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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 6 Documents
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Search results for , issue "Vol 5, No 2 (2019)" : 6 Documents clear
SENSITIVITY AND SPECIFICITY OF RAPID TEST BRUGIA MALAYI Kumalasari, Tri Novia
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7983

Abstract

Filariasis is a chronic infectious disease caused by the filarial worm that attacks the lymph veselle and lymph nodes. There are three species of filarial worms known to cause 90% of filariasis cases they were: Wuchereria bancrofti, Brugia malayi and Brugia timori. Microscopic examination of the thick blood clots using peripheral blood of patients at night is a conventional technique. In the global filariasis elimination program, WHO has recommended serodiagnosis methods. For filariasis Brugia, the best serodiagnosis method currently available is the detection of IgG4 anti-filarial antibodies. Research Objectives were to determine the sensitivity and specificity of the Brugia Rapid Test comparing to blood clots method with Giemsa staining in detecting Brugia malayi in the village of Sungai Rengit Murni Talang Kelapa District Banyuasin Regency. The Method used in the study was diagnostic test. The research was conducted in the village of Sungai Rengit Murni Banyuasin Regency on June 20, 2013. The number of samples were 80 people taken using simple random Sampling. Giemsa staining and Brugia Rapid Test were used as examination method. Based on the findings of the 80 samples examined, the examination result using Giemsa method was 0 (0%) and the method of Brugia Rapid were 22 people (27.5%) The Sensitivity of Brugia Rapid Test compared to Giemsa method was 0%, the spesifisitasnya was 72,5%; 0% positive predictive value and 100% negative predictive value.
RATIONALIZATION OF CALCIUM ANTAGONIST IN PREECLAMPSIA Novianty, Novianty; Tanzil, Sutomo; Theodorus, Theodorus
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7984

Abstract

Preeclampsia is a hypertension condition after the 20th week of pregnancy with proteinuria. Eclampsia is a preeclampsia with convulsion and or coma. In Indonesia preeclampsia and eclampsia still one of the main causes of maternal and perinatal mortality. The aim of this study was to know the pattern of utilization of calcium antagonists in hypertension in pregnancy in Mohammad Hoesin Hospital. Drug utilization study has been done at medical records ward in November until December 2013. The population is medical records of hypertension in pregnancy patients at The Medical Record Installation of Obstetrics and Gynecology Department of Mohammad Hoesin Hospital from July until December 2012. The sample is 63 medical records which fulfill the inclusion criteria. The result is tabulated in percentage and presented descriptively. There were 63 pregnant women with hypertension. Hypertension in pregnant women aged between 33 till 37 years old (40%). Hypertension in pregnant women was found in first pregnancy (11.3%). Hypertension in pregnant women was hypertension stage two (68.2%). Calcium antagonists that mainly used were nifedipine and amlodipine. Nifedipine was given orally in 10 mg dose three times daily (100%). Amlodipine was given orally in 10 mg dose once a day (100%). The most frequent drug that was given at the same time with hypertension drugs is magnesium sulphate (89%). The use of calcium antagonists in hypertension in pregnancy at Obstetrics and Gynecology Department of Mohammad Hoesin Hospital has been rational
ANTIBACTERIAL EFFECT PROPOLIS AGAINST ESCHERICHIA COLI AND SHIGELLA DYSENTERIAE IN VITRO Ferdi, Roni; Saleh, Irsan; Theodorus, Theodorus; Salni, Salni
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7982

Abstract

The bacteria that often cause infectious diarrhea are Escherichia coli and Shigella dysenteriae. Excessive and less rational use of antibiotics in diarrhea cases encourages the development of multi drug pathogen resistance. Propolis is one solution to overcome diarrheal infections. The purpose of this study was to determine the ability of the antibacterial effects of propolis extract on Escherichia coli and Shigella dysenteriae bacteria in in vitro testing with various concentrations. Research in laboratory experiments in vitro. The sample in this study was the bacteria Escherichia coli and Shigella dysenteriae with the stages of research starting from the extraction process carried out using a multilevel extraction method. The results showed that the smallest concentration of n-hexane fraction which still inhibited the growth of Escherichia coli and Shigella dysenteriae bacteria was 250 µg / ml and this concentration was expressed as KHM value. The equality test of 250 µg / ml n-hexane propolis fraction was equivalent to 4.0 µg / ml ciprofloxacin to Escherichia coli and equivalent to 4.6 µg / ml ciprofloxacin against Shigella dysenteriae, while the equality test concentration of 250 µg / ml ethyl acetate propolis equivalent to 5.2 µg / ml of ciprofloxacin against Escherichia coli and equivalent to 4.5 µg / ml of ciprofloxacin against Shigella dysenteriae. The conclusion of this study is that n-hexane extract and ethyl acetate propolis have antibacterial effectiveness against Escherichia coli and Shigella dysenteriae. The n-hexane and ethyl acetate propolis fractions have lower antibacterial activity compared to ciprofloxacin in inhibiting the growth of Escherichia coli and Shigella dysenteriae. Antibacterial compounds contained in the n-hexane fraction and ethyl acetate propolis are flavonoids and phenol 
HORMONE PROFILE OF DISORDER OF SEX DEVELOPMENT (DSD) PATIENTS IN PALEMBANG Maritska, Ziske; Prananjaya, Bintang Arroyantri; Parisa, Nita; Quardetta, Rovania Yantinez
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7987

