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All Journal Indonesian Journal of Cancer The Indonesian Biomedical Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian kepada Masyarakat Nusantara
MANUEL HUTAPEA, MANUEL
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Public Health Social Sciences

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Hubungan Invasi Pembuluh Limfe Dengan Metastasis ke Kelenjar Getah Bening Pelvis pada Kanker Serviks Stadium IB dan IIA HUTAPEA, MANUEL; -, SUHATNO; FAUZIAH, DYAH
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (847.694 KB)

Abstract

Objective: to know the result of Hematoxyllin-eosin and immunostainning D2-40 Podoplanin examination in detecting lymph vessel invasion (LVI) and to analyze correlation between lymph vessel invasion with pelvic lymph node metastasis in stage IB and IIA cervical cancer. Design of this research was cross-sectional study. The clinicopathological data of 41 patients with stage IB and IIA cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy (RHPL) at Dr. Soetomo Hospital, Surabaya, from January 2008 to June 2013 were retrospectively reviewed. Age, histology type, clinical stage, tumor size, number of removed pelvic lymph node, parametrial invasion and LVI were analyzed to define their correlation with pelvic node metastases. Immunohistochemical staining using MAb-D2-40 Podoplanin was used to detect lymph vessel invasion on the corresponding HE slides. Eligible criteria are paraffin wax embedded tissue from cervix cancer patients was diagnosed as cervix cancer, and patient’s medical record can be found and filled completely. Ineligible criteria are patients which is had chemotherapy or radiotherapy before surgery or patient’s paraffin wax embedded tissue was damaged. The correlation among variables was analyzed using Phi correlation test. Results: among of total 41 patients , lymph vessel invasion (LVI) was detected in 7 (17.07%) D2-40 Podoplanin slides, and 9 (21.95%) HE slides. Agreement rate with Kappa statistic between two method was significant, k = 0,381, p = 0,014. Lymph node metastasis was found in 6 (14.63%) samples. Positive LVI detected by D2-40 Podoplanin was significantly correlated with lymph node metastasis (? = 0.362; p = 0.02), but positive LVI detected by HE was not significantly correlated (? = 0.281; p = 0.072).
Hubungan Invasi Pembuluh Limfe Dengan Metastasis ke Kelenjar Getah Bening Pelvis pada Kanker Serviks Stadium IB dan IIA HUTAPEA, MANUEL; -, SUHATNO; FAUZIAH, DYAH
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (847.694 KB)

Abstract

Objective: to know the result of Hematoxyllin-eosin and immunostainning D2-40 Podoplanin examination in detecting lymph vessel invasion (LVI) and to analyze correlation between lymph vessel invasion with pelvic lymph node metastasis in stage IB and IIA cervical cancer. Design of this research was cross-sectional study. The clinicopathological data of 41 patients with stage IB and IIA cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy (RHPL) at Dr. Soetomo Hospital, Surabaya, from January 2008 to June 2013 were retrospectively reviewed. Age, histology type, clinical stage, tumor size, number of removed pelvic lymph node, parametrial invasion and LVI were analyzed to define their correlation with pelvic node metastases. Immunohistochemical staining using MAb-D2-40 Podoplanin was used to detect lymph vessel invasion on the corresponding HE slides. Eligible criteria are paraffin wax embedded tissue from cervix cancer patients was diagnosed as cervix cancer, and patients medical record can be found and filled completely. Ineligible criteria are patients which is had chemotherapy or radiotherapy before surgery or patients paraffin wax embedded tissue was damaged. The correlation among variables was analyzed using Phi correlation test. Results: among of total 41 patients , lymph vessel invasion (LVI) was detected in 7 (17.07%) D2-40 Podoplanin slides, and 9 (21.95%) HE slides. Agreement rate with Kappa statistic between two method was significant, k = 0,381, p = 0,014. Lymph node metastasis was found in 6 (14.63%) samples. Positive LVI detected by D2-40 Podoplanin was significantly correlated with lymph node metastasis (? = 0.362; p = 0.02), but positive LVI detected by HE was not significantly correlated (? = 0.281; p = 0.072).
Clinicopathological of Pre-Operative Thrombocytosis in Epithelial Ovarian Cancer Sugandi, Catherine; Maulida, Widya; Hutapea, Manuel
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 2 April 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i2.1903

