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All Journal IDJP (Indonesian Journal of Pharmaceutics) Journal of Science and Applicative Technology Jurnal Pengabdian Masyarakat Bangsa Rafflesia Journal of Natural and Applied Sciences (RJNAS)
M Alvien Ghifari
Department Of Chemistry, Institut Teknologi Sumatera, Lampung Selatan, 35365
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Potential of Stimuli-Responsive Star Polymer for Cancer Targeting Patihul Husni; Muhammad Alvien Ghifari; Norisca Aliza Putriana
Indonesian Journal of Pharmaceutics Vol 2, Issue 3, Sept - Dec 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i3.30026

Abstract

Application of stimuli-responsive star polymers in cancer targeting and drug delivery has been extensively researched because of their several advantages in comparison with their linear counterparts. Functionalization and recombination of various arm architectures of the star polymer are very possible to be conducted to suit various needs. The star polymers could not only load more therapeutic drug due to more arms than linear polymers but also be functionalized with targeted moieties for more targeted delivery. Furthermore, the chains in star polymers could be regulated to produce stimuli-responsive star polymer for cancer targeting. The review article aimed to describe the benefits of star polymers and the types of stimuli-responsive delivery system for cancer targeting. Over the last decade, stimuli-responsive star polymers for cancer targeting using either internal stimuli (e.g., pH, redox, enzyme, hypoxia) or external stimuli (e.g., thermal, ultrasound, light, magnetic) has garnered immense interest for researchers. Possibility to mimic a complex natural phenomenon  could be achieved by incorporating various stimuli-responsive functionalities in the star polymer.
Identification of Alkaloid Compounds from Cytotoxic Active Fraction in Peperomia pellucida M Alvien Ghifari; Enny Fachriyah; Khairul Anam; Dian Nopitasari; Kautsar Elvira; Rama Esa Perdana
Journal of Science and Applicative Technology Vol 5 No 1 (2021): Journal of Science and Applicative Technology June Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/jsat.v5i1.394

Abstract

Peperomia pellucida attracts a lot of interest due to its bioactivity and has been used in various folk medicine. In this report, n-hexane, dichloromethane, and ethyl acetate fraction of Peperomia pellucida extract were examined for its cytotoxic activity against Artemia salina larvae using the BSLT method. The ethyl acetate fraction showed higher cytotoxic activity than n-hexane and dichloromethane. The LC50 of ethyl acetate, n-hexane, and dichloromethane fractions was 39.665, 278.920, and 60.808 ppm, respectively. Mayer and Dragendorff tests give a positive result to the alkaloid constituent in ethyl acetate fraction. The alkaloids in Peperomia pellucida were extracted using ethyl acetate and further separated using chromatography techniques. Two alkaloid components were identified in ethyl acetate fraction from Peperomia pellucida as Piperine and Nigramide N by using LC-MS/MS.
Pelatihan Pembuatan Sabun dari Minyak Goreng Bekas di Desa Padang Rejo, Pringsewu Demi Dama Yanti; M Alvien Ghifari; I Putu Mahendra; Aditya Ayuwulanda; Reyhan Puji Putranto; Rahmat Kurniawan; Arif Ashari; Sahri Tarigan; Cresentia Aurora Mizuki; Octakireina Liesaini Daefisal; Nevia Lingga; Renaldi Malai; Stevanny Nadzma
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 6 (2023): Agustus
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i6.272

Abstract

Minyak goreng bekas atau yang biasa disebut sebagai minyak jelantah merupakan limbah minyak goreng dari berbagai sumber yang telah digunakan untuk memproses berbagai jenis bahan makanan. Kegiatan sosialisasi ini bertujuan untuk menambah wawasan masyarakat tentang bahaya minyak goreng bekas dan manfaat lainnya. Kegiatan dilakukan dengan memberikan paparan bahaya yang disebabkan oleh minyak goreng bekas bagi Kesehatan manusia dan lingkungan dilanjutkan dengan praktek pembuatan sabun dari minyak goreng bekas. Masyarakat Desa Padang Rejo merasa puas dengan kegiatan yang dilakukan dan bersedia berpartisipasi pada kegiatan-kegiatan pengabdian mendatang. Berdasarkan hasil pretes dan postes yang dilakukan, terjadi peningkatan pemahaman masyarakat tentang bahaya minyak goreng bekas dan manfaatnya sebagai bahan pembuatan sabun. Peningkatan pemahaman ini dievaluasi dari kenaikan nilai postes terhadap pretes sebesar 39,69%.
Green Synthesis Nanopartikel Perak (AgNPs) Menggunakan Bioreduktor Alami Ekstrak Daun Ilalang (Imperata cylindrica L) Annisaa Siti Zulaicha; Iwan Syahjoko Saputra; Indah Puspita Sari; M Alvien Ghifari; Yoki Yulizar; Yogi Nopiandi Permana; Sudirman Sudirman
RAFFLESIA JOURNAL OF NATURAL AND APPLIED SCIENCES Vol. 1 No. 1 (2021): April
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/rjna.v1i1.15588

Abstract

Ilalang (Imperata cylindrica L) merupakan tumbuhan liar yang jarang dimanfaatkan. Daun ilalang mengandung senyawa bioaktif seperti alkaloid dan flavonoid. Senyawa flavonoid dapat digunakan sebagai zat reduktor alami dalam sintesis nanopartikel perak (AgNPs). Tujuan pada penelitian ini adalah sintesis nanopartikel perak menggunakan bioreduktor alami dari ekstrak daun ilalang. Sintesis nanopartikel perak menggunakan metode green synthesis (reduktor alam). Terbentuknya koloid nanopartikel perak terlihat secara visual ditandai dengan perubahan warna koloid menjadi coklat setelah penambahan ekstrak daun ilalang. Hasil UV-Vis menunjukkan nanopartikel perak memiliki puncak serapan pada panjang gelombang 420 nm dengan nilai absorbansi 1,9. FTIR memperlihatkan spektrum pengurangan puncak serapan nanopartikel perak pada bilangan gelombang 3356 cm-1. Hasil XRD dan PSA menunjukkan nanopartikel perak memiliki rata-rata ukuran kristal 19 nm dan distribusi ukuran partikel sebesar 1160 nm. Nanopartikel perak memiliki bentuk bulat dengan ukuran partikel 20 nm yang terlihat pada morfologi hasil TEM
Co-Authors Arif Ashari Ayuwulanda, Aditya Cresentia Aurora Mizuki Demi Dama Yanti Dian Nopitasari Enny Fachriyah I Putu Mahendra Indah Puspita Sari Iwan Syahjoko Saputra Kautsar Elvira Khairul Anam Nevia Lingga Norisca Aliza Putriana Octakireina Liesaini Daefisal Patihul Husni Rahmat Kurniawan Rama Esa Perdana Renaldi Malai Reyhan Puji Putranto Sahri Tarigan Siti Zulaicha, Annisaa Stevanny Nadzma Sudirman Sudirman Yogi Nopiandi Permana Yoki Yulizar