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All Journal Alchemy : Journal of Chemistry Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Tropical and Infectious Disease Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Majalah Obstetri dan Ginekologi SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Asia Humanism : Jurnal Pengabdian Masyarakat Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Jurnal Masyarakat Madani Indonesia Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Widya Medika
Aty Widyawaruyanti
Departemen Ilmu Kefarmasian Fakultas Farmasi Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EKSTRAK ETANOL AKAR DAN DAUN DARI TANAMAN Calotropis gigantea AKTIF MENGHAMBAT PERTUMBUHAN SEL KANKER KOLON WiDr SECARA IN VITRO Mutiah, Roihatul; Widyawaruyanti, Aty; Sukardiman, Sukardiman
Journal of Islamic Pharmacy Vol 1, No 1 (2015): Jurnal Farmasains
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.4278

Abstract

Penelitian ini bertujuan untuk mengetahui perbandingan aktivitas antikanker ekstrak etanol bagian akar, daun dan bunga dari tanaman Calotropis gigantea terhadap sel kanker kolon WiDr. Pengujian efek penghambatan pertumbuhan antikanker dilakukan dengan metode MTT. Hasil menunjukkan bahwa ekstrak etanol bagian akar dan daun  Calotropis gigantea  mempunyai aktivitas antikanker terhadap sel kanker kolon WiDr yang lebih tinggi berturut turut dengan IC50 44.20 μg/ml; 48.50 μg/ml dibanding bagian bunga (IC50 3576 μg/ml) sehingga bagian akar dan daun dapat direkomendasikan untuk uji lebih lanjut dalam pengembangan fitofarmaka.Kata kunci: Calotropis gigantea, WiDr cell line, anti kanker
Profil Fitokimia Ekstrak Etanol Bunga Kasumba Turate (Carthamus tinctorius L.) yang Berpotensi Sebagai Antimalaria Hamsidi, Rini; Widyawaruyanti, Aty; Hafid, Achmad Fuad; Ekasari, Wiwied; Malaka, Muhammad Hajrul; Kasmawati, Henny; Akib, Nur Illiyyin; Wahyuni, W; Sabarudin, S
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 4, No 2 (2018): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.085 KB) | DOI: 10.33772/pharmauho.v4i2.6267

Abstract

Bunga Kasumba turate (Carthamus tinctorius Linn) dari suku Asteraceae merupakan tumbuhan obat tradisional etnis Sulawesi Selatan yang secara empiris digunakan dalam pengobatan campak. Ekstrak etanol dari kasumba turate memberikan peningkatan aktivitas imunoglobulin G (IgG) dan  aktivitas imunoglobulin A (IgA) yang sangat signifikan. Penelitian menunjukkan ekstrak etanol bunga C. Tinctorius L memiliki potensi sebagai antimalaria secara in vitro dengan nilai IC50 sebesar 1,06 µg/ml. Sampel bunga C. tinctorius L. kering sebanyak 3 Kg dicacah hingga menjadi serbuk sebanyak 870 gram kemudian diekstraksi secara maserasi dengan menggunakan pelarut etanol 80%. Hasil maserasi dipekatkan dengan vacuum rotary evaporator pada suhu 50°C sehingga diperoleh ekstrak kental sebanyak 178,7gram. Profil fitokimia menunjukkan ekstrak etanol bunga C. tinctorius L. mengandung senyawa metabolit antara lain saponin, terpenoid, flavonoid, tanin dan antrakuinon.Kata kunci: Skrining, ekstrak, kasumba turate, obat tradisional, antimalaria
Comparison of Ethanol Extract from Roots, Leaves, and Flowers of Calotropis gigantea as Anticancer on T47D Breast Cancer Cell Lines Mutiah, Roihatul; Sukardiman, Sukardiman; Widyawaruyanti, Aty; Zulaikah, Siti
ALCHEMY Vol 5, No 1 (2016): ALCHEMY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.215 KB) | DOI: 10.18860/al.v5i1.3690

