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All Journal The Indonesian Journal of Public Health Cermin Dunia Kedokteran Cermin Dunia Kedokteran
Mahardhika, Gembong Satria
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Health Professions Medicine & Pharmacology Public Health

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Potensi Candesartan dalam Terapi COVID-19 Handoko, Amelia; Mahardhika, Gembong Satria; Zain, Haidar
Cermin Dunia Kedokteran Vol 49, No 2 (2022): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (17.995 KB) | DOI: 10.55175/cdk.v49i2.1732

Abstract

Coronavirus disease 2019 (COVID-19) akibat severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2) menyebabkan kerusakan paru dan mortalitas bagi penderitanya. Di awal pandemi COVID-19, penggunaan obat antihipertensi RAS blocker diduga berperan dalam keluaran yangkurang baik pada pasien COVID-19 dengan hipertensi karena secara teoritis akan meningkatkan ekspresi ACE2 dan memperbanyak jalan masuk virus ke dalam organ. Beberapa penelitian terkini menyatakan sebaliknya. Studi preliminary menunjukkan penurunan mortalitas dan luarankritis pasien dengan terapi ARB. Candesartan dalam studi in-vitro dapat mengurangi badai sitokin pada COVID-19 dan berpotensi mengurangi efek destruktif lain dari infeksi SARS-CoV-2. Candesartan dapat menekan inflamasi berlebih dan mengurangi stres oksidatif, sehingga berpotensibermanfaat dalam terapi infeksi akut SARS-CoV-2. Candesartan juga bermanfaat mengurangi komplikasi jangka panjang, bermanfaat untuk fungsi paru dan organ-organ lainnya.
STUNTING REDUCTION STRATEGY IN INDONESIA: MATERNAL KNOWLEDGE ASPECTS Putri, Prima Maharani; Shafira, Aqilla Shafa; Mahardhika, Gembong Satria
The Indonesian Journal of Public Health Vol. 19 No. 2 (2024): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v19i2.2024.329-343

Abstract

Introduction: Based on an Indonesian Ministry of Health report, the incidence of stunting has decreased from 24.4% in 2021 to 21.6% in 2022. Reducing stunting rates in children is a global nutrition target in 2025. One of the causes of nutritional problems in children is inadequate intake of nutrients according to their nutritional needs. Based on the above explanation, maternal nutritional knowledge and the government’s role are essential in reducing stunting in Indonesia. Aim: The research investigation was aimed at investigating the level of maternal nutritional awareness as well as the government's participation in reducing stunting in children under the age of five. Methods: This quantitative study was an analytical observational design using a cross-sectional study approach. The samples were mothers of children under five carried out using non-probability purposive sampling, while respondents for the stunting intervention program provider used the snowball sampling technique. Data collection was conducted in locations with high prevalence of stunting, comprising two distinct groups of participants. Result: The statistical result using chi-square shows a significant correlation between maternal nutritional knowledge and the government’s role in reducing stunting in children under five, with a   p-value (0.000) < α (0.05) and p-value (0.008) < α (0.05). Conclusion: There is a relationship between the level of nutritional knowledge of mothers under five and the role of the government in the incidence of stunting. There is a need for further and multidisciplinary management in stunting cases, especially in Indonesia.
Diagnosis Sarkopenia pada Geriatri Menggunakan Akselerometer Actigraph wGT3XBT: Tinjauan Naratif: Analisis Hurulhanifa, Fatmanur; Laranti, Nimas Adiani Sekar; Shabrina, Hanifa Nur; Agatri, Norina; Mahardhika, Gembong Satria
Cermin Dunia Kedokteran Vol 52 No 10 (2025): Oktober 2025
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i10.1421

Abstract

Sarcopenia is a degenerative condition of age-related decline in muscle mass and strength. The worldwide occurrence of sarcopenia varied from 8% to 36% in those under the age of 60, and from 10% to 27% in those aged 60 and above. There is 9.92% or around 26.82 million, elderly people in Indonesia. Several studies have stated that in 2020, the incidence of sarcopenia in Indonesia ranged from 9.1% to 59%. Various studies have shown that accelerometers can provide a quantitative measurement of physical activity, positively correlated with muscle mass and strength in the elderly. Accelerometers, particularly the Actigraph wGT3X-BT, offer an objective approach to measuring physical activity and provide important insights into sarcopenia. Accelerometers offer an unbiased method for quantifying physical activity, offering valuable information on sarcopenia, and serving as a clinical diagnostic tool for this disorder characterized by reduced muscle mass and function. Literature review suggests that the Actigraph wGT3X-BT accelerometer has great potential for early detection and diagnosis of sarcopenia. The integrated use of this technology is expected to improve the accuracy of diagnosis and enable more effective interventions, thereby improving the quality of life of the elderly in Indonesia.
Co-Authors Agatri, Norina Handoko, Amelia Hurulhanifa, Fatmanur Laranti, Nimas Adiani Sekar Putri, Prima Maharani Shabrina, Hanifa Nur Shafira, Aqilla Shafa Zain, Haidar