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INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Biomarker PlGF/sFlt-1 sebagai Pendeteksi Dini Preeklampsia Rano K. Sinuraya; Hidayatun Nisa; Trifena Lokajaya; Tri N. S. Puri
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2459.903 KB) | DOI: 10.15416/ijcp.2017.6.2.123

Abstract

Program Millenium Development Goals (MDGs) yang dilakukan sejak tahun 2003 belum berhasil mencapai tujuannya, termasuk untuk meningkatkan kesehatan ibu dengan target menurunkan Angka Kematian Ibu (AKI) sebesar tiga perempatnya antara tahun 1990 sampai 2015. Program ini kemudian dilanjutkan menjadi Sustainable Development Goals (SDGs) dengan salah satu fokusnya yaitu menurunkan AKI hingga di bawah 70 per 100.000 kelahiran hidup serta mengurangi sepertiga kematian bayi prematur akibat penyakit tidak menular. Angka kematian ibu di Indonesia cukup tinggi apabila dibandingkan dengan negara-negara lainnya di wilayah Asia Tenggara. Pada umumnya penyebab utama kematian ibu adalah pendarahan (28%), preeklampsia (PE)/eklampsia (24%), infeksi (11%), komplikasi persalinan (5%) dan abortus (5%). Preeklampsia (PE) merupakan penyakit hipertensi yang disertai dengan proteinuria yang terjadi pada saat usia kehamilan mencapai 20 minggu (trimester kedua). Penyakit ini umumnya tidak terdiagnosis namun terlihat setelah berdampak pada gangguan ibu dan janin dan apabila tidak ditangani dengan segera, maka dapat menyebabkan kematian bagi ibu pada proses persalinan. Dilaporkan bahwa rata-rata insiden kejadia PE di seluruh dunia adalah 2–10%. Berbagai upaya terus dilakukan untuk menurunkan angka kematian Ibu, salah satunya adalah dengan pencarian metode deteksi dini. Tujuan penulisan review ini adalah untuk mengkaji metode deteksi dini apa yang paling efektif dan efisien untuk mengatasi PE. Metode dalam review ini adalah penelusuran data berbasis Pubmed, Scopus dan Google Scholar dan tanpa pembatasan index factor dengan menggunakan kata kunci “biomarker, preeclampsia”, “early detection, preeclampsia”. Hasil review menunjukkan bahwa biomarker placental growth gactor (PlGF) dan soluble Fms-like tyrosine kinase 1 (sFlt-1) merupakan biomarker spesifik dengan sensitivitas dan spesifisitas yang tinggi dalam pendeteksian PE.Kata kunci: Biomarker PlGF/sFlt-1, deteksi dini, preeklampsia PlGF/sFlt-1 as Early Detection Biomarker for PreeclampsiaAbstract Millennium Development Goals (MDGs) had been conducted since 2003 with uncomplished outcome target, particularly improving maternal health and lowering maternal mortality until one-fourth of population from 1990 until 2015. Then, this program was continued through Sustainable Development Goals (SDGs) in 2015 with lowering maternal mortality below 70 per 100,000 live births and reducing premature mortality due to one-third because of uncommunicable diseases. Maternal mortality in Indonesia is quite high compared with the other countries in the Southeast Asia. Generally, the main causes of maternal death are haemorrhage (28%), preeclampsia (PE)/eclampsia (24%), infection (11%), complications from birth delivery (5%), and unsafe abortion (5%). Preeclampsia (PE) is a hypertension disease accompanied with proteinuria that occuring in 20 weeks of pregnancy (second trimester). The disease is commonly unvisible and underdiagnosed until clinical manifestations were presented (e.g. maternal and fetal disorders). However, it can lead to maternal death during childbirth if this problem not addressed seriously. It was reported that the average incidence of PE reached 2–10% worldwide. Various efforts have been undertaken to lowering maternal mortality that is early detection of PE. The purpose of this review was to analyze the most effective early detection method to overcome PE based on literaure review. The methods of this review were data-based searching based on Pubmed, Scopus and Google Scholar, without limitation of index factor by using the keyword “biomarkers, preeclampsia”, “early detection, preeclampsia.” The results of the review showed that placental growth factor biomarkers (PlGF) and soluble Fms-like tyrosine kinase 1 (sFlt-1) is the specific biomarkers with high sensitivity and specificity in detection of PE.Keywords: Biomarker PlGF/sFlt-1, early detection, preeclampsia
Efficacy of Bacillus clausii and Saccharomyces boulardii in Treatment of Acute Rotaviral Diarrhea in Pediatric Patients Salloju Vineeth; Shagamreddy Saireddy; Thallapalli Keerthi; Prasantha K. Mantada
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2514.704 KB) | DOI: 10.15416/ijcp.2017.6.2.91

