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Acta Pharmaceutica Indonesia
Published by Institut Teknologi Bandung
ISSN : 0216616X     EISSN : 27760219     DOI : -
Core Subject :
Acta Pharmaceutica Indonesia merupakan jurnal resmi yang dipublikasikan oleh Sekolah Farmasi Institut Teknologi Bandung. Jurnal ini mencakup seluruh aspek ilmu farmasi sebagai berikut (namun tidak terbatas pada): farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik. Acta Pharmaceutica Indonesia is the official journal published by School of Pharmacy Institut Teknologi Bandung. The journal covers all aspects of pharmaceutical issues which includes these following topics (but not limited to): pharmaceutics, pharmaceutical chemistry, biological pharmacy, pharmaceutical biotechnology, pharmacology and clinical pharmacy.
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Articles 4 Documents
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Search results for , issue "Vol. 46 No. 1 (2021)" : 4 Documents clear
NMR Study of Methyl β-orsellinate from Dirinaria sp. was Collected from Coastal Areas of Teluk Nipah, Pulau Pangkor, Perak Malaysia Andi Rifki Rosandy; Nurul Nadiah Binti Abdul Rahman; Rozida Khalid; Agus Chahyadi; Elfahmi Elfahmi
Acta Pharmaceutica Indonesia Vol. 46 No. 1 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

The research was carried out to isolate and characterize the methyl β-orsellinate of lichen Dirinaria sp. collected from the coastal areas of Teluk Nipah, Pulau Pangkor, Perak Malaysia. The sample was extracted in methanol for three times at room temperature. Subsequently, the crude extracts and further analysed using thin-layer chromatography (TLC) and vacuum liquid chromatography (VLC). To derive the pure compounds, the isolation step was performed using radial chromatography (RC). The chemical structure of the isolated compound was determined by several spectroscopies i.e. infra-red (IR), nuclear magnetic resonances (NMR), and mass spectrometric (MS). The compound was identified as methyl β-orsellinate.  
Development and Validation of Spectrofluorometric Method for the Determination of Ascorbic Acid in Several Dosage Forms by Using Methylene Blue Benny Permana; Debora Ronauli; Ilma Nugrahani
Acta Pharmaceutica Indonesia Vol. 46 No. 1 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Ascorbic acid or vitamin C is one of the most widely consumed supplement and available at the market in several preparations such as tablet, sweetlet, effervescent tablet, and ready to drink product. Spectrofluorometric method has been developed in this study for quantitative determination of ascorbic acid in various forms of products based on the reaction between ascorbic acid and methylene blue. Methylene blue concentration decreased along with the addition of ascorbic acid due to a redox reaction which caused the formation of colorless leuco-methylene blue and dehydroascorbic acid. The fluorescence intensity of methylene blue was measured at excitation and emission wavelengths of 664 nm and 686 nm respectively. The proposed method was found to have a good selectivity, linearity, accuracy, and precision. Validation studies demonstrated a good linearity for the method with a correlation coefficient > 0.999 and Vx0 < 2%. The accuracy test also met the requirements with the recoveries were not less than 90.0% and not more than 110.0%. Precision test gave a relative standard deviation (% RSD) not more than 2%. The ascorbic acid content in several marketed products was evaluated by this new spectrofluorometric method and the result was in good agreement for effervescent tablet, isotonic drink and lozenges with the label claim and specification. Due to its simplicity, the method can be used to analyze vitamin C in different product forms.
Role of the Arachidonic Acid Cascade in the Expression of Withdrawal Signs in Alcohol Dependent Mice: Kusnandar Anggadireja; Razana Bt. Adam Lee
Acta Pharmaceutica Indonesia Vol. 46 No. 1 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Withdrawal symptom in alcohol dependence is one the main problems in treating alcohol addiction. This study was aimed to clarify the role of the arachidonic acid cascade in the expression of withdrawal signs in animal model of alcohol dependence. Dependence was induced by repeated administration of 15% ethanol in 0.2% sucrose solution for 17 days. On the 18th day, the ethanol was not given, and one hour after the supposed time of ethanol administration, diclofenac at 10 mg/kg was injected i.p. to induce withdrawal. Observation of behavioral withdrawal signs was performed for 30 minutes, starting 25 minutes after diclofenac injection. Following behavioral observation, forced swimming test ensued to assess depression during withdrawal. In different group of mice, ibuprofen at 7.5 mg/kg was given every other day during ethanol regimen, 30 minutes prior to ethanol. Results showed that diclofenac induced the expression of withdrawal signs in mice receiving repeated alcohol. Incidences of facial preening (P<0.01), forepaw licking (P<0.01), grooming (P<0.01) and forepaw tremor (P<0.001) increased significantly by at least three times the normal value. In mice pretreated with ibuprofen significant decreases in body weight reduction (300%, P<0.01) and immobility time (50%, P<0.05) were observed compared to that of ethanol group. Taken together, the data indicates that suppressed arachidonic acid cascade signaling is involved in the expression of alcohol withdrawal.
Front Matter Vol 46 No 1 (2021) Acta Pharmaceutica Indonesia
Acta Pharmaceutica Indonesia Vol. 46 No. 1 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

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