Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Majalah Obat Tradisional

TradMedJ
Website

Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

Arjuna Subject : -

Articles 8 Documents

Search results for , issue "Vol 21, No 1 (2016)" : 8 Documents clear

PENGARUH SUHU PENGERINGAN GRANUL KOMBINASI MINYAK SERAI DAPUR - DAUN JERUK PURUT TERHADAP JUMLAH KEHILANGAN MINYAK DAN AKTIVITAS LARVASIDANYA Sri Mulyani; Annisa Khoiri Z.; M. Syafii Nusri
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Granules of lemongrass and kaffir lime oil are reported to have larvicidal activity against the mosquito Aedes aegypti, with LC50 of 38.30ppm and 39.58ppm, while LC90 of 51.57ppm and 79.43ppm respectively. During the manufacture of granules, loss of oil are reported by 64.20% to 65.91% for lemongrass and kaffir lime oil. This research aims to make granules combination from lemongrass and kaffir lime oils by varying the temperature of the drying granules and testing its larvicidal activity against Ae. aegypti. Oil combination is selected by using analysis simplex lattice design, and the combination chosen is made of granules, in drying room temperature for 24h, a temperature of 50°C for 2h 30min and a temperature of 70°C for 1h. Larvicidal activity testing against larvae of Ae. aegypti is done by using the third instar larvae 20 for each granule solution made in 5 series of concentration, and left exposed for 24h. The number of deaths of larvae is calculated and analyzed by modified probit analysis Finney to determine LC50 and LC90. The results showed the combination lemongrass-kaffir lime oil is selected ratio of 9:1, and drying the granules with a temperature of 70°C for 1h produces the greatest larvicidal activity with 63.17ppm LC50 and LC90 of 85.04ppm.

OPTIMASI KOMPOSISI ETANOL-AIR SEBAGAI CAIRAN PENYARI DALAM PRODUKSI EKSTRAK KERING DAUN SAMBUNG NYAWA [Gynura procumbens (Lour.) Merr.)] Tantri Lilis Nareswari; Triana Hertiani
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Sambung Nyawa leaves (Gynura procumbens (Lour.) Merr has been widely used as herbal medicine which requires a quality improvement of the dry extract for industrial production. Extraction solvent optimization is one key factor which determines the quality. This research aims was to find out the optimal ethanol-water composition as extraction solvent by using Simplex Lattice Design (SLD) method of which the total phenolics, total flavonoids and DPPH radical scavenging activity were used as quality parameters. Dried leaves as raw materials were pulverized and screened at Mesh 60, macerated (1:5) with ethanol-water compositition as 1:0; 0.7:0.3; and 0.5:0.5 v/v, shaked for 24 h, filtered. The procedure was repeated twice. Filtrates were collected of which lactose were added (1:2)w/w and spray dried at 100C for 30 min. Dried extracts yielded were evaluated the quality by using SLD method of which the total phenolics, total flavonoids as well as DPPH radical scavenging activity were used as parameters. Optimal SLD response was revealed at the ethanol:water composition of 0.66:0.34 – 0.75:0.25 v/v (Rtotal>0.9). No significant difference of the above mentioned parameters between the values resulted from the experiment and SLD formula. Correlation analyses of total phenolics and total flavonoids towards DPPH-radical scavenging activity were found as 95.29% and 1.25%, respectively.

EVALUASI SIFAT FISIK DAN DAYA IRITASI SEDIAAN LOTION MINYAK ATSIRI BUNGA CENGKEH (SYZIQIUM AROMATICUM) DENGAN BERBAGAI VARIASI KONSENTRASI Fadzil Latifah; Nining Sugihartini; Tedjo Yuwono
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

In this study, the lotion contained essential oil of clove Syzigium a romaticum which contained eugenol as the active ingredient. Eugenol has been scientifically proven as anti-inflammatory. Because its activity, the study about development of dosage form is needed. Aims of this study was to know the physical properties of spreadibility, adhesivity, pH, viscosity and irritation index of lotion with variation concentration of essential oil.Thisstudywasstartedwithaformulationoflotionwith variationconcentrationofessentialoil5%(FI); 10% (FII); 15% (FIII). Lotion was evaluated physical properties with parameters spreadibility, adhesivity, viscosity and pH. The evaluation of iritation index was done using guinea pig test animals. Data were analyzed statistically with One Way Anova at confidence level of 95% to detect a significant difference between the treatment groups. The results of the study showed the variation consentration did not influence pH the increasing concentration caused a decreasing spredibility P<0.05 and increasing adhesivity P<0.05. The all of concentration did not irritated the skin of guinea pigs.

