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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 9 Documents

Search results for , issue "Vol 21 No 3, 2010" : 9 Documents clear

Ability of fermented soymilk byLactobacillus plantarum 1 in bile acids binding Yusmarini .; Indrati R.; Utami T.; Marsono Y
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Some lactic acid bacteria (LAB) strains have been isolated from spontaneously fermented soymilk which showing proteolytic activity. These isolated were expected could producing bioactive peptides that could lowering cholesterol content when they used for soymilk fermentation. This research was aimed to determine the proteolytic activity of Lactobacillus plantarum 1 R.1.3.2 and L. plantarum 1 R.11.1.2 comparing with L. acidophilus FNCC 0051 as acontrol. Furthermore soymilk fermented with these isolates were monitored for their ability to bind bile acid and these results were compared with the control of soymilk with no fermentation. Proteolytic activities (U/mL) were measured spectrophotometrically using tyrosin as a standard product, while bile acid binding capacity (µM/100 mg protein) using Total bile Acid Binding Kit. The results show that all isolates use in this study had no different proteolytic activity nor bile acid binding capability to that of control strain. The fermentation process could increased their ability to bind with the bile acid.Key words :fermented soymilk, proteolytic lactic acid bacteria, bile acid binding

The effect of fumaric acid-sodium bicarbonate on the green tea effervescent granule’s quality made by dry granulation Agatha Budi Susiani Lestari; Maria Yuli Trisusilawati
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Tea plant (Camellia sinensis L.) had been known contains epigallocathecin gallate (EGCG) that can be used to maintain the healthy. In this research, the green tea will be tried to be formulated in effervescent dosage form, with the focus on the effect among fumaric acid, sodium bicarbonate, or the interaction between fumaric acid and sodium bicarbonate on the green tea extract effervescent granule’s physical properties, that made by dry granulation method. Physical properties of effervescent granule that been study were moisture content, flow rate, disintegration time, and pH of the solution. The result showed that sodium bicarbonate was dominant in determining pH, granule flow rate and moisture content of granule, whereas fumaric acid dominant in disintegration time of effervescent granule.Key words: green tea, fumaric acid, effervescent granule, dry granulation

Purification and characterization of anti-multidrug resistances bacteria from actinomycetes associated sponge Herlina Rante; Wahyono .; Yosi B. Murti; Gemini Alam
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Actinomycetes are one kind of the microorganisms that very important producer of secondary metabolites for drugs.Active substances of microbial origin have been searched through a series of screening methos to obtain novel compounds and strains. The purpose of this research was to characterize the antibacterial coumpound from actinomycetes associated sponge and identification of actinomycetes base on morfology and fisiology characteristic. Isolation of actinomycetes from sponge were done bypour and spreap plate. A total of actinomycetes strain were isolated from sponges collected at Barrang Lompo island, Makassar, South Sulawesi, Indonesia. One of them showed strong activity against antibiotic resistant bacteria with concentration 0.0195µg. Characterisation of antimicrobial coumpound base on IR spectrum determined derivate of carboxylic acid. The result obtained from the morphological and physiological characterisation, determined the strain a Streptomyces spKey words: sponges, actinomycetes, secondary metabolic, bacteria resistan

Effects of brown algae extract to function of aorta endothelium cell in diabetic rats Muhamad Firdaus; Made Astawan; Deddy Muchtadi; Tutik Wresdiyati; Sarwono Waspadji; Setyawati S. K.
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Macro and microvascular disease are currently the principal causes of morbidity and mortality in diabetes mellitus patients. Loss of the modulatory role of the endothelium may be a critical and initiating factor in the development of diabetic vascular disease. Polyphenol is known behave protective active compound to function endothelium cell. Polyphenol that contained in brown algae was phlorotannin. The aim of the present study was to investigate the effects of S. echinocarpum extract on endothelial dysfunction in aorta of streptozotocin diabetic rats. This experiment was conducted by complete randomized design in 2 months old of male albino Sprague Dawley strain of rats, 125-150 grams body weight. The rats divided in fivegroups, each group consist of 6 rats. First group: normal which is given 1 mL of extract vehicle orally; second group: diabetic rats which is given 1 mL of extract vehicle orally; third group: diabetic rats which is treated extract 150 mg/kg BW dose orally; fourth group: diabetic rats which is treated extract 300 mg/kg BW dose orally; and fifth group: diabetic rats which is treated extract 450 mg/kg BW orally. Diabetic rats prepared by injection of 45 mg/kg streptozotocin intraperitoneally. Extract was given to diabetic rats during 90 days. The result showed that brown algae extract rearrange endothelium cell function of diabetic rats by increasing relaxation, releasing of EDRF and decreasing of MDA. Based on these observations, it was concluded that S. echinocarpum extract recovers the endothelial dysfunction associated with diabetes. This effect appears to be due to its antioxidant properties.Key words: diabetes, EDRF, endothelial dysfunction, MDA, S. Echinocarpum

Component and antibacterial activity of crystal fraction from Zingiber zerumbetessential oil Sri Mulyani
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aims of the study was to determine of the crystal fraction from Zingiber zerumbet essential oils. The components examination was performed by GC-MS method using the solvent n-hexane and anti bacterial activity was tested against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 35218 using agar diffusion method with coconut oil solvent. The components that can be identified are α-humulene, caryophyllene oxide, β-selinene, and zerumbone. Crystal fraction solution able to inhibit of S. aureusATCC 25923 at the concentration 25 % and up to 50 % has not been able to inhibit E. coli ATCC 35218.Key words : Zingiber zerumbet, Lempuyang gajah, Crystal fraction, anti-bacterial

