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Medula

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Published by Universitas Halu Oleo

ISSN : 23391006 EISSN : 24430218 DOI : http://dx.doi.org/10.33772/medula

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

MEDULA mengundang kontribusi bagi penelitian original dan fundamental pada bidang kesehatan sebagai sebuah artikel yang melewati proses review.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 13 Documents

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Search results for , issue "Vol 6, No 3 (2019): Edisi Suplemen" : 13 Documents clear

Antibacterial Activities of Kacapiring Leaf Ethanol Extract (Gardenia jasminoides Ellis) on the Bacteria of Staphylococcus aureus and Propionibacterium acnes Nuralifah Nuralifah; Fery Indradewi Armadani; Ni Nyoman Fitri Astari
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACTBackground and Objective(s): Infection is the process of entering pathogenic bacteria or microorganisms into the body capable of causing disease. Bacterial infections can cause skin infections such as acne. Acne is inflammation that is accompanied by blockage of the oil glands of the skin and hair (pilosebasea duct). Gardenia jasminoides Ellis is a plant that empirically can be used to treat infectious diseases caused by bacteria. This study was conducted to determine the antibacterial activity of the extracts of kacapiring leaves (Gardenia jasminoides Ellis) against Staphylococcus aureus and Propionibacterium acnes bacteria. Methods: Making extracts was done by maceration method using 96% ethanol. The concentrations of extracts used were 5%, 10% and 15%, with chloramphenicol and clindamycin as positive controls and distilled water as negative controls. Antibacterial activity was tested by the Cup-plate technique. Results: The antibacterial activity of kacapiring leaves ethanol extract to S. aureus showed that at concentrations of 5%, 10% and 15% the inhibitory power diameters values were respectively 5.58 mm, 9.3 mm and 11.41 mm while the antibacterial activity of extracts kacapiring leaves ethanol to P. acnes bacteria at concentrations of 5%, 10% and 15% had inhibitory power diameters of 6.33 mm, 9.25 mm and 11 mm respectively. Conclusion: Ethanol extract of kacapiring leaves has antibacterial activity against Staphylococcus aureus and Propionibacterium acnes bacteria. At a concentration of 5% and 10%, it shows the moderate category and at a concentration of 15% shows a strong category.Keywords: antibacterial, cup-plate technique , gardenia jasminoides

(Ointment Formulation from N-Hexane Extract of Majapahit Leaves (Crescentia cujete l.) and its Antibacterial Activity Evaluation against Pseudomonas aeruginosa) Fery I Armadany; Andi E.P. Putri; Erlina D. Sasmin; Mallarangeng Andi N.T.A. Mallarangeng
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACT Background: Majapahit leaves (Crescentia cujete L.) are known to contain biochemical compounds namely tannins, terpenoids, alkaloids, and saponins which are effective as antimicrobials. Objective(s): This study aimed to formulate ointment from n-hexane extract of majapahit leaves and to known its antimicrobial activity against P. aeruginosa. Methods: ointment ingredients are vaselin, cera alba, liquid paraffin, and menthol and 2% of Majapahit leaves n-hexane extract. Ointment stability test included organoleptic, homogeneity, viscosity, pH, and irritation tests. Evaluation of stability of ointment was obtained by using cycling test method. The irritation test was carried out by open patch test on 6 panellists. Diffusion method is used to obtain antimicrobial activity. Results: The antimicrobial activity (diameter inhibition zone) of the ointment against Pseudomonas aeruginosa bacteria was 11 mm and the positive control was 13 mm. The formula showed no change on texture, colour, aroma, viscosity, homogeneity, but there was slight increase in viscosity and pH. The ointment showed non-irritating for panellists thus the ointment formulation is safe for topical use. Conclusion: 2% n-hexane extract of Majapahit leaves can be formulated into ointment with good stability with strong antibacterial activity and non-irritating. Keywords: antibacterial activity, majapahit leaves, N-hexane extract, ointment, Pseudomonas aeruginosa

