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INDONESIA
Indonesian Journal of Cancer
Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)
ISSN : 19783744     EISSN : 23556811     DOI : -
Core Subject : Health,
Health Professions
The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.
Arjuna Subject : -
Articles 14 Documents
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Search results for , issue " Vol 8, No 1 (2014): Jan - Mar 2014" : 14 Documents clear
Case Report of Malignant Lymphoma of the Breast ASHARIATI, AMI; DJATMIKO, ARIO; ALI, ISKANDAR
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Four cases of breast malignant lymphoma (BML) are discussed, diagnosed and managed. The issue of diagnosing BML, showed how different these 4 cases were, in particular in the imaging ultrasonography (USG). Generally, the USG of ductal carcinoma is irregular solid mass, while the USG of BML is compliant with cystic forms. Case 1 is 68 years old woman with left breast tumor. USG revealed hypoechoic lesion in the left breast with FNA result of malignant lymphoma, but still differential diagnosis with ductal carcinoma of the breast Mamma. Case 2 is a 52 years old woman who had left breast tumor. The USG revealed malignant lesion, left axilla node positive, although FNA result was ductal carcinoma, after simple mastectomy, the frozen section revealed malignant lymphoma. Case 3 is a 51 years old woman, USG of the left breast revealed malignant lesion, left axilla node positive, and excision biopsy revealed non-Hodgkin’s lymphoma diffuse large cell. Case 4 is a 51 years old woman, the USG revealed irregular hypoechoic lesions in both breasts and left supraclavicula node 5 mm. Core biopsy revealed bilateral breast non Hodgkin’s lymphoma subcutaneous, T-cell lymphoma. The therapeutic management of breast lymphoma is controversial and is not fully established yet. A strategy consisting of three cycles of CHOP followed by involved-field radiation therapy is reportedly superior to eight cycles of CHOP alone.
Diffuse Large B Cell Lymphoma, Bilateral Lower Extremity Lymphedema, and Ulcerated Inguinal Lymph Node LUGITO, NATA PRATAMA HARDJO; KURNIAWAN, ANDREE; YANTO, THEO AUDI
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Lymphedema (LE) is a chronic medical condition characterized by lymphatic fluid retention, resulting in tissue swelling. There are two general classifications of LE; primary and secondary which are based on two mechanisms; lymphatic obstruction and lymphatic interruption. The most common cause of LE in the developing world is secondary to an infection known as filariasis. Cancer including Hodgkin and non-Hodgkin lymphomas; and its treatment are some causes of secondary LE. LE also could maintain the persistence of an occult localization of lymphoma. This case illustration describes a female, 57 year-old with stage II lymphedema of both legs, bilateral inguinal lymphadenopathies that were biopsied. The filarial blood examination was negative. Biopsies showed diffuse large B-cell lymphoma.
Pengaruh Autoclave terhadap Properti Fisik dan Histopatologi Tulang: Sebuah Penelitian Dasar Rekonstruksi WIRATNAYA, I GEDE EKA; KAMAL, ACHMAD FAUZI; PATTIATA, RINO
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Background: Autoclave autograft is a promising alternative procedure in surgical treatment of bone tumors. A minimum effective autoclaving time of 15 minutes at 134°C to devitalise tumour cells. This study aims to know the effect of autoclave to physical properties and histopathology of bone.Methods: We performed experimental study in 28 femoral bone of goat (Capra Aergagus circus) at age 1?2 year old. We divide into two groups with simple random sampling to be 14 autoclave and 14 control group. Autoclaving was performed to the bone at 134°C for 15 minute. We examined physical properties each 7 autoclave group to axial and bending force compared with physical properties of the control group. We also examined histopatology of the bone both groups. Independent t-test statistical analysis to evaluate the difference of axial and bending force between autoclave and control group.Results: There were significant difference between autoclave and control group in axial force (p = 0.000) and bending force (p = 0.03). Physical properties of autoclave bone decreased 58.58 % in axial force and 20.33% bending force to control group. Histopathology examination revealed that all osteocytes were death in autoclave group but without matrix changes.Conclusion: Autoclave at 134°C for 15 minute caused physical properties of bone decrease and statistically significant difference. It also made all osteocytes died but without matrix disturbance.
Peran Asam Klorogenat Terhadap Ekspresi Gen; miRNA 146 A, Caspase 3, Cyclin D1, dan Kematian Sel Kanker Hepatoseluler Model Cell Lines Hep-G2 SUKOHAR, ASEP; HERAWATTI, HENING; WITARTO, ARIEF B
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Chlorogenic acid (CA) is the active compound isolated from medicinal plants, can be used as a chemopreventive agents of hepatocellular cancer (HCC). It works as an exogenous antioxidant and inhibit growth of cancer cells through the inhibition of free radicals. The purpose of this study is to know mechanism of CA in inhibition to growth of Hep-G2 through apoptosis stimulation. In vitro study was performed Hep-G2 cells. The samples were divided into the control group treatment and experiment group expose to 727, 500 and 250 ?M and 3 times repetition. Expression of miRNA 146 A, caspase 3 and cyclin D1 examined by RT-PCR CFX-96. Samples were analysed at 0, 8, 18, and 24 hours after exposure CA. The data were statistically tested by repeated measurement, pearson, and multivariate regression. The results showed that cell death of Hep-G2 were increase as the dose increase and time, at 8 hours after exposure CA cell death of Hep-G2 increased as much as 35,68, 37,75, 40,86%. At 18 hours cell death of Hep-G2 increased as much as 54,56, 56,48, and 59,73%. At 24 hours cell death of Hep-G2 increased as much as 67,73, 69,37, and 72,16%. The lowest expression miRNA 146 A in group 24 hours after exposure at doses of 727 ?M CA (0,85), followed by 500 ?M (1,28) and the highest expression at a dose of 250 ?M (1,61). The result of repeated measurement test: miRNA 146 A and caspase 3 at 8th and 18th hours was significantly different to the 24th with p<0.05. The expression of caspase 3 increase from 0-24 hours, the highest expression of caspase 3 in group 18 hours after exposure at doses CA at 750 ?M (3,86). After 18 hours, expression caspase 3 decreased and the lowest in group 24 hours after exposure: at a dose of 250 ?M (1,52). Expression of cyclin D1 decrease from 0-24 hours with the highest expression at 0 hours (4,35) at a dose of 250 ?M and the lowest expression at 24 hours after exposure to CA (0,32) at a dose of 727 AK ?M.
Hubungan Invasi Pembuluh Limfe Dengan Metastasis ke Kelenjar Getah Bening Pelvis pada Kanker Serviks Stadium IB dan IIA HUTAPEA, MANUEL; -, SUHATNO; FAUZIAH, DYAH
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Objective: to know the result of Hematoxyllin-eosin and immunostainning D2-40 Podoplanin examination in detecting lymph vessel invasion (LVI) and to analyze correlation between lymph vessel invasion with pelvic lymph node metastasis in stage IB and IIA cervical cancer. Design of this research was cross-sectional study. The clinicopathological data of 41 patients with stage IB and IIA cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy (RHPL) at Dr. Soetomo Hospital, Surabaya, from January 2008 to June 2013 were retrospectively reviewed. Age, histology type, clinical stage, tumor size, number of removed pelvic lymph node, parametrial invasion and LVI were analyzed to define their correlation with pelvic node metastases. Immunohistochemical staining using MAb-D2-40 Podoplanin was used to detect lymph vessel invasion on the corresponding