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WMJ (Warmadewa Medical Journal)
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Published by Universitas Warmadewa
ISSN : 25274627     EISSN : 25799010     DOI : doi.org/10.22225/wmj
Core Subject : Health,
Health Professions Medicine & Pharmacology
WMJ (Warmadewa Medical Journal) is the Journal of Medicine & Health, contains scientific articles (Original/ Research Articles, Review Articles, Case Reports) by academic community of the Faculty of Medicine and Health Sciences Warmadewa University, other Faculties of Medicine and Health Sciences and other related Institutions. It is the medium for hardskill and softskills development as an integral part of the Tri Dharma Perguruan Tinggi (Education, Research, Public Service) and health services in the forms of media of communication, information, scientific education, as a subsystem of Medicine and Health holistic and comprehensive services.
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Articles 1 Documents
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Search results for , issue "110-116" : 1 Documents clear
Role of Secretome in Age-related Changes in the Male Reproductive System: An Add-on Review on the Gut-Brain Axis Mahardhika, Gembong Satria; Norina Agatri
WMJ (Warmadewa Medical Journal) 110-116
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.10.2.10116.110-116

Abstract

Humans are unable to prevent the ageing process. The secretome is a group of bioactive molecules released by cells that may exert paracrine effects on adjacent cells. Recent research indicates that the cellular secretome of mesenchymal stem cells (MSCs) may be useful in the management of idiopathic male infertility. This narrative review was derived from journal articles retrieved through various search engines, including PubMed, Google Scholar, and EBSCO, which were used to compile the reference list. Subsequently, relevant information and journals were collected and reviewed by the authors. The secretome can be examined from multiple perspectives. It may be linked to morphological, histological, and physiological changes in the male reproductive system associated with ageing. These processes may be improved by incorporating the secretome as an anti-inflammatory, anti-apoptotic, and anti-aging agent. Normal gut–testis microbial cooperation supports overall health. Food intake or illness can disrupt the gut microbiota, triggering a cascade that affects fertility. Dysbiotic conditions increase inflammatory markers and damage the gut epithelium, allowing bacteria and inflammatory cytokines to enter the circulation. The secretome also plays a role in balancing the microbiome within the gut–brain axis, thereby contributing to the prevention of fertility impairment. The presence of the secretome may serve as a modulatory factor for age-related changes in male reproductive function, particularly fertility components. Further investigation through additional related studies and systematic reviews is needed to enhance understanding of the relationship between these variables.

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