Acute Toxicity Test of Gedi (Abelmoschus manihot L.) Ethanol Leaves Extract to Histopatology of Liver Mice Mutmainna Mutmainna; Yenti Purnamasari; Parawansah Parawansah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACTBackground: Abelmoschus manihot L.are widely used as a daily dish of dishes and traditional medicine to treat various diseases. It contains alkaloids, triterpenoids, saponins, and flavonoids wich can be toxic agent at variable dose. Purpose: This study aimed determine the effect of ethanol extract of abelmoschus manihot L. on histopatologic image of mice liver tissue. Methods: This is quasi experimental study with post test only control group design. Fourty five mice (mus musculus) as the subject of this research, they divided into 5 groups, group I threated by 50 mg /kgBB extract, group II threated by 200 mg / kgBB extract, group III threated by 800 mg / kgBB extract, group IV threated by 3,200 mg / kgBB extract, and group V as negative control. Treatment was done for 14 days and terminated at next day for histopatology examination use them liver tissue. Result: Histopathological examination of liver cells within normal limits. In the treatment group of 50 mg liver tissue of mice who died during treatment on day 7 and day 10 showed liver tissue necrosis. In the treatment group of 200 mg and 800 mg of liver tissue showed the presence of liver cell necrosis, and cell boundaries appeared unclear. In the treatment group of 3200 mg liver tissue showed necrotic cells, lysi s cells, unclear cell boundaries and necrotic cells more widely.Conclusion: As a conclusion there an histopatologic changes of microscopic examination of mice liver cells in the form of necrosis and, there is not significant difference in ALT and AST between the control group.Keywords : Abelmoschus manihot L. extract, acute toxicity, liver histopathology

Relationship between Quality of Health Services and Satisfaction of National Health Insurance Participant in the District Hospital of North Buton in 2018 Asmarani Dian Pratiwi; Nina Indriyani N; Erik Astrada; Rhenislawaty Rhenislawaty
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACTLatar Belakang: Kualitas layanan kesehatan merupakan upaya yang dilakukan oleh petugas kesehatan, dokter, perawat, dan paramedis lainnya dalam hal memenuhi kebutuhan dan keinginan pelanggan dan penyediaan pengiriman untuk mengimbangi harapan pelanggan. Kualitas layanan kesehatan yang diberikan terdiri dari aspek bukti fisik, keandalan, daya tanggap, jaminan danempati. Tujuan Penelitian: Tujuan penelitian ini adalah untuk mengetahui hubungan kualitas pelayanan kesehatan dengan kepuasan peserta Asuransi Kesehatan Nasional di RSUD Buton Utara. Metode Penelitian: Penelitian ini menggunakan metode analitik-observasional dengan pendekatan cross sectional. Populasi penelitian ini adalah pasien yang berpartisipasi dalam Asuransi Kesehatan Nasional di Rumah Sakit Kabupaten Buton Utara dari Agustus hingga September 2018 dengan populasi 64. Dengan sampel 55 sampel diambil menggunakan metode accidental sampling. Data tentang kualitas layanan dan kepuasan pasien diperoleh melalui kuesioner. Analisis data menggunakan metode uji korelasi Spearman rank dan dianggap signifikan jika p <0,05. Hasil Penelitian: Hasil penelitian menunjukkan bahwa ada hubungan yang signifikan antara kualitas layanan dan kepuasan pasien. Hal ini dapat dilihat dari dimensi reliabilitas, yaitu p -value 0,000 (<0,05), dari dimensi responsi yaitu p-value 0,000 (<0,05), dimensi jaminan adalah p-value 0,000 (<0,05)), dan dari dimensi empati itu adalah nilai p-value 0,000 (<0,05) sedangkan pada dimensi buktifisik yang diperoleh p-value adalah 0,000 (<0,05). Dalam penelitian ini diperoleh responden yang menyatakan puas dengan pelayanan kesehatan dengan persentase 80,0% sedangkan mereka yang menyatakan ketidakpuasannya dengan persentase 20,0%. Simpulan: simpulan dari penelitian ini, terdapat hubungan antara kualitas pelayanan dan kepuasan peserta Asuransi Kesehatan Nasional di RSUD Buton Utara. Kata Kunci: bukti fisik, jaminan, keandalan, kepuasan pasien, pasien JKN