HE slides. Eligible criteria are paraffin wax embedded tissue from cervix cancer patients was diagnosed as cervix cancer, and patient’s medical record can be found and filled completely. Ineligible criteria are patients which is had chemotherapy or radiotherapy before surgery or patient’s paraffin wax embedded tissue was damaged. The correlation among variables was analyzed using Phi correlation test. Results: among of total 41 patients , lymph vessel invasion (LVI) was detected in 7 (17.07%) D2-40 Podoplanin slides, and 9 (21.95%) HE slides. Agreement rate with Kappa statistic between two method was significant, k = 0,381, p = 0,014. Lymph node metastasis was found in 6 (14.63%) samples. Positive LVI detected by D2-40 Podoplanin was significantly correlated with lymph node metastasis (? = 0.362; p = 0.02), but positive LVI detected by HE was not significantly correlated (? = 0.281; p = 0.072).
Faktor yang Berhubungan dengan Terinfiltrasinya Areola dan Papilla pada Karsinoma Payudara Operabel HERIADY, YUSUF; ACHMAD, DIMYATI
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Mastectomy is one of the most frequent surgery performed for operable breast cancer and included resection of the nipple-areola complex (NAC). The risk of local recurrence behind the nipple areolar complex (NAC) is the main limitating of the nipple-sparing mastectomy (NSM) procedure. The aim of this study is to investigate the incidence and to determine associated risk factors with cancer infiltration to nipple-areola complex (NAC) in operable breast cancer patients. This is an observational analytic, cross sectional study using retrospective medical record of patients with mastectomy, at Soedarso Hospital Pontianak from 2006 to 2013. Results: In a period of 7 year, we included 310 patients, the mean age is 47,3 years (24-78 years). The NAC involvements 30,6%. In bivariate analysis showed that age, tumor size, tumor stage, lymh node status, lymvovascular invasion and tumor distance are associated with NAC involvement. In the multivariate analysis showed that only lymh node status (p = 0,001; prevalence odds ratio [POR], 1.52; 95% confidence interval [CI], 1.18?1.95), tumor distance (p<0.001; POR, 0.47; CI, 0.36?0.61) and tumor size (p = 0.012; POR, 2.05; CI, 1.17?3.60) are the only variables that remain significant predictors of NAC involvement. In the logistic regression analysis showed that high risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4. Conclusions: NAC involvement is 30,6%. Predictor factors of NAC involvement are lymh node status, tumor distance and tumor size. High risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4.
Penanganan Terkini Metastasis Kelenjar Getah Bening pada Karsinoma Sel Skuamus (KSS) Penis RAKHMAN, MOCHAMMAD REZA ARIEF; UMBAS, RAINY
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Recently, the incidence of penile cancer were increased. Two tertier hospital in Jakarta reporting an escalation in the average penile cancer patients from 1,8 to 6,2 per year in the last 16 years (1988-2005). The incidence of regional lymph node metastases was affected by the tumour grading. Only 2 out of 47 cases (4%) in Tis or Ta, 5 out of 73 cases in pT1 (G1/G1-2) and 9 out of 24 cases (38%) in pT1 (G2). 59% inguinal metastase was discovered in pT2. 5 years survival rate was 95% in negative lymphatic nodes, 76% in positive lymphatic node and 0% when pelvic metastatic was found.This study provides information about recent treatments for lymph node metastase in penile squamus cell carcinoma (SCC). Treatment for regional lymph node metastase by NCCN guidelines depends on tumour grade, palpability, nodul size, mobility, unilateral or bilateral. The treatment itself can be surgical (ILND,PLND), radiotherapy and chemotherapy
Faktor yang Berhubungan dengan Terinfiltrasinya Areola dan Papilla pada Karsinoma Payudara Operabel HERIADY, YUSUF; ACHMAD, DIMYATI
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (610.582 KB)

