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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Ilmu Kefarmasian Indonesia Journal of Fundamental and Applied Pharmaceutical Science Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Media Farmasi Indonesia

Agatha Budi Susiana Lestari

Fakultas Farmasi Universitas Sanata Dharma Yogyakarta

Author-ID : 2387484

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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FORMULASI TABLET EFFERVESCENT EKSTRAK DAUN SINGKONG (Manihot utillissima Pohl.) DAN EKSTRAK HERBA PEGAGAN (Centella asiatica (L.) Urban) Serevino L. Ambuk; Agatha Budi Susiana Lestari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Abstract: Asiaticoside compound in gotu kola extract (Centella asiatica (L.) Urban) and rutincompound in extract of cassava leaves (Manihot utillissima Pohl.) has been proofed fordegenerative diseases treatment. Effervescent tablet was chosen to facilitate the herb gotu kolaextract and cassava leaves extract because of fresh sensation and easy to use. The aims of thisstudy was investigated the effect of tartaric acid, sodium bicarbonate, their interactions, anddiscovered the optimum composition in order to producing effervescent tablets for qualityrequirements. Quality requirements term in this study were the moisture content of granule, tablethardness, friability of tablets, dissolution time. The results showed that tartaric acid significantlyinfluenced moisture content of granules, tablets friability, dissolution time of tablets, whilesodium bicarbonate significantly affected tablets hardness. Based on super imposed contourplot, the optimum composition for effervescent tablets was at the level 1000 mg tartaric acid and1120 mg sodium bicarbonate.Keywords: gotu kola extract, cassava leaves extract, effervescent tablet

The effect of fumaric acid-sodium bicarbonate on the green tea effervescent granule’s quality made by dry granulation Agatha Budi Susiani Lestari; Maria Yuli Trisusilawati
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Tea plant (Camellia sinensis L.) had been known contains epigallocathecin gallate (EGCG) that can be used to maintain the healthy. In this research, the green tea will be tried to be formulated in effervescent dosage form, with the focus on the effect among fumaric acid, sodium bicarbonate, or the interaction between fumaric acid and sodium bicarbonate on the green tea extract effervescent granule’s physical properties, that made by dry granulation method. Physical properties of effervescent granule that been study were moisture content, flow rate, disintegration time, and pH of the solution. The result showed that sodium bicarbonate was dominant in determining pH, granule flow rate and moisture content of granule, whereas fumaric acid dominant in disintegration time of effervescent granule.Key words: green tea, fumaric acid, effervescent granule, dry granulation

The micromeritics parameter changing of three inhalation dosage forms Riswaka Sudjaswadi; Agatha Budi Susiana Lestari
Indonesian Journal of Pharmacy Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Droplet and particle size measurements obtained after spraying of three inhalation aerosols dosage forms by microscopic methods, had been carried out, and their distributions had also been reported.The results showed that the geometric mean diameter ( dg ) is getting higher since the first spray to the last. Whilst the geometric standard deviation ( τg ) fluctuated preferably to the moderate polydispersity.Key words : inhalation aerosols, geometric diameter and standard deviation

Optimasi Formula Sediaan Krim Sunflower (Helianthus annuus L.) Oil Eva Husein; Agatha Budi Susiana lestari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Sunflower oil is one of the components of moisturizing cream that keeps the moisture of the skin. To produce a good quality cream, it is necessary to select appropriate emulsifying agent. This study aims to find the optimum composition between Tween 80 and Span 80 as an emulsifying agent in the preparation of sunflower oil cream, to meet physical properties and physical stability in terms of viscosity, spread ability and viscosity shift for 30 days. The ability of the cream to maintain skin moisture was tested using the Transepidermal Water Loss (TEWL) method. This study used a 22 experimental research design with the Simplex Lattice Design. The results showed there are 3 formulas of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% that fulfill the requirements with 143,3-153,3 dPas in viscosity, spread ability in range 5,0-5,3 cm, and viscosity shift between 4,3-6,8%. Based on TEWL test, the optimum formula obtained has a moisturizing effect with a TEWL value 17,9-38,0%. It conclude, sunflower oil could be formulated into moisturizing cream using combination of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% to fulfill the requirements for 30 days and could keep the skin moisture.

Pengaruh Purifikasi n-Heksana pada Serbuk Simplisia terhadap Kadar Asiatikosida, Penangkapan Radikal Bebas dan Kadar Fenol Total Ekstrak Etanolik Herba Pegagan (Centella asiatica (L.) Urban) AGATHA BUDI SUSIANA LESTARI; ACHMAD FUDHOLI; AKHMAD KHARIS NUGROHO; ERNA PRAWITA SETYOWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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It has been proven that gotu kola (Centella asiatica (L.) Urban) have an antioxidant activity that make it possible to use in preventing degenerative illness. The aims of this study are to find the effect of n-hexane purification before maceration on asiaticoside content, free radical scavenging activity and total phenolic content of gotu kola ethanolic extract. The gotu kola extract was made by maceration process using the mix of ethanol and aquadest as solvents in different proportion, which are 100%:0% (E100), 75%:25% (E75), 50%:50% (E50), 25%:75% (E25), and 0%:100% (E0). The determination of asiaticoside content in gotu kola ethanolic extract was measured using Thin Layer Chromatography (TLC) Densitometry method, free radical scavenging activity was measured using diphenylpicryl hydrazyl (DPPH) and defined by parameter of IC , and total phenolic content was defined by equivalency of galic acid using Folin-Ciocalteau. The results show that the hexane purification would increasing total phenolic content significantly in ethanolic extract which extracted with solvents in proportion of ethanol:aquades 75%:25% (E75), 50%:50% (E50), and 25%:75% (E25), but not significant in decreasing of IC . Statistically, n-hexane purification was also not significant to increasing asiaticoside content in gotu kola ethanolic extract.

Optimasi Rasio Asam Tartrat-Natrium Bikarbonat dalam Granul Effervescent Ekstrak Teh Hijau secara Granulasi Kering AGATHA BUDI SUSIANA LESTARI; BIRGITA NATALIA DESIHAPSARI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The aims of this research are to determine the effects of tartaric acid, sodium bicarbonate and their interaction on the physical properties of effervescent granule made by dry granulation and also to determine the optimum composition area of tartaric acid and sodium bicarbonate that produce qualified effervescent granule. The experimental study employed factorial design with two factors, i.e. tartaric acid and sodium bicarbonate, and two levels, i.e. high level and low level. The formulas were optimized on their physical properties, i.e. the granules flow rate, moisture content, disintegration time and pH of the solution. The data were statistically analyzed using Yate’s treatment with 95% level of confidence. The results show that tartaric acid was dominant in determining the disintegration time of the effervescent granules, while sodium bicarbonate was dominant in determining the moisture content of the effervescent granules. Interaction between tartaric acid and sodium bicarbonate significantly determined the flow rate of the effervescent granules and the pH of the solution. The optimum composition area of tartaric acid and sodium bicarbonate was not produced because there was one physical property of the effervescent granule that was not fulfilled, i.e. the granules moisture content.

Optimasi Formula Sediaan Fast Disintegrating Tablet (FDT) Ekstrak Etanolik Herba Pegagan (Centella asiatica (L.) Urb.) Agatha Budi Susiana Lestari; Achmad Fudholi; Akhmad Kharis Nugroho; Erna Prawita Setyowati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

It has been proven that Centella asiatica (L.) Urb. herbs have an antioxidant activity that make it possible to used in preventing degenerative illness. Centella asiatica (L.) extract has been formulated to fast disintegrating tablet (FDT) dosage form. The aims of this study are to find the optimum formula of FDT of Centella asiatica (L.) Urb. The simplex lattice design method with 3 factors (which are mannitol as diluents, crospovidone as superdisintegrant and povidone as binder) and 2 levels of each was used. Centella asiatica (L.) Urb. extract was produce from maceration process using ethanol-water in ratio 75%:25% as a solvent. Direct compress method was used to produce the FDT. The results show that the optimum composition between excipients FDT formula could be reached, which fullfiled the physical properties parameter which are the hardness, friability and disintegration time of FDT.

Aktivitas Antioksidan Ekstrak Daun Sirih Merah (Piper crocatum) Hasil Optimasi Pelarut Etanol-Air AGATHA BUDI SUSIANA LESTARI; YOHANES DWIATMAKA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Red bettle (Piper crocatum) is one of the plants which is extensively explored and has many biological activity. In this research, it is done the optimization of 96% ethanol and water composition as solvents in the process of extraction of red bettle leaves in percentage ratio of 100:0 (P1), 75:25 (P2), 50:50 (P3), 25:75 (P4), and 0:100 (P5) using Simplex Lattice Design (SLD). The aim of this research were to find the optimum composition of solvent which can obtain extract with the highest antioxidant activity. The antioxidant activity of red bettle leaves extract was measured by radical scavenging method using DPPH (diphenylpicryl hydrazyl), and assessed using parameter of EC50. The result showed that red bettle leaves extract which produced with ethanol-water as a solvent in percentage (%) of 75:25 (P2) has the higest antioxidant activity, with the smallest EC50’s value of 301,10 μg/ml.

Optimasi Kecepatan dan Waktu Pencampuran dalam Pembuatan Emulgel Ekstrak Teh Hijau AGATHA BUDI SUSIANA LESTARI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 2 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The aims of the research are to determine the Significant effect factor among mixmg rate, mixing time and their interaction on the physical properties and stability of green tea emulgel and to determine the optimum composition area which can produce good emulgel. In our previous investigation was determined the optimum composition between emulsifying agent (Tween 80 and Span 80) and gelling agent (Carbopol) This research determined the optimum mixing process, particularly on mixing rate and mixing time usig the factorial design with two factors (mixing rate and mixing time) and two levels (high level and low level). The physical properties and stability parameter investigated were including viscosity, spreading ability and viscosity shift atter storage at predetermined temperature and humidity for a month. The results showed that mixing rate Significantly influence on the viscosity and spreading ability and the mixing time significantly influence on the Viscosity shift. The optimum composttion area was not produced because the factorial design equation for viscosity respond and viscosity shin were not significant so can not be used to predict responds.

PENGARUH PROSES PENCAMPURAN TERHADAP SIFAT FISIK SEDIAAN VIRGIN COCONUT OIL(VCO) COLD CREAM Octavianus Rico Aditya Putra; Agatha Budi Susiana Lestari
Media Farmasi Indonesia Vol. 8 No. 1 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract The aim of the research was to investigate the significant effect among mixing time, mixing rate, and their interaction on the Virgin Coconut Oil (VCO) Cold Cream’s. In this research, the physical as properties of cold cream studied were viscosity, spreadability and viscosity shift. The result showed that mixing time, mixing rate and their interaction did not significantly affect the viscosity, spreadability, and viscosity shift responses.

Co-Authors ACHMAD FUDHOLI Akhmad Kharis Nugroho Aldo Christian Jonathan Angelina, Desak Made Rachel Bianca Levie Tania BIRGITA NATALIA DESIHAPSARI Dewi Setyaningsih ERNA PRAWITA SETYOWATI Eva Husein Gani, Michael Raharja Maria Yuli Trisusilawati Martina Indah Anita Octavianus Rico Aditya Putra Okana, Lie Dofi Ananda Madelin Putu Dyana Christasani Rini Dwiastuti Riswaka Sudjaswadi Serevino L. Ambuk Sutristio, Kezia Livianthi Kirana Budhi Winarti, Elisabet Yohanes Dwiatmaka

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