Abstract

This research aims to find out the anticancer activity of ethanol extract from the roots, leaves, and flowers of Calotropis gigantea. This experiment was conducted by MTT method on T47D breast cancer cell line. The result showed that the root of Calotropis gigantea was more cytotoxic (IC50 89.76 μg/mL) on T47D breast cancer cell line than the leaves (IC50 459.51 μg/mL) and the flowers (IC501000). Based on the result, roots are potent to be chemotherapeutic agent, especially in breast cancer.
PELATIHAN PEMBUATAN ES KRIM HERBAL DAN INOVASI KEMASAN PRODUK JAMU DI DUSUN KIRINGAN-JETIS, BANTUL, YOGYAKARTA Widyowati, Retno; Ekasari, Wiwied; Purwitasari, Neny; Widyawaruyanti, Aty; Sukardiman, Sukardiman; Wahyuningsih, Iis
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol 4, No 1 (2020)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.661 KB) | DOI: 10.12928/jp.v4i1.1200

Abstract

Dusun Kiringan-Jetis, Bantul, merupakan desa wisata jamu gendong dengan penduduk mayoritas berprofesi sebagai pengrajin jamu. Jamu yang mereka jual secara turun-temurun terbatas dalam bentuk jadi dan setengah jadi. Perlu adanya peningkatan diversifikasi produk jamu untuk meningkatkan nilai jualnya. Kegiatan pengabdian pada masyarakat ini bertujuan untuk meningkatkan ketrampilan usaha dalam meningkatkan kualitas dan mengembangkan produk jamu yang akan dijual. Untuk dapat mencapai tujuan yang diinginkan dari kegiatan ini maka dilakukan upaya: (1) Edukasi dan pelatihan ketrampilan membuat es krim herbal dan (2) edukasi dan pelatihan ketrampilan membuat inovasi kemasan produk jamu yang aman dan menarik.Tim pelaksana kegiatan ini terdiri dari dosen dan mahasiswa S1 Fakultas Farmasi Universitas Airlangga dan Universitas Ahmad Dahlan. Dari kegiatan tersebut terlihat antusias para peserta pelatihan, peningkatan pengetahuan dan ketrampilan dalam pembuatan es krim herbal dan inovasi kemasan produk. Hal ini terlihat dari peningkatan skor post-testsetelah dilakukan pelatihan.Besar harapan para peserta kegiatan untuk dapat mengaplikasikan pengetahuan yang didapat sehingga dapat meningkatan perekonomian Dusun Kiringan-Jetis, Yogyakarta
Pendampingan Pemanfaatan Toga Menjadi Produk Bernilai Ekonomi dalam Rangka Penguatan Program Asuhan Mandiri di Kabupaten Lamongan Idha Kusumawati; Suciati Suciati; Pratiwi Soesilawati; Aty Widyawaruyanti; Retno Widyowati; Tutik Sri Wahyuni; Neni Purwitasari; Rice Disi Oktarina; Subhan Rullyansyah
Humanism : Jurnal Pengabdian Masyarakat Vol 3, No 1 (2022): April
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/hm.v3i1.12901

Abstract

Kegiatan asuhan mandiri Toga atau yang juga dikenal dengan asman TOGA diintegrasikan dengan program PKK yang dalam pelaksanaannya dikoordinir oleh kader Asman dan didampingi fasilitator dari Puskesmas. Program ini dibawah pembinaan oleh Dinas Kesehatan Kabupaten/Kota. Desa Canditunggal yang terletak di wilayah Kecamatan Kalitengah Kabupaten Lamongan mempunyai kebun TOGA yang asri terbentang di tengah jalan desa. Kebun TOGA ini merupakan hasil kegiatan ibu-ibu PKK yang juga merupakan kader asman TOGA. Pada awalnya kebun TOGA ini hanya untuk keindahan saja. Untuk itu pada kegiatan pengabdian masyarakat yang dilakukan kali ini bertujuan untuk memberdayakan ibu-ibu PKK tersebut agar dapat memanfaatkan TOGA khususnya dalam membuat produk dari daun katuk menjadi produk bernilai ekonomi untuk memperbanyak ASI. Kegiatan dilakukan dengan pemberian materi dan pelatihan pembuatan produk. Antusiasme, kreatifitas dan inovasi dari ibu-ibu PKK kader asman TOGA Desa Canditunggal ini merupakan potensi yang sangat besar untuk keberhasilan pemanfaatn TOGA untuk menciptakan produk-produk yang bernilai ekonomi.  Kata Kunci: Asman, daun katuk, TOGA
Skrining Aktivitas Antimalaria Beberapa Tanaman Indonesia Hasil Eksplorasi Dari Hutan Raya Cangar, Batu-Malang, Jawa Timur Achmad Fuad Hafid; Nike Puliansari; Nur Suci Lestari; Lidya Tumewu; Abdul Rahman; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.387 KB) | DOI: 10.20473/jfiki.v3i12016.7-11

Abstract

Background: Malaria is the most important parasitic disease. Malaria control which depends on specific chemotherapy now complicated by resistance of Plasmodium falciparum to most commonly available antimalarial drug. Such situation has heralded the need for alternative antimalarial therapy. Objective: This research aim was to find new antimalarial candidates from some Indonesia plants collected from Cangar National Forest, Batu-Malang, East Java. Methods: Eleven samples of leaves and stem extracts were screened against Plasmodium falciparum 3D7 culture which maintained in RPMI-1640 Medium. Samples tested in concentration of 0.01, 0.1, 1, 10 and 100 µg/ml. Probit analysis was used to determine IC50. Results: In vitro antimalarial activity revealed that only three crude extracts samples from Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract had good antimalarial activity with IC50 value of 0.33, 0.20 and 0.55 µg/ml, respectively. Conclusions: Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract might be a good candidate for antimalarial natural product resources.
Anti-Hepatitis C Virus Activity of Various Indonesian Plants from Balikpapan Botanical Garden, East Borneo Rina Puspitasari; Tutik Sri Wahyuni; Achmad Fuad Hafid; Adita Ayu Permanasari; Lidya Tumewu; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.48-54

Abstract

Background: Hepatitis C Virus infection is a serious health problem that leads to chronic liver disease, liver cirrhosis, hepatocellular carcinoma, which causes high morbidity. Direct-Acting Antiviral Agents have been used as anti-hepatitis C Virus therapy. However, it was covered only in limited patients due to the high cost. Moreover, serious side effects and resistance cases were also reported in some HCV genotypes. Objective: This research aimed to find new anti-HCV from some Indonesia plants collected from Balikpapan Botanical Garden, East Borneo. Methods: Twenty-one leaf and stem barks extracts were successively extracted in n-hexane, dichloromethane, and methanol. Extracts were screened for their anti-HCV activity under in vitro culture cells in the concentration of 30 µg/mL. Plant extracts were inoculated in the Human Hepatocellular 7it and infected with HCV Japanese Fulminant Hepatitis strain 1a. Determination of 50% Inhibitory Concentration (IC50) value was further conducted at concentration of 100; 30; 10; 1; 0.1; 0.01 µg/ml of extracts. Results: In vitro anti-HCV activity revealed that among 21 plants extract, 11 extracts, namely, n-hexane extract from Luvunga scandens leaves, DCM extract from the leaf of L. scandens, Artocarpus sericicarpus, Artocarpus dadah, Eusideroxylon zwageri, Neolitsea cassiaefolia, methanol extract from A. sericicarpus and A. anisophyllus leaves, DCM extract from A. anisophyllus and A. elmeri stem bark, methanol extract from A. dadah stem bark, having potential inhibition with IC50 range 0.08 ± 0.05 to 12.01 ± 0.95 µg/mL. Conclusions: These results indicate that the eleven extracts could be good candidates as sources of anti-HCV agents.
Comparison of the provision of champedon trunk shell capsule extract and artesunate on placental histopathologic classification in pregnant mice (Mus musculus) malaria model Achmad Yunus; Budi Prasetyo; Erry Gumilar Dachlan; Aty Widyawaruyanti; Widjiati Widjiati
Majalah Obstetri dan Ginekologi Vol. 25 No. 3 (2017): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.244 KB) | DOI: 10.20473/mog.V25I32017.71-76

Abstract

Objectives: To compare the effect of chemphedon trunk shell capsule extract with artesunate on placental histopathologic classification in pregnant mice malaria’s models.Materials and Methods: This study was a randomized experi-mental laboratory study in BALBc strains mice with controls. A total of 30 pregnant mice were divided into 3 groups. On day 10 each group was infected with P. berghei. Furthermore, on day 11 each group was subjected to thin blood smear examination and subsequent infection when administered antimalarial positive. Group P1 received Chemphedon trunk shell extract 100 mg/kg BW/day per sonde two times per day for 5 days. Group P2 received 36.4 mg artesunate/kg BW/day for 3 days followed by CMC Na per sonde for 2 days, and group P3 received placebo (CMC Na) for 5 days. On day 16 the mice were dissected on 16 days of pregnancy and the placenta was taken and preparations were made to observe histopathological classification of the placenta according to Rogerson. Grouping was performed accor-ding to placental histopathological classification by Rogerson.Results: Groups receiving cemphedon trunk shell capsule extract, artesunate and placebo revealed p=0.004 (p<0.05), showing that there were two groups with significant difference. To determine which group had significant difference, the test was followed by Mann-Whitney post-hoc test. The results showed chempedon trunk shell capsule group and placebo obtained p=0.007 (p<0.05), indicating significance. Artesunate and placebo groups revealed p=0.003 (p<0.05), also indicating significance. The test results of chemphedon trunk shell capsule extract and artesunate groups showed p=0.475 (p<0.05), indicating no significant differences.Conclusion: Placental histopathologic classification on pregnant mice malaria’s model that received antimalarial chemphedon trunk shell capsule extract of 100 mg/kg BW is better than place-bo and equivalent to artesunate of 36.4mg/kg BW.
Sambiloto (AS201-01) is better than standard antimalarial drug (DHP) in reducing Toll-Like Receptor 2 (TLR2) on placenta malaria model Masyitah Hamidah; Aty Widyawaruyanti; Widjiati Widjiati; Budi Prasetyo
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (687.733 KB) | DOI: 10.20473/mog.V26I22018.74-82

Abstract

Objectives: To compare the TLR2 expression in the placenta between treated by sambiloto EA-96 fraction tablet (AS201-01) and dihydroartemisinin-piperaquine phosphate (DHP)Materials and Methods: Experimental study using 24 pregnant mice. All sample divided into 4 groups with randomization are uninfected group, Plasmodium infected group and given placebo, sambiloto (AS201-01) and DHP. Then performed surgery and placental sampling were staining with adopting in tunnel assay method to measure the TLR2 expression of placental.Results: The expression of TLR2 in uninfected group has the lowest rate compared to other groups. The infected and placebo treated group has the highest TLR2 expression campared with sambiloto and DHP. The sambiloto group has not differ signi-ficantly with the group uninfected and lower than DHP.Conclusion: Tablet of sambiloto EA-96 fraction (AS201-01) decreased TLR2 expession better than with DHP tablet.
The effect of sambiloto tablet (AS201-01) on placental Chondroitin Sulfate A (CSA) expression of pregnant mice infected by Plasmodium berghei Nasrul Wahdi; Widjiati Widjiati; Aty Widyawaruyanti; Budi Prasetyo
Majalah Obstetri dan Ginekologi Vol. 26 No. 2 (2018): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.829 KB) | DOI: 10.20473/mog.V26I22018.83-90