Abstract

Abstract Objective: To investigate the clinicopathological of preoperative thrombocytosis in patients with epithelial ovarian cancer at dr. Soedarso Regional General Hospital Pontianak. Methods: A cross-sectional retrospective study was conducted over three months from January 2022 to March 2022, and bivariate analysis was performed using the Chi-Square test. Results: A total of 28 subjects met the inclusion criteria, with 19 subjects had thrombocytosis (67.9%) and 9 subjects did not experience thrombocytosis (32.1%). Meanwhile, the results of the Chi Square Test showed a relationship between thrombocytosis and histopathological type in the subjects (p=0.036). Conclusion: Preoperative thrombocytosis is associated with the histopathological type of epithelial ovarian cancer at dr. Soedarso Regional General Hospital Pontianak. Keywords: epithelial ovarian cancer, histopathology, stage, thrombocytosis
Sosialisasi Pembukaan Lahan Perladangan Berbasis Kearifan Lokal di Dusun Terentang Sanggau Nuryanti, Aktris; Karlina, Dina; Sari, Devina Puspita; Leksono, Agus Satrio; Hutapea, Manuel
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 3 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN) Edisi Mei- Agustus
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i3.3835

Abstract

Pembukaan lahan perladangan seringkali dilakukan dengan cara pembakaran, yang berdampak negatif terhadap lingkungan dan kesehatan. Pada tahun 2023, luas areal kebakaran hutan dan lahan di Kalimantan Barat menunjukan peningkatan kebakaran lahan. Kajian ini menilai perlunya peningkatan kesadaran masyarakat mengenai pembukaan lahan berbasis kearifan lokal untuk mengurangi dampak negatif pembakaran lahan. Dengan demikian tujuan utamanya adalah Masyarakat dapat memahami cara pembukaan lahan berbasis kearifan lokal. Metode yang digunakan oleh Tim Pengabdian Kepada Masyarakat Fakultas Hukum Universitas Tanjungpura adalah dengan melakukan penyuluhan atau sosialisasi mengenai pembukaan lahan perladangan berbasis kearifan lokal di Dusun Terentang, Desa Subah, Kecamatan Tayan Hilir, Kabupaten Sanggau yang telah dilaksanakan pada 16 Juni 2024. Berdasarkan pelaksanaan sosialisasi tersebut, didapati terdapat petani yang melakukan pembukaan lahan perladangan dengan cara pembakaran dan belum memahami tata cara pembakaran terbatas dan terkendali, bahwa pembakaran lahan hanya dapat dilakukan terhadap area paling maksimal 2 hektar untuk satu kepala keluarga dan harus memastikan bahwa pembakaran tersebut tidak menyebabkan api merambat keluar areal ladang, sawah, dan kebun masyarakat ketika melakukan pembakaran, dikarenakan telah memperhatikan dan menerapkan aspek teknis, dan/atau tradisi berdasarkan kearifan lokal masyarakat adat setempat. Dengan adanya sosialisasi tersebut, warga Dusun Terentang memahami akan pentingnya pembukaan lahan berbasis kearifan lokal.
Penelitian Terbaru terhadap 3 (Tiga) Jenis Ekstrak Teripang di Pulau Tegal Mas, Lampung Hutapea, Manuel; Swandiny, Greesty Finotory; Syafawi, M. Irfan; Putra, Fahreza Pratama; Kokadir, Sucipto; Basilianus, Edward; Putri, Vinessa Gracia; Abdillah, Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1447

