukan terhadap ER-α (Reseptor Estrogen Alfa) dan ER-β (Reseptor Estrogen Beta) menggunakan metode penambatan molekul dengan AutoDockTools (versi 1.5.6), divisualisasi dengan Discovery Studio Visualizer, dan analisis hasil farmakokinetika serta toksisitas dari senyawa melalui situs pre-ADMET. Hasil penambatan diperoleh dua senyawa turunan xanton sebagai lead compound terhadap ER-β yaitu Demetilcalabaxanton memiliki nilai energi bebas ikatan (ΔG) -10,36 kKal/mol dengan residu asam amino yang terikat Thr347, Met343 dan Trapezifolixanton memiliki nilai energi bebas ikatan (ΔG) -10,37 kKal/mol dengan residu asam amino Glu305 yang mempunyai potensi lebih baik, sedangkan untuk obat pembanding tamoksifen memiliki nilai energi bebas ikatan (ΔG) -8,54 kKal/mol dan Klomifen -8,87 kKal/mol. Berdasarkan analisis hasil prediksi, lead compound Demetilcalabaxanton dan Trapezifolixanton memiliki sifat farmakokinetika yang baik dengan nilai CaCo-2 17,63 dan 4,036; HIA 94,35% dan 93,38%; PPB 95,63% dan 91,53% sedangkan hasil toksisitas diperoleh tidak karsinogen dan tidak mutagen. Kata kunci:Antikanker, kulit buah manggis, penambatan molekul, reseptor estrogen beta, xanton.
STUDI PENAMBATAN MOLEKULSENYAWA DARI UMBI BAWANG DAYAK (Eleutherine Palmifolia (L) Merr.) SEBAGAI OBAT ANTIKANKER SERVIKS Tedjo Narko; Benny Permana; Riska Prasetiawati; Dang Soni; Faridhatul Khairiyah
Jurnal Ilmiah Farmako Bahari Vol 8, No 2 (2017): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.242 KB) | DOI: 10.52434/jfb.v8i2.643

Abstract

Kanker serviks adalah kanker yang terjadi karena sel epitel serviks mengalami mutasi genetik sehingga terjadi pembelahan sel yang tidak terkendali. Umbi bawang dayak merupakan salah satu tumbuhan khas Indonesia yang senyawanya telah diteliti menunjukkan aktivitas menghambat pertumbuhan kanker serviks (sel HeLa). Tujuan penelitian ini yaitu untuk mendapatkan kandidat senyawa baru sebagai antikanker serviks yang berasal dari senyawa umbi bawang Dayak sehingga dapat menjadi alternatif sumber bahan baku obat melalui metode penambatan molekul pada dua reseptor yaitu 5UU1 dan 3ERT. Semua senyawa umbi bawang Dayak ditambatkan pada reseptor target menggunakan program AutoDock Tools. Validasi metodetelah dilakukan dengan nilaiRMSD (Root Mean Square Deviation)yang diperoleh 0,282Å dan 0,436Å. Analisis hasil penambatan molekulmenunjukkan bahwa senyawa eleutherinoside A dapat diprediksi memiliki interaksi yang paling baik dengan nilai energi energi bebas (∆G) sebesar -9,55 kkal/mol pada reseptor 5UU1 dan -7,63 pada reseptor 3ERT daripada obat pembanding 5 Fluorourasil sebesar -3,91 kkal/mol pada reseptor 5UU1 dan -4,20 kkal/mol pada reseptor 3ERT. Untuk uji preADME sel Caco-2 sebesar 11,77 nm/sec; HIA sebesar 74,29%; dan ikatan protein plasma sebesar 66,28%. Senyawa ini pun memenuhi aturan Lipinski serta tidak bersifat toksik. Kata kunci:Kanker Serviks, Penambatan Molekul, Senyawa Umbi Bawang Dayak
Co-Authors Adi Suwandi Anna Yuliana, Anna Asman Sadino Choong Chie Weng Debora Ronauli Dian Ayu Eka Pitaloka Elin Julianti Faridhatul Khairiyah Fuji Ayu Noviartika Ilma Nugrahani Indra Wibowo Indra Wibowo Marlia Singgih Marlia Singgih Wibowo Meilia Suherman Muhammad Haqqi Hidayatullah Nadiyah Athifah Salim Martak Nurani Istiqomah Rahmawati Rahmawati Rika Hartati Riska Prasetiawati Sakti Nunggal Agung Samuel Gunadi Tanusondjaja Selvira Anandia Intan Maulidya Slamet Ibrahim Soni, Dang Sophi Damayanti Tedjo Narko Titah Yudistira Tri Suciati Weng, Choong Chie Yani Triyani