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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 6, Issue 2, May - August 2024" : 5 Documents clear
Comparative Dissolution Formulation and Test Simvastatin Ko-Crystal Tablets With Isonicotinamide As Coformer Sopyan, Iyan; Novianti, Ina; Abdassah Bratadiredja, Marline; Salsabila Hapsari, Raira; Setiawati, Ervina
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i3.55250

Abstract

Simvastatin is a statin drug used to lower plasma cholesterol in all types of hyperlipidemia. Simvastatin is included in BCS class II with poor solubility.  One of the efforts made to increase the solubility of simvastatin is the formation of co-crystals. Co-crystal is a modified type of crystal habit, which consists of two or more molecules in the same crystal lattice. The purpose of this study was to obtain the best excipient combination formula on the simvastatin co-crystalline tablet with isonicotinamide as a coformer and its comparable dissolution test results. The excipient combination optimization was carried out using a two-level factorial method. The optimized Avicel pH 102 and Primogel produced four combination designs on ready-made formulas, namely F1 Avicel pH 102: Primogel (79:2), F2 Avicel pH 102: Primogel (79:8), F3 Avicel pH 102: Primogel (85: 2) and F4 Avicel pH 102: Primogel (85: 8). The evaluation includes evaluating the mass of the print and the quality of the tablets. The excipient combination design solution in the best formula is Avicel pH 102 and Primogel with a ratio (79: 8). The method used in a comparable dissolution test is to compare the values of F1 (difference factor) and F2 (similarity factor) using BootStrap software. The F2 values observed were 50.3 at pH 1.2, 56.09 at pH 4.5, and 59.23 at pH 6.8, which indicates that the simvastatin co-crystalline tablet has similarities with the innovator tablet. The excipient combination design solution in the best formula is Avicel pH 102 and Primogel with a ratio (79: 8). The method used in a comparable dissolution test is to compare the values of F1 (difference factor) and F2 (equation factor) using BootStrap software. The F2 values observed were 50.3 at pH 1.2, 56.09 at pH 4.5, and 59.23 at pH 6.8, which indicates that the simvastatin co-crystalline tablet has similarities with the innovator tablet.Keywords: Simvastatin, co-crystal, two-stage factorial, comparable dissolution                     test.
Solid Dispersion Powder of Sargassum cristaefolium extract by solvent evaporation technique Amalia, Eri; Khairunnisa, Nada; Aghnia Khairinisa, Miski; Gozali, Dolih
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