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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 10 Documents
 1 
Search results for , issue "Vol 15, No 2 (2018)" : 10 Documents clear
Reduksi Kadar Besi Dalam Air Sumur di Lingkungan Universitas Muhammadiyah Surakarta dengan Filter Pawarti, Hesti; Citradewi, Lia Intan; Fadhilla, Aulia Tassya; Suhendi, Andi
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.6527

Abstract

Iron was silvery white, clay, and can be formed.  it was usually obtained as hematite in nature. Iron was a chemical element that could be found in almost all places on the face of the earth, in all parts of the geological layer, and all bodies of water. In surface water, Fe was rarely found more than 1 mg / L, but in the water, Fe content could be much higher. When it accumulated in the body, iron could cause health problems, such as skin irritation, respiratory problems, and cause cancer in a long time. This study aims to determine the reduction of iron content in well water at the Universitas Muhammadiyah Surakarta (UMS) using the Spectrophotometry method with phenanthroline reagents. The samples were taken as many as five points in three different regions, namely Tanuragan (near the river), Menco and Nilasari (dense settlements), and Gonilan (near the rice fields) showed positive results containing iron with the highest levels in the sample without filtering at 9,478 ppm. These levels decreased after filtration using four filters, namely filters made of carbon, cotton, foam, carbon three layers in each sample. The iron content reduction was best to use cotton filters with 100% reduction in percent.
Karakterisasi Fisik dan Aktivitas Antioksidan Masker Wajah Gel Pell Off Yang Mengandung Sari Buah Naga (Hylocerus polyrhizus) Setiawati, Ririn; Sukmawati, Anita
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.7245

Abstract

Damaged skin due to free radicals from ultraviolet radiation can be prevented using antioxidants. Red dragon fruit (Hylocereus polyrhizus) containing antioxidants can be made into a peel off gel face mask using gelatin as a gelling agent to be applied easily to the skin. The purpose of this study is to determine the effect of various gelatin concentrations on the physical properties and antioxidant activity of peel off gels containing red dragon fruit juice. The peel off gels face mask were made using various gelatin concentration i.e 7.5% w/w (F1); 10% w/w (F2); and 12.5% w/w and containing 10% w/w red dragon fruit. The peel off gels then evaluated for physical properties and antioxidant activity using DPPH. The result showed that the increasing of the gelatin concentration would increase the drying time and adhesive ability of the peel off gels. The escalation of gelatin concentration from 7.5% w/w (F1) to 10% w/w (F2) did not affect the spreading ability of the peel off gel. However, the spreading ability of the peel off gel decreased with the increasing concentration of gelatin from 10% w/w (F2) to 12.5% w/w (F3). The antioxidant test of peel off gel had an average percentage of inhibition of 9.101% (F1); 12.469% (F2); and 15.109% (F3). Based on the results of physical properties and antioxidant activity showed that formula 2 was recomended.
Uji Aktivitas Antijamur Gel Serbuk Lidah Buaya (Aloe vera L.) Berbasis Carbopol 934 Terhadap Candida albicans dan Trichophyton mentagrophytes Afifah, Hani; Nurwaini, Setyo
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.7658

Abstract

Fungal infections that occur in the skin and nails were caused by fungi such as Candida albicans and Trichophyton mentagrophytes. Aloe vera contains saponins and acemannan that were effective as an antifungal. This study aims to determine the effect of carbopol concentration variation on aloe vera gel to antifungal activity of Candida albicans and Trichophyton mentagrophytes.Aloe vera powder was obtained from freeze drying aloe vera juice which had been frozen. Aloe vera powder was formulated in gel form using carbopol base with concentration 0.5; 1.0; 1.5; and 2.0 %w/w. The aloe vera gel was tested for its physical properties and then tested the antifungal activity using the diffusion method of wells.The result of evaluation of physical properties showed the high concentration of carbopol then pH, viscosity, adhesiveness increased, and spreading capacity decreased. The results of antifungal activity test showed that aloe vera powder had activity on Candida albicans and Trichophyton mentagrophytes with inhibition zone of 15 ± 3 mm and 13 ± 0,5 mm. Aloe vera gel test results with variation of carbopol concentration 0.5; 1.0; 1.5; and 2.0 %w/w did not affect the antifungal activity of Candida albicans and Trichophyton mentagrophytes.
Uji Aktivitas Antibakteri Sediaan Obat Kumur Dari Ekstrak Etanol 70% Batang Sambung Nyawa (Gynura procumbens (Lour.) Merr.) Terhadap Bakteri Streptococcus mutans Gurning, Dame; Nathaniel, Dicki; Meila, Okpri; Sagala, Zuraida
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.5880

Abstract

Karies gigi merupakan suatu masalah pada mulut yang disebabkan oleh bakteri Streptococcus mutans, prevalensi karies gigi telah mencapai hingga 60% di Indonesia. Penggunaan obat kumur dinilai efektif, karena dapat membersihkan mulut sampai ke sela-sela gigi. Pada penelitian ini dilakukan uji aktivitas antibakteri sediaan obat kumur dari ekstrak etanol batang sambung nyawa (Gynura procumbens (Lour.) Merr.) terhadap bakteri Streptooccus mutans dengan seri konsenterasi ekstrak 2,5%; 5% dan 10%. Pengujian aktivitas antibakteri dilakukan dengan menggunakan metode difusi cakram. Uji aktivitas antibakteri ekstrak batang sambung terhadap bakteri Streptococcus mutans dilakukan sebagai uji pendahuluan dan hasilnya didapatkan Konsenterasi Hambat Minimum (KHM) terhadap pertumbuhan bakteri Streptococcus mutans ada pada konsenterasi ekstrak 2,5% dengan rata-rata zona hambatan sebesar 7,80 mm. Rata-rata zona hambat terhadap pertumbuhan bakteri Streptococcus mutans lebih tinggi dalam sediaan obat kumur dibandingkan dengan bentuk ekstrak yang masih murni, dikarenakan adanya beberapa bahan pada formulasi sediaan obat kumur yang dapat berfungsi sebagai agen antibakteri, seperti gliserin, menthol dan natrium benzoat. Zona hambatan terhadap pertumbuhan bakteri Streptococcus mutans meningkat seiring dengan meningkatnya konsenterasi dari ekstrak etanol batang sambung nyawa. Data zona hambat pertumbuhan bakteri dianalisis menggunakan One Way ANOVA dengan taraf kepercayaan 95%. Evaluasi stabilitas dari sediaan obat kumur meliputi pemeriksaan organoleptis, homogenitas dan pH yang dilakukan selama empat minggu penyimpanan pada suhu ruang menunjukkan hasil yang stabil.
Uji Aktivitas Antibakteri Ekstrak Etanol Bawang Dayak (Eleutherine palmifolia (L.) Merr) Terhadap Bakteri Staphylococcus aureus Warsiti, Warsiti; Wardani, Sisca Dwikusuma; Ramadhan, Ardea Achmad; Yuliani, Ratna
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.6526

Abstract

Staphylococcus aureus is an infectious bacteria with pus because of tissue damage. Infectious diseases caused by S. aureus include wound infections, ulcers, pimples, and impetigo. Dayak onions have the benefit of being antibacterial. This research aims to study the antibacterial activity of ethanolic extract of Dayak onions against  Staphylococcus aureus. The antibacterial study was carried out using the disk diffusion method. Identification of bacteria by Gram staining showed Gram-positive bacteria which can ferment mannitol with the mannitol test. A bacterial sensitivity test was conducted using three antibiotics i.e. cefoxitin 30μg, vancomycin 30μg, and linezolid 30μg. The bacteria was sensitive to all of the three antibiotics, with the inhibitory zone of 23.5 mm; 17 mm and 27.5 mm, respectively. Vancomycin 30μg was used as a positive control, resulted in average diameter of the inhibitory zone of 17.83  2.25 mm, whereas a control solvent DMSO (Dimethyl sulphoxide) did not produce zones. The ethanolic extract of Dayak onion in the concentration of 25%; 50%; 75% and 100% showed the average diameter of inhibitory zones of 8.17  0.29  mm; 10.67  1.44 mm; 10.33  1.53 mm; and 12.33  1.61  mm, respectively
Karakterisasi Fisik dan Aktivitas Antioksidan Masker Wajah Gel Pell Off Yang Mengandung Sari Buah Naga (Hylocerus polyrhizus) Ririn Setiawati; Anita Sukmawati
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.7245