Abstract

Diarrhea disease is considered as major health problem in developing countries. Rotavirus is the most common identifiable viral cause of diarrhea in all children and belongs to Reoviridae family. Rotavirus infection occasionally leads to severe dehydration in infants and children. The objective of the study is to assess the efficacy of Bacillus clausii and Saccharomyces boulardii on the treatment of rotaviral diarrhea, and also to assess its effect on vomiting and fever in pediatric patients. This study conducted at Rainbow Children’s Hospital, Hyderabad, India, from January 2016 until June 2016 and adopts prospective observational parallel study design. From 104 patients enrolled, 80 fulfilled inclusion criteria and 24 were excluded from the study. Patients were divided into two groups based on the treatment. Group I patients were treated with Bacillus clausii and Group II patients were treated with Saccharomyces boulardii. Total mean duration of diarrhea was significantly shorter in Group II (S. boulardii) in comparison with Group I (B. clausii). S. boulardii significantly (p≤0.005) decreased the duration of diarrhea which is 25.2 hours over B. clausii. Both probiotic preparations were equal in efficacy on treating the vomiting and fever (p≥0.005). S. boulardii and B. clausii were well accepted and tolerated by the children and there were no reports of any adverse effects during the study period.Keywords: Bacillus clausii, probiotics, rotaviral diarrhea, Saccharomyces boulardii Efektivitas Bacillus clausii dan Saccharomyces boulardii dalam Pengobatan Diare Akut akibat Rotavirus pada Pasien AnakAbstrakPenyakit diare merupakan salah satu masalah kesehatan yang paling utama di negara-negara berkembang. Rotavirus merupakan virus famili Reoviridae yang umumnya menjadi penyebab diare pada anak. Infeksi rotavirus dapat menyebabkan dehidrasi berat pada bayi dan anak-anak. Tujuan penelitian ini adalah untuk mengukur efektivitas Bacillus clausii dan Saccharomyces boulardii pada pengobatan diare rotavirus dan juga untuk menilai pengaruhnya terhadap muntah dan demam pada pasien anak-anak. Studi ini dilakukan di Rumah Sakit Rainbow Children, Hyderabad, India, pada bulan Januari–Juni 2016 dan menggunakan desain penelitian paralel observasional prospektif. Dari 104 pasien yang terdaftar, sebanyak 80 pasien memenuhi kriteria inklusi dan 24 pasien masuk ke dalam kriteria eksklusi. Pasien dibagi ke dalam dua kelompok berdasarkan pengobatan. Kelompok I merupakan pasien yang diberikan Bacillus clausii dan Kelompok II merupakan pasien yang diberikan Saccharomyces boulardii. Durasi rata-rata diare spada Kelompok II secara signifikan lebih pendek dibandingkan Kelompok I. S. boulardii secara signifikan menurunkan durasi diare (p≤0.005) yaitu 25,2 jam lebih cepat dari B. clausii. Kedua preparat probiotik sama efektifnya dalam mengobati muntah dan demam (p≥0.005). S. boulardii dan B. clausii dapat diterima dengan baik dan ditoleransi oleh anak-anak, serta tidak ada laporan tentang efek samping selama masa studi.Kata kunci: Bacillus clausii, diare rotavirus, probiotik, Saccharomyces boulardii
Mutasi Gen blaCTX-M sebagai Faktor Risiko Penyebab Resistensi Antibiotik Devinna Kang; Rano K. Sinuraya; Tina Rostinawati; Rizky Abdulah
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7051.55 KB) | DOI: 10.15416/ijcp.2017.6.2.135