Hubungan Kualitas Air Minum dan Kebiasaan Makan/Minum di Luar Rumah dengan Terjadinya Demam Tifoid pada Pasien Rawat Inap di RSUD Kota Kendari Zida Maulina Aini
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACT Background: Typhoid fever is a disease which arouse from the infection from Salmonella Typhi superbug through either the contaminated food or drink.It is recorded in 2016, Typhoid fever belongs to the highest ten contagious diseases in Southeast Sulawesi and comes in fifth with the cases of 4.641 sufferers. Purpose: This research study is aimed to know the bearing of quality of water, source of hygienic water and outdoor eating/drinking habit and the cause of typhoid fever to inpatients at Regional General Hospital in Kendari. Method: This research is an observational- descriptive study with a cross sectional design. 38 people of all the inpatients who had more than three days fever were used to be the total of sampling of this research. The instrument of this study is in the form of questioner. The Chi-square trial formula at significant rates (α = 0.05) was used in this research to analyze the data. Result: It is found that out of the 38 respondents, those who measure up for the quality of water are 16 respondents while who do not are 22 respondents with the value of (p=0,544). Meanwhile, there are 20 respondents of good outdoor eating or drinking habit and 18 respondents of the bad one with the value of (p=0,049).Keyword: typhoid fever, outdoor eating/drinking habit, quality of water

Antibacterial Activity Test on Ethanol Extract of Gedi Leaf (Abelmoschus manihot L.) on the Growth of Escherichia coli and Staphylococcus aureus Lista Yul Zamrul; Hartati Hartati; Parawansah Parawansah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACTBackground: Infectious diseases are one of the major causes of death worldwide, mostly caused by bacteria. The use of less targeted antibiotics leads to resistance cases, thus encouraging the discovery of alternative medicine.In general, gedy leaves are known as animal feed but gedy leaves contain antibacterials such as flavonoids, saponins, tannins and terpenoids. Research Purpose:This study aims to determine the antibacterial activity of ethanol extract of gedy leaves on the growth of E. coli and S. aureus. Research Method: This research uses post test only control design, free variable is ethanol extract of gedi leaves and dependent variable is bacterial growth inhibition zone. Ginger leaf ethanol extract was obtained by maceration method for 3 x 24 hours. The test of antibacterial activity using the well diffusion method. Research result: The results of ethanol extract of gedi leaf with concentration of 2.5 mg/ml, 1.25 mg/ml and 0.625 mg/ml resulted in inhibition zone to E. coli growth successively; they were 11.33 mm, 8 mm and 6.3 mm. Extracts of the same concentration also showed inhibition of S. aureus growth with inhibit zone of 8 mm, 3.6 mm and 2 mm. Conclution:The conclusion of this research is the extract ethanol of gedi leaf has antibacterial activity against E. coli and S. aureus.Keywords: Antibacterial,E. coli and S. aureus , Gedi leaf (Abelmoschus manihot L.), Infection.

