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All Journal Farmaka IDJP (Indonesian Journal of Pharmaceutics) Jurnal Ilmiah Farmasi Farmasyifa Journal of The Indonesian Society of Integrated Chemistry Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Patihul Husni
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Potensi Penggunaan Fitokonstituen Tanaman Indonesia sebagai Bahan Aktif Tabir Surya: Review SHEILA PRATIWI; Patihul Husni
Farmaka Vol 15, No 4 (2017): Farmaka Desember
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.656 KB) | DOI: 10.24198/jf.v15i4.14581

Abstract

Radiasi sinar ultra violet (UV) terpapar pada kulit manusia setiap harinya, hanya saja paparan tersebut tidak dapat terukur ataupun terlihat secara kasat mata. Paparan sinar UV berlebih dapat menyebabkan banyak penyakit kulit seperti sunburn, eritema, bahkan sampai terjadinya kanker kulit. Tabir surya menjadi salah satu sediaan yang ditawarkan industri farmasi untuk menghalau ataupun mengurangi penyerapan sinar UV pada kulit. Dewasa ini, banyak pengembangan sediaan dari bahan alam karena dianggap lebih aman dan memiliki efek samping yang lebih rendah dibandingkan dengan bahan sintetik. Dalam review ini dibahas mengenai beberapa fitokonstituen dari bahan alam yang memiliki potensi untuk kemudian dapat dikembangkan menjadi bahan aktif sediaan tabir surya.Kata Kunci: fitokonstituen, ultra violet, tabir surya, herbal
SMART INSULIN PATCH: INOVASI SISTEM PENGHANTARAN INSULIN TRANSDERMAL ASTRI SULASTRI; Patihul Husni
Farmaka Vol 15, No 4 (2017): Farmaka Desember
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.554 KB) | DOI: 10.24198/jf.v15i4.14638

Abstract

Diabetes mellitus merupakan gangguan metabolik kronik yang ditandai dengan peningkatan kadar glukosa darah. Sebagian besar pasien diabetes diresepkan insulin dengan alasan karena tubuh mereka tidak mampu memproduksi insulin (diabetes tipe 1) atau insulin yang dihasilkan tidak sensitif (diabetes tipe 2). Masalah pada terapi insulin timbul akibat injeksi berulang setiap hari dan pengambilan sampel darah yang mengakibatkan rasa sakit serta timbul trauma atau kerusakan pada kulit sehingga sulit untuk mencapai rejimen pengobatan yang optimal. Kepatuhan terhadap rejimen pengobatan cenderung lebih tinggi jika prosedurnya sederhana dan tidak menimbulkan rasa sakit. Olehkarena itu, dikembangkan smart insulin patch sebagai alternatif strategi pengobatan pada pasien diabetes dengan menerapkan teknologi microneedle untuk meningkatkan penghantaran insulin transdermal dan mengoptimalkan efek terapi. Teknologi microneedle menjadi pilihan yang memungkinkan untuk meningkatkan kontrol glikemik karena prosedurnya sederhana, tidak menimbulkan rasa sakit dan dapat meningkatkan kepatuhan pasien terhadap rejimen pengobatan.Kata kunci: diabetes mellitus, microneedle, smart insulin patch  
Potential of Stimuli-Responsive Star Polymer for Cancer Targeting Patihul Husni; Muhammad Alvien Ghifari; Norisca Aliza Putriana
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.30026

Abstract

Application of stimuli-responsive star polymers in cancer targeting and drug delivery has been extensively researched because of their several advantages in comparison with their linear counterparts. Functionalization and recombination of various arm architectures of the star polymer are very possible to be conducted to suit various needs. The star polymers could not only load more therapeutic drug due to more arms than linear polymers but also be functionalized with targeted moieties for more targeted delivery. Furthermore, the chains in star polymers could be regulated to produce stimuli-responsive star polymer for cancer targeting. The review article aimed to describe the benefits of star polymers and the types of stimuli-responsive delivery system for cancer targeting. Over the last decade, stimuli-responsive star polymers for cancer targeting using either internal stimuli (e.g., pH, redox, enzyme, hypoxia) or external stimuli (e.g., thermal, ultrasound, light, magnetic) has garnered immense interest for researchers. Possibility to mimic a complex natural phenomenon  could be achieved by incorporating various stimuli-responsive functionalities in the star polymer.
Formulation of Peel-off Gel Mask containing Mung Bean (Vigna radiata (L.) Wilczek) Extract Patihul Husni; Ella Masliana Dewi
Indonesian Journal of Pharmaceutics Vol 1, Issue 2, May - August 2019
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (7303.212 KB) | DOI: 10.24198/idjp.v1i2.19894