Abstract

Sea cucumbers are deep-sea-dwelling invertebrate animals that are rich in nutrients and have been empirically used to prevent various degenerative diseases, especially due to their ability to dampen free radicals. The purpose of this study was to identify, and determine antioxidant activity, total phenolic content, and toxic properties in extracts of several sea cucumber species originating from Tegal Mas Island, Lampung. The identification results of the three sea cucumber species were Stichopus vastus Sluiter (SV), Stichopus monotuberculatus Quay & Gaimard (SM), and Stichopus quadrifasciatus Massin. (SQ). The extraction was performed by kinetic maceration against all parts of the sea cucumber using a 70% ethanol solvent. Antioxidant activity test using the DPPH (2,2-diphenylpicrilhydrazyl) free radical suppression method and determination of the total phenolic content using the Folin-Ciocalteu method. The results showed that SV had the highest total phenolics and antioxidants with the lowest toxicity. However, optimisation of extraction between wet and dry sea cucumbers is still required. Extraction optimisation with various solvents can also be done to gain secondary metabolites more effectively.
Elevated Serum Tumor Markers (HE4 and ROMA Score) and Increased Treg Cells Distinguished Ovarian Cancer and Benign Tumor Hutapea, Manuel; Syamsudin, Syamsudin; Kurnia, Iin; Fattah, Miswar; Hikmat, Ujang Saeful; Putri, Vinessa Gracia
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.3027

Abstract

BACKGROUND: Tumor markers such as human epididymis protein 4 (HE4), cancer antigen 125 (CA-125), and risk of ovarian malignancy algorithm (ROMA) are frequently utilized for diagnostic and prognostic purposes. Lymphocytes, essential immune cells, play a significant role in eliminating cancer cells. However, the precise correlation between tumor markers and lymphocytes remains incompletely elucidated. The aim of this study was to explore the correlation between tumor markers and lymphocyte subtype profiles in differentiating ovarian cancer and benign tumors.METHODS: This was a cross-sectional study involving 12 ovarian cancer and 17 benign ovarian tumor patients. Blood samples were collected for the characterization of T lymphocytes, B lymphocytes, natural killer (NK), and T regulatory (Treg), which were analyzed using flowcytometry. Additionally, tumor markers HE4 and CA-125 were measured from patient serum using the chemiluminescent microparticle immunoassay (CMIA) method.RESULTS: Benign ovarian tumors and ovarian cancer can be distinguished by a significant increase in HE4 levels (p=0.004), ROMA (p=0.004), and Treg cells (CD4+/CD25+/FOXP3+, p=0.017). Furthermore, the correlation between tumor markers and lymphocytes indicates that an increase in ROMA was weakly correlated with an increase in the percentage of T regulatory cells (CD4+/CD25+/FOXP3+, r=0.553, p=0.006) and B lymphocytes (CD19+, r=0.528, p=0.010), accompanied by a decrease in the number of T lymphocytes (CD3+, r=-0.598, p=0.003), T helper lymphocytes (CD3+CD4+, r=-0.594, p=0.003), and cytotoxic lymphocytes (CD3+CD8+, r=-0.510, p=0.013).CONCLUSION: The elevation of serum tumor markers (HE4 and ROMA) accompanied by an increase in Treg cells can distinguish between benign ovarian tumor patients and ovarian cancer patients.KEYWORDS: tumor marker, CA-125, HE4, ROMA, subtype of lymphocytes, ovarian cancer
Co-Authors . Syamsudin Aktris Nuryanti, Aktris Basilianus, Edward DYAH FAUZIAH, DYAH Fattah, Miswar Hikmat, Ujang Saeful Iin Kurnia Karlina, Dina Kokadir, Sucipto Leksono, Agus Satrio Maulida, Widya Putra, Fahreza Pratama Putri, Vinessa Gracia Sari, Devina Puspita Sugandi, Catherine SUHATNO -, SUHATNO Swandiny, Greesty Finotory Syafawi, M. Irfan Syamsudin Syamsudin