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INDONESIA
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES
Published by Universitas Udayana
ISSN : 20854773     EISSN : 23022906     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesia Journal of Biomedical Science (IJBS), Print-ISSN 2085-4773; E-ISSN 2302-2906 is an international and peer-reviewed journal published twice per year in print and online by Indonesian of Biomedical Association in collaboration to Postgraduate School of Biomedicine Udayana University, Bali-Indonesia which was founded in 2007. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of biomedical scholarship, and to encourage a vigorous dialogue between biomedical scholars and researches. The Journal welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and biomedical researchers all over the world.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol. 6, No. 1 Januari 2012" : 7 Documents clear
CHARACTERISTIC AND CORRELATION BETWEEN TIME AND COMPLICATION AFTER DESTRUCTIVE EYE PROCEDURE PATIENT AT PLASTIC AND RECONSTRUCTION DIVISION SANGLAH HOSPITAL’S EYE CLINIC BALI-INDONESIA Triharpini, N; Sukartini, D; Yuliawati, P.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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Abstract

ABSTRACT Destructive eye procedure can be carried out by enucleation, evisceration and excenteration. Some efforts have been developed to reduce the complications, but it still occur within several years after the operation. This research aims to find out the characteristic and correlation between time and complications in patient after destructive eye procedure at Plastic and Reconstruction Division Sanglah Hospital’s Eye Clinic. For addition, characteristic of other patients in plastic and reconstruction also provided. This report is an analytical cross sectional study. Data were collected retrospectively from medical report of patients with history of destructive eye procedure in Sanglah Hospital’s eye clinic from January 1st until December 31st 2010. Patient’s characteristics were presented as frequency, percentage, mean, and standard deviation. Correlations between variables were statistically analyzed with Correlation of Lambda. Eye trauma, anophthalmic socket and nasolacrimal duct obstruction were the most common diagnosis at plastic and reconstruction division Sanglah Hospital’s eye clinic. There were 17 patients with history of destructive eye procedure in this report, including 76.5% male and 23.5% female. There is 58.8% destructive eye procedure held in age 13-50 year, mean 30.75 (SD 19.81). Infection (35.3%), trauma (23.5%) and tumor (11.8%) were the most common cause of destructive eye procedure in this study. Complications of destructive eye procedure occur in 70.6% of patient with contracted socket was the most common complication (58.3%). There was medium correlation between time and complication after the procedure, but the correlation was not statistically significant (r = 0.40; p > 0.05). In conclusion, from this study we obtained that there was medium correlation between time and complication after the procedure, but the correlation was not statistically significant.
TOPICAL APPLICATION OF ETHANOL EXTRACT OF STARFRUIT LEAVES (AVERRHOA BILIMBI LINN) INCREASES FIBROBLASTS IN GINGIVAL WOUNDS HEALING OF WHITE MALE RATS Hartini, IGAA
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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Abstract

ABSTRACT Injuries to the gingiva are often encountered because of abnormalities in the oral cavity. Gingival wound healing is more complex because it lies in an open area, often contaminated and exposed to various types of bacteria in the oral cavity. Gingiva wound healing is determined by increase of fibroblasts. Plants widely used by humans as medicine is star fruit (Averrhoa Bilimbi Linn). This study aims to determine an increase of gingival fibroblasts on wound healing of male white rats given various concentrations of starfruit leaves extract topically. The study was conducted with a pretest-posttest control group design, consisted of four groups: the control group with distilled water and the groups treated with ethanol extract of starfruit leaves with a concentration of 10%, 20% and 40%. The result based on comparison test between the groups with One Way Anova, showed that the average amount of fibroblast in four groups after receiving the treatment was significantly different (p<0.01). The result of the test showed an increase in the number of fibroblasts in groups concentration of 10% and 20%, there was a decline observed in group concentration of 40%. It was concluded that application of ethanol extract of starfruit leaves with concentration of 10% increase the highest number of fibroblasts in the rat gingival wound healing process.
VARIES SHUTTLE RUN EXERCISE METHODS INCREASE AGILITY OF STUDENTS OF SMK NEGERI 2 TONDANO KABUPATEN MINAHASA Sarapung, M; Pangkahila, J. A.; Adiputra, N.; Adiatmika, IPG
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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Abstract

