cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota bandung,
Jawa barat
INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 2, Issue 2, May - August, 2020" : 5 Documents clear
Cellulose Nanocrystals Preparation as Pharmaceuticals Excipient : a Review Margaretha Efa Putri; Anis Yohana Chaerunisaa; Marline Abdassah; Iman Rahayu
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.26422

Abstract

Cellulose nanocrystals is a cellulose derivates which has been widely researched and observed as an chemical agent. Different with cellulose that has been widely used as pharmaceutical excipient especially in solid dosage form, cellulose in nanocrystals form is not available in pharmaceutical grade. Cellulose nanocrystals have different characteristics and quality which is depend on its preparation including sourcing, isolation procedure, and hydrolysis reaction involved. This difference is very important to deeply observed its impact in pharmaceutical dosage form with different active ingredients. In addition, cellulose nanocrystals should meet FDA requirement as pharmaceutical excipient. This review  describe cellulose nanocrystals preparation and its characteristics, its application to active pharmaceutical ingredients, and its properties in order to meet FDA requirement.Keywords: Cellulose, nanocrystals, pharmaceutical excipient
Formulation and Stability Testing of Griseovulfin Microemulsion iyan sopyan; Dolih Gozali; Eka Paramudya
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27574

Abstract

The use of drugs that are less soluble in water will become clinically less efficient, this is caused by the low penetration of the drug into the body. A microemulsion is a dispersion system such as an emulsion that can increase the solubility of drugs that are sometimes difficult to dissolve in water. Microemulsions have long-term stability, clear, transparent, and good penetration capabilities. In this study, a microemulsion formulation with active ingredients griseofulvin and virgin coconut oil was conducted as an oil phase. The resulting microemulsion evaluates physical stability during 35 storage days. The results showed that the microemulsion preparation remained stable during storage time without changes in color, odor, and consistency, while the pH and dosage viscosity experienced less significant changes. The consequences of the centrifugation test at 3700 rpm for 5 hours and freezing tests for 24 days showed stable preparation and cannot be separated. The diffusion test results obtained by FG2 had the largest permeation percentages of 3.6136%, FG3 2.8724%, and the smallest FG1 2.0477%.Keywords: microemulsion, griseofulvin, stability, diffusion test
Characterization Methods of Amorphous Form Stability in Solid Dispersion : A Review Maria Elvina Tresia Butarbutar; Nasrul Wathoni; Yoga Windu Wardhana
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27123

Abstract

Solubility as a cause of ineffective active pharmaceutical ingredients (API) needs to be a concern. One of the solutions to increase the solubility by choosing active ingredients in the amorphous form. However, the amorphous form tends to be unstable because it has high Gibbs free energy and molecular mobility. To overcome those properties solid dispersion methods can be an answer. The dispersion of the amorphous form in the polymer is expected to prevent the transformation of API to crystal stable form. The solid dispersion (SD) resulted needs for physicochemical characterization to prove the ability of SD to maintain the amorphous form. Therefore, the physicochemical properties of the amorphous solid dispersions (ASDs) have to analyze there in any interactions that are able to occur between the drug and the polymer. Also for evaluate the stability of the ASDs within a certain period. In the article presents, some articles related with ASDs and its characterization will studying, include several product on the market as example. The number of literature used in this article is 69 articles.Keywords: Solubility, amorphous for, solid dispersion, characterization ASDs.
Interaction of Warfarin with Herbs Based on Pharmacokinetic and Pharmacodynamic Parameters Amelia Soyata; Aliya Nur Hasanah; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27289

Abstract

Warfarin is an oral anticoagulant that has been widely used and has strong efficacy, but the use of warfarin is still a concern because of its narrow therapeutic index which cause interactions when co-administration with drugs, herbs or food. This interaction can affect the pharmacokinetics and pharmacodynamics of warfarin and the most fatal effect from warfarin interactions is bleeding. In this review article data on warfarin-herbs interactions were collected based on pharmacokinetic parameters (AUC0-∞, Cmax, T1/2, Cl/F, and V/F), while pharmacodynamic parameters (International normalized ratio (INR), platelet aggregation, AUC INR and Protombine Time). As a result some herbs had significant interactions with warfarin. Herbs that affect warfarin pharmacokinetic were Danshen gegen, echinacea, St. John's wort and caffeine and herbs that affect pharmacodynamic were policosanol, Ginkgo biloba, cranberry, St. John's wort, ginseng, pomegranate, Psidium guajava and curcumin, so co-administration warfarin with herbs need to be considered.Keywords: Warfarin, Interactions, Herbs, Pharmacokinetics, Pharmacodynamics
Enhancement of Solubility BCS Class II and IV Pharmaceuticals by Liqusolid Technique: A review Dwi Retno Sari; Yoga Windhu Wardhana; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27297

Abstract

Many techniques can be used to improve drug solubility, which is the development of the liquisolid technique. This technique has a mechanism for increasing the surface area of the drug as well as wetting from the addition of non-volatile solvents resulting in a lower surface tension and contact angle, so the solubility and drug release very increases. Liquisolid tablets show a lower contact angle compared to the conventional tablets. The liquisolid technique approach is also promising because the process is simple in making low production costs and allows the manufacturing industry, including non-volatile solvents, fillers, dryers, and disintegrants. Liquisolid characterized by specific instruments such as powder x-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and scanning electron microscope (SEM). Several liquisolid techniques are described in this review. The liquisolid technique is proven and able to change the physicochemical properties of active pharmaceutical ingredients, especially the solubility, drug release, and stability of the formula so that this technique can be a solution for class II and IV BCS pharmaceutical active drug classes.Keywords: Active Pharmaceutical Ingredients, Contact Angle, Solubility, Drug Release, Stability, Liquisolid Technique

Page 1 of 1 | Total Record : 5

 1 

Filter by Year

2020 2020


Reset
Filter By Issues
All Issue Vol 7, Issue 1, Jan - April 2025 Vol 6, Issue 3, Sept - Dec 2024 Vol 6, Issue 2, May - August 2024 Vol 6, Issue 1, Jan - April 2024 Vol 5, Issue 3, Sept - Dec 2023 Vol 5, Issue 2, May - August 2023 Vol 5, Issue 1, Jan - April 2023 Vol 4, Issue 3, Sep - November, 2022 Vol 4, Issue 2, May - August, 2022 Vol 4, Issue 1, Jan - April 2022 Vol 3, Issue 3, Sept - Dec 2021 Vol 3, Issue 2, May - August, 2021 Vol 3, Issue 1, Jan - April 2021 Vol 2, Issue 3, Sept - Dec 2020 Vol 2, Issue 2, May - August, 2020 Vol 2, Issue 1, Jan - April 2020 Vol 1, Issue 3, Sept - Dec 2019 Vol 1, Issue 2, May - August 2019 Vol 1, Issue 1, Jan - April 2019 More Issue