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INDONESIA
journal of internal medicine
Published by Universitas Udayana
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 8 Documents
 1 
Search results for , issue "Vol. 11, No. 1 Januari 2010" : 8 Documents clear
EFEK SITOTOKSIK DAN ANTIPROLIFERATIF EKSTRAK ETANOL UMBI UBI JALAR UNGU (Ipomoea batatas L) TERHADAP SEL LINE KANKER PAYUDARA T47D 1 Sumardika, I Wayan; Wiwiek Indrayan, Agung; Jawi, I Made; Suprapta, Dewa Ngurah; Adnyan, Losen
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Cancer is still one of the leading death causes worldwide. Consuming antioxidants can reduce the cancer incidence. Anthocyanin that contained in purple sweet potatoes can inhibit DNA damages. In order to prove the activity of purple sweet potatoes on cancer cell, it is necessary to have some direct research on cancer cell line.This study is a simple experimental research method. The activities of the anticancer are evaluated from cytotoxic and antiproliferative effects on cell line breast cancer T47D. Cytotoxic effects is examined with cultured cell stained with tryphan blue exlusion. Each well are contain of 36,000 cells, which is given ethanol extract purple sweet potatoes with 10 dose variation starting from 500  g/mL up to 10,000  g/mL replicated three times, then the inhibitory percentage is calculated. Antiproliferative activity is evaluated by incubating cancer cells that have been given ethanol extract purple sweet potatoes in 3 doses variation; 500, 1,000 and 2,000  g/ml in 24, 48 and 72 hours.Result of this study showed that ethanol extract purple sweet potatoes had cytotoxic activities on T47D breast cancer cell line in these dose variations, 500; 1,000; 2,000; 3,000; 4,000; 5,000; 6,000; 7,000; 8,000; 9,000 and 10,000  g/ml. The cytotoxic activity on each of dose variations above are 27.56; 42.67; 57.78; 66.67; 72.44; 79.56; 85.33; 87.56; 92.44;100; and 100 %. Ethanol extract purple sweet potatoes showed antiproliferative activities on T47D breast cancer cells in 24, 48, 72 hours incubation in concentrations 500; 1,000; and 2,000  g/ml; those are 35,700; 29,800; 25,500 cells (24 hours); 72,500; 60,300; 52,600 cells  (48 hours); 149,500;122,600;107,300 cells  (72 hours). In conclusion, ethanol extract purple sweet potatoes had cytotoxic and antiproliferative activities on cell line breast cancer T47D.
PENDEKATAN DIAGNOSIS DAN TERAPI FIBROSIS HATI Anom S, Tjok Istri; Wibawa, I Dewa Nyoman
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Liver Þ brosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most typesof chronic liver. The gold standard to assess disease severity of liver Þ brosis is liver biopsy, despite noninvasive methodsavailable today. A noninvasive tool (Þ bro scan) has been developed these days. This tool is similar to ultrasound in assessingliver elasticity. There are three methods frequently used to assess liver Þ brosis, Ishak score, Metavir score, and Desmet/Scheuerstaging system. The principles of antiÞ brotic therapy are: (a) to treat primary disease; (b) to reduce inß ammation responseor to avoid stimulation of stellate cell activation; (c) to reduce stellate cell activation; (d) to neutralize proliferation response,Þ brogenic response, contractic response, and/or stellate cell proinß ammation; (e) to stimulate apoptosis of stellate cell; and (f) toincrease degradation of Þ brotic tissue.
KADAR ADIPONEKTIN PLASMA PADA PASIEN YANG MENJALANI HEMODIALISIS DI RUMAH SAKIT SANGLAH DENPASAR Sanjaya, Surya; Suwitra, Ketut
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Adiponectin, a cytokine with anti-inß ammatory properties that is secreted from adipose tissue. Adiponectin has beenshown to be a predictor of cardiovascular events in the general population and patients who undergoing hemodialysis. The aimof this study is to evaluate serum adiponectin in patient undergoing regular hemodialysis.A cross sectional study involved 53 reguler hemodialysis patient at Sanglah hospital. Inclusion criteria was patientundergoing regular hemodialysis more than three month and twice a week. We exclude severe infections, abnormality of liverfunctions test, malignancies and diabetes mellitus.The mean of age and abdominal circumference was 48.01 ± 12.3 years old and 79.5 ± 9.99 cm. Systolic and diastolicblood pressure pre hemodyalisis was 140 ± 20.7 mmHg and 83.3 ± 10.7 mmHg. Systolic and diastolic blood pressure posthemodialysis was 148.6 ± 23.6 mmHg and 85.6 ± 11.5 mmHg, respectively. We found serum level of calcium 9.5 ± .97 mmol/l,inorganic phospat 6.4 ± 2.1 mmol/l, BUN 84.8 ± 19.9 mg/dl, serum creatinin 16.1 ± 3.9 mg/dl, hemoglobine levels 7.7 ± 1.4 g/dland blood glucose levels 92.9 ± 1.4 mg/dl. Serum levels of adiponectin was 15.4 ± 5.98 mg/l compare with normal levels 5.52mg/l. Levels of serum adiponectin in regular hemodialysis patients is three fold higher than normal population.