Abstract

Damaged skin due to free radicals from ultraviolet radiation can be prevented using antioxidants. Red dragon fruit (Hylocereus polyrhizus) containing antioxidants can be made into a peel off gel face mask using gelatin as a gelling agent to be applied easily to the skin. The purpose of this study is to determine the effect of various gelatin concentrations on the physical properties and antioxidant activity of peel off gels containing red dragon fruit juice. The peel off gels face mask were made using various gelatin concentration i.e 7.5% w/w (F1); 10% w/w (F2); and 12.5% w/w and containing 10% w/w red dragon fruit. The peel off gels then evaluated for physical properties and antioxidant activity using DPPH. The result showed that the increasing of the gelatin concentration would increase the drying time and adhesive ability of the peel off gels. The escalation of gelatin concentration from 7.5% w/w (F1) to 10% w/w (F2) did not affect the spreading ability of the peel off gel. However, the spreading ability of the peel off gel decreased with the increasing concentration of gelatin from 10% w/w (F2) to 12.5% w/w (F3). The antioxidant test of peel off gel had an average percentage of inhibition of 9.101% (F1); 12.469% (F2); and 15.109% (F3). Based on the results of physical properties and antioxidant activity showed that formula 2 was recomended.
Uji Aktivitas Antijamur Gel Serbuk Lidah Buaya (Aloe vera L.) Berbasis Carbopol 934 Terhadap Candida albicans dan Trichophyton mentagrophytes Hani Afifah; Setyo Nurwaini
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.7658

Abstract

Fungal infections that occur in the skin and nails were caused by fungi such as Candida albicans and Trichophyton mentagrophytes. Aloe vera contains saponins and acemannan that were effective as an antifungal. This study aims to determine the effect of carbopol concentration variation on aloe vera gel to antifungal activity of Candida albicans and Trichophyton mentagrophytes.Aloe vera powder was obtained from freeze drying aloe vera juice which had been frozen. Aloe vera powder was formulated in gel form using carbopol base with concentration 0.5; 1.0; 1.5; and 2.0 %w/w. The aloe vera gel was tested for its physical properties and then tested the antifungal activity using the diffusion method of wells.The result of evaluation of physical properties showed the high concentration of carbopol then pH, viscosity, adhesiveness increased, and spreading capacity decreased. The results of antifungal activity test showed that aloe vera powder had activity on Candida albicans and Trichophyton mentagrophytes with inhibition zone of 15 ± 3 mm and 13 ± 0,5 mm. Aloe vera gel test results with variation of carbopol concentration 0.5; 1.0; 1.5; and 2.0 %w/w did not affect the antifungal activity of Candida albicans and Trichophyton mentagrophytes.
Uji Aktivitas Antibakteri Ekstrak Etanol Bawang Dayak (Eleutherine palmifolia (L.) Merr) Terhadap Bakteri Staphylococcus aureus Warsiti Warsiti; Sisca Dwikusuma Wardani; Ardea Achmad Ramadhan; Ratna Yuliani
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.6526

Abstract

Staphylococcus aureus is an infectious bacteria with pus because of tissue damage. Infectious diseases caused by S. aureus include wound infections, ulcers, pimples, and impetigo. Dayak onions have the benefit of being antibacterial. This research aims to study the antibacterial activity of ethanolic extract of Dayak onions against  Staphylococcus aureus. The antibacterial study was carried out using the disk diffusion method. Identification of bacteria by Gram staining showed Gram-positive bacteria which can ferment mannitol with the mannitol test. A bacterial sensitivity test was conducted using three antibiotics i.e. cefoxitin 30μg, vancomycin 30μg, and linezolid 30μg. The bacteria was sensitive to all of the three antibiotics, with the inhibitory zone of 23.5 mm; 17 mm and 27.5 mm, respectively. Vancomycin 30μg was used as a positive control, resulted in average diameter of the inhibitory zone of 17.83  2.25 mm, whereas a control solvent DMSO (Dimethyl sulphoxide) did not produce zones. The ethanolic extract of Dayak onion in the concentration of 25%; 50%; 75% and 100% showed the average diameter of inhibitory zones of 8.17  0.29  mm; 10.67  1.44 mm; 10.33  1.53 mm; and 12.33  1.61  mm, respectively
Reduksi Kadar Besi Dalam Air Sumur di Lingkungan Universitas Muhammadiyah Surakarta dengan Filter Hesti Pawarti; Lia Intan Citradewi; Aulia Tassya Fadhilla; Andi Suhendi
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.6527