ABSTRACT Achievment of Indonesian athletes at international level are only resting on badminton, archery, and weight lifting. Meanwhile, other sports do not exhibit encouraging achievement. Agility is one of the important factor on sports including group and individual sports. This is an experimental research with randomized pretest posttest conrol group design. Sample are 75 students recruited from SMK Negeri 2 Tondano Kabupaten Minahasa. Sample was grouped into 5 groups, each group composed of 15 students. The five groups observed were group 1 with treatment of 4 x 30 m shuttle run, group 2 treated with 8 x 15 m shuttle run, group 3 with 12 x 10 m shuttle run, group 4 within 16 x 7.5 m shuttle run, and the last is control group. Exercise was carried out for 6 weeks with a frequent of 3 time per week. Agility pre and posttest data were analysed using anova oneway followed by LSD Post Hoct Test at 5% significant level. This study obtained that there were a significant different among the five groups observed. Shuttle run exercise method with dose of 16x7.5 m increase the highest agility.
IN VITRO INHIBITION ZONE TEST OF BINAHONG (ANREDERA CORDIFOLIA) TOWARDS STAPHYLOCOCCUS AUREUS, ENTEROCOCCUS FAECALIS, ESCHERICHIA COLI, AND PSEUDOMONAS AERUGINOSA Amertha, IBPM; Soeliongan, S; Kountul, C
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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Abstract

ABSTRACT This is a true experimental research with post test-only control group design. The study was conducted to test the inhibitory zone of the Binahong leaf extract (Anredera cordifolia) against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Binahong leaf extract is prepared using maceration technique, by soaking it in a sealed jar for 24 hours with 95% methanol. Then subsequently filtered using a funnel with filter paper, and the filtrate is collected inside an erlenmeyer. The filtrate then concentrated using a rotavapor, this concentrated extract dissolved into aquadest with a concentration of 50 ppm, 100 ppm and 1000 ppm. By taking a few colonies with a sterile loop into a stock of Staphylococcus aureus, Enterococcus faecalis, Esherichia coli, Pseudomonas aeruginosa then scratch it into MH blood agar medium, and incubate it for 24 hours with a temperature of 370C. The next day, bacterial suspension was made in test tube, which already contains 0.9% NaCl. The suspension tturbidity is equivalent to 0.5 Mc Farland. Bacterial inhibition zone of binahong leaf extract (Anredera cordifolia) is tested using absorbance disc method or better known as the Kirby-Bauer method. First, pour 10 ml of agar medium (± 400C) into a cup (petridish) and then wait until it’s cold. After the medium becomes solid, the suspension of bacteria Staphylococcus aureus, Enterococcus faecalis, Esherichia coli, and Pseudomonas aeruginosa are slowly smeared with sterile cotton sticks on the surface of the media. Soak the paper discs into binahong leaf extract (Anredera cordifolia) with concentrations of 50, 100, and 1000 ppm, for about 5 minutes, and placed it on the surface of the petridish, together with the positive control (amoxicillin) and negative control (aquadest). Then incubate it at 370C for 24 hours. The effectiveness of binahong leaf extract (Anredera cordifolia) inhibition zone, can be determined by measuring the diameter of clear zone around the paper using a sliding-term. Binahong leaf extract (Anredera cordifolia) zone of inhibition is negative, a very slight different is showed by the amoxicillin inhibition zone, for having a clear zone diameter of 28 mm for Staphylococcus aureus and Esherichia coli, and 21 mm for Enterococcus faecalis. This fact is probably caused by several things concerning the mechanism of action of a substance as an anti bacterial of the binahong leaf extract (Anredera cordifolia).
THE MOLECULAR BASIS OF RESISTANCE ANTIRETROVIRAL MARKERS AND POLYMORPHISMS OF THE HUMAN IMMUNODEFICIENCY VIRUS-1 SUBTYPE CRF01-AE PROTEASE GENE IN NAÏVE AND TREATMENT FAILURE PATIENTS IN BALI Sri Budiyanti, N.; Suata, I K.; Merati, K. T. P.; Mahardika, I G.N.K.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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ABSTRACT Application of antiretrovirals (ARVs) in patients with Human Immunodeficiency Virus (HIV) infection has proven to reduce mortality rates and prolong life expectancy. On the other hand, the use of antiretroviral drugs has incited the emergence of HIVDR. The resistance is due to mutation at genes associated with drug resistance. Nowadays, the determination of resistance markers mutations are based on HIV-1 subtype B. However, the majority of HIV in Indonesia, particularly in Bali are of subtype CRF01_AE. Genetic variation between HIV viruses has led to variations in subtypes; therefore, resistance markers of subtype B could be polymorphisms of non-B subtypes. This study aims to determine the number and types of the resistance markers mutations and polymorphisms that occur on the PR gene of HIV-1 subtype CRF01_AE of naïve and treatment failure patients in Bali. This is an observational cross-sectional analytical study, conducted at two VCT clinics in Denpasar, during the period of April 2010 until October 2011. Samples consist of 18 HIV patients with treatment failure and 30 naïve HIV patients. Mutations were evaluated using PCR, sequenced and aligned were carried out using MEGA4. Interpretations of the mutations were made based on the Stanford HIV database. Hypothesis tests used were Mann-Whitney because of abnormal distribution of data. Hypothesis was accepted if the significant level p<0.05. This study found that of the demographic data, only the predisposing factors of the two groups were significantly different (p<0.05). Two patients with treatment failure and 5 naïve patients were found to have L10LV/I mutations. Only one patient with treatment failure had the I54FI mutation. No major mutations were found among the two study groups. The number and types of minor mutations were not significantly different (p>0.05) between the naïve group and treatment failure group. M36I and H69K polymorphisms of the PR gene were found in all the study samples. In conclusion of this study, two types of major mutations were found, L10LV/I and I54FI. The number and types of the resistance markers mutations towards the protease inhibitor (PI) group were not significantly different between the two study groups. M36I, H69K mutations of the PR gene are markers of polymorphisms of HIV-1 subtype CRF01_AE.
THE HUMORAL IMMUNITY RESPONSE OF DOG VACCINATED WITH ORAL SAG2 AND PARENTERAL RABISIN AND RABIVET SUPRA92 -, Faizah; Mantik-Astawa, IN; Putra, AAG; -, Suwarno
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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ABSTRACT This research aims to determine whether SAG2 oral vaccine induced antibody response as high as that of parenteral vaccine (Rabisin and Rabivet Supra 92). The experimental design applied was randomized pre and post control group design with 4 treatments (oral SAG2 vaccine, parenteral rabisin, parenteral Rabivet Supra 92 and control without vaccination) and with 9 replication. As many as 36 kampung dogs used and the anti rabies antibody was determined by enzyme-linked immunosorbent assay (ELISA) at day 0, 21, 56, 84, 119, and 147 post vaccination. The antibody titer induced by oral SAG2 vaccine raised more slowly but persisted longer than parenteral vaccine. On day 21 after vaccination, the average antibody titers induced by oral SAG2 vaccines (0.501 IU/ml) was still significantly lower than those induced by parenteral Rabisin (3.504 IU/ml) and Rabivet Supra92 (2.545 IU/ml). However, by day 119 after vaccination the average antibody titer induced by SAG2 oral vaccine (0.889 IU/ml) was significantly higher (p <0.05) as compared to those of parenteral Rabisin (0.625 IU/ml) and Rabivet Supra 92 (0.223 IU/ml). The antibody response induced by SAG2 oral vaccine appears to persist longer than parenteral vaccines and it can therefore be used as an alternative vaccine to combat rabies in animals, especially for dogs kept in free range.
ROLE OF EXCLUSIVE BREASTFEEDING AND S-IGA ANTIBODIES ANTIROTAVIRUS BREAST MILK TOWARDS RISK OF ACUTE ROTAVIRUS DIARRHEA IN INFANTS AGE OF 1-6 MONTHS: DO THEY CORELATE TO BREASTFEEDING "DAILY DOSE" AND ANTIBODY TITERS? Lely, Oka; -, Soetjiningsih; Wibawa, I D. N.; Mantik Astawa, IN
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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Abstract

