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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 16 Documents
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Search results for , issue "Vol 19, No 1 (2014)" : 16 Documents clear
FLAVONOID PROFILE OF Clitoria ternatea Linn Selvamaleeswaran Ponnusamy; Wesely Ebenezer Gnanaraj; Johnson Marimuthu Antonisamy
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (815.418 KB) | DOI: 10.22146/tradmedj.8083

Abstract

The present study was aimed to reveal the flavonoid profile of Clitoria ternatea L leaves, stem and seeds using the HPTLC analysis. The powdered leaves, stem and seed samples were extracted with 150 mL of methanol for 8-12 h by using the Soxhlet apparatus. The Ethyl acetate-butanone-formic acid-water (5:3:1:1) was employed as mobile phase for flavonoids. The developed plate was sprayed with 1% ethanolic aluminium chloride as spray reagent and dried at 100°C in hot air oven for 2min. The plate was photo-documented at UV 366 nm and daylight using Photo-documentation chamber.The methanolic extract of stem, leaves and seeds of Clitoria ternatea showed the presence of 24 bands with 18 different Rf values with range 0.01 to 0.96.  Out of 24 bands, 10 bands with seven Rf values viz., 0.04, 0.10, 0.28, 0.37, 0.49, 0.65 and 0.85 were idenified as flavonoids, the other bands were noted as unknown metabolites. Developed HPTLC chromatogram of Clitoria ternatea methanolic extracts of vegetative and reproductive parts could be used efficiently for identification, and quality assessment of the plant in the pharmaceutical industries. These profiles may used as chemical marker to solve plant systematic problems.
EFEK HIPOURISEMIA EKSTRAK ETANOL AKAR TUMBUHAN TUNJUK LANGIT (Helminthostachys zaylanica Linn Hook) TERHADAP MENCIT JANTAN GALUR SWISS Fitrya Fitrya; Muharni Muharni
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (866.831 KB) | DOI: 10.22146/tradmedj.8085

Abstract

Tunjuk langit (Helminthostachys zeylanica) rhizome has been used as traditional medicines. i.e. anticancer and antiinflammation. Other studies revealed that the rhizome of tunjuk langit has antioxidant, anticancer, neuroprotective and anti-inflammatory effects. The main purpose of this research is to understand the hipouricemia potency of ethanol extract of tunjuk langit compared to that of alopurinol. In this study, 50 mice were divided into 10 groups (n=5 per group). Group I: normal group (CMC-Na 0.5% with dose of 10 mL/kg BB), Group II : negative control, Group III-VI : positive control (alopurinol with doses of 5, 10, 20 and 40 mg/kg BB) and VII-X : Ethanol extract with doses of 20, 40, 80, and 160 mg/kg BB. These groups were treated for 30 days. The uric acid level of their blood was measured on the day-0 and these groups were then inducted with a mixture of chicken liver juice (25 ml/kg BW 2 times/days) and  Gnetum gnemon seeds (2g/kg BW per day) from day-0 until day-30. The blood uric acid levels were measured on the 10th and 15th days. Extract tests were orally injected to the groups with each dose starting from the 15th day until 30th day. Meanwhile, chicken liver juice was also still given constantly within these days. The uric acid level and the percentage of its degradation of each group were measured on the 20th, 25th and 30th days. Based on the in vivo study, it could be concluded that the ethanol extract of Tunjuk langit has hipouricemia potency. The hipouricemia effects of ethanol extract with doses of 80 and 160 mg/kg BW are 91.95% and 91.77% compared to those of allopurinol with doses of 20 and 40 mg/kgBW, respectively. Based on relation between percentage of the degradation uric acid level and the extract concentration, ED50 value of the extract is 135.76 mg/kg BW.
AKTIVITAS SITOTOKSIK EKSTRAK ETANOLIK DAUN ALPUKAT (Persea americana Mill.) PADA SEL KANKER LEHER RAHIM HeLa Ana Mardiyaningsih; Nur Ismiyati
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (697.394 KB) | DOI: 10.22146/tradmedj.8087

Abstract

Cervical cancer is one of the most common cancer in women. The high mortality rate indicates that chemotherapy has not overcome cancer disease. Strategies and development of cervical cancer treatment should be pursued. Avocado leaf (Persea americana Mill) is one of natural product that had antioxidant activity by scavenging radicals and cytotoxic activity. The aim of the study was to identify the cytotoxic activity on HeLa cervix cancer cells and to identify the chemical subtance groups of avocado leaves ethanol extract as chemopreventive agent. Active contents of avocado leaves was extracted by maceration with 96% ethanol. Chromatographic test were done to identify the chemical substances of avocado extract. Cytotoxic activity of avocado leaves ethanol extract was measured using MTT assay. The result of the phytochemical screening with thin layer chromatography test showed that the extract of avocado leaf contained flavonoids, alcaloids, and saponin. Avocado leaves ethanol extract inhibited HeLa cell growth with the IC50 of 360 µg/mL. Morphology of Hela cell showed that extract inhibited cell growth in dose dependent.
OPTIMASI EKSTRAKSI AMPAS TEH HIJAU (Camellia sinensis) MENGGUNAKAN METODE MICROWAVE ASSISTED EXTRACTION UNTUK MENGHASILKAN EKSTRAK TEH HIJAU Dwi Handayani; Abdul Mun’im; Anna S. Ranti
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1040.214 KB) | DOI: 10.22146/tradmedj.8088

Abstract

Indonesia has a great wealth of biodiversity, but unfortunately the natural resources has been little studied and used in the therapy. One of the plants, grown in Indonesia is tea. Tea waste is waste from the tea industry, is quite a lot and has not been used optimally. This study aims to obtain the most effective green tea waste extraction conditions using MAE (Microwave Extraction Assisted) to produce green tea extract that has antioxidant optimum. From the research, the optimum MAE conditions are 450 W power, 60% ethanol, solid solvent comparison 1: 8 and 8 minutes extraction to produce extracts with optimum levels of polyphenols. Extracts obtained have moisture content of 7.83%, pH 5.5, and total polyphenols, total flavonoids, gallic acid, catechin, EGCG and caffeine respectively by 7.1%, 1.04%, 2.76%; 0.83%, 5.18% and 1.03%. Compared with the existing reference, extracts obtained qualify as cosmetic raw materials.
EFEK PENGHAMBATAN EKSTRAK N-HEKSANA BUAH MENGKUDU (Morinda citrifolia L.) TERHADAP REAKSI ANAFILAKSIS KUTANEUS AKTIF PADA TIKUS WISTAR YANG DIINDUKSI VAKSIN HEPATITIS B Ediati Sasmito; Agung Endro Nugroho; Yose V. Sagala
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (896.869 KB) | DOI: 10.22146/tradmedj.8089

Abstract

Noni (Morinda citrifolia L.) is one of medicinal plants that are  commonly known for its medical treatment usage. Noni is reported for the pharmacological effects, including analgesic, antihypertensive and immunomodulator. This research aims to prove that the n-hexane extract of noni fruits can inhibit active cutaneous anaphylaxis reaction in male wistar rats induced hepatitis B vaccine. This research used an active cutaneous anaphylaxis methode followed by hystopathological observation. Active cutaneous anaphylaxis test was done for 2 weeks. Test animals were divided into five groups: untreated control, treatment with n-hexane extract of noni dose of 50mg, 100mg dan 200mg/kgBW rats, and cromolyn treated group with dose of 2. mg/kg BW rats as positive control.  Animals were sensitized 2times (once every week) with hepatitis B vaccine (dose of 145µg/kgBW) subcutaneously on the back. In the second week, random four rats of each groups were sacrificed and the skin tissues and livers were taken. Tissues were created as histopathology preparations with hematoxyllin-eosin coloring. The presence of anaphylaxis reactions, shown by inflammatory cell infiltration, were observed from the histopathology preparations. The result of this research showed that the administration of n-hexane extract of noni fruits treatment dose of 50mg, 100mg, and 200mg/kgBW on male Wistar rats induced hepatitis B vaccine can inhibit active cutaneous anaphylaxis reaction.
PERBANDINGAN METODE EKSTRAKSI DAN VARIASI PELARUT TERHADAP RENDEMEN DAN AKTIVITAS ANTIOKSIDAN EKSTRAK KUBIS UNGU (Brassica oleracea L. var. capitata f. rubra) Rima Yulia Senja; Elisa Issusilaningtyas; Akhmad Kharis Nugroho; Erna Prawita Setyowati
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1042.505 KB) | DOI: 10.22146/tradmedj.8090

Abstract

Red Cabbage (Brassica oleracea L. Var. Capitata f. rubra) has a high anthocyanin content therefore it can be potential as a natural antioxidant. In this research, the antioxidant activity of the red cabbage extract was evaluated quantitatively with a spectroscopy method using DPPH reagent to obtain the value of IC50 . This research was divided into 2 stages. First, the influence of solvent variant to the extract yield of red cabbage powder and the maximum wavelength (λ) using a maceration protocol. The kind of solvent (70%, 80%, 95%, and 96% of ethanol) with addition 3% of citric acid. Second, the influence of extraction methods in neutral condition to the antioxidant activity. The results show the red cabbage powder maceration with 96% ethanol solvent (acid condition) exhibits  the highest yield. The fresh red cabbage soxhletation with 96%  ethanol (neutral condition) exhibits 288,5 nm maximum wavelength (λ) and 168,78 mg/mL of IC50 value.

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