Abstract

Mung bean (Vigna radiata (L.) Wilczek) is one of the plants that rich in antioxidant compound. Antioxidant is a compound that can inhibit the skin aging process because of photoaging. The aim of this study was to formulate peel-off gel mask containing mung bean (Vigna Radiata (L.) Wilczek) extract  using polyvinyl alcohol (PVA) as a base of mask and Hidroxy Prophyl Methyl Cellulose (HPMC) as a viscosity increasing agent and to determine the antioxidant activity of the peel-off gel mask. Antioxidant activity was tested using DPPH (1,1-diphenyl-2-pycrilhidrazil) assay. Mung bean was extracted by maceration method using ethanol 96%. The concentration of mung bean extract in the peel-off mask gel was 4% and various concentration of PVA were 5% (F1), 7.5% (F2), 10%(F3). The evaluations were organoleptic, pH, viscosity, drying and film forming, and gel spreadness. The study result showed that the organoleptic of the gel was brownish yellow with pH approximately 6, 196-513 cps in viscosity, 0.0646-0.0730 cm/g in gel spreadness and 27.6-54.5 second in drying and film forming. F3 containing mung bean extract 4%, PVA 10%, HPMC 2%, propylene glycol 15%, potassium sorbate 0,2%, olive oil 0,5%, alpha tocopherol 0,05 and aquadest ad 100% was the best formula with IC50 value was 85,2793 ppm and significantly different than F1 and F2 (p < 0.05).Keywords: peel-off gel mask, mung bean extract, Vigna radiata (L.) Wilczek, antioxidant
Plant Extract Loaded Nanoparticles Patihul Husni; Zelika Mega Ramadhania
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.34032

Abstract

Plant extract, a natural source containing complex mixture of compounds, offers many properties such as antiparasitic, antibiotic, antioxidant, anti-hypertensive, antiviral, insecticide, anticancer, antifungal, hypoglycemic properties. Recent research has been focused on developing formulation the plant extracts not only to deliver them safely but also to enhance its therapeutic efficacy. Nanotechnology-based strategies have been proposed as a system that can be used to formulate plant extracts. Plant extract loaded nanoparticles (NPs) is aimed to facilitate in crossing the biological barriers, to increase bioavailability of poorly water-soluble phytochemicals, to encapsulate mixture compounds of different phytochemicals, to provide targeted delivery of phytochemicals to specific organs resulting in low toxicity, to get effective purification process,  to mask unpleasant taste and odor, to protect sensitive phytochemicals from biological (e.g. enzyme, pH) and environmental (e.g. light, temperature, humidity) degradation, to control release of encapsulated phytochemicals, and to provide a more flexible control over the size and shape of the NPs. This review is focused on plant extract loaded NPs including its advantages, stages for developing formulation of plant extract loaded NPs, and nanosystem used to loading plant extract. In addition, this review also depicts studies which have been conducted by many researchers in developing plant extract loaded NPs. The data were collected from published journals with 21 and 39 journals as primary and supporting literatures, respectively. Plant extracts loaded NPs could be a promising delivery system for active phytochemical contained in the plant extract which is not only to deliver them safely but also to enhance its therapeutic efficacy.Keywords: plant, extract, nanoparticle
FORMULASI KRIM EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lamk) Patihul Husni; Alika Nuansa Pratiwi; Ardian Baitariza
Jurnal Ilmiah Farmasi Farmasyifa Vol 2, No 2 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v2i2.4796

Abstract

Salah satu tanaman berkhasiat antiinflamasi adalah tanaman kelor (Moringa oleifera Lamk) sehingga berpotensi dibuat sediaan krim. Penelitian ini bertujuan untuk mendapatkan formula terbaik krim ekstrak etanol daun kelor (Moringa oleifera Lamk). Penelitian dilakukan dengan membuat sediaan krim dengan tiga formula berbeda (F1, F2 dan F3) yang mengandung ekstrak daun kelor 10% b/b. Evaluasi sediaan krim dilakukan selama 4 minggu penyimpanan meliputi uji organoleptik (warna, aroma dan bentuk), homogenitas, pH, viskositas, daya tercuci, tipe krim, dan uji iritasi. Hasil penelitian menunjukkan bahwa seluruh formula (F1, F2 dan F3) memenuhi syarat krim yang baik dan tidak mengiritasi. Formula krim yang paling baik berdasarkan uji penyimpanan selama 4 minggu adalah F3 dengan komposisi formula berupa ekstrak daun kelor 10%, asam stearat 10%, paraffin cair 2%, setil alkohol 2%, span 80 1,5%, tween 80 3,5%, gliserin 7,5%, titan dioksida 0,7%, oleum rosae 15 tetes, nipagin 0,18%, nipasol 0,02%, aquadest add 50% b/b.
FORMULASI DAN UJI STABILITAS FISIK GRANUL INSTAN SERBUK KERING TANGKAI GENJER (Limnocharis flava (L.) Buchenau.) SEBAGAI SUPLEMEN PENAMBAH SERAT Patihul Husni; Muchamad Luthfi Fadhiilah; Uswatul Hasanah
Jurnal Ilmiah Farmasi Farmasyifa Vol 3, No 1 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v3i1.5163

Abstract

Serat dibutuhkan dalam pencernaan adalah agar proses pencernaan dapat bekerja secara maksimal. Genjer (Limnocharis flava (L.) Buchenau.) merupakan tanaman yang bagian tangkainya banyak mengandung serat. Kandungan serat yang tinggi pada genjer terutama pada bagian tangkainya berpotensi untuk dikembangkan sebagai suplemen makanan penambah serat berupa granul instan. Tujuan penelitian ini adalah untuk mendapatkan formula terbaik granul instan secara fisik. Granul instan dibuat dengan metode granulasi basah menggunakan variasi konsentrasi PVP sebagai pengikat. Uji stabilitas fisik granul instan dilakukan pada suhu kamar selama satu bulan meliputi uji waktu alir, sudut diam, indeks kompresibilitas, kandungan lembab dan waktu larut. Hasil penelitian menunjukkan bahwa waktu alir granul 8-14 detik untuk 100 gram granul, sudut diam sekitar 40o, indeks kompresibilitas 11-15%, kandungan lembab sekitar 2% dan waktu larut 1-2 menit. Berdasarkan hasil uji stabilitas fisik, formula terbaik granul instan serbuk kering tangkai genjer adalah F2 dengan komposisi serbuk kering tangkai genjer 100 mg, laktosa 70%, PVP 3%, aspartam 1,5%, manitol 20%, Natrium Benzoat 0,5%, Green tea flavor 5% b/b dan etanol qs dengan total bobot granul 1000 mg.
Modifikasi Viskositas Kappa Karagenan Sebagai Gelling Agent Menggunakan Metode Polymer Blend Anis Yohana Chaerunisaa; Patihul Husni; Fairuzati Anisah Murthadiah
Journal of The Indonesian Society of Integrated Chemistry Vol. 12 No. 2 (2020): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v12i2.12040

Abstract

[ Viscosity Modification of Kappa Carrageenan as Gelling Agent Using Polymer Blend Method ] Gelling agent merupakan zat hidrokoloid yang dapat meningkatkan viskositas dan menstabilkan sediaan gel. Karagenan sebagai salah satu gelling agent memiliki konsistensi yang kaku dan padat. Untuk mendapatkan gel karagenan dengan viskositas yang memenuhi standar suatu gelling agent, tetapi memiliki sifat fisikokimia dan stabilitas yang memenuhi syarat, maka diperlukan modifikasi pada kappa karagenan. Salah satu metode modifikasi gelling agent adalah metode polymer blend. Modifikasi viskositas dari gel karagenan dilakukan dengan mencampurkan kappa karagenan dengan berbagai tipe gelling agent yaitu iota karagenan, carbomer 940, natrium karboksimetilselulosa, natrium alginat, dan gelatin dengan perbandingan 10:90, 20:80, 30:70, 40:60, 50:50. Hasil penelitian menunjukan bahwa modifikasi terbaik yang sesuai dengan standar gel adalah pada campuran gel kappa karagenan : carbomer 940 dengan perbandingan 90:10 dan campuran gel kappa karagenan : natrium karboksimetil selulosa dengan perbandingan 70:30. Percampuran kappa karagenan dengan iota karagenan, carbomer 940, natrium karboksimetil selulosa (NaCMC), natrium alginat dan gelatin mempengaruhi viskositas, sineresis, swelling ratio, kekuatan gel dan kekerasan gel, namun tidak mempengaruhi pH dan rheologi dari gel.
Peran Badan Pengawas Obat dan Makanan (BPOM) dalam Pengendalian Resistensi Antimikroba di Indonesia Muthia Izati; Patihul Husni; Yosita Aulia Mustofa
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.571

Abstract

Antimicrobial resistance when microbes such as bacteria, viruses, fungi, and parasites bo longer respond to antimicrobial medicines. Antimicrobial resistance is one of the 10 health threats faced by the global community. Controlling antimicrobial resistance involves various governmental agencies, including the Indonesia Food and Drug Authority (BPOM), which has responsibilities in the field of drug and food surveillance in Indonesia. The article is prepared to examine the role of BPOM in the Control of Antimicrobial Resistance in Indonesia. The article is prepared using a normative approach, which is a study of articles referring to normative laws found in legislation. The role of BPOM role in antimicrobial resistance control in Indonesia includes the drafting, strengthening, and implementation of policies surveillance of antimicrobial lifecycle, public education, and conducting joint inspection inspection with relevated institutions. The results of this article show that controlling antimicrobial resistance in Indonesia requires coordination and cooperation from all relevant institutions.
Co-Authors Alika Nuansa Pratiwi Anis Yohana Chaerunisaa Ardian Baitariza ASTRI SULASTRI Ella Masliana Dewi Fairuzati Anisah Murthadiah M Alvien Ghifari Muchamad Luthfi Fadhiilah Muthia Izati Norisca Aliza Putriana SHEILA PRATIWI Uswatul Hasanah Yosita Aulia Mustofa Zelika Mega Ramadhania