ABSTRACT Exclusive breastfeeding reduces the incidence of diarrhea, especially in children who live in densely populated neighborhood. This study aims to determine the relationship between exclusive breastfeeding and breast milk contains antirotavirus s-IgA antibodies towards risk of acute rotavirus diarrhea in infants aged of 1-6 months. Case-control study design is applied to determine the relationship between exclusive breastfeeding and breast milk contains s-IgA antibodies antirotavirus with risk of acute rotavirus diarrhea. Cases in this study were patients with acute rotavirus diarrhea and controls were patients without acute rotavirus diarrhea. Cases and controls were matched based on age. There were 23 cases and 69 controls. The proportion who received exclusive breastfeeding was 34.8% in cases and 34.4% in controls, with OR of 1.21 (95% CI: 0.45 to 3.28) and p = 0.28. Breast milk contains sIgA antibodies antirotavirus for case was 17.39% and controls was 23.2%, OR was 1.12 (95% CI: 0.29 to 4.29), p = 0.203. In conclusion, exclusive breastfeeding and breast milk contains sIgA antibodies antirotavirus were not associated with risk of acute rotavirus diarrhea in infants 1-6 months. This may be caused by differences in population and demographic studies as well as low of milk sIgA antibody antirotavirus titters. Further research of breastfeeding regardless of antirotavirus containing high antibody titters sIgA is needed.

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