Abstract

Saat ini, lebih dari setengah antibiotik yang digunakan di dunia merupakan kelompok β-laktam namun efektivitas klinis antibiotik tersebut kini terbatas karena resistensi antibiotik terhadap mikroorganisme penyebab penyakit infeksius. Beberapa mekanisme resistensi terhadap Enterobacteriaceae terutama disebabkan hidrolisis antibiotik oleh enzim spesifik, yang disebut dengan β-laktamase. Enzim β-laktamase menunjukkan kelompok besar enzim yang berbeda secara genetik dan fungsional yaitu extended-spectrum β-lactamase (ESBL) yang diketahui menimbulkan ancaman resistensi yang serius. Lokalisasi plasmid dari gen yang disandi terhadap distribusi enzim pada patogen meningkat setiap tahunnya. ESBL yang memiliki penyebaran yang luas dan relevan secara klinis adalah ESBL kelas A yaitu jenis Temoniera (TEM), Sulphydryl variable (SHV) dan Cefotaxime (CTX-M). Tujuan penulisan review ini adalah untuk mengkaji varian gen blaCTX-M yang banyak menyebabkan peningkatan resistensi antibiotik. Metode yang digunakan pada review ini yaitu penelusuran data berbasis Pubmed, Scopus dan Google Scholar tanpa pembatasan indeks faktor dengan kata kunci “blaCTX-M”, “Extended-spectrum β-lactamase”, dan “antibiotic resistance”. Simpulan dari review ini yaitu ESBL jenis CTX-M telah menggantikan jenis TEM dan SHV secara dominan pada dekade terakhir. ESBL yang dihasilkan oleh Klebsiella pneumoniae diketahui muncul sebagai salah satu patogen nosokomial utama. Infeksi nosokomial yang disebabkan oleh CTX-M-15 pada Klebsiella pneumoniae mengalami peningkatan dalam beberapa tahun terakhir ini.Kata kunci: CTX-M, ESBL, extended-spectrum β-lactamase, Klebsiella pneumoniae Gene blaCTX-M Mutation as Risk Factor of Antibiotic ResistanceAbstractCurrently there are more than half from all antibiotics used in the world which is belong to β lactam group, but clinical effectiveness of the antibiotics are limited by antibiotic resistance of microorganisms as causative agents from infectious diseases. Several resistance mechanisms for Enterobacteriaceae are mostly caused by enzymatic hydrolysis of antibiotics specific enzymes, called β lactamases. β lactamases represent a large group of enzyme which is genetically and functionally different as extended‑spectrum β-lactamase (ESBL) and known as greatest threat of resistence. Plasmid localization from the encoded gene and enzyme distribution among the pathogen increases every year. Most widespread and clinically relevant ESBL are class A ESBL of Temoniera (TEM), Sulphydryl variable (SHV) and Cefotaxime (CTX-M) types. The purpose of this review was to analyze variant of blaCTX-M gene which cause the most increase incidence of antibiotic resistance. The methods of this review were data-based searching based on Pubmed, Scopus and Google Scholar, without limitation of index factor by using the keyword “blaCTX-M”, “Extended-spectrum β-lactamase”, and “antibiotic resistance”. The conclusion of the review is CTX-M type ESBL have replaced TEM and SHV type as dominant enzyme in last decade. ESBL produced by Klebsiella pneumoniae have emerged as one of major nosocomial pathogens. Nosocomial infection caused by CTX-M-15 in Klebsiella pneumoniae dramatically increased in recent years.Keywords: CTX-M, ESBL, extended-spectrum β-lactamase, Klebsiella pneumoniae
Daya Terima Sediaan Puyer Racikan Obat Anti Tuberkulosis di Salah Satu Rumah Sakit di Bandung Widyastiwi Widyastiwi; Ganthina Sugihartina; Indro Pamudjo
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (594.287 KB) | DOI: 10.15416/ijcp.2017.6.2.99