SEORANG PENDERITA DENGAN KARSINOMA SEL SKUAMUS ESOFAGUS Arsana, I Putu; Wibawa, I Dewa Nyoman
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Oesophageal carcinoma still rare in Indonesia. Several centers reported low prevalence of oesophageal carcinoma.Three patients found in Palembang in one year, while four patients found in Bandung within ! ve years. Esophageal carcinomawas found in 1.1% of all cancer, and 7% of all digestive organ cancers in United States. Oesophageal carcinoma have mortalityratio of 0.95%. Oesophageal carcinoma more frequent in men with a ratio of 3:1. Diagnosis by anamnesis, physical examination,routine blood tests, barium esophagogram, esofago-gastroduodenoscopy, chest and abdominal CT-scan or MRI, bronchoscopy,endoscopic ultrasound, and also with laparoscopy. A 55-years old Balinese woman came with complaints of dif! culty inswallowing and diagnosed as squamous cell middle third oesophageal carcinoma stage III. Anamnesis, barium esofagogram,gastroduodenum endoscopy (OGD), and histopathological biopsy con! rmed the diagnosis of this patient. This patient givenchemotherapy with combination of 5-" uorouracil (5-FU) 40 mg/day and cisplatin 1500 mg/day 2 ? 3 cycles every 3 weeks
HUBUNGAN ANTARA SUDUT KELENGKUNGAN THORAK DAN SELISIH TINGGI BADAN UKUR DAN TINGGI BADAN HITUNG BERDASARKAN TINGGI LUTUT PADA PASIEN USIA LANJUT DI POLIKLINIK GERIATRI RUMAH SAKIT SANGLAH DENPASAR Wiryani, Cilik; Kuswardhani, Tuty; Aryana, Suka; Astika, Nyoman; -, Yanson; Widana, K
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Anthropometric measurements are part of the nutritional assessment which is an important component of health care.Measuring the individual!s stature with accuracy is very important because it is a basis for estimating basal energy expenditureand consequent nutrient needs and to calculate indices of nutrient status. However, common methods of nutritional anthropometricassessment are not entirely satisfactory for all elderly persons. Certain measurements such as stature may be difÞ cult to obtainbecause of postural changes, thinning of the disks of the spinal column, and diminution in the height of the vertebrae, all of whichare associated with aging.This study conducted to investigate the correlation between thoracic hyperkyposis with the difference of height calculatedwith WHO formula and actual height measurements in elderly patients among geriatric outpatient clinic, Sanglah hospital. Thisis a descriptive study at August 2008. Height was calculated with WHO formula. For men 59.01 + (2.08 x knee height) and forwomen 75 + (1.91 X knee height) - (0.17 X age) and compared with actual height measurements. Data analyzed with analyticdescriptive Spearman!s correlation.There were 91 elderly patients included, male 38 (41.8%), female 53 (58.2%). Mean of age was 70.61 years ± 5.75 SD,actual height measurements was 155.30 cm ± 9.37 SD, height calculated with formula was 160.35 cm ± 8.59 SD, knee heightwas 49.60 ± 3.39 SD, thoracic hyperkiposis was -17.210 ± -11.7 SD and the difference between height formula and actual heightmeasurements was 4.99 cm ± 5.84 SD.There were no correlation between thoracic hyperkyposis and the difference of heightcalculated with WHO formula and actual height measurement with r = 0.001, p = 0.993. There were no correlations betweenbetween thoracic hyperkyposis with the difference of height calculated with speciÞ c formula and actual height measurements inelderly patients among geriatric outpatient clinic, sanglah hospital
STROKE NON HEMORAGIK DENGAN FIBROMA VENTRIKEL KIRI William, Yosef; Putra Gunadhi, I Gusti Ngurah
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Cardiac ! broma is a rare case. It?s incidents about 3.2% from all incident of cardiac and pericardia tumor, that most oftenfound in infancy and adolescence, and less frequently in adults. Cardiac ! broma is a benign solitary tumor of the heart which isconsist of ! brous tissue that most commonly in the left ventricle or the interventricular septum. This case was a male 51 yearsold with chief complaint of decrease of consciousness about 3 days prior admitted to hospital. He was consulted from neurologistwith stroke non hemorrhagic. He was used to be a smoker since young adult. At ! rst time, we found weakness both of extremity,and cardiomegaly without abnormality in heart?s sound. ECG shown inferior old myocardial infarction. The head CT Scan shownthere was a infarct in capsulla interna of left sub cortex hemisphere. And from echocardiography, we found there?s a mass onleft ventricular with its size was 2 x 2.5 cm. We diagnosed with observation of left ventricular mass caused by probable cardiacmyxoma, coronary arterial disease/OMI inferior/FC II, and stroke non hemorrhagic. After two months he had stroke, patient hada total resection of his cardiac tumor. It was done with open heart technique. From histologic ! ndings, we found a white solidmass in macroscopic, and in microscopic, there was ! brous tissue with focal calci! cation at the edge of tissue, which surroundednecrosis coagulated area. One week after surgery, he was went home in well condition and had some medications, i.e. vitamin Bcomplex, acetosal 100 mg od , and captopril 6.25 mg tid. A cardiac ! broma was a rare cardiac tumour. Until now, pathogenesisof cardiac ! broma still unknown. Diagnostic of cardiac ! broma can get from echocardiography and histologic examination.Treatment of cardiac ! broma are symptomatic for its complication, and invasive procedure, i.e. total or subtotal resection, andcardiac transplantation
TINGKAT KETERGANTUNGAN NIKOTIN DAN FAKTOR-FAKTOR YANG BERHUBUNGAN PADA PEROKOK DI DESA PENGLIPURAN 2009 Bagus Artana, IGN; Ngurah Rai, IB
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Smoking causes many harmful side effects to our health. Cardiac diseases, lung and respiratory problems, and almostevery malignancies had a very close relationship with cigarrete smoking. Smoking cessation is a di! cult thing to do. We haveto obtain data about nicotine dependence before starting a smoking cessation program for patients or in comunity. Nicotinedependence based on structural interview using The Fagerström Test for Nicotine Dependence (FTND) questionaire. We conducta population-based survey to ! nd out about nicotine dependence in a traditional balinese vilage, called Penglipuran. Penglipuranis one sample of traditional vilage in Bali with very tight traditional law. We found 72 smokers among 920 people in Penglipuran(7.78%) with mean age 40.67 ± 14.05 years old and almost 100% was male (only one female sample). They started to smokeat very young age (18.24 ± 3.07 years old) and take approximately 8.44 ± 6.76 cigarettes per day. We found the mean nicotinedependence level was 3.63 ± 1.41 (moderate dependence). As for factors related to nicotine dependence, we found that smokingonset, occupation, and length of smoking correlate with nicotine dependence signi! cantly (p < 0.05). While the other factors suchas age, sex, and educational level didn?t have any correlation with nicotine dependence. Our survey conclude that Penglipuransmokers had moderate nicotine dependence.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN MAKROSITOSIS PADA PASIEN HIV/AIDS YANG MENDAPAT TERAPI ZIDOVUDIN DI RUMAH SAKIT SANGLAH DENPASAR Ridana Wibawa, Ketut; Parwati Merati, Tuti; Somia, Agus; Utama, Susila
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Zidovudine is a Þ rst line drug used for treating HIV/AIDS patients in Indonesia and has been associated with prolongedsurvival, a reduction in the frequecy and severity of opportunistic infections, transient increases in the number of CD4 Tlymphocytes, and decreases in serum HIV p24 antigen. However prolong use of zidovudine associated with bone marrowtoxicity manifested by macrocytosis until anemic condition which need the transfusion. Some factors has been identiÞ ed canincreasing the bone marrow toxicity like: age, sex, cotrimoxazole, anemic and neutropenia condition, CD4 count < 200 cells/ L,vit B12 and folic acid level.To determine the risk factors correlated with incident of macrocytosis on HIV/AIDS patients treated with zidovudine,an analytical retrospective cross sectional study was done. The patients were selected using WHO criteria and the antiretoviraltherapy as Depkes guideline which zidovudine base with dose 600 mg/day. The age, sex, cotrimoxazole use and CD4 count wereassesed from all the patients by review medical record when the macrocytosis exist.This study included 140 subyects, age arround 19 ! 65 years old, sex male 72 % and female 28%. Cotrimoxazole use as atreatment or prophylaxis for PCP infection is 90% and the median CD4 count is 24.5 cells/ L. The incidence of macrocytosis is54.3% which is 46.4% without anemia and 7.9% present with anemia. The mean MCV value before zidovudine therapy is 86.27fL and elevated to 110.11 fL after zidovudine therapy. The median time of macrocytosis is 5 month. With bivariat analysis wedidn"t Þ nd correlation betwen age, sex, cotrimoxazol use and CD4 count with incident of macrocytosis (age p = 0.935 95% CIOR = 0.963 sex p = 0.800 95% CI OR = 0.846 cotrimoxazol use p = 0.237 95% CI OR = 0.403 and CD4 count p= 0.646 95%CI = 0.997 respectively).This study concluded no correlation betwen age, sex, cotrimoxazol use and CD4 count with incident of macrocytosis onHIV/AIDS patients whom treated with zidovudine. We suggest to routinely monitoring the MCV value every a month in a year,be cause the incidence of macrocytosis cause by toxicity effect of zidovudine to bone marrow is high.

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