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Potensi Candesartan dalam Terapi COVID-19 Handoko, Amelia; Mahardhika, Gembong Satria; Zain, Haidar
Cermin Dunia Kedokteran Vol 49, No 2 (2022): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (17.995 KB) | DOI: 10.55175/cdk.v49i2.1732

Abstract

Coronavirus disease 2019 (COVID-19) akibat severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2) menyebabkan kerusakan paru dan mortalitas bagi penderitanya. Di awal pandemi COVID-19, penggunaan obat antihipertensi RAS blocker diduga berperan dalam keluaran yangkurang baik pada pasien COVID-19 dengan hipertensi karena secara teoritis akan meningkatkan ekspresi ACE2 dan memperbanyak jalan masuk virus ke dalam organ. Beberapa penelitian terkini menyatakan sebaliknya. Studi preliminary menunjukkan penurunan mortalitas dan luarankritis pasien dengan terapi ARB. Candesartan dalam studi in-vitro dapat mengurangi badai sitokin pada COVID-19 dan berpotensi mengurangi efek destruktif lain dari infeksi SARS-CoV-2. Candesartan dapat menekan inflamasi berlebih dan mengurangi stres oksidatif, sehingga berpotensibermanfaat dalam terapi infeksi akut SARS-CoV-2. Candesartan juga bermanfaat mengurangi komplikasi jangka panjang, bermanfaat untuk fungsi paru dan organ-organ lainnya.
STUNTING REDUCTION STRATEGY IN INDONESIA: MATERNAL KNOWLEDGE ASPECTS Putri, Prima Maharani; Shafira, Aqilla Shafa; Mahardhika, Gembong Satria
The Indonesian Journal of Public Health Vol. 19 No. 2 (2024): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v19i2.2024.329-343

Abstract

Introduction: Based on an Indonesian Ministry of Health report, the incidence of stunting has decreased from 24.4% in 2021 to 21.6% in 2022. Reducing stunting rates in children is a global nutrition target in 2025. One of the causes of nutritional problems in children is inadequate intake of nutrients according to their nutritional needs. Based on the above explanation, maternal nutritional knowledge and the government’s role are essential in reducing stunting in Indonesia. Aim: The research investigation was aimed at investigating the level of maternal nutritional awareness as well as the government's participation in reducing stunting in children under the age of five. Methods: This quantitative study was an analytical observational design using a cross-sectional study approach. The samples were mothers of children under five carried out using non-probability purposive sampling, while respondents for the stunting intervention program provider used the snowball sampling technique. Data collection was conducted in locations with high prevalence of stunting, comprising two distinct groups of participants. Result: The statistical result using chi-square shows a significant correlation between maternal nutritional knowledge and the government’s role in reducing stunting in children under five, with a   p-value (0.000) < α (0.05) and p-value (0.008) < α (0.05). Conclusion: There is a relationship between the level of nutritional knowledge of mothers under five and the role of the government in the incidence of stunting. There is a need for further and multidisciplinary management in stunting cases, especially in Indonesia.
Pemanfaatan Kadaver dalam Pendidikan Kedokteran: Apakah Mutlak? Pembahasan pada Ruang Lingkup Hukum Kesehatan Mahardhika, Gembong Satria; Arjadi, Fitranto; Putri, Prima Maharani; Nitiprodjo, Abdul Hakim
Majalah Kedokteran Indonesia Vol 75 No 1 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.1-2025-1184

Abstract

Cadavers retain significant value within the realm of medicine, particularly in the context of anatomy laboratories, where they serve as crucial educational tools. Cadavers are of significant importance in facilitating the educational experience within the anatomy laboratory. Numerous research investigations have indicated that the decrease in anatomical knowledge is purportedly a contributing factor to the rise in “surgical errors” and subsequent surge in medicolegal litigation. Utilisation of cadavers for medical education and research should be conducted in a discerning, proficient, and optimal manner. At the fundamental level, individuals can access educational materials from sources such as prosection, plastination, or anatomy museums. The primary focus in higher education is placed on cadaveric dissection, particularly in relation to the development of clinical skills relevant to surgical practise.
Investigating Nasal Anatomy in the Javanese Ethnic Group in Indonesia Agatri, Norina; Mahardhika, Gembong Satria; Mas'ud, Ahmad Fawzy; Arjadi, Fitranto
Jurnal Kesehatan Vol 16 No 2 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i2.4998

Abstract

The nasal is a fundamental anatomical feature of humans and serves as a benchmark for beauty ideals. Rhinoplasty is a popular procedure worldwide. References to anatomical elements are crucial when discussing the distinct nasal shapes of each race, particularly in the context of Indonesia. Research is scarce on the nasal morphology of the Javanese ethnic group, resulting in a lack of precise quantitative measurements for their specific nasal form. The study conducted was a cross-sectional investigation with a sample of 50 individuals, consisting of 20 males and 30 females of Javanese ethnicity. The analysis was performed to determine the precise quantities of the three variables under investigation, specifically intercanthal distance, alar width, and base of nasal width. The mean figure at the intercanthal was 2.38 cm, alar base 2.92 cm, and base of nasal width 3.46 cm. The T-test results are significant for the base of nasal width variable at a p-value of 0.002. The acquired data were subsequently juxtaposed with data from various races in Indonesia and other regions, serving as a benchmark for rhinoplasty operations specifically for individuals of Javanese descent in Indonesia. The data reveal a significant gender gap in the Javanese base of nasal width. A study reveals that Javanese nasals are shorter and wider than those of other ethnicities, suggesting that rhinoplasty may be recommended over non-surgical methods.
Diagnosis Sarkopenia pada Geriatri Menggunakan Akselerometer Actigraph wGT3XBT: Tinjauan Naratif: Analisis Mahardhika, Gembong Satria; Hurulhanifa, Fatmanur; Laranti, Nimas Adiani Sekar; Shabrina, Hanifa Nur; Agatri, Norina
Cermin Dunia Kedokteran Vol 52 No 10 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i10.1421

Abstract

Sarcopenia is a degenerative condition of age-related decline in muscle mass and strength. The worldwide occurrence of sarcopenia varied from 8% to 36% in those under the age of 60, and from 10% to 27% in those aged 60 and above. There is 9.92% or around 26.82 million, elderly people in Indonesia. Several studies have stated that in 2020, the incidence of sarcopenia in Indonesia ranged from 9.1% to 59%. Various studies have shown that accelerometers can provide a quantitative measurement of physical activity, positively correlated with muscle mass and strength in the elderly. Accelerometers, particularly the Actigraph wGT3X-BT, offer an objective approach to measuring physical activity and provide important insights into sarcopenia. Accelerometers offer an unbiased method for quantifying physical activity, offering valuable information on sarcopenia, and serving as a clinical diagnostic tool for this disorder characterized by reduced muscle mass and function. Literature review suggests that the Actigraph wGT3X-BT accelerometer has great potential for early detection and diagnosis of sarcopenia. The integrated use of this technology is expected to improve the accuracy of diagnosis and enable more effective interventions, thereby improving the quality of life of the elderly in Indonesia.