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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 14 Documents
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Search results for , issue "Vol 19, No 2 (2022)" : 14 Documents clear
Formulation of Nifedipine–Polyvinyl Pyrrolidone (PVP) Solid Dispersion System and Intrinsic Dissolution Rate Evaluation Riza Maulana; Henry Harto; Tiara Dewi Salindri Pratama
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 2 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i2.20545

Abstract

Nifedipine is a drug that acts as an antihypertensive and anti-angina. Nifedipine is known as a drug with poor water solubility. This characteristic will affect the intrinsic dissolution rate so that it can affect the absorption process and reduce the amount of drug that reaches systemic circulation. One of the strategies to increase the intrinsic dissolution rate is developing nifedipine to solid dispersions form. This study aims to observe the intrinsic dissolution rate of nifedipine after it has been made into a solid dispersion. Four samples were prepared, including three solid dispersions of nifedipine-PVP K-30 and one sample of pure nifedipine. The results of the intrinsic dissolution tests are then interpreted through the intrinsic dissolution rate constant (G). The solid dispersions with concentration of nifedipine-PVP K-30 90%:10%; 75%:25%; 60%:40% (w/w), and pure nifedipine produced G values of 3.63; 9.33; 12.63; and 2.08 µg/mm2. min1, consecutively. It shows that the formulation of nifedipine-PVP K-30 solid dispersions has higher G values than pure nifedipine. In addition, increasing PVP K-30 concentration up to 40 % (w/w) can increase the intrinsic dissolution rate of the nifedipine-PVP K-30 solid dispersion system.
Analisis Perbedaan Kejadian Ikutan Pasca Imunisasi (KIPI) Vaksin Coronavac Dosis Pertama dan Kedua pada Masyarakat Provinsi Jawa Tengah Arifin Santoso; Indriyati Hadi Sulistyaningrum; Fildza Huwaina Fathnin; Atma Rulin Dewi Nugrahaeni; Abdur Rosyid; Syifa Audina Banin
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 2 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i2.19746

Abstract

Adverse events following immunization (AEFI) for the coronavac vaccine are still widely found in Indonesia, especially in Central Java that happened in the first and second dose. The purpose of this study was to determine the difference between AEFI of the first and second dose of coronavac vaccine among recidents in Central Java. This cross-sectional study used a questionnaire with respondents from the recidents of central Java who carried out the first and second dose of coronavac. Statistical descriptive analysis, then an analysis of the differences of AEFI of the first and second dose of coronavac was carried out with dependent sample t-test. The results showed that the most common AEFI of coronavac were muscle pain at the first dose (11,2%) and the second dose (9,2%), followed by lethargy at the first dose (10,1%) and the second dose (8,3%), then pain accompanied by weakness in the arm injected at the first dose (8,8%) and the second dose (8,6%), and the swelling at the injection site at the first dose (7,5%) and the second dose (7,7%). There was no significant difference between AEFI that occurred after coronavac vaccination at the first and second dose as indicated by p value 0,320 (p 0,05).
Front Matters Vol.19, No 2, 2022 Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 2 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i2.21249

Abstract

Kajian Interaksi Antar Obat Terhadap Profil Glikemik Pada Pasien Diabetes Rawat Inap Rumah Sakit Islam Sultan Agung Semarang Willi Wahyu Timur; Rikma Eliya Ussa; Naniek Widyaningrum
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 2 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i2.18583

Abstract

Drug interactions are conditions when the use of drugs can affect the effects of other drugs pharmacokinetic or pharmacodynamically. Effects caused by interactions between drugs in the form of expected effects or adverse effects for patients. In general, drug interactions occur in patients with diabetes mellitus because they receive treatment therapy for more than one kind of drug, so there is a chance for interactions that will interfere with controlling sugar levels. This study aims to see the relationship between drug interactions with blood sugar levels. This type of research is observational with a descriptive analytic design using retrospective data collection. The population in this study were all inpatients with diabetes mellitus without or with comorbidities of Hypertension, Dyslipidemia, Dyspepsia, Congestive Heart Failure, and Coronary Artery Disease at Sultan Agung Islamic Hospital, Semarang. Samples were taken from as many as 51 patients with the purposive sampling technique. Data was collected by collecting inpatient medical records. Statistical analysis using the Chi-Square test. Based on statistical analysis, it was found that the p-value of 0.001 can be concluded that there is an interactive relationship between drugs and blood sugar levels in inpatients with diabetes at Sultan Agung Islamic Hospital, Semarang.

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