Potensi Estrak Daun Miana (Coleus atropurpureus) Menghambat Pertumbuhan Malassezia furfur pada Penderita Pityriasis versicolor Anita Rahmawati; Effendy Rasiyanto
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACTBackground: Pitryasis versicolor is one of the fungal infections of the skin caused by the fungusMalassezia furfur often infecting residents in tropical climates due to the temperature and humidity suitable for the growth of the fungus, so an alternative drug is needed such as herbs such as miana leaves which contain plants flavonoids, saponins, steroids, tannins, essential oils, eugenol, polyphenol compounds, alkaloids, ethyl salicylates, calcium oxalate, and rosmarinic acid (RA) compounds.Pusrpose: The purpose of this study was to determine the antifungal potential of miana leaf extract against Malassezia furfur fungi isolated from patients with Pitryasis versicolor (Panu). Method: This type of research is a laboratory experiment with the paper disk method. Result: The research results obtained from the inhibitory test were Miana leaf extract with a concentration of 250 mg / ml, 125 mg / ml, 62.5 mg / ml, 31.25 mg / ml, and 15.625 mg/ ml, with the diameter of each inhibition zone 0.00 mm. Conclusion: From the results of the study it can be concluded that miana leaf extract does not have the potential to inhibit the growth of Malassezia furfur fungus due to Tinea versicolor.Keywords: inhibition test, Malassezia furfur, Pitryasis versicolor

COBEK ANTIK : The Effect of Cocor Bebek Leaves Extract to Blood Sugar Level on Diabetic Model Rat Putu Ayu Sawitri; Wayan Chandra Sety Dewi; Annisa Rizky Amalia; I Putu Sudayasa; Gayuh Agastia
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRAK Latar Belakang: Indonesia merupakan negara yang memiliki keanekaragaman hayati yang dapat diolah menjadi berbagai macam obat. Salah satunya adalah cocor bebek (Kalanchoe pinnata). Kalanchoe pinnata mengandung fenol total, Flavonoid, Lycophenes dan β–Carotenes dan diketahui memiliki berbagai macam aktivitas farmakologi antara lain penyembuh luka, anti-diabetes, anti- inflamasi dan analgesik yang baik, bahkan secara empiris efektif sebagai antipiretik. Tujuan: penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak daun cocor bebek (Kalanchoe pinnata) terhadap kadar gula darah tikus diabetes. Metode : Daun cocor bebek yang sudah dikeringkan diekstraksi dengan metode maserasi menggunakan pelarut etanol. Tikus yang digunakan sebanyak 15 ekor yang dibagi menjadi 5 kelompok. Kelompok I sebagai kontrol positif diberikan suspense glibenclamide ,dan kelompok II, III, dan IV sebagai kelompok perlakuan yang diberikan suspense ekstrak etanol daun cocor bebek dengan masing-masing konsentrasi 10%, 20%, 30% b/v. Dan kelompok V sebagai kontrol negatif diberikan NaCMC 1% b/v. Hasil : Hasil penelitian berdasarkan analisis uji normalitas Shapiro-Wilk dilanjutkan dengan uji beda T berpasangan menujukkan bahwa pemberian ekstrak daun cocor bebek dengan konsentrasi 5%,10%,15% b/v dapat berpengaruh sebagai antidiabetik dan khusus untuk konsentrasi ekstrak 30% memiliki pengaruh yang lebih baik dan memiliki kemiripan dengan kelompok kontrol positif yang diberi obat glibenclamide. Simpulan : pemberian ekstrak daun cocoe bebek, berpengaruh terhadap penuruan kadar gula darah tikus model diabetik. Daun cocor bebek dapat dikembangkan menjadi produk herbal anti diabetik alias Cobek Antik. Kata kunci: antidiabetik, cocor bebek, gula darah, Kalanchoe pinnata, tikus diabetik

