cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota bandung,
Jawa barat
INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 2, Issue 3, Sept - Dec 2020" : 5 Documents clear
Simple and Rapid Method for Determination of Abemaciclib in Human Serum using Supported Liquid Extraction Pretreatment and LC-MS/MS Analysis Naoto Sekizaki; Hideaki Yashima; Takuya Araki; Koujirou Yamamoto
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.31586

Abstract

We developed a simple and rapid method for the determination of abemaciclib in human serum using supported liquid extraction (SLE) method for pretreatment and LC-MS/MS. Abemaciclib was extracted using SLE method with methyltert-butyl ether (MTBE) as elution buffer, and analyzed by LC-QTOF MS system, LCMS9030 (Shimadzu). Abemaciclib and fluconazole (internal standard) were detected with ESI spray in positive ionization mode, and the transition were set at 507.3/393.1629 for abemaciclib and 307.1/220.0677 for fluconazole. The retention times of abemaciclib and fluconazole were 2.76 and 2.98 min, respectively, and good linearity was obtained from 20–1,000 ng/mL for abemaciclib. The regression equation (weight = 1/x2) describing the calibration curve in human serum was y = 0.0196 x – 0.056 (R2 = 0.999), where y is the peak area ratio of abemaciclib against the IS and x is the nominal concentration of abemaciclib. The intra- and inter-assay accuracy varied between -4.3–1.7%, and the precision varied between 0.90–6.19%. The mean recovery rate of abemaciclib was 87.7 ± 4.3%, and the mean matrix factor was 1.00 ± 0.083. Our method offers speed and simplicity of sample preparation, which is one of great advantages in the analysis of clinical specimens. We believe that the present method will contribute to establishing a methodology for determining the optimal dose of abemaciclib for individual patients. Key words: abemaciclib, SLE, supported liquid extraction, quantification
Formulation of Coated Tablets Film of Jengkol Fruit Seeds (Pithecellobium lobatum Benth.) as A Selenium Herbal Supplement Dolih Gozali; Mutakin Mutakin; Yunita Yunita; Norisca Aliza Putri
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.31561

Abstract

The correlation between the high content of selenium (Se) in plasma and the low prevalence of cardiovascular disease has been published in previous epidemiological studies. The content of Se in the plasma is determined by daily intake. A preliminary surveillance of Se content of several plants showed that the seeds of jengkol (Pithecellobium lobatum Benth.) has the highest concentration of Se. This study aims to develop a pharmaceutical formulation of Se supplement for adjuvant therapy of cardiovascular disease. The jengkol seeds was made into film coated tablets with a wet granulation method. Optimization of the core tablet formula was carried out with variations of binder concentration and coating material. Evaluation was carried out on uniformity of size and weight, disintegration time, hardness and friability. The content evaluation was carried out including the levels of Se, water content, ash, fat, protein, carbohydrate and crude fiber. The results showed that the F3 had the lowest friability and highest hardness. The coating of tablets using PVA has covered the smell of jengkol seed. The evaluation results showed that film coated tablets contained the Se level content of 0.074 ± 0.004 µg/g, water content of 2.19%, ash content of 1.88%, fat content of 0.89%, protein content of 0.66%, carbohydrate content of 94.38% and crude fiber content 1.79%. The results showed that the jengkol seed film coated tablet formulation could be used as a supplement in additional therapy for cardiovascular disease.Keywords    : Pithecellobium lobatum, film coated tablet, herbal supplement, selenium
Formulation, Characterization, and Herbal Drug Delivery Applications of Ethosome, Transfersome, and Transethosome Luthfia Azzahra; Soraya Ratnawulan Mita; Sriwidodo Sriwidodo
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.29154

Abstract

Herbal compounds have different physicochemical properties. Its use on the oral route often has low biological availability. Therefore, alternative transdermal routes are used through the skin. The stratum corneum skin layer is the most difficult layer to penetrate. Therefore it is necessary to use a drug delivery system such as ethosome, transfersome or transethosome to increase transdermal drug delivery. This review article aims to look at the potential of ethosome, transfersome, and transethosome in increasing their ability to deliver herbal drugs in terms of their formulation and characterization. Literature searches were performed using online search engines namely NCBI and Google Scholar with the keywords ‘Transdermal Drug Delivery System’, 'Ethosome', 'Transfersome', and 'Transethosome'. The result showed compositions of ethosomes are phospholipids, water, and ethanol. The composition of transfersome is phospholipid, water, and edge activator. Transethosomes are a combination of phospholipids, water, ethanol, and edge activators. The role of ethanol and edge activator is thought to increase skin permeation. Transdermal drug delivery systems can be used on herbal drugs to increase transdermal drug delivery.Keywords: Transdermal, Ethosome, Transfersome, Transethosome, Herbal.
Microcrystalline Cellulose Isolated from Rami (Boehmeria nivea L. Gaud) used as a Disintegrant in Dimenhydrinate Tablets Nagina Gulab Belali; Anis Y. Chaerunisaa; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.30857