Abstract

Di berbagai rumah sakit di Indonesia, praktik peracikan Obat Anti Tuberkulosis-Kombinasi Dosis Tetap (OAT-KDT) untuk anak dalam bentuk sediaan puyer masih dilakukan sampai saat ini. Meskipun memiliki masalah pada stabilitas dan kualitas sediaan, praktik peracikan puyer OAT tetap dilakukan sebagai upaya individualisasi dosis dan memudahkan pemberian obat pada pasien anak, sehingga diharapkan mampu meningkatkan daya terima pasien terhadap OAT. Daya terima pasien terhadap obat memiliki dampak yang signifikan terhadap kepatuhan yang akhirnya memengaruhi keberhasilan terapi. Penelitian ini bertujuan untuk mengetahui daya terima sediaan puyer racikan OAT dan keberhasilannya di salah satu rumah sakit di Bandung dan dilakukan pada bulan Maret hingga November tahun 2015. Desain penelitian adalah potong lintang dan sampel diambil dengan cara accidental sampling. Kriteria inklusi adalah pasien anak usia 0–14 tahun dengan diagnosis tuberkulosis dan menerima sediaan puyer racikan OAT. Data dikumpulkan melalui wawancara terpimpin menggunakan kuesioner tertutup yang tervalidasi dan reliabel mengenai penerimaan pasien ditinjau dari segi kepraktisan, rasa, dan bau obat. Responden adalah orang tua pasien anak sebanyak 50 orang. Hasil penelitian menunjukkan sediaan puyer racikan OAT diterima baik oleh 40,0% pasien, cukup diterima oleh 52,0% pasien, dan kurang diterima oleh 8% pasien. Faktor usia memengaruhi penerimaan pasien terhadap sediaan puyer racikan (r=0.338). Keberhasilan terapi dicapai oleh 94,6% pasien dengan lama pengobatan 6–9 bulan. Penelitian ini menghasilkan simpulan bahwa penggunaan sediaan puyer racikan dapat diterima baik oleh pasien dengan tingkat keberhasilan terapi yang tinggi. Sediaan puyer racikan merupakan bentuk sediaan yang disarankan untuk pasien anak karena dapat meningkatkan daya terima pasien anak terhadap OAT-KDT.Kata kunci: Daya terima, keberhasilan terapi, Obat Anti Tuberkulosis, puyer racikan Acceptability of Anti-Tuberculosis Compounded Medicines at a Hospital in BandungAbstractIndonesian government has provided anti-TB drugs as a fixed-dose combination to eradicate tuberculosis. For pediatric patients with swallowing problems, compounded medicine is a common solution despites its stability and quality problems. Compounded medicine prescribing is intended to improve patient acceptability of medicine. Patient acceptability, especially in pediatric, will play a significant role to increase patient’s adherence, and in a bigger picture, affect its efficacy. This study was aimed to determine the acceptability level of compounded medicines and its therapy outcomes at a hospital in Bandung. This study was conducted with a cross-sectional design using accidental sampling method. Inclusion criteria were pediatric patients aged 0–14 years who have diagnosed tuberculosis and received compounded medicines. Study was held in March until November 2015 at a hospital in Bandung. A valid and reliable questionnaire was provided as an instrument to interview respondents about practicality, taste, and a smell of medicines. Total of 50 patients’ parent had participated in this study as respondent. The results showed that compounded medicine was acceptable by pediatrics patients. Acceptability of compounded medicines was affected by age factor (r=0.338). Therapeutic success of compounded medicine was achieved by 94.6% of patients with 6–9 months duration of treatment. In conclusion, the use of compounded medicines are acceptable by patients with a satisfactory outcomes therapy.Keywords: Acceptability, anti-tuberculosis drugs, compounded medicines, therapy outcomes
Korelasi Antropometri terhadap Profil Lipid pada Masyarakat Pedesaan Cangkringan, Kabupaten Sleman, Daerah Istimewa Yogyakarta Phebe Hendra; Dita M. Virginia; Fenty Fenty; Aris Widayati
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.091 KB) | DOI: 10.15416/ijcp.2017.6.2.107

Abstract

Prevalensi abnormalitas profil lipid cukup besar pada masyarakat pedesaan. Pengukuran profil lipid (kolesterol total (KT), low density lipoprotein (LDL), high density lipoprotein (HDL), dan trigliserida (TG)) di laboratorium membutuhkan implementasi teknologi kesehatan sedangkan di daerah pedesaan kurang tenaga medis dan permasalahan ekonomi. Pengukuran antropometri yang mudah, tidak invasif, ekonomis, dan dapat dilakukan oleh tiap individu diharapkan dapat memprediksi abnormalitas profil lipid bagi masyarakat pedesaan. Penelitian ini bertujuan untuk mengobservasi korelasi pengukuran antropometri dengan abnormalitas profil lipid di daerah pedesaan. Penelitian ini merupakan penelitian observasional dengan desain potong lintang. Pengukuran antropometri meliputi Body Mass Index (BMI), lingkar pinggang (LP), dan rasio lingkar pinggang panggul (RLPP). Kriteria inklusi adalah penduduk Kecamatan Cangkringan, Sleman, DI Yogyakarta berumur 40–60 tahun, tidak ada riwayat penyakit kardiometabolik, tidak edema, dan konsumsi obat‑obatan terkait kardiometabolik. Lokasi penelitian dipilih menggunakan klaster random sampling. Sampel penelitian dipilih secara purposive sampling dan diperoleh besar sampel 100 responden. Analisis data menggunakan Kolmogorov-Smirnov, Mann‑Whitney, dan Spearman. Hasil penelitian ini menunjukkan korelasi antara BMI (r= –0,286; p=0,044), LP (r= –0,410; p=0,003), dan RLPP (r= –0,365; p=0,009) terhadap HDL pada kelompok wanita. Terdapat juga korelasi antara BMI (r=0,325; p=0,021), LP (r=0,394; p=0,005), dan RLPP (r=0,368; p=0,009) terhadap trigliserida pada kelompok wanita. Terdapat korelasi antara BMI terhadap KT (r=0,285;p=0,045), LDL (r=0,344;p=0,014), dan TG (r=0,446; p=0,001). Parameter LP pria memiliki korelasi terhadap HDL (r= –0,355; p=0,011) dan TG (r=0,488; p=0,000). Parameter RLPP pria memiliki korelasi terhadap seluruh profil lipid; terhadap KT (r=0,287; p=0,043), LDL (r=0,338; p=0,016), HDL (r=0,316; p=0,025), dan TG (r=0,359; p=0,011). Simpulan, pada kelompok wanita pengukuran anthropometri memiliki korelasi terhadap HDL dan TG, sedangkan parameter RLPP lebih sensitif pada kelompok pria.Kata kunci: Antropometri, masyarakat pedesaan, profil lipid Correlation between Anthropometric Measurement and Lipid Profile among Rural Community at Cangkringan Village, District Sleman, Yogyakarta ProvinceAbstractAbnormality lipid prevalence was higher in rural area communities. Measurement of lipid profile (total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG)) needs implementation of health technology whereas in rural areas lack of medical professional and economic problems. Anthropometric measurement is easy, non-invasive, economical, and every individual could do this independently, which is expected to predict abnormality of lipid profile in rural communities. Anthropometric measurements are easy and non-invasive. This study aimed to observe correlation between anthropometric measurements with abnormality of lipid profile in rural areas. This study was an observational study with cross-sectional design. Anthropometric measurements in this study were body mass index (BMI), waist circumference (WC), and waist to hip ratio (WHR). The inclusion criteria were person whose residence in Cangkringan village, Sleman, Yogyakarta Province, aged 40–60 years old, no history of cardio-metabolic disease, not edema, and no consumption of drugs associated cardio-metabolic. Locations were selected using random cluster sampling technique. Samples were selected by purposive sampling and obtained 100 respondents. Data analyzed using Kolmogorov‑Smirnov, Mann-Whitney, and Spearman. This study showed correlation between BMI (r= –0,286; p=0,044), WC (r= –0,410; p=0,003), WHR (r= –0,365; p=0,009) with HDL on women group. There was correlation between BMI (r=0,325; p=0,021), WC (r=0,394; p=0,005), WHR (r=0,368; p=0,009) with triglyceride on women. On men, there was correlation between BMI to TC (r=0,285;p=0,045), LDL (r=0,344;p=0,014), TG (r=0,446; p=0,001); WC have correlation to HDL (r= –0,355; p=0,011) TG (r=0,488; p=0,000); WHR have correlation with TC (r=0,287; p=0,043), LDL (r=0,338; p=0,016), HDL (r=0,316; p=0,025), TG (r=0,359; p=0,011). In conclusion, all anthropometric measurements (BMI, WC, and WHR) have correlation with HDL and TG on women group, whereas WHR has more sensitive correlation on men group.Keywords: Anthropometric, lipid profiles, rural areas communities
Improving Outpatient’s Quality of Life Through Patient Adherence of Antihypertensive Therapy Using “Mobile Phone (SMS) and Brief Counseling‑5A” in Polyclinic of Internal Medicine at PKU Muhammadiyah Bantul Hospital, Yogyakarta Ginanjar Z. Saputri; Akrom Akrom; Endang Darmawan
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2507.788 KB) | DOI: 10.15416/ijcp.2017.6.2.67

Abstract

The Health-Related Quality of Life (HRQoL) is one of the important psycho-social characteristics that can affect patient’s ability to manage therapy. Poor of knowledge of hypertension and the changing lifestyle can affect the quality of life of patients. One of the pharmacist’s interventions in hypertension management is to conduct counseling. Motivational counseling helps health service to assess patient’s understanding and patient’s readiness to change patient’s behavior. Some motivational counseling methods still need to be developed. Therefore, this study aims to find the influence of the “brief counseling-5A” and “motivational SMS” by a pharmacist on the quality of life and blood pressure control in hypertension patients in the internal disease polyclinic, PKU Muhammadiyah Bantul Hospital, Yogyakarta. The study has been done by using the quasi-experimental method with prospective data collection during the period of January until April 2013. Sixty patients have met inclusion criteria and were divided into two groups. Thirty patients (50%) received “brief counseling-5A” and “motivational SMS” as intervention group and the other thirty patients (50%) received usual care as a control group. The data collection was done by interviewing patients. Medication adherence and QoL were assessed by using Morisky Medication Adherence Scale (MMAS) and SF-36. The values of blood pressure are taken from patient’s medical records. Patient’s quality of life showed a good improvement during post study. It is shown in 8 different domains including pain, fatigue, physical function, emotional function, social function, role physical, mental health, and general health. In intervention group, physical function, emotional function, and pain showed highly significant improvement (p<0.05). Systolic and diastolic blood pressure in the intervention group decreased significantly (p<0.05) (systolic p=0.001 and diastolic p=0.018) in the post study. From this study, it is concluded that the “brief counseling-5A by pharmacist” and “motivational SMS” had a positive impact on patient’s QoL and patient’s blood pressure, hence, the therapy outcome has been achieved.Keywords: Adherence, blood pressure, brief counseling, hypertension, quality of life, SMS Peningkatan Kualitas Hidup (QoL) Melalui Kepatuhan Terapi Antihipertensi dengan Mobile Phone Text Messaging (SMS) dan Brief Counseling-5A pada Pasien Rawat Jalan Poliklinik Penyakit DalamRumah Sakit PKU Muhammadiyah Bantul, YogyakartaAbstrakHubungan kesehatan dan kualitas hidup (Health Related Quality of Life) merupakan salah satu karakter psiko‑sosial penting yang dapat memengaruhi kemampuan pasien dalam penatalaksanaan terapi. Kurangnya pengetahuan mengenai hipertensi dan perubahan gaya hidup dapat memengaruhi kualitas hidup pasien. Salah satu intervensi farmasis dalam penatalaksanaan hipertensi adalah konseling. Konseling motivasional membantu pelayanan kesehatan untuk menggali pemahaman pasien serta kesiapan pasien untuk berubah. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian brief counseling-5A disertai SMS motivasi oleh farmasis terhadap kualitas hidup dan pengontrolan tekanan darah pasien hipertensi di poliklinik penyakit dalam RS PKU Muhammadiyah Bantul, Yogyakarta. Penelitian dilakukan secara kuasi eksperimental dengan pengambilan data secara prospektif selama periode Januari hingga April 2013. Sejumlah 60 subjek yang memenuhi kriteria inklusi dibagi menjadi dua kelompok yaitu 30 pasien (50%) mendapatkan brief counseling-5A serta SMS motivasional (kelompok perlakuan) dan 30 pasien (50%) mendapatkan pelayanan kefarmasian konvensional (usual care) sebagai kontrol. Pengumpulan data dilakukan dengan melakukan wawancara dan pengisian kuesioner kepatuhan Morisky Medication Adherence Scale (MMAS), dan kuesioner kualitas hidup SF-36. Nilai tekanan darah diambil dari catatan medis. Kualitas hidup pasien hipertensi menunjukkan peningkatan rerata pada kunjungan kedua (post) di semua domain baik nyeri, fatigue, fungsi fisik, fungsi emosi, fungsi sosial, keadaan fisik, keadaan emosi (status mental), dan keadaan umum (kesehatan umum). Perubahan yang bermakna (p<0,05) terjadi pada domain fungsi fisik (FF), fungsi emosi (FE) dan nyeri. Terjadi penurunan tekanan darah sistolik (p=0,001) dan diastolik (p=0,018) pada kelompok perlakuan sementara pada kelompok kontrol tidak terjadi penurunan tekanan darah sistolik (p=0,730) dan diastolik (p=0,786). Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa pemberian brief counseling-5A serta SMS motivasional oleh farmasis pada pasien hipertensi memberikan pengaruh positif terhadap kualitas hidup pasien dan tekanan darah sehingga tujuan terapi antihipertensi tercapai.Kata kunci: Brief counseling, hipertensi, kepatuhan, kualitas hidup, SMS, tekanan darah

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