Abstract

Mastectomy is one of the most frequent surgery performed for operable breast cancer and included resection of the nipple-areola complex (NAC). The risk of local recurrence behind the nipple areolar complex (NAC) is the main limitating of the nipple-sparing mastectomy (NSM) procedure. The aim of this study is to investigate the incidence and to determine associated risk factors with cancer infiltration to nipple-areola complex (NAC) in operable breast cancer patients. This is an observational analytic, cross sectional study using retrospective medical record of patients with mastectomy, at Soedarso Hospital Pontianak from 2006 to 2013. Results: In a period of 7 year, we included 310 patients, the mean age is 47,3 years (24-78 years). The NAC involvements 30,6%. In bivariate analysis showed that age, tumor size, tumor stage, lymh node status, lymvovascular invasion and tumor distance are associated with NAC involvement. In the multivariate analysis showed that only lymh node status (p = 0,001; prevalence odds ratio [POR], 1.52; 95% confidence interval [CI], 1.18?1.95), tumor distance (p<0.001; POR, 0.47; CI, 0.36?0.61) and tumor size (p = 0.012; POR, 2.05; CI, 1.17?3.60) are the only variables that remain significant predictors of NAC involvement. In the logistic regression analysis showed that high risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4. Conclusions: NAC involvement is 30,6%. Predictor factors of NAC involvement are lymh node status, tumor distance and tumor size. High risks of NAC involvement are tumor distance >1?2 cm with T2 and lymph node status > 4 or with T3 and lymph node status negative or positive> 1; tumor distance >2?3 cm with T3 and lymph node status > 4.
Pengaruh Autoclave terhadap Properti Fisik dan Histopatologi Tulang: Sebuah Penelitian Dasar Rekonstruksi WIRATNAYA, I GEDE EKA; KAMAL, ACHMAD FAUZI; PATTIATA, RINO
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (612.906 KB)

Abstract

Background: Autoclave autograft is a promising alternative procedure in surgical treatment of bone tumors. A minimum effective autoclaving time of 15 minutes at 134C to devitalise tumour cells. This study aims to know the effect of autoclave to physical properties and histopathology of bone.Methods: We performed experimental study in 28 femoral bone of goat (Capra Aergagus circus) at age 1?2 year old. We divide into two groups with simple random sampling to be 14 autoclave and 14 control group. Autoclaving was performed to the bone at 134C for 15 minute. We examined physical properties each 7 autoclave group to axial and bending force compared with physical properties of the control group. We also examined histopatology of the bone both groups. Independent t-test statistical analysis to evaluate the difference of axial and bending force between autoclave and control group.Results: There were significant difference between autoclave and control group in axial force (p = 0.000) and bending force (p = 0.03). Physical properties of autoclave bone decreased 58.58 % in axial force and 20.33% bending force to control group. Histopathology examination revealed that all osteocytes were death in autoclave group but without matrix changes.Conclusion: Autoclave at 134C for 15 minute caused physical properties of bone decrease and statistically significant difference. It also made all osteocytes died but without matrix disturbance.
Penanganan Terkini Metastasis Kelenjar Getah Bening pada Karsinoma Sel Skuamus (KSS) Penis RAKHMAN, MOCHAMMAD REZA ARIEF; UMBAS, RAINY
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.11 KB)

Abstract

Recently, the incidence of penile cancer were increased. Two tertier hospital in Jakarta reporting an escalation in the average penile cancer patients from 1,8 to 6,2 per year in the last 16 years (1988-2005). The incidence of regional lymph node metastases was affected by the tumour grading. Only 2 out of 47 cases (4%) in Tis or Ta, 5 out of 73 cases in pT1 (G1/G1-2) and 9 out of 24 cases (38%) in pT1 (G2). 59% inguinal metastase was discovered in pT2. 5 years survival rate was 95% in negative lymphatic nodes, 76% in positive lymphatic node and 0% when pelvic metastatic was found.This study provides information about recent treatments for lymph node metastase in penile squamus cell carcinoma (SCC). Treatment for regional lymph node metastase by NCCN guidelines depends on tumour grade, palpability, nodul size, mobility, unilateral or bilateral. The treatment itself can be surgical (ILND,PLND), radiotherapy and chemotherapy

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