Abstract

Objectives: To determine the effect of Sambiloto tablet (AS201-01) in reducing the placental Chondroitin Sulfate A (CSA) Expression of pregnant mice infected Plasmodiumberghei.Materials and Methods: Experimental study using 24 pregnant mice were divided into 4 groups with randomization. Uninfected group, the placebo group, the Sambiloto tablet (AS201-01) group and the DHP tablet (as a standart drug) group. The last three groups, were infected with P. bergheion day 9th of pregnancy, and the treatment was started at day 11th of pregnancy, and samples were terminated at day 15th of pregnancy by surgery. Placental sampling were stained with Tunnel assay to measure placental CSA antibodies.Results: The placental Chondroitin Sulfate A (CSA) expression. Uninfected group compared to Sambiloto tablet (AS201-01) groups was not significantly different (p>0.05), uninfected group compared with the other treatment groups differ meaningfully (p<0.05). Placebo group compared with all groups significantly different (p<0.05). Sambiloto tablet (AS201-01) group compared to uninfected group (p>0.05) was not significantly different, with another group was significantly different (p<0.05). DHP tablet group compared to all the groups was significantly different (p<0.05).Conclusion: Placental Chondroitin Sulfate A (CSA)expression of mice infected by Plasmodium berghei treated with Sambiloto tablet (AS201-01) lower than DHP tablet. 
Co-Authors Abdul Rahman Achmad Fuad Achmad Fuad Hafid Achmad Toto Poernomo Achmad Yunus Adita Ayu Permanasari, Adita Ayu Adita Ayu Permatasari AGUS HARIANTO Agus Pratiwi Andang Miatmoko Budi Prasetyo Chie Aoki-Utsubo Corry, Maylisa Natalia Dahri, Baso Desak Ketut Ayu Aryani Devanus Lahardo Diyah, Nuzul Wahyuning Djoko Agus Purwanto Edhi, Narendrani Sasmitaning Einstenia Kemalahayati Erry Gumilar Dachlan, Esti Hendradi Firmansyah Ardian Ramadhani Hadi Kuncoro Hadi Poerwono Handayani, Rosita Hanifah Khairun Nisa Hasan, Muhammad Amir Hidayati, Agriana Rosmalina Hidayatus, Laila Nur Hilkatul Ilmi Hilkatul Ilmi Hilkatul Ilmi Idha Kusumawati Iis Wahyuningsih Ilmi, Hilkatul Indah Tantular Isnaeni Isnaeni Kasmawati, Henny Kholis Amalia Nofianti Lahardo, Devanus Laura Wihanto Lidya Tumewu Malaka, Muhammad Hajrul Maria Lucia Ardhani Dwi Lestari Marsih Wijayanti Masyitah Hamidah Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Myrna Adianti Nasrul Wahdi Neni Purwitasari Ni Luh Rustini Ni Putu Ariantari Nike Puliansari Nur Illiyyin Akib Nur Suci Lestari Oktarina, Rice Disi Paramita, Diajeng Putri Pratiwi Soesilawati Purwitasari, Neni Purwitasari, Neny Retno Sari Retno Widyowati Rice Disi Oktarina Riesta Primaharinastiti, Riesta Rina Puspitasari Rini Hamsidi Roihatul Mutiah Sabar Deyulita Sabarudin Sabarudin Siti Zulaikah SOFIANA SARI Subhan Rullyansyah Suciati Suciati Suciati Suciati Sukardiman Suryanto, Suryanto Syahrani, Achmad Taslim Ersam Tri Widiandani Tutiek Purwanti Tutik Sri Wahyuni Utami Islamiati W Wahyuni, W Wicaksana, Firman Widjiati Widjiati Widjiati Widjiati Wiwied Ekasari Yusuf Alif Pratama