Effect of Stenochlaena palustris extract on circulating endothelial cellsMarmota caligata induced fever Suhartono, Eko; Bakhriansyah, M.; Handayani, Rini
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Fever is increasedÂ temperatureÂ regulationÂ ofÂ theÂ body.Â InÂ theÂ processÂ is accordingÂ indirectÂ whichÂ increasedÂ ofÂ freeÂ radicals,Â asÂ anionÂ superoxideÂ (â€¢O2) andÂ willÂ triggerÂ oxidativeÂ stressÂ happened.Â Oxidative stress will effect in endothelial damaged. A celluler marker of damage the endothelium is increased number of CirculatingÂ EndothelialÂ Cells (CEC).Â TheÂ aimÂ ofÂ thisÂ researchÂ isÂ to valuated the influence of watery plant kalakai extract (Stenochlaena palustris)to numberÂ ofÂ CirculatingÂ EndothelialÂ CellsÂ inÂ MarmotaÂ caligata hadÂ beenÂ feverÂ and to calculated the average of CEC. The research is true experimental study, with Posttest-Only with Control Group Design, with 2 control group and 5 treatments groupÂ ofÂ eachÂ 4Â MarmotaÂ caligata. The CEC isÂ Â measuredÂ byÂ HladovecÂ method. DataÂ wasÂ analyzedÂ byÂ usingÂ Kruskal-WallisÂ testÂ with confidenceÂ rateÂ atÂ 95Â %. TheÂ analyzedÂ resultsÂ gotÂ pÂ =Â 0.001Â (pÂ <Â 0.05)Â means thereÂ beÂ aÂ significant differentÂ betweenÂ treatmentÂ group.Â From theÂ result, canÂ beÂ concludeÂ thatÂ the present of wateryÂ plant kalakaiÂ extract is decreasing CEC in plasma of Marmota caligatafever induced.Key words: Fever, Circulating Endothelial Cells, Stenochlaena palustris

The effect of avocado butter to characteristics of emullient W/O cream Teti Indrawati; Herlina Yuanita Sari
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Avocado butter is an unsafonifiable fraction of avocado oil that contains of 25-30 % fitosterol as anti-aging agent. In this research, the influence of 6 variation avocado butter between 1–11 % to o/w cream characteristics has been researched. O/W cream has been made by meltingand mixing methods at 700C, and than cream product was evaluated. The result showed that o/w cream characteristics were progressively influenced by amount of avocado butter. In using avocado butter between 1–7 % in creams, the value of pH, viscosity, and particle size in product creams progressively go down, but theirs spread-abilities progressively go up. On the contrary cream characteristics that usage 9% of avocado butter, the value of viscosity and particle size began to go up while pH, but spread-abilities go down.Key words :avocado butter, O/W cream, cream characteristic, stability

Co-processing of the arrowroot-chitosan by spray drying Yudi Wicaksono; Yuli Witono; Herlina .; Nuri .
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Starch is one of the most widely used excipient in the manufacture of solid dosage forms. One of few problems associated with starch is its poor flowability so can’t used as excipient in direct compression tablet. The purpose of these studies was to develop of the arrowroot starch for use as excipient in direct compression tablet. The arrowroot starch was co-processing with chitosan by spray drying. The suspension of arrowroot starch-chitosan for feed in spray drying were prepared with three different ratios (1:1, 2:1 and 3:1). The product of co-processing were evaluated for morphology, moisture content, viscosity, angle of repose, flow rate of granules, bulk density, tapped density and Carr’s index. Results showed that co-process excipient of arrowroot starch-chitosan have spherical in shape, moisture content in the range of 4.70–5.10 % w/w, viscosity in the range of 1.77-2.17 mPas, angle of repose was found to be < 380, flow rate of granules in the range of 1,5 – 4,0 g/s, bulk density in the range of 0.47-0.59 g/mL, tapped density in the range of 0.59–0.79 g/mL l and Carr’s index in the range of 19.03-25.08 %.Key words: arrowroot starch, co-process excipient, direct compression

Effect of cengkeh leaves and kayu manis cortex essential oils blend as anti dental plaque Ardani, Marisya; Pratiwi, Sylvia Utami Tunjung; Hertiani, Triana
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Dental plaque is a mouth cavity health problem related to microbial biofilm, where Streptococcus mutans is predominant. Adding of essential oils blend in mouthwash has been reported to increase the dental plaque inhibitory activity. The essential oils of clove leaves (Syzygium aromaticum (L.) Merr. & Perry) and cinnamon cortex (Cinnamomum burmanniNees ex Bl.), are known as potential antibacterial and antibiofilm towards S. mutans. This research aims were to reveal the influence of blending the clove leaves and cinnamon cortex essential oils in antibacterial and anti biofilm activity against S. mutans and to find out the optimum composition. Antibacterial assay was performed in nutrient broth media, on microplate flat-bottom polystyrene 96 wells. Biofilm formation inhibition and degradation assays were done in BHI + 2 % sucrose on microplate flexible U-bottom PVC 96 wells. Crystal violet1 % was used to stain the biofilm and Optical Density(OD) was measured at λ 595 nm. Simplex Lattice Design formula was used to calculate the blend optimum composition. TLCbioautography and GC-MS assays were done to revealthe active substances. As conclusion, it was proven that blending the clove leaves and cinnamon cortex essential oils increased the antibacterial and biofilm degradation potency, but reduced the biofilm formation inhibitory effect against S. mutans. The optimum composition of the essential oils blend was 27:73 (% v/v). From our results we suggest that the clove leaves and cinnamon cortex essential oil blend used in this study be developed as anti dental plaque.Key words : clove leaves, cinnamon cortex, essential oils blend, Streptococcus mutans

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Contact Name
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Journal Mail Official
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Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA