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All Journal Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia JFIOnline Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Applied Research (IJAR) International Journal of Islamic and Complementary Medicine Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia Journal of Agropharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

Yudi Wicaksono

Faculty Of Pharmacy, University Of Jember

Author-ID : 3236644

Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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PREPARASI DAN EVALUASI EKSIPIEN KO-PROSES PATI SINGKONG-KITOSAN YANG DIBUAT SECARA SPRAY DRYING Wicaksono, Yudi; Witono, Yuli; Herlina, .; Nuri, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 2 (2010)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Tapioca starch is pharmaceutical excipient for diluent of tablet with poorly in flowability and compactibility. Chitosan is biodegradle polymer and have been widely used for pharmaceutical excipient. It have a marked tendency to plastic deformation, and a good compression behaviour. Co-processing is the one of the most widely explored and commercially utilized method for the preparation of directly compressible excipient. The aim of study was to develop direct compression excipient of the tapioca starch-chitosan using co-processing method by spray drying. Co-processed excipient were prepared by spray drying suspension of feed of the chitosan - tapioca starch in different ratios (1:2, 1:3 & 1:4). The co-processed excipients were evaluated for morphology, moisture content, angle of repose, flow rate of granules, bulk density, tapped density, Carr’s index, viscosity and melting point. The result showed co-processed excipient of tapioca starch-chitosan have spherical in shape, moisture content in the range of 4.04 – 5.39 %, angle of repose was found to be < 380, flow rate of granules in the range of 1.3 – 3.8 g/s, bulk density in the range of 0.46 – 0.57 g/ml, tapped density in the range of 0.57 – 7.58 g/ml, Carr’s index in the range of 19.16-27.11 %, viscosity in the range of 1.77-2.17 mPas and melting point in the range of 195.33-198.50 0C. ABSTRAK Pati singkong adalah eksipien farmasi untuk pengisi tablet dengan sifat alir dan kompaktibilitas tidak baik. Kitosan adalah polimer biodegradabel dan telah digunakan secara luas untuk eksipien farmasi. Kitosan mempunyai kecenderungan untuk deformasi plastis dan sifat kompresi yang baik. Ko-prosesing adalah salah satu metode komersial yang digunakan secara luas untuk pembuatan eksipien cetak langsung. Tujuan dari penelitian ini adalah untuk mengembangkan eksipien cetak langsung dari pati singkong-kitosan dengan menggunakan metode ko-prosesing secara spray drying. Eksipien ko-proses disiapkan dengan menspray drying suspensi cairan umpan dari kitosan-pati singkong dalam perbandingan yang berbeda (1:2, 1:3 dan 1:4). Eksipien ko-proses dievaluasi untuk morfologi, kandungan lembab, sudut diam, kecepatan alir granul, berat jenis nyata, berat jenis mampat, indeks Carr's, viskositas dan titik lelehnya. Hasil menunjukkan eksipien ko-proses pati singkong-kitosan mempunyai bentuk sferis, kandungan lembab dalam rentang 4,04 – 5,39 %, sudut diam <380 , kecepatan alir granul dalam rentang 1,3 – 3,8 g/s, berat jenis nyata dalam rentang 0,46 – 0,57 g/ml, berat jenis mampat dalam rentang 0,57 – 7,58 g/ml, Indeks Carr's dalam rentang 19,16-27,11 %, viskositas dalam rentang 1,77-2,17 mPas dan titik leleh dalam rentang 195,33-198,50 0C.

PREPARASI DAN EVALUASI EKSIPIEN KO-PROSES PATI SINGKONG-KITOSAN YANG DIBUAT SECARA SPRAY DRYING Wicaksono, Yudi; Witono, Yuli; Herlina, .; Nuri, .
Jurnal Farmasi Indonesia Vol 5, No 2 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i2.41

Tapioca starch is pharmaceutical excipient for diluent of tablet with poorly in flowability and compactibility. Chitosan is biodegradle polymer and have been widely used for pharmaceutical excipient. It have a marked tendency to plastic deformation, and a good compression behaviour. Co-processing is the one of the most widely explored and commercially utilized method for the preparation of directly compressible excipient. The aim of study was to develop direct compression excipient of the tapioca starch-chitosan using co-processing method by spray drying. Co-processed excipient were prepared by spray drying suspension of feed of the chitosan - tapioca starch in different ratios (1:2, 1:3 & 1:4). The co-processed excipients were evaluated for morphology, moisture content, angle of repose, flow rate of granules, bulk density, tapped density, Carrâ??s index, viscosity and melting point. The result showed co-processed excipient of tapioca starch-chitosan have spherical in shape, moisture content in the range of 4.04 â?? 5.39 %, angle of repose was found to be <Â 380, flow rate of granules in the range of 1.3 â?? 3.8 g/s, bulk density in the range of 0.46 â?? 0.57 g/ml, tapped density in the range of 0.57 â?? 7.58 g/ml, Carrâ??s index in the range of 19.16-27.11 %, viscosity in the range ofÂ 1.77-2.17 mPas and melting point in the range of 195.33-198.50 0C. ABSTRAK Pati singkong adalah eksipien farmasi untuk pengisi tablet dengan sifat alir dan kompaktibilitas tidak baik. Kitosan adalah polimer biodegradabel dan telah digunakan secara luas untuk eksipien farmasi. Kitosan mempunyai kecenderungan untuk deformasi plastis dan sifat kompresi yang baik. Ko-prosesing adalah salah satu metode komersial yang digunakan secara luas untuk pembuatan eksipien cetak langsung. Â Tujuan dari penelitian ini adalah untuk mengembangkan eksipien cetak langsung dari pati singkong-kitosan dengan menggunakan metode ko-prosesing secara spray drying. Eksipien ko-proses disiapkan dengan menspray drying suspensi cairan umpan dari kitosan-pati singkong dalam perbandingan yang berbeda (1:2, 1:3 dan 1:4). Eksipien ko-proses dievaluasi untuk morfologi, kandungan lembab, sudut diam, kecepatan alir granul, berat jenis nyata, berat jenis mampat, indeks Carr's, viskositas dan titik lelehnya. Hasil menunjukkan eksipien ko-proses pati singkong-kitosan mempunyai bentuk sferis, kandungan lembab dalam rentang 4,04 â?? 5,39 %, sudut diam <380 , kecepatan alir granul dalam rentang 1,3 â?? 3,8 g/s, berat jenis nyata dalam rentang 0,46 â?? 0,57 g/ml, berat jenis mampat dalam rentang 0,57 â?? 7,58 g/ml, Indeks Carr's dalam rentang 19,16-27,11 %, viskositas dalam rentangÂ 1,77-2,17 mPas dan titik leleh dalam rentang 195,33-198,50 0C.

Optimasi Hidroksipropil Metilselulosa dan Polivinil Pirolidon dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida Lusia Oktora Ruma Kumala Sari; Septi Sudianingsih; Yudi Wicaksono
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.12228

Diltiazem HCl is a class of benzodiazepine calcium channel blockers used to treat angina pectoris, arrhythmias, and hypertension. Diltiazem HCl improves first-pass metabolism, a short half time of 3-5 hours, and bioavailability of diltiazem for oral administration of about 40%. Mucoadhesive buccal film diltiazem HCl releases the drug to the buccal mucosa, so the first pass metabolism can be avoided because of its absorption through the venous system that flows from the cheek. This study aimed to study HPMC polymers and polyvinyl pyrrolidone (PVP) polymers on swelling index, residence time, mucoadhesive strength of mucoadhesive buccal film diltiazem HCl, FTIR, and drug release. The prepared film was evaluated for swelling index, mucoadhesive strength, and mucoadhesive residence time. The optimal amount for HPMC was 35 mg, and PVP was 15 mg. The combination of polymers with this amount can produce a swelling index was 3,00, mucoadhesive strength was 41,87 gF, and mucoadhesive residence time was 330,66. FTIR test indicated that there was no interaction between active function clusters of Diltiazem HCl and other excipients. The release of the optimum formula in the 360th minute was about 97.847%, following in the zero-order release model and Higuchi.

Development of cassava starch-avicel PH 101 for coprocess diluent of direct compression tablet Yudi Wicaksono; Nailis Syifa'
Indonesian Journal of Pharmacy Vol 19 No 4, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Cassava starch is tablet excipient with poor of both flowability and compressibility which can not be used as diluent of direct tablet compression. The purpose of this research was to develop co-process of cassava starch-Avicel PH 101 for diluent of direct compression tablet. To achieve this goal, the thing that has been done are : (1) isolation of cassava starch (2) co-processing of cassava starch-Avicel PH 101 (3) testing of mechanic-physic properties of co-process of cassava starch-Avicel PH 101 (4) evaluation of co-process of cassava starch-Avicel PH 101 as diluent of direct compression tablet. The results indicated that ratio cassava starch-Avicel PH 101 (60:40) provided co-process with the best of mechanical-physical and compression properties. The best of mechanical-physical properties were flowability about 6,70±0,28 g/dt and tapping index about 12,57±1,18.%. The best compression properties of cassava starch-Avicel PH 101 co-process were crushing strength about 4,97±0,23 kp and friability about 0,52±0,03.% with disintegration time and tablet uniformity fulfill with requirement of pharmacopoeia.Key words: cassava starch, Avicel PH 101, co-process, direct compression tablet

Co-processing of the arrowroot-chitosan by spray drying Yudi Wicaksono; Yuli Witono; Herlina .; Nuri .
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Starch is one of the most widely used excipient in the manufacture of solid dosage forms. One of few problems associated with starch is its poor flowability so can’t used as excipient in direct compression tablet. The purpose of these studies was to develop of the arrowroot starch for use as excipient in direct compression tablet. The arrowroot starch was co-processing with chitosan by spray drying. The suspension of arrowroot starch-chitosan for feed in spray drying were prepared with three different ratios (1:1, 2:1 and 3:1). The product of co-processing were evaluated for morphology, moisture content, viscosity, angle of repose, flow rate of granules, bulk density, tapped density and Carr’s index. Results showed that co-process excipient of arrowroot starch-chitosan have spherical in shape, moisture content in the range of 4.70–5.10 % w/w, viscosity in the range of 1.77-2.17 mPas, angle of repose was found to be < 380, flow rate of granules in the range of 1,5 – 4,0 g/s, bulk density in the range of 0.47-0.59 g/mL, tapped density in the range of 0.59–0.79 g/mL l and Carr’s index in the range of 19.03-25.08 %.Key words: arrowroot starch, co-process excipient, direct compression

COCRYSTAL OF ATORVASTATIN CALCIUM – MALONIC ACID Yudi Wicaksono; Budipratiwi Wisudyaningsih; Tri Agus Siswoyo
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Cocrystal is a relatively new solid form of activepharmaceutical ingredient that offers an alternativeplatform in improving physicochemical properties ofactive pharmaceutical ingredients Padrela et al.,2009; Mashhadi et al., 2004. Cocrystal is defined asa stoichiometric multi-component system connectedby non-covalent interactions where all thecomponents neutral and solid under ambientconditions Thakuria et al., 2013. Cocrystal can beconstructed through interaction hydrogen bonding,pi-stacking, and van der Waals forces  Mashhadi etal., 2004. A pharmaceutical cocrystal is composed ofan API and an appropriate coformer as carboxylicacids and amides Qiao et al., 2011.Cocrystallization of active pharmaceutical ingredientis an opportunity for enhancement of importantphysiochemical properties of an activepharmaceutical ingredient without changing itsmolecular structure Maeno et al., 2014.Atorvastatin Calcium (AC), ([(R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid), calcium salt (2:1)trihydrate ([C33H34FN2O5]2Ca.3H2O), is considered asone of the most effective of synthetic lipid loweringagent Shete et al., 2010. The drug is orally used toreduce of total cholesterol, low density lipoproteinand triglycerides Anwar et al., 2011. There are 42crystalline structures of AC Shayanfar et al., 2013.However, chance to create AC into another crystalstructure to improving physicochemical properties ofAC is still fully open Chadha et al., 2012.In the present study, we explored cocrystallization ofAC by solvent evaporation method. This study aimedto confirm whether AC was able to form cocrystalwith malonic acid (MA) as coformer. AC-MAcocrystal was prepared by solvent evaporationmethod by using methanol as solvent.Characterization of cocrystal was done by powder Xraydiffractometry (PXRD), differential scanningcalorimetry (DSC), fourier transform infrared (FTIR)spectroscopy and scanning electron microscopy(SEM).

Analysis of Solid-State Interactions of Ketoprofen-Coformer Binary Mixtures by DSC and Hot Stage Microscopy Yudi Wicaksono; Dwi Setyawan; Siswandono Siswandono
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Ketoprofen is a non-steroidal anti-inflammatory drug with poor water solubility, so the absorption is less than optimal. One method to improve the solubility of ketoprofen is through the formation of multicomponent solid forms. The success of the formation of the multicomponent solid forms is strongly influenced by interactions between components in their solids. In this study, the analysis of the interactions in solid form of ketoprofen-coformers was carried out using the differential scanning calorimetry (DSC) and hot stage microscopy (HSM) with adipic acid and isonicotinamide as coformers. From the experimental results, the mixtures of ketoprofen-adipic acid show a solid-liquid phase diagram that indicates a simple eutectic system with eutectic points on the molar fraction of ketoprofen 0.9 and temperature at 92.9 °C. The ketoprofen-isonicotinamide mixtures have a eutectic system with the peritectic point. The solid-liquid phase diagram has indicated that the ketoprofen-adipic acid in eutectic composition forms a miscible liquid phase without interaction in its solid form, whereas the ketoprofen-isonicotinamide forms a miscible liquid phase accompanied by interaction with the excess component. The results of the HSM analysis showed the same phenomenon as the result of the DSC experiment and have confirmed with the FTIR analysis

EFFECT OF TEMPERATURE AND pH OF MODIFICATION PROCESS ON THE PHYSICAL-MECHANICAL PROPERTIES OF MODIFIED CASSAVA STARCH Yudi Wicaksono; Nuri Nuri; Budipratiwi Wisudyaningsih
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

The use of cassava starch for excipient in the manufacturing of the tablet has some problems, especially on physical-mechanical properties. The purpose of this study was to determine the effect of the differentness of temperature and pH in the process of modification on the physical-mechanical properties of modified cassava starch. Modifications were performed by suspending cassava starch into a solution of 3 % (w/v) PVP K30. The effect of the difference of temperature was observed at temperatures of 25; 45 and 65 0C, while the effect of the difference of pH was observed at pH of 4.0; 7.0 and 12.0. The results showed that the temperature and pH did not affect the physical-mechanical properties of the modified cassava starch. Modification of cassava starch at pH and temperature of 7.0 and 45 0C was produced modified cassava starch with the most excellent solubility, while the best swelling power were formed by the modification process at pH and temperature of 7.0 and 25 0C. Overall, the most excellent compression properties of modified cassava starch resulted from the modification process at pH 12.

Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method Yudi Wicaksono; Dwi Setyawan; Siswandono Siswandono
Indonesian Journal of Chemistry Vol 17, No 2 (2017)
Publisher : Universitas Gadjah Mada

The purpose of this work was to explore the formation of ketoprofen-malonic acid cocrystal by solvent evaporation method. Early detection of cocrystal formation was conducted by hot stage microscopy and solid-liquid phase diagram. Cocrystal were prepared by solvent evaporation method by using isopropyl alcohol as solvent. Characterization of cocrystal was done by Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy and Scanning Electron Microscopy (SEM). The results of hot stage microscopic and solid-liquid phase diagram indicated formation of ketoprofen-malonic acid cocrystal. PXRD and DSC measurements showed stoichiometric ratio of cocrystal ketoprofen-malonic acid (2:1). The ketoprofen-malonic acid cocrystal had melting point at 86.2 °C and unique peaks of PXRD pattern at 2θ of 6.1°, 17.8°, 23.2° and 28.6°. FTIR spectra indicated the formation of cocrystal due to interaction of C=O ketone group of ketoprofen with MA molecule. SEM images show that ketoprofen-malonic acid cocrystal have multi-shaped particles with rough surfaces.

Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures Yudi Wicaksono; Budipratiwi Wisudyaningsih; Frida Oktaningtias Widiarthi; Tri Agus Siswoyo
Indonesian Journal of Chemistry Vol 17, No 3 (2017)
Publisher : Universitas Gadjah Mada

Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic acid. The thermodynamics of binary mixtures of atorvastatin calcium - succinic acid were determined by differential scanning calorimeter. Meanwhile, thermomicroscopy and microstructure were determined by a polarized microscope equipped with a heating stage and camera. The results showed that melting points of atorvastatin calcium and succinic acid respectively were 159.35 and 188.51 °C. The solid-liquid phase diagram of atorvastatin calcium - succinic acid indicates the existence of two eutectic points at 136.57 °C and 120.96 °C respectively on the mole fraction of atorvastatin calcium 0.3 and 0.5. Tamman diagram accurately shows mole fraction of atorvastatin calcium at eutectic point 0.33 and 0.46 respectively for eutectic points 130.0 °C and 134.0 °C. Determination of Jackson’s roughness parameter showed a value of atorvastatin calcium, succinic acid and eutectic mixtures > 2 which indicates that the interfaces of remelting crystals were smooth. Microstructure of remelting crystal of atorvastatin calcium and succinic acid respectively was irregular form and crossed plates. The results of thermomicroscopy of binary mixtures of atorvastatin calcium-succinic acid were consistent with differential scanning calorimetry curves and solid-liquid phase diagram.

Co-Authors Ameliana, Lidya Barikah, Kuni Zu'aimah Barikah, Kuni Zuaimah Barikah, Kuni Zu’aimah Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Dwi Nurahmanto Dwi Setyawan Eka Deddy Irawan Elok Rimadani Frida Oktaningtias Widiarthi Herlina . Herlina . Jingga, Mutiara Dara Kuni Zu''aimah Barikah Kuni Zu’aimah Barikah Laily, Aisyah Prida Lita Putri Ayu Lestari Lusia Oktora Ruma Kumala Sari Lusia Oktora Ruma Kumala Sari nafisah isnawati Nailis Syifa' Nuri Nuri . Nuri Nuri Nuri Nuri Nuri, . Nuri, . Prihandini , Khairinna Priyadi, Karina Priyadi Devi Wahyu Putri, Salsabila Bara Rahardi, Verdian Septi Sudianingsih Seva, Any You Shafira Faradiba Tsaniyah Siswandono, S. Siswandono, Siswandono Susanti, Devi Feby Tri Agus Siswoyo Viddy Agustian Rosyidi Wisudyaningsih , Budipratiwi Wiwien Sugih Utami Yuli Witono Yunita Armiyanti Zulfatul Maskuriah, Dian

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