ANALISIS SIDIK JARI KROMATOGRAM Stevia rebaudiana SECARA HIERACHIAL CLUSTER ANALYSIS (HCA) DAN PRINCIPAL COMPONENT ANALYSIS (PCA) Yohanes Martono; Sugeng Riyanto; Sudibyo Martono; Abdul Rohman
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Bioactivity herbal plant is influenced by its active compounds and consistency. Stevia rebaudiana contains bioactive compounds, diterpene glycosides which have antidiabetes activity. The goal of this study was to develop fingerprints analysis of S. rebaudiana based on High Performance Liquid Chromatography (HPLC) chromatogram. S. rebaudina leaves were taken from different planting area, leave ages, and seeds source. S. rebaudiana leaves were analyzed using isocratic Reversed Phase High Performance Liquid Chromatography (RP-HPLC). Fingerprints analysis of S. rebaudiana was done using chemometrics of Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA). Peak marker “common peak” were identify using Cluster Observation in HCA analysis at each peaks retention time formed in chromatogram. Retention times giving similarity value more than 0,90 were identified as “common peak”. HCA analysis resulted in 5 “common peak” identification as peaks marker particularly at peak no 1, 2, 4, 6 and 7. HCA analysis was also clustered samples into 3 main cluster. PCA analysis was optimized by calculated peak area whose N > 2000 particularly peak no 4, 6, and 7. PCA analysis result can be used to classify chromatogram based on original seeds, planting area and leave ages. Fingerprints analysis developed can be used an alternative method for quality control of S. rebaudiana herbal plants based on its bioactive compounds systemic characteristics.

STANDARDISASI KUALITAS EKSTRAK BATANG BROTOWALI (Tinospora crispa) Harwoko Harwoko; Nur Amalia Choironi
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Brotowali (Tinospora crispa) has been traditionally used for the treatment of gout and scientifically reported as analgesic, anti-inflammatory, and antihyperuricemic agents. Tinospora crispa stem is one of herbal medicine material that its quality should be standardized. This study aims to determine the quality parameters of the T. crispa ethanolic extract included specific and non-specific parameters. Brotowali stem were macerated using ethanol 70%, then the non-specific parameters such as the water content, total ash, total contaminant number of bacteria and fungus were determined. The specific parameters including organoleptic properties, water soluble extract, ethanol soluble extract, and the thin layer chromatography (TLC) profile have also been determined. The parameter values were compared to the qualification of traditional medicine from Department of Health (Depkes R.I.). The result showed that T.crispa stem ethanolic extract has the water content was 8.12±0.06% and the total ash was 5.20 ± 0.12%. The microbiology results showed that the total contaminant of bacteria as much as 5 x 102 CFU/g and fungus as much as 5 x 103 CFU/g. This extract was brown viscous extract, bitter taste and characteristic odor with water soluble fraction was 45.09 ± 0.67% and ethanol soluble fraction was 14.19 ± 0.14%. The TLC profile of ethanolic extract indicates the existence of flavonoids and alkaloids. Total flavonoids of brotowali extract (32.65 ± 0.20%) rutin equivalent.

PENGARUH HIDROLISIS ASAM-BASA TERHADAP AKTIVITAS PENANGKAPAN RADIKAL 2-2’ DIFENIL-1-PIKRIL HIDRAZIL (DPPH) FRAKSI AIR DARI EKSTRAK ETANOLIK BUAH TALOK (Muntingia calabura L.) Tatang Irianti; Yosi Bayu Murti; Damiana Nitya Kanistri; Desi Riza Pratiwi; Kuswandi Kuswandi; Ratih Anggar Kusumaningtyas
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The investigation of talok fruits (Muntingia calabura L.) was shown the antioxidant activity of aqueous fraction of the ethanolic extract is relatively low. Hydrolysis treatment has increased the antioxidant activity by releasing the flavonoid aglycone from glycoside form. This study aims to determine the effect of acid and alkaline hydrolysis, and hydrolysis time on the antioxidant activity of aqueous fraction of calabura fruits ethanolic extract. The antioxidant activity of acid hydrolyzed aqueous fractions in 1 and 3h hydrolysis, respectively 9.5 and 1.5 times more potent than the aqueous fraction, while the alkaline in 1 and 3h hydro-lysis were 2.5 and 6.5 times. Flavonoid aglycone liberated on acid hydrolysis and alkaline had different anti-oxidant activity. The value of IC50 by acid hydrolyzed aqueous fraction in 1h and 3h hydrolysis of 20.55 and 97.88μg/mL, while the alkaline in 1h and 3h hydrolysis of 66.64 and 25.53μg/mL. One hour acid hydrolysis had antioxidant activity greater than 3h whereas in alkaline the greatest antioxidant activity is shown in 3h.