Abstract

Apart from being based on clinical findings, the determination of the diagnosis of Disorders of sex development (DSD) is also supported by a variety of supporting examinations such as chromosome analysis, radiology, and laboratory examinations, one of which is the examination of hormone levels. Examination of hormone levels can provide a picture of gonadal and adrenal function, which is useful both for screening and for determining the diagnosis of DSD. The study that aims to identify the hormone profile of DSD patients in Indonesia is still very minimal, and this study is the first study to review the profile of DSD hormones in RSUP Dr. Mohammad Hoesin Palembang. This study is a descriptive study using secondary data from the medical records of DSD patients who underwent hormonal examinations during the 2013-2017 period. Of the total 173 DSD patients who came for treatment at the Dr. Mohammad Hoesin Palembang during the last five years, only 22 (12.72%) patients underwent hormone testing. There were 13 hormone profiles that were examined in DSD patients at RSUP Dr. Mohammad Hoesin Palembang with the hormone testosterone (54.54%) as the most frequently examined hormone. Hormone profile examination as a screening aid and diagnosis of DSD has not become one of the most common supporting examinations carried out at Dr. RSUP. Mohammad Hoesin Palembang.
RELATIONSHIP OF BIORHYTHMS CYCLE WITH COMPUTER BASED TEST (CBT) VALUES IN MEDICAL EDUCATION STUDY PROGRAM STUDENTS AT THE FACULTY OF MEDICINE, SRIWIJAYA UNIVERSITY Dita, Nurul Salmah Alia; bahar, Erial; Roflin, Eddy
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7985

Abstract

  The human body has many rhythms, one of which is biorhythms. Biorhythms consist of three cycles namely physical, emotional and intellectual cycles. Each cycle has positive, negative and critical phases. When taking an exam, a person needs good physical, mental, and intellectual condition. By using the biorhythms cycle, one can see these conditions in order to prepare for the exam. This research is an observational analytic study with cross sectional design. The sample consisted of 386 students of the Medical Education Study Program of Sriwijaya University in 2014 and 2015 in total sampling that met the inclusion criteria. Data taken in the form of secondary data consisting of CBT scores, exam dates, and entry points obtained from the academic section of the Faculty of Medicine, Sriwijaya University, while data on birth dates, BMI and IQ scores were taken from the questionnaire. Biorhythm cycle data is retrieved using biorhythm software. Data processing was performed using Kruskal Wallis test analysis and Linear Regression. From the results of bivariate analysis with the Kruskall Wallis test it is found that IQ scores have a relationship with CBT values (p = 0.010), university entrance has a relationship with CBT values (p = 0,000), and the physical cycle of biorhythms is related to CBT values (p = 0.011), However, in multivariate analysis (Linear Regression) the physical cycle of biorhythms has no relationship with the value of CBT. There is no correlation between biorhythms cycles and CBT scores in the Medical Education Study Program students at the Faculty of Medicine, Sriwijaya University.
CORRELATION BETWEEN SERUM FERRITIN LEVELS AND NUTRITIONAL STATUS OF THALASSEMIA-BETTA MAJOR PATIENTS Rafika, Rafika; Marwoto, Djoko; Hayati, Lusia
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7986

Abstract

Thalassemia is a chronic disease that requires repeated blood transfusions, due to impaired hemoglobin synthesis due to mutations of one or more globin genes. Continuous transfusion can cause iron accumulation in the body, especially the heart, liver and endocrine organs, and can cause stunted growth and malnutrition or poor nutrition. This study aims to determine the correlation between serum ferritin levels and the nutritional status of thalassemia-betta major patients in RSUP Dr. Moh. Hoesin Palembang. This research is an observational analytic study with cross sectional design. The sample of this study was thalassemia-betta major patient who was hospitalized in the Department of Pediatrics. Mohammad Hoesin from October to November 2016 who met the participation criteria. Of the 43 patients, the majority (60.5%) had lean bodies according to their weight index according to age (BW / U) and were short stature according to their height index according to age (TB / U), but only 14.0% of patients had undernourished nutrition BB / TB index. Obtained average values of serum ferritin 2837.69 g / L, with a range of 278.7-13867 g / L. The results of the correlation test between serum ferritin levels and nutritional status indicate p = 0.326 and r = 0.153. There was no significant correlation between serum ferritin levels and the nutritional status of thalassemia-betta major patients.

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