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All Journal Medicina journal of internal medicine Buletin Udayana Mengabdi E-Jurnal Medika Udayana Jurnal Veteriner Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Essential: Essence of Scientific Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran
I Wayan Sumardika
Department Of Pharmacology And Therapy, Faculty Of Medicine, Universitas Udayana, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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WATER EXTRACT OF SWEET POTATO LEAF IMPROVED LIPID PROFILE AND BLOOD SOD CONTENT OF RATS WITH HIGH CHOLESTEROL DIET Sumardika, I Wayan; Jawi, I Made
Medicina Vol 43 No 2 (2012): Mei 2012
Publisher : Medicina

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Abstract

Food stuffs with high flavonoids content  are believed to prevent various diseases caused by oxidative stress because of its antioxidants effect.  Purple sweet potato leaves have been proved containing high flavonoids, and can be developed very easily. To prove antioxidant and hypolipidemic properties of the water extract of purple sweet potato leaves, one research was conducted in the Department of Pharmacology, Faculty of Medicine, Udayana University. The study design was randomized control group pre- and post-test.  Twenty adult male wistar rats were divided into two groups of 10 rats. Both groups of rats were given high-cholesterol diet for three months to induce dyslipidemia. Control group of 10 rats were given only high-cholesterol diet alone, whereas the treatment group also treated with purple sweet potato leaf water extract with a dose of 6 cc per day divided into two doses. Before treatment and after treatment, lipid profile and blood SOD levels were measured. The results showed a decrease in total cholesterol, triglycerides and LDL cholesterol significantly in the treated group (P = 0.0001). In the treatment group there was also an increase in HDL cholesterol and blood SOD which was significantly differ than the control group (P = 0.0001). From the results of this study, it can be concluded that administration of water extract of purple sweet potato leaves can improve the lipid profile and increase blood SOD of rat given high-cholesterol diet.
EFEK SITOTOKSIK DAN ANTIPROLIFERATIF EKSTRAK ETANOL UMBI UBI JALAR UNGU (Ipomoea batatas L) TERHADAP SEL LINE KANKER PAYUDARA T47D 1 Sumardika, I Wayan; Wiwiek Indrayan, Agung; Jawi, I Made; Suprapta, Dewa Ngurah; Adnyan, Losen
journal of internal medicine Vol. 11, No. 1 Januari 2010
Publisher : journal of internal medicine

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Abstract

Cancer is still one of the leading death causes worldwide. Consuming antioxidants can reduce the cancer incidence. Anthocyanin that contained in purple sweet potatoes can inhibit DNA damages. In order to prove the activity of purple sweet potatoes on cancer cell, it is necessary to have some direct research on cancer cell line.This study is a simple experimental research method. The activities of the anticancer are evaluated from cytotoxic and antiproliferative effects on cell line breast cancer T47D. Cytotoxic effects is examined with cultured cell stained with tryphan blue exlusion. Each well are contain of 36,000 cells, which is given ethanol extract purple sweet potatoes with 10 dose variation starting from 500  g/mL up to 10,000  g/mL replicated three times, then the inhibitory percentage is calculated. Antiproliferative activity is evaluated by incubating cancer cells that have been given ethanol extract purple sweet potatoes in 3 doses variation; 500, 1,000 and 2,000  g/ml in 24, 48 and 72 hours.Result of this study showed that ethanol extract purple sweet potatoes had cytotoxic activities on T47D breast cancer cell line in these dose variations, 500; 1,000; 2,000; 3,000; 4,000; 5,000; 6,000; 7,000; 8,000; 9,000 and 10,000  g/ml. The cytotoxic activity on each of dose variations above are 27.56; 42.67; 57.78; 66.67; 72.44; 79.56; 85.33; 87.56; 92.44;100; and 100 %. Ethanol extract purple sweet potatoes showed antiproliferative activities on T47D breast cancer cells in 24, 48, 72 hours incubation in concentrations 500; 1,000; and 2,000  g/ml; those are 35,700; 29,800; 25,500 cells (24 hours); 72,500; 60,300; 52,600 cells  (48 hours); 149,500;122,600;107,300 cells  (72 hours). In conclusion, ethanol extract purple sweet potatoes had cytotoxic and antiproliferative activities on cell line breast cancer T47D.
Doxycycline sebagai Kemoprofilaksis Malaria untuk Wisatawan Wangi, Yan Sista; Sumardika, I Wayan
Cermin Dunia Kedokteran Vol 42, No 6 (2015): Malaria
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.362 KB) | DOI: 10.55175/cdk.v42i6.1002