Abstract

Microcrystalline cellulose was isolated from rami (Boehmeria Nivea L. Gaud), and applied as disintegrant in tablets of dimenhydrinate, made by direct compression and wet granulation. The aim of this study is to produce dimenhydrinate tablets with Microcrystalline Cellulose Rami (MCC Rami) isolated from Rami (Boehmeria Nivea L. Gaud), as a disintegrant and assess the effect of MCC Rami and Granulation technique on physical properties of drug such as, disintegration time, drug release and dissolution. Formulations of dimenhydrinate 100mg tablets were prepared with a combination of mannitol and lactose as a filler and MCC Rami as disintegrant in a concentration of 10-20%. The formulas were directly compressed or were compressed into tablets after wet granulation. The mechanical properties, drug release, physical properties and effects of process parameters, methods of applying disintegrant in tablet formulas were examined. A significant difference in disintegration time of tablets that were produced by direct compression and wet granulation was seen, that can be attributed to the porous structure of granules that enhanced fast disintegration, which had eventually improved dissolution and drug release. F1 and F2 with MCC Rami and physical mixture of MCC Rami with crosspovidone as a disintegrant that were directly compressed disintegrated in 79 and 72 seconds respectively thats not a significant difference, however when MCC was applied in an intragranular way its disintegration time is 67 seconds. The results showed that the method of disintegrant application and press of tableting has a significant effect on drug release and dissolution.Keywords : Microcrystalline Cellulose, wet granulation, disintegrant, Boehmeria Nivea L. Gaud.
Potential of Stimuli-Responsive Star Polymer for Cancer Targeting Patihul Husni; Muhammad Alvien Ghifari; Norisca Aliza Putriana
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.30026

Abstract

Application of stimuli-responsive star polymers in cancer targeting and drug delivery has been extensively researched because of their several advantages in comparison with their linear counterparts. Functionalization and recombination of various arm architectures of the star polymer are very possible to be conducted to suit various needs. The star polymers could not only load more therapeutic drug due to more arms than linear polymers but also be functionalized with targeted moieties for more targeted delivery. Furthermore, the chains in star polymers could be regulated to produce stimuli-responsive star polymer for cancer targeting. The review article aimed to describe the benefits of star polymers and the types of stimuli-responsive delivery system for cancer targeting. Over the last decade, stimuli-responsive star polymers for cancer targeting using either internal stimuli (e.g., pH, redox, enzyme, hypoxia) or external stimuli (e.g., thermal, ultrasound, light, magnetic) has garnered immense interest for researchers. Possibility to mimic a complex natural phenomenon  could be achieved by incorporating various stimuli-responsive functionalities in the star polymer.

Page 1 of 1 | Total Record : 5

 1 

Filter by Year

2020 2020


Reset
Filter By Issues
All Issue Vol 7, Issue 1, Jan - April 2025 Vol 6, Issue 3, Sept - Dec 2024 Vol 6, Issue 2, May - August 2024 Vol 6, Issue 1, Jan - April 2024 Vol 5, Issue 3, Sept - Dec 2023 Vol 5, Issue 2, May - August 2023 Vol 5, Issue 1, Jan - April 2023 Vol 4, Issue 3, Sep - November, 2022 Vol 4, Issue 2, May - August, 2022 Vol 4, Issue 1, Jan - April 2022 Vol 3, Issue 3, Sept - Dec 2021 Vol 3, Issue 2, May - August, 2021 Vol 3, Issue 1, Jan - April 2021 Vol 2, Issue 3, Sept - Dec 2020 Vol 2, Issue 2, May - August, 2020 Vol 2, Issue 1, Jan - April 2020 Vol 1, Issue 3, Sept - Dec 2019 Vol 1, Issue 2, May - August 2019 Vol 1, Issue 1, Jan - April 2019 More Issue