Abstract

Iron was silvery white, clay, and can be formed.  it was usually obtained as hematite in nature. Iron was a chemical element that could be found in almost all places on the face of the earth, in all parts of the geological layer, and all bodies of water. In surface water, Fe was rarely found more than 1 mg / L, but in the water, Fe content could be much higher. When it accumulated in the body, iron could cause health problems, such as skin irritation, respiratory problems, and cause cancer in a long time. This study aims to determine the reduction of iron content in well water at the Universitas Muhammadiyah Surakarta (UMS) using the Spectrophotometry method with phenanthroline reagents. The samples were taken as many as five points in three different regions, namely Tanuragan (near the river), Menco and Nilasari (dense settlements), and Gonilan (near the rice fields) showed positive results containing iron with the highest levels in the sample without filtering at 9,478 ppm. These levels decreased after filtration using four filters, namely filters made of carbon, cotton, foam, carbon three layers in each sample. The iron content reduction was best to use cotton filters with 100% reduction in percent.
Uji Aktivitas Antibakteri Sediaan Obat Kumur Dari Ekstrak Etanol 70% Batang Sambung Nyawa (Gynura procumbens (Lour.) Merr.) Terhadap Bakteri Streptococcus mutans Dame Gurning; Dicki Nathaniel; Okpri Meila; Zuraida Sagala
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.5880

Abstract

Karies gigi merupakan suatu masalah pada mulut yang disebabkan oleh bakteri Streptococcus mutans, prevalensi karies gigi telah mencapai hingga 60% di Indonesia. Penggunaan obat kumur dinilai efektif, karena dapat membersihkan mulut sampai ke sela-sela gigi. Pada penelitian ini dilakukan uji aktivitas antibakteri sediaan obat kumur dari ekstrak etanol batang sambung nyawa (Gynura procumbens (Lour.) Merr.) terhadap bakteri Streptooccus mutans dengan seri konsenterasi ekstrak 2,5%; 5% dan 10%. Pengujian aktivitas antibakteri dilakukan dengan menggunakan metode difusi cakram. Uji aktivitas antibakteri ekstrak batang sambung terhadap bakteri Streptococcus mutans dilakukan sebagai uji pendahuluan dan hasilnya didapatkan Konsenterasi Hambat Minimum (KHM) terhadap pertumbuhan bakteri Streptococcus mutans ada pada konsenterasi ekstrak 2,5% dengan rata-rata zona hambatan sebesar 7,80 mm. Rata-rata zona hambat terhadap pertumbuhan bakteri Streptococcus mutans lebih tinggi dalam sediaan obat kumur dibandingkan dengan bentuk ekstrak yang masih murni, dikarenakan adanya beberapa bahan pada formulasi sediaan obat kumur yang dapat berfungsi sebagai agen antibakteri, seperti gliserin, menthol dan natrium benzoat. Zona hambatan terhadap pertumbuhan bakteri Streptococcus mutans meningkat seiring dengan meningkatnya konsenterasi dari ekstrak etanol batang sambung nyawa. Data zona hambat pertumbuhan bakteri dianalisis menggunakan One Way ANOVA dengan taraf kepercayaan 95%. Evaluasi stabilitas dari sediaan obat kumur meliputi pemeriksaan organoleptis, homogenitas dan pH yang dilakukan selama empat minggu penyimpanan pada suhu ruang menunjukkan hasil yang stabil.

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