Abstract

Malaria merupakan penyakit menular yang dapat menginfeksi wisatawan. Salah satu cara pencegahannya yaitu menggunakan kemoprofilaksis. Tinjauan ini membahas doxycycline sebagai kemoprofilaksis malaria untuk wisatawan dengan meninjau beberapa artikel yang didapat dari media Internet (Google dan The New England Journal of Medicine). Doxycycline memiliki efektifitas cukup baik sebagai kemoprofilaksis malaria, khususnya di area yang resisten multiobat. Doxycycline juga lebih baik dibandingkan mefloquine. Obat ini memiliki efek samping rendah tetapi tidak dianjurkan untuk ibu hamil dan anak usia di bawah 8 tahun karena risiko komplikasi perubahan warna gigi. Jika dibandingkan dengan atovaquone/proguanil, harga doxycycline lebih terjangkau.Malaria is a contagious disease that can infect travelers to endemic countries. The infection should be prevented with chemoprophylaxis. This article reviews doxycycline as chemoprophylaxis for traveler’s malaria through articles retrieved from Internet (Google and The New England Journal of Medicine). Doxycycline is effective as chemoprophylaxis, especially in multidrug resistant area. It is more effective than mefloquine. Doxycycline has very low side effect, but not recommended for pregnant women and child under 8 years old because of complications of teeth discoloration and deposition in bone. Compared to atovaquone/proguanil, doxycycline is cheaper. 
PERBANDINGAN KEJADIAN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) PADA PUSKESMAS I UBUD DAN PUSKESMAS II DENPASAR SELATAN JANUARI – OKTOBER 2012 Ni Luh Guantari; Agung Wiwiek Indrayani; I Wayan Sumardika
E-Jurnal Medika Udayana vol 4 no 6(2015):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Infeksi Saluran Pernapasan Akut (ISPA) merupakan penyakit dengan kejadian yang cukup tinggi di lingkungan tropis, salah satunya di Indonesia. Menurut UNICEF tahun 2001, kejadian ISPA dipengaruhi faktor lingkungan. Berdasarkan hal tersebut, maka penelitian ini dilakukan pada tempat dengan karakteristik lingkungan yang berbeda yaitu di wilayah kerja Puskesmas I Ubud dan Puskesmas II Denpasar Selatan. Penelitian ini bertujuan untuk  mengetahui pola distribusi ISPA di kedua puskesmas tersebut. Metode penelitian adalah deskriptif potong lintang dengan melihat jumlah insiden, perbandingan kasus berdasarkan jenis kelamin, umur dan distribusi tiap bulan. Hasil penelitian didapatkan insiden ISPA di Puskesmas II Denpasar Selatan cenderung lebih tinggi (21,9 %) dibandingkan dengan Puskesmas I Ubud (13,5 %). Distribusi tiap bulan berfluktuasi namun cenderung tinggi pada awal tahun. Kejadian ISPA relatif sama antara laki-laki dan perempuan.  Pneumonia hanya ditemukan pada usia kurang dari 5 tahun  dan kejadian pneumonia di Puskesmas II Denpasar Selatan cenderung lebih tinggi dibandingkan dengan Puskesmas I Ubud. Kesimpulan dari penelitian ini adalah kejadian ISPA di Puskesmas II Denpasar Selatan (urban) cenderung lebih tinggi dibandingkan dengan Puskesmas I Ubud (rural), dimana perbedaan ini kemungkinan disebabkan oleh perbedaan letak geografis dan tingkat polusi.
Pencegahan Gangguan Fungsi Ginjal Karena Stres Oksidatif pada Tikus Diabetes dengan Ubi Jalar Ungu I Made Jawi; I Wayan Sumardika; Ni Made Linawati
Jurnal Veteriner Vol 15 No 2 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Recently, anthocyanins-rich food, is believed to prevent tissue damages due to oxidative stress. This studyaimed to investigate the protective effect of water extract of Balinese purple sweet potatoes which containhigh anthocyanins to the renal tissues of diabetic rats. A total of 30 adult male rats were divided into threegroups using randomized post-test only control group design, respectivelly. Animals in group 1 (diabeticgroup) were given streptozotocin 60 mg/kg; group 2 (diabetic+extract/ treatment group) at 3 days after theanimals were given streptozotocin they were given 4 mL per day of the extract for 50, group 3 (control group)animals were given placebo. At day 50 of the treatment, the blood and renal tissue superoxidase dismutase(SOD) and malondialdehyde (MDA), creatinin and blood urea nitrogen (BUN) level of all rats were measured.The data were analyzed using analysis of variance. The results showed a significant increase of blood andrenal tissues MDA and BUN level in group 1 (p<0,05). In addition, a decrease of SOD and creatinin level(p<0,05) were also seen in this group. In comparison to animals in group 2, the increase of blood MDA andBUN level as well the decrease of SOD and, creatinin level were significantly lower (p<0,05). From thesefindings, it can be concluded that aqueous extract of Balinese purple sweet potato can prevent renalfunction disorders due to oxidative stress.
CORED (CHRONIC-RELAPSING DEPRESSION) PREVENTION: PENDEKATAN NOVEL BERBASIS APLIKASI SELULER PADA PASIEN GANGGUAN DEPRESI Sandra Sandra; Ni Putu Nadia Ramayanti; Made Syanindita Putri Larasati; I Made Siswadi Semadi; I Made Winarsa Ruma; I Wayan Sumardika
Essence of Scientific Medical Journal Vol 18 No 2 (2020): Volume 18 No. 2 (Juli - Desember 2020) Essential: Essence of Scientific Medical
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2020.v18.i02.p03