Manfaat Kesehatan Tanaman Pala (Myristica fragrans) (Health Benefits of Nutmeg (Myristica fragrans )) Lisna Rosalia Agaus; Reski Vinalia Agaus
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRACTIntroduction: Myristica fragrans has its origins in the Spice Islands of Indonesia, formerly known as the spice islands. Fragrant rich nutmeg is one of the highly prized spices known since antiquity for its aromatic, aphrodisiac, and curative properties. Since ancient times, nutmeg has been used as a remedyfor various ailments or to improve health in general. Purpose: Although the culinary value of this magical spice is well-known, its medicinal and therapeutic values are mostly unheard of. So that, the purpose of this research is to clarify the health benefits of nut meg. Methode: This research is an descriptive research. Result: Health benefits nutmeg is used as a stomachic, stimulant, carminative as well as for intestinal catarrh and colic, headaches, diarrhea, vomiting, nausea, fever, bad breath, to stimulate appetites and to control flatulence. It is also valuable for its aphrodisiac and antiinflammatory properties. Studies show that it can help lower blood pressure and sooth a stomach ache as well as stop diarrhea and (in low dose) help to detoxify the body, stimulate the brain.Conclusion: Nut meg have many health benefits so nut meg must be processed to be a good herbal product which is easilya acessible to the public. Keywords: Health benefits, nutmeg

Perbandingan Visual Analogue Scale antara Pemberian Analgetik Asam Mefenamat, Paracetamol dan Ibuprofen Peroral Sebelum Sirkumsisi Agussalim Ali; Zida Maulina; Raja Al Fath; Muh. Zainsa Asfar
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

ABSTRAK Latar belakang: Nyeri akibat operasi merupakan keadaan yang sangat dikuatirkan oleh pasien sebelum menjalani operasi. Warfield dan Kahn melaporkan 57% dari pasien yang akan dioperasi menaruh perhatian yang serius terhadap kekuatiran nyeri pasca operasi dan 80% dari mereka ternyata mengalami nyeri sedang sampai berat setelah operasi. Dalam sirkusmsisi analgesik yang biasa digunakan yaitu Asam Mefenamat, Paracetamol, dan Ibuprofen. Tujuan: Penelitian ini beetujuan untuk mengetahui perbandingan visual analogue scale (VAS) 1 jam setelah sirkumsisi (T1),2 jam setelah sirkumsisi (T2) dan 3 jam setelah sirkumsisi (T3) antara pasien dengan pemberian analgetik asam mefenamat, paracetamol, dan ibuprofen peroral pre sirkumsisi. Metode: Jenispenelitian ini termasuk penelitian quasi-experimental dengan model posttest design only yang dilakukan di wilayah Kec. Abuki. Jumlah sampel pada penelitian ini adalah 30 sampel, yang terdiri dari 10 sampel asam mefenamat, 10 sampel paracetamol, dan 10 sampel ibuprofen. Penelitan ini dianalisis menggunakan SPSS dengan uji kruskal-wallis. Hasil: Pada T1 menunjukan bahwa terdapat perbedaan rata – rata pada tiap kelompok pemberian obat. Asam mefenamat memiliki nilai rata - rata VAS 2,50, paracetamol 3.00 dan ibuprofen 2,30 dengan p-value 0,018. Pada T2 rata – rata VAS yaitu asam mefenamat 4,30, paracetamol 4,70 dan ibuprofen 4,10 dengan p-value 0,252. Pada T3 rata – rata VAS tiap kelempok obat yaitu, asam mefenamat 7,00, paracetamol 7,50, dan ibuprofen6,40 dengan p-value 0,003. Simpulan: Terdapat perbedaan rata-rata VAS pada T1, T2 dan T3, dengan kelompok terendah yaitu pada kelompok ibuprofen.Kata kunci : Asam mefenamat, Ibuprofen, Paracetamol, Sirkumsisi, Visual analogue scale.

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Home Page

OAI Link

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Contact Name Sulastrianah

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Phone +6285242541601

Journal Mail Official sulastrianahmuhtadi@gmail.com

Editorial Address Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

Location Kota kendari, Sulawesi tenggara INDONESIA

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Contact Name
Sulastrianah

Contact Email
sulastrianahmuhtadi@gmail.com

Phone
+6285242541601

Journal Mail Official
sulastrianahmuhtadi@gmail.com

Editorial Address
Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

Location
Kota kendari,

Sulawesi tenggara

INDONESIA