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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 42 Documents
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Search results for , issue "Vol 13, No 2 (2024)" : 42 Documents clear
Exploring the Therapeutic Potential of Kalanchoe Pinnata: A Comprehensive Analysis of Bioactive Compounds and Pharmacological Activities Bhusal, Dakshina; Poudel, Manila; Tamang, Ashika; Dhital, Sujan; Parajuli, Nirmal; Shrestha, Timila; Bharati, Samjhana; Maharjan, Binita; Adhikari Subin, Jhashanath; Marasini, Bishnu Prasad; Shrestha, Ram Lal Swagat
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.617-625

Abstract

Natural products are vital in drug discovery for their bioactive compounds. This study evaluated Kalanchoe pinnata's leaf extracts for antidiabetic, antimicrobial, antioxidant, and cytotoxic properties. GC-MS identified seven components in hexane and twenty in methanol extracts. The ethyl acetate extract had high phenolic (485.17 mg GAE/g) and flavonoid (40.25 mg QE/g) contents. Methanol extract showed strong antioxidant (IC50: 293.53 µg/mL) and anti-alpha glucosidase (IC50: 195.39 µg/mL) activity. Antimicrobial tests showed varied effectiveness, while chloroform and acetone extracts exhibited notable cytotoxicity. ADMET predictions assessed absorption and blood-brain barrier penetration, highlighting K. pinnata's potential for drug development.
Application of Taguchi Experimental Design in Optimization of Levulinic Acid Production from Cellulose Derived From Millet Stalk Ibrahim, Shehu; Muhammad, Abdullahi Sokoto; Umar, Kabiru Jega; Muhammad, Ibrahim Magami
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.627-633

Abstract

Cellulose is the primary component of lignocellulosic biomass and the main source of renewable materials in chemical industry. This study aims at optimizing the production of levulinic acid from cellulose derived from millet stalk using Taguchi experimental design approach. The millet stalks were pretreated by acid and alkali treatment method. The extractives, hemicellulose, lignin, and cellulose contents of the millet stalks were estimated using dry-weight basis technique. Levulinic acid production from the millet stalk was carried out in Teflon lined stainless steel autoclave (50cm3) using standard method. The optimum conditions for the production of levulinic acid were evaluated using Taguchi experimental design method. Levulinic acid was characterized using GC-MS and FT-IR techniques. The cellulose content of the millet stalk was significantly (p < 0.05) higher than the other components. FT-IR spectrum showed the presence of O-H, C=O, C-H, and C-O stretch in the levulinic acid. The highest (95%) yield of the levulinic acid was obtained with an acid concentration of 0.2M at 2000C, for 4 hours. The optimum temperature, acid concentration, and time for the production of levulinic acid from the millet stalk were 2000C, 0.2M, and 4 hours, respectively. Levulinic acid is characterized by a range of functional groups.Keywords: Cellulose, Levulinic acid, Millet stalk, Optimization, Taguchi design

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