Abstract

ABSTRAK Pendahuluan: Gangguan depresi merupakan salah satu gangguan mood yang dapat berdampak serius bagi kehidupan seseorang, baik dalam kesehatan maupun fungsinya dalam masyarakat. Gangguan ini juga memiliki risiko kekambuhan sehingga dapat berdampak pada depresi kronis. Maka dari itu, diperlukan suatu pendekatan terapi untuk mengurangi beban tersebut dan meningkatkan kualitas hidup pasien yang sebelumnya didiagnosis dengan gangguan depresi. Implementasi aplikasi seluler dapat menjadi pilihan untuk memitigasi hal tersebut. Studi ini bertujuan untuk meninjau pendekatan terapi aplikasi seluler untuk mencegah progresi dan kekambuhan pada gejala depresi. Pembahasan: Upaya untuk mencegah progresi dan kekambuhan dari gangguan depresi dapat dilakukan melalui aplikasi seluler CORED (Chronic-Relapsing Depression) Prevention yang berfokus pada: (1) Follow Up, (2) Bantuan manajemen waktu, (3) Pelatihan meditasi dan mindfulness, dan (4) Layanan Group-Therapy. Intervensi pada empat hal tersebut memiliki efek klinis yang baik untuk mencegah rekurensi pada pasien gangguan depresi. Selain itu, mengingat akan tingginya risiko kekambuhan pada depresi, maka aplikasi ini dilengkapi dengan Patient Health Questionnaire-9 (PHQ-9) sebagai alat skrining untuk mendeteksi warning sign di mana pasien harus kembali menjalankan terapi dalam lingkup klinis. Simpulan: Penggunaan aplikasi, dengan berpedoman pada prinsip-prinsip yang tepat, diharapkan dapat memberikan efek yang maksimal serta dapat bersifat efektif baik dari segi waktu maupun biaya. Penelitian lebih lanjut perlu dilakukan untuk meneliti implementasi aplikasi yang lebih terintegrasi untuk menilai efektivitas dari penggunaan aplikasi seluler sebagai pencegah kekambuhan dan depresi kronis pada pasien gangguan depresi.
Doxycycline sebagai Kemoprofilaksis Malaria untuk Wisatawan Yan Sista Wangi; I Wayan Sumardika
Cermin Dunia Kedokteran Vol 42, No 6 (2015): Malaria
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i6.1002

Abstract

Malaria merupakan penyakit menular yang dapat menginfeksi wisatawan. Salah satu cara pencegahannya yaitu menggunakan kemoprofilaksis. Tinjauan ini membahas doxycycline sebagai kemoprofilaksis malaria untuk wisatawan dengan meninjau beberapa artikel yang didapat dari media Internet (Google dan The New England Journal of Medicine). Doxycycline memiliki efektifitas cukup baik sebagai kemoprofilaksis malaria, khususnya di area yang resisten multiobat. Doxycycline juga lebih baik dibandingkan mefloquine. Obat ini memiliki efek samping rendah tetapi tidak dianjurkan untuk ibu hamil dan anak usia di bawah 8 tahun karena risiko komplikasi perubahan warna gigi. Jika dibandingkan dengan atovaquone/proguanil, harga doxycycline lebih terjangkau.Malaria is a contagious disease that can infect travelers to endemic countries. The infection should be prevented with chemoprophylaxis. This article reviews doxycycline as chemoprophylaxis for traveler’s malaria through articles retrieved from Internet (Google and The New England Journal of Medicine). Doxycycline is effective as chemoprophylaxis, especially in multidrug resistant area. It is more effective than mefloquine. Doxycycline has very low side effect, but not recommended for pregnant women and child under 8 years old because of complications of teeth discoloration and deposition in bone. Compared to atovaquone/proguanil, doxycycline is cheaper. 
Plasmodium falciparum Serine Repeat Antigen 5 (PfSERA5): current vaccine candidate for Plasmodium falciparum malaria Ayuti Bulaan; W. Riski Widya Mulyani; Agung Nova Mahendra; I Wayan Sumardika
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (853.556 KB) | DOI: 10.15562/ism.v11i1.573

Abstract

Background: Most of the malaria cases are caused by Plasmodium falciparum infection. The prevalence of cases and high mortality rates due to malaria should be watched out globally. However, currently, efforts to prevent and treat malaria suffer obstacles due to resistance to insecticides and antimalarial drugs. For these reasons, other preventive measures are needed, such as vaccines. This study aims to review the Plasmodium falciparum Serine Repeat Antigen 5 (PfSERA5) as a potential candidate for Plasmodium falciparum malaria vaccine development. Methods: Of the 65 journals reviewed, 51 journals were found to be suitable as references for this paper. The keywords included in selected search engines are "malaria" "PfSERA5", "Plasmodium falciparum", and "malaria vaccine". Search results and studies show that the erythrocytic phase of the vaccine can fight malaria parasites that escape the liver stage while reducing or eliminating clinical symptoms. Data were analyzed and written in a narrative form.Results: PfSERA5 is an asexual erythrocytic stage antigen that accumulates in the parasitophorous vacuole. The PfSERA5, SE47 and SE36 (modified SE47) domains can induce the formation of antibodies that protect against falciparum malaria infection in vivo and in vitro. This protective mechanism, caused by PfSERA5 (anti-SE47 and anti-SE36) specific antibodies, occurs through inhibition of parasite growth and merozoite lysis. PfSERA5 also does not show antigenic variations and has limited polymorphism, so the probability of resistance can be reduced. Conclusion: Based on this, PfSERA5 has great potential as an effective erythrocytic phase vaccine candidate. However, further studies are needed regarding the toxicological and pharmacological properties of PfSERA5, both in vivo and in clinical settings.
Uji Aktivitas Peningkatan Fibrogenesis Salep Ekstrak Daun Binahong (Anredera Scandens (L.) Moq.) 10% Dalam Penyembuhan Luka Diabetes Pada Tikus Galur Sprague dawley I Putu Riska Ardinata; Bagus Komang Satriyasa; I Wayan Sumardika
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 1 (2023): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i1.11376