UJI TOKSISITAS AKUT EKSTRAK ETANOL KELOPAK ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS Sprague Dawley Fita Sari; Nurkhasanah Nurkhasanah; Moch. Saiful Bachri
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Roselle (Hibiscus sabdariffa L.) was used as a traditional medicine because it has antioxidant activity. Traditional medicine used to treat a disease should consider the safety aspects through the toxicity tests. This study aims to determine the acute toxicity of the ethanolic extract from the calyx of Hibiscus sabdariffa L., activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and hepar histopathology in Sprague Dawley (SD) rats. Acute toxicity tests was done by orall administration of single dose ethanolic extract at dose 40, 200, 1000 and 5000 mg/kg BB. The test was observed during 14 days post treatment. The activity of AST, ALT and ALP were measured by specthrophotometer UV-Vis Diasys® method. The results showed that LD50 of ethanolic extract of calyx roselle was found at 850,90 mg/kg BW, the activity of AST, ALT, ALP did not different significantly in the treatment to be and control group (p <0.05) and histopathological data found structural change and tissue in hepar. Tthe delayed toxic effects until day 14 was also not found. These research found that ethanolic extract of calyx roselle was toxic SDrats.

KANDUNGAN VITAMIN C, VITAMIN A DAN ALPHA HYDROXY ACID DALAM BENGKOANG (Pachyrhizus Erosus) Ardian Widyatmoko; Dwi Hastutik; Ari Sudarmanto; Endang Lukitaningsih
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Bengkoang or Pachyrhizus erosus has been used as a traditional cosmetic material since many years ago. Until now, many cosmetic preparations using bengkoang as a main material have been produced by cosmetic industries, mainly for skin care, whitening and sunscreen preparation. However, content of vitamin A, vitamin C and alpha hydroxyl acid has not been discovered yet. These compounds are essential in skin care process because of their activities in cell regeneration, antioxidant as well as peeling of dead skin cell layer. The aim of this research is to provide information about the content of three compounds in bengkoang. Vitamin A has been analysed by spectrophotometer, vitamin C analysed using titration method and alpha hydroxyl acid analysed using gas chromatography. The result showed that concentrations of vitamin A and vitamin C are 179.21 ± 8.19 ppm and 0.31 ± 0.06 %, respectively. Meanwhile the content of alpha hydroxyl acid was 0.80 ± 0.01% (measured as glycolic acid).

Page 1 of 1 | Total Record : 8

Filter by Year

2016 2016

Filter By Issues

All Issue Vol 30, No 2 (2025) Vol 30, No 1 (2025) Vol 29, No 3 (2024) Vol 29, No 2 (2024) Vol 29, No 1 (2024) Vol 28, No 3 (2023) Vol 28, No 2 (2023) Vol 28, No 1 (2023) Vol 27, No 3 (2022) Vol 27, No 2 (2022) Vol 27, No 1 (2022) Vol 26, No 3 (2021) Vol 26, No 2 (2021) Vol 26, No 1 (2021) Vol 25, No 3 (2020) Vol 25, No 2 (2020) Vol 25, No 1 (2020) Vol 24, No 3 (2019) Vol 24, No 2 (2019) Vol 24, No 1 (2019) Vol 23, No 3 (2018) Vol 23, No 2 (2018) Vol 23, No 1 (2018) Vol 22, No 3 (2017) Vol 22, No 2 (2017) Vol 22, No 1 (2017) Vol 21, No 3 (2016) Vol 21, No 2 (2016) Vol 21, No 1 (2016) Vol 20, No 3 (2015) Vol 20, No 3 (2015) Vol 20, No 2 (2015) Vol 20, No 2 (2015) Vol 20, No 1 (2015) Vol 20, No 1 (2015) Vol 19, No 3 (2014) Vol 19, No 3 (2014) Vol 19, No 2 (2014) Vol 19, No 2 (2014) Vol 19, No 1 (2014) Vol 19, No 1 (2014) Vol 18, No 3 (2013) Vol 18, No 3 (2013) Vol 18, No 2 (2013) Vol 18, No 2 (2013) Vol 18, No 1 (2013) Vol 18, No 1 (2013) Vol 17, No 3 (2012) Vol 17, No 3 (2012) Vol 17, No 2 (2012) Vol 17, No 2 (2012) Vol 17, No 1 (2012) Vol 17, No 1 (2012) Vol 16, No 3 (2011) Vol 16, No 3 (2011) Vol 16, No 2 (2011) Vol 16, No 2 (2011) Vol 16, No 1 (2011) Vol 16, No 1 (2011) Vol 15, No 3 (2010) Vol 15, No 3 (2010) Vol 15, No 2 (2010) Vol 15, No 2 (2010) Vol 15, No 1 (2010) Vol 15, No 1 (2010) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Pudyastuti Kusumaningrum

Contact Email
mot.farmasi@ugm.ac.idm

Phone
-

Journal Mail Official
mot.farmasi@ugm.ac.id

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Pudyastuti Kusumaningrum

Contact Email mot.farmasi@ugm.ac.idm

Phone -

Journal Mail Official mot.farmasi@ugm.ac.id

Editorial Address -

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Pudyastuti Kusumaningrum

Contact Email
mot.farmasi@ugm.ac.idm

Phone
-

Journal Mail Official
mot.farmasi@ugm.ac.id

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA