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Majalah Obstetri dan Ginekologi

MOG
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Published by Universitas Airlangga

ISSN : 08540381 EISSN : 25981013 DOI : 10.20473/mog.V27I32019.90-93

Core Subject : Health,

Health Professions Medicine & Pharmacology

Majalah Obstetri & Ginekologi (MOG) or the Journal of Obstetrics & Gynecology Science is a scientific journal published by the Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, in collaboration with the Indonesian Obstetrics and Gynecology Association (POGI) of Surabaya branch.

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Articles 7 Documents

Search results for , issue "Vol. 26 No. 2 (2018): August" : 7 Documents clear

Sambiloto (AS201-01) is better than standard antimalarial drug (DHP) in reducing Toll-Like Receptor 2 (TLR2) on placenta malaria model Masyitah Hamidah; Aty Widyawaruyanti; Widjiati Widjiati; Budi Prasetyo
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Objectives: To compare the TLR2 expression in the placenta between treated by sambiloto EA-96 fraction tablet (AS201-01) and dihydroartemisinin-piperaquine phosphate (DHP)Materials and Methods: Experimental study using 24 pregnant mice. All sample divided into 4 groups with randomization are uninfected group, Plasmodium infected group and given placebo, sambiloto (AS201-01) and DHP. Then performed surgery and placental sampling were staining with adopting in tunnel assay method to measure the TLR2 expression of placental.Results: The expression of TLR2 in uninfected group has the lowest rate compared to other groups. The infected and placebo treated group has the highest TLR2 expression campared with sambiloto and DHP. The sambiloto group has not differ signi-ficantly with the group uninfected and lower than DHP.Conclusion: Tablet of sambiloto EA-96 fraction (AS201-01) decreased TLR2 expession better than with DHP tablet.

The effect of sambiloto tablet (AS201-01) on placental Chondroitin Sulfate A (CSA) expression of pregnant mice infected by Plasmodium berghei Nasrul Wahdi; Widjiati Widjiati; Aty Widyawaruyanti; Budi Prasetyo
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Objectives: To determine the effect of Sambiloto tablet (AS201-01) in reducing the placental Chondroitin Sulfate A (CSA) Expression of pregnant mice infected Plasmodiumberghei.Materials and Methods: Experimental study using 24 pregnant mice were divided into 4 groups with randomization. Uninfected group, the placebo group, the Sambiloto tablet (AS201-01) group and the DHP tablet (as a standart drug) group. The last three groups, were infected with P. bergheion day 9th of pregnancy, and the treatment was started at day 11th of pregnancy, and samples were terminated at day 15th of pregnancy by surgery. Placental sampling were stained with Tunnel assay to measure placental CSA antibodies.Results: The placental Chondroitin Sulfate A (CSA) expression. Uninfected group compared to Sambiloto tablet (AS201-01) groups was not significantly different (p>0.05), uninfected group compared with the other treatment groups differ meaningfully (p<0.05). Placebo group compared with all groups significantly different (p<0.05). Sambiloto tablet (AS201-01) group compared to uninfected group (p>0.05) was not significantly different, with another group was significantly different (p<0.05). DHP tablet group compared to all the groups was significantly different (p<0.05).Conclusion: Placental Chondroitin Sulfate A (CSA)expression of mice infected by Plasmodium berghei treated with Sambiloto tablet (AS201-01) lower than DHP tablet.

Combination of palonosetron-dexamethasone is more effective than ondansetron-dexamethasone as single cisplatin antiemetic chemotherapy Agung Sunarko Putra; Suhatno Suhatno
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Objective: To know the efficacy differences between two groups of drug combination ondansetron-dexamethasone (A) and ondan-setron-dexamethasone (B) to prevent emetic rsponses after chemotherapy cisplatin administration (CINV).Materials and Methods: A prospective double blind randomized clinical trial study held in Dr. Soetomo General Hospital involving 66 subjects, devide into two groups randomly 33 patients each. One group receive palonosetron-dexamethasone combination therapy compare to ondansetron-dexamethasone combination as standart therapy in gynecologic oncology Dr. Soetomo Hospital in a control group as cisplatin chemotharapy CINV prophylaxis. The research was conducted from June till October 2014 in the Dr. Soetomo General Hospital-Surabaya. Assessment and measurement of the response of nausea and frequency of vomiting according Gralla scale, changes in plasma density and electrolyte serum (Na, K, and Cl) as a result of dehydration caused by nausea and vomiting, as well as counting the onset of nausea and vomiting occur.Results: There was significant differences between the results of the combination therapy compared ondansetron-dexamethasone to palonosetron-dexamethasone for nausea and vomiting (p=0,001). 31 subjects suffers nausea in ondansetron group, while 9 subjects suffers nausea in palonosetron group. Vomiting occurs in 17 subjects from ondansetron group, and only 1 subject from palono-setron group during study. Changes in plasma density significant in palonosetron group, and natrium in ondansetron group. For K and Cl not significantly difference in both groups before and after cisplatin chemotherapy administration.Conclusion: Palonosetron-dexamethasone combination is super-ior as cisplatin CINV prophylaxis in response to nausea and vomiting frequency, and also give longer protection compare to ondansetron-dexamethasone significantly. The plasma density and electrolyte serum changes are varied in numbers and also influenced by many factors including physical status and nutrition, also intake of each patients.

Postplacental insertion of IUCD Cu T 380A at transcesarean section does not influence bleeding and infection at puerperial period Menik Utami; Baksono Winardi
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Objective: To determine the difference of the puerperial bleeding and puerperial infection women who had intrauterine contraceptive device (IUCD) T380A insertion at caesarean section compare with women who had caesarean section without IUCD insertion.Materials and Methods: This study was an observasional analytic prospective cohort. Participants allocated to 2 groups : IUCD inserted during cesarean and cesarean with no device inserted. Subject research monitoring at 10 and 40 day of puerperial period.Results: Puerperial bleeding of group with IUCD insertion is 99,309+32,845 ml and group without IUCD is 88,010+30,824 ml, with the analysis test got p=0,085 (p>0,05) means no difference between two groups.Level hemoglobin at post cesarean section (day-0), 10 and 40 day, proportion increasing severity of anemia and duration of lochia rubra were analized and got p>0,05, no difference between two groups. Duration of puerperial bleeding period, median group with IUCD 40 days (25-50) and group without IUCD 30 days (26-45), with analized test got p<0,05. Duration of puerperial bleeding were significantly difference. Proportion of clinical sign puerperial infection 3 (6,4%) of group with IUCD and 2 (4,1%) of group without IUCD, with analized test got p=0,614 (p>0,05), no difference between two groups. Level of leucocyte at post cesarean section (day-0), 10 and 40 day, the difference both two groups was not significant (p>0,05). In this research the difference puerperial bleeding and proportion puerperial infection between two groups (women who had IUCD T380A insertion at caesarean section compare with women who had caesarean section without IUCD insertion) was no significant.Conclusion: Insertion IUCD Cu T 380A postplacental at caesarean section is safety.

Increased Brain Derived Neurothropic Factor in the cerebrum and cerebellum of Rattus norvegicus newborn with exposure to Mozart's music in default sequence compared with the reversed sequence and without exposure during gestation Agustina Hidayati; Hermanto Tri Joewono; Widjiati Widjiati
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Objectives: To analyze the differences in the expression of Brain Derived Neurothropic Factor (BDNF) in Rattus norvegicus cerebrum and cerebellum of newborn between those exposed to Mozart's music composition in default sequence, reverse sequence, and without exposure in the womb.Materials and Methods: Analytical laboratory experimental study with randomized post test only control group design using animal models Rattus norvegicus. The animal models were divided into three groups: control group without any exposure, the treatment groups with exposure to Mozart's music in default sequence and another group in reverse sequence since day 10 of gestation. We used a comparison test in the analysis of BDNF expression.Results: We found significant difference in BDNF expression with p value 0.004 (mean 8.98±1.31 default sequence group, 5.58±3.08 reverse sequence group, 6.80±1.95 control) in the cerebrum. We found significant difference of BDNF expression with p value 0.003 (mean 9.48±1.41 default sequence group, 6.02±3.25 reverse sequence group, 7.14±2.54 control) in the cerebellum. In cerebrum dan cerebellum we found significant difference between standard Mozart’s music and control (cere-brum p=0.018, cerebellum p=0.001), and we found significant difference between standard Mozart’s music and reverse Mozart’s music (cerebrum p=0.001, cerebellum p=0.008) and no significant difference in reverse Mozart and control (cerebrum p=0.264, cerebellum p=0.490)Conclusion: Sequence in Mozart’s music is very important in increase expression of BDNF.

Apoptosis index of cerebrum and cerebellum neuronal cells in Rattus norvegicus neonates born from mothers treated with 50% food restriction during gestation Andita Hapsari; Hermanto Tri Joewono; Widjiati Widjiati
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Objective: To analyze the difference of neuronal apoptotic index on Rattus norvegicus offspring in cerebrum and cerebellum between food restriction 50% group and control.Materials and Methods: An analytical experimental study with single blind randomized post test only control group using animals subjects Rattus norvegicus. This study was conducted at animal laboratory, Veterinary Faculty, Universitas Airlangga. Animal subjects were divided into food restriction 50% group and control. The apoptotic index was analyzed using comparison test, with significancy p<0.05.Results: There was significant difference of neuronal apoptotic index on Rattus norvegicus offspring between FR 50% group and control in cerebrum with p= 0.002 (mean 6,12±3,51 in FR 50% group, 2,81±2,16 in control group), and cerebellum with p= 0.026 (mean 5,56±3,03 in FR group, 3,43±2,58 in control group).Conclusions: Food restriction 50% during gestation has signifi-cant influence on neuronal apoptotic index in cerebrum and cerebellum of Rattus norvegicus offspring.

Role of family structure and parenting style in adolescent pregnancy in Surabaya, Indonesia Anifah, Fulatul; Dasuki, Djaswadi; K, Herlin Fitriana; Triratnawati, Atik
Majalah Obstetri & Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Objectives: This study aimed to examine the relationship between family structure and parenting style and their association with adolescent pregnancy in Surabaya. Materials and Methods: A mixed-methods approach was employed, combining a case–control design with a case study. Data were collected through questionnaires and in-depth interviews. The study included 46 adolescents (23 cases and 23 controls) selected using purposive sampling, along with six adolescents as key qualitative participants. Quantitative data were analyzed using univariate, bivariate (Chi-square), and multivariate (multiple logistic regression) analyses with a significance level of p = 0.05 and a 95% confidence interval (CI). Qualitative data were analyzed thematically based on in-depth interviews. Results: Family structure was not statistically significant (OR = 10.53; 95% CI = 0.657–168.93), though it showed social relevance. Parenting style was also not significantly associated with adolescent pregnancy (OR = 1.191; 95% CI = 0.373–3.806). However, respondent education was significantly associated with adolescent pregnancy (OR = 559.76; 95% CI = 3.608–23,026.4). No significant associations were found for parental education, employment status, or residential setting. Parenting style appeared to be influenced by the quality of communication between parents and adolescents. Conclusions: Low educational attainment was identified as a major risk factor for adolescent pregnancy. Additionally, adolescents from extended families or single-parent households appeared more likely to experience teenage pregnancy.

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Jl. Airlangga No.4 - 6, Airlangga, Kec. Gubeng, Kota SBY, Jawa Timur 60115

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Jawa timur

INDONESIA