Abstract

Desain penelitian ini adalah eksperimen labrotatorik post test only. Penelitian menggunakan tikus jantan Galur Sprague dawley yang sudah diiduksi dengan STZ (Streptozotocin) dengan dosis 40mg/kgBB. Tikus dibagi ke dalam 4 kelompok yaitu normal yang tidak dberikan perlakuan apapun, negatif yang hanya diberikan perlukaan, positif diberikan salep gentamisin, dan kelompok uji ekstrak yang diberikan salep 10%. Dilakukan uji untuk melihat peningkatan aktivitas fibrogenesis berupa pembentukan jaringan ikat dengan melihat sel fibroblast dengan histopatologi.Hasil penelitian menunjukkan bahwa kelompok uji yang diberi salep ekstrak 10% daun Anredera scandens (L.) Moq. skoring histopatologi fibrogenesis pada kelompok esktrak 10% daun Anredera scandens (L.) Moq. Menunjukkan rata-rata nilai skor sebesar 3,5 yang signifikan (P=0,032) dibandingkan kelompok negatif dengan nilai rata-rata sebesar 2,75 pada hari ke-14. Namun jika dibandingkan dengan skoring kelompok positif sebesar 3,5 kelompok esktrak daun Anredera scandens (L.) Moq. menunjukkan nilai skor tidak signifikan (P=1,000) atau memiliki kemampuan yang setara dalam pembentukan jaringan ikat.Berdasarkan penelitian didapatkan hasil ekstrak daun Anredera scandens (L.) Moq. memiliki kemampuan dalam meningkatkan aktivitas fibrogenesis secara histopatologi mampu mempercepat pembentukan jaringan ikat pada hari ke-14 yang setara dengan kontrol positif.
PELATIHAN PEMBUATAN SABUN PADAT DAN CAIR BERBAHAN EKSTRAK RIMPANG TEMULAWAK DAN SAMBILOTO PADA IBU-IBU PKK DESA MAMBANG, SELEMADEG TIMUR, TABANAN I.G.A. Artini; A.W. Indrayani; N.W.S. Dewi; I.W. Sumardika; I.G.M.G.S.C. Trapika; I.M. Jawi; B.K. Satriyasa; I.G.M. Aman; A.N. Mahendra; I.A.A. Widhiartini; D.K. Ernawati; N.W. Tianing; N.L. Suriani; I.G. Wiranatha
Buletin Udayana Mengabdi Vol 22 No 2 (2023): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2023.v22.i02.p03

Abstract

Temulawak is one of medicinal plants which possess antibacterial activity against two major causes of infection in acne namely Staphylococcus epidermidis and Propionibacterium acnes. The active compounds of temulawak are curcumin and xanthorrhizol essential oil, which possess antibacterial activity as antiseptic and antibiotic. Sambiloto (known as Andrographis paniculate), contains active compound andrographolide, which is also assumed to possess antibacterial activity. This community program was the implementation of our research for community wellbeing, which aimed to raise the knowledge and skill of PKK women at Mambang village, Selemadeg Timur, Tabanan especially in producing liquid and solid soap from natural substances (temulawak and sambiloto extract). The program was conducted by visiting our partner company PT Bali Tangi and training for liquid and solid soap production from temulawak and sambiloto (as one form of temulawak and sambiloto utilization for skin health especially for acne management). We assess participant knowledge improvement by using questionaire before and after conducting the activity. There was an improvement in participant knowledge regarding the production of soap from natural substances (temulawak and sambiloto). In conclusion, this program had increase the knowledge and skill of PKK women at Mambang village regarding liquid and solid soap production from natural substances. Keywords: antiacne, liquid soap, sambiloto, solid soap, temulawak
Co-Authors A.N. Mahendra A.W. Indrayani Agung Nova Mahendra Agung Wiwiek Indrayan Agung Wiwiek Indrayani Ayuti Bulaan Bagus Komang Satriyasa Desak Ketut Ernawati Dewa Ngurah Suprapta I Gde Suranaya Pandit I Made Jawi I Made Siswadi Semadi I Made Winarsa Ruma I Putu Riska Ardinata I Wayan Putu Sutirta Yasa I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Junior, Darren Losen Adnyan MADE RATNA SARASWATI . Made Syanindita Putri Larasati N.W. Tianing N.W.S. Dewi Ni Luh Guantari Ni Luh Suriani Ni Made Linawati Ni Putu Nadia Ramayanti Pande Ayu Naya Kasih Permatananda Saktivi Harkitasari, Saktivi Sandra Sandra Sumadewi, Komang Trisna Tresnayanthi, Kadek Ayu Sri W. Riski Widya Mulyani Wangi, Yan Sista Winanti, Kadek Dinda Ayu Sri Wulandari, Putu Kintan Yan Sista Wangi