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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 16 Documents
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Search results for , issue "Vol. 8 No. 2 (2022): July" : 16 Documents clear
Cinnamomum burmannii EXTRACT AMELIORATES HIGH GLUCOSE-INDUCED BRAIN APOPTOSIS IN ZEBRAFISH EMBRYOS THROUGH INHIBITION OF PROCASPASE-9 : IN SILICO AND IN VIVO STUDY Umi Kalsum; Husnul Khotimah; Theakirana Firdaus; Editya Fukata; Nurfaizah Titisari Sulihah; Fitrah Aulia Lisabilla; Happy Kurnia Permatasari; Sri Andarini
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.10

Abstract

Background: Brain is an organ that is prone to oxidative stress and subsequent apoptosis due to high aerobic metabolism and relatively low antioxidants, especially under hyperglycemic condition. Cinnamomum burmanii (CB) is a species that is abundant in Indonesia, therefore it is of special concern for researchers to identify the anti-apoptotic effect of CB. Objective: This study was initiated to determine the effect of CB extract on the inhibition of brain apoptosis in zebrafish embryos exposed to high glucose and to investigate its anti-apoptosis mechanism by molecular docking approach. Methods: Molecular docking was conducted to determine the interaction between several CB extracts main constituents with target protein procaspase-9, compared to control ligand Saxagliptin. Zebrafish embryos were used to assess the effect of 4% glucose exposure and three doses of CB extract treatment (1.25, 5, and 10 µg/ml) on apoptosis in brain region. High-glucose condition in zebrafish embryo was confirmed with overexpression of Phosphoenolpyruvate carboxykinase (PEPCK). Apoptosis was evaluated by performing acridine orange (AO) staining and quantified by ImageJ software. Results: Molecular docking study indicated that main CB compounds, namely epicatechin, displayed stronger molecular interactions with procaspase-9 compared to control ligand Saxagliptin. There were increased numbers of apoptotic cells seen around brain region in glucose-treated group. Meanwhile, supplementation of CB extract at dose of 10 µg/ml resulted in decreased amount of apoptotic cells in brain region. Conclusion: The results suggest that CB extract protects from hyperglycemic-induced apoptosis in zebrafish embryos brain by modulating procaspase-9.
DYKE-DAVIDOFF-MASSON SYNDROME: MYOCLONIC SEIZURES AND HEMIHYPERTROPHY IN LATE CHILDHOOD: A CASE REPORT Halil Ural Aksoy; Senem Ayça; Celil Yılmaz; Muzaffer Polat
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.16

Abstract

Dyke-Davidoff-Masson Syndrome (DDMS) is a rare syndrome characterized with specific clinical and radiological findings due to involvement of the developing brain with cerebral hemiatrophy of one hemisphere. The syndrome was first described from Dyke, Davidoff and Masson in 1933 in a series of nine patients. Syndrome has two forms, congenital and acquired forms and etiological factors vary due to involvement of the brain. Most common clinical symptom are focal or secondary generalized seizures. Hemiparesis, facial asymmetry, intellectual disability, mental retardation, and hemihypertrophy also seen in clinical process. In magnetic resonance imaging (MRI) DDMS has unique radiological findings. Seizures are commonly refractory to treatment and aim of the treatment is to control seizures and improve mental and intellectual capabilities. Prognosis is good when clinical findings occur after two years old.
ETIOLOGY, DIAGNOSIS, AND MANAGEMENT OF CHILDHOOD MICROCEPHALY: A SINGLE-CENTER RETROSPECTIVE STUDY Deniz Güven; Didem Ardıçlı; Dilek Sarıcı
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.3

Abstract

Background: Microcephaly is a condition that causes a reduction in brain volume as well as cognitive and motor impairments. It can be seen alone or in conjunction with a variety of genetic disorders and environmental factors. Microcephaly is still a poorly defined condition, identifying the etiological causes is critical for providing genetic counseling, and preventing potential consequences. Objective: The aim of this study was to assess the etiology, diagnosis, and management of the childhood microcephaly. Methods: We conducted a retrospective analysis on 50 children with microcephaly (25 males, 25 females) who presented to University of Health Sciences, Ankara Keçiören Training and Research Hospital between 2017-2021.The demographic features of the patients, neuroimaging, clinical and laboratory findings were examined. Results: The etiology of microcephaly was documented in 76% of all patients. Genetic causes were identified in 16 % of the patients; including Aicardi Goutieres Syndrome,Williams Syndrome , Wolfram Syndrome, Rett Syndrome and Asparagine Synthetase Deficiency. Syndactyly, scoliosis, Poland syndrome, dysmorphic face, alopecia, auricular ear deformities, hearing loss, strabismus, nystagmus, hydronephrosis, single umbilical artery, and cardiac septal defect were detected systemic malformations associated with microcephaly. In sixty percent of the patients, a neuroimaging was performed; results were abnormal in 24% of the patients. The mean follow-up period of the patients was 1.88± 0.6 years. Cognitive impairment was associated with microcephaly in 38% of the cases, and epilepsy in 20%. Of those 28% of the children required special education. One patient was operated by neurosurgeon due to craniosynostosis. Conclusion: Microcephaly is still a poorly defined condition, identifying the etiological causes is critical for providing genetic counseling, and preventing potential consequences.
EVALUATION OF TREATMENT OUTCOMES OF VESTIBULAR MIGRAINE PATIENTS Abolfazl Atalu; Firouz Amani; Aran Nikpay
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.4

Abstract

Background: Currently there are several treatment plans for prophylaxis of vestibular migraine, but these treatments are based on physician's observations and there have not been studied on a consensual treatment plan. Objective: Based on diagnostic criteria, we collected vestibular migraine patients and created an individualized treatment plan for 3 months to interpret treatment results. Methods: In this prospective cross-sectional study, 28 patients with headache and dizziness diagnosed for vestibular migraine were enrolled. Demographics, clinical picture, and treatment results were evaluated for all patients   at baseline and after three months follow-up duration. Collected data analyzed by statistical methods in SPSS. Results: Due to results, all of the patients with vestibular migraine were female and mostly were in the 30 to 50 years old age group. Dizziness, Headache before vestibular symptoms, increased intensity of headache on excretion, intermediate to high migraine intensity, and throbbing pain were the most common symptoms in the patients. The most common drugs used in the treatment were somatriptan, topiramate and Magnesium+Vitamin B6. After 3 months of treatment, duration, intensity, and frequency of migraine and frequency of dizziness episodes were significantly decreased but there was not a significant relationship between treatment plan and dizziness episodes in terms of duration and intensity. Conclusion: Effectiveness of the drugs in decreasing dizziness episodes can be explained by the effect of the drugs in preventing migraine episodes, whereas in recent studies non-pharmocologic treatments have had a significant effect on decreasing dizziness intensity and duration. Using both pharmacologic and non-pharmocologic methods in combination, is recommended for the treatment of the vestibular migraine.
KABUKI SYNDROME AND EPILEPSY Marina Zhitomirskaya; Galina Treskina; Nina Dengina; Galina Odinstova
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.5

Abstract

Background: Kabuki syndrome is a rare disease. In 2018, a global consensus on diagnostic criteria for Kabuki syndrome (KS) was published, diagnosing KS both with and without molecular genetic confirmation. Neurological symptoms are a major clinical problem in more than 80% of cases. Seizures occur with a frequency of 10% to 40% in Kabuki syndrome. Various degrees of severity of epilepsy in KS have been reported. There are isolated cases of West syndrome in KS worldwide. Objective: To investigate the frequency of epilepsy in KS and the features of West syndrome comorbid with KS, using evidence from reviews and describing the clinical presentation based on the history of a patient with molecularly positive KS. Methods: The study design was a two-centre retrospective observational study. Study subjects were paediatric patients with genetically verified KS. We conducted our own observation of 4 patients with KS and detailed a clinical case of a male patient with West syndrome in KS. Results: Epilepsy was found in 2 patients. Onset of epilepsy at 1.5 and 20 months of age. Both cases were characterised by a severe course of epilepsy. A rare form of epilepsy in KS, West syndrome, was described in patient M. Initial complaints included first seizures and delay  in psychomotor development from 1.5 months of age. The clinical features of West syndrome, an electroencephalographic image, MRI of the brain, and the patient's seizure management were presented. Conclusion: Epilepsy in KS is not an uncommon clinical symptom that exacerbates the underlying disease. KS in combination with West syndrome exacerbates neurological deficits and leads to a significant delay in psycholinguistic and psychomotor development against a background of low efficacy of medication and differential effects of hormones and ketogenic diet.
LIGHT EXPOSURE’S EFFECTS ON INACTIVE STATE DURATION AND SLEEP LATENCY IN ZEBRAFISH (DANIO RERIO) LARVAE INSOMNIA MODEL Zamroni Afif; Mochammad Istiadjid Eddy Santoso; Husnul Khotimah; Irawan Satriotomo; Edi Widjajanto; Masruroh Rahayu; Shahdevi Nandar Kurniawan; Dheka Sapti Iskandar; Annisatul Hakimah; Syafiatul Azizah; Nurvia Andriani; Kartika Agustina
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.11

Abstract

Background: Insomnia is defined as difficulty falling or staying asleep or a sleep state that cannot restore the body's condition. The zebrafish (Danio rerio) is a vertebrate model that has been extensively studied to study sleep and neurological disorders. One of the most widely used methods to examine the effect of the light-dark cycle on the circadian system is by exposing animals and humans to pulse wave light. Objective: To see the effect of light exposure on zebrafish larvae by looking at inactive state duration and sleep latency in zebrafish (Danio rerio) larvae insomnia model. Methods: This study used four groups of zebrafish larvae i.e : (1) normal group (2) minutes of light exposure and 2 minutes off (2/2)), (3) Four minutes of light exposure and 1 minute off (4/1), and (4)  24 hours on (24/0). Observation of larval movement was carried out on 5, 6, and 7 dpf (day post fertilization). Observation time was 30 minutes before and after turned off of light exposure. Results: There were significant differences on days 5, 6, and 7 between the normal group and the three light treatment groups on inactive state duration and sleep latency in dark and light conditions with p-values (p<0.05) and (p< 0.031), but there was no significant difference among groups of light exposure 2 minutes on 2 minutes off, 4 minutes on 1 minute off, and 24 hours on. The 24-hour on treatment showed the most inactive state duration among the light treatments, while the sleep latency was found in the 24-hour treatment. Conclusion: Light treatment of 2 minutes on 2 minutes off, 4 minutes on 1 minute off, and 24 hours on can cause insomnia, but the most substantial insomnia effect is obtained from the 24-hour treatment.

Page 2 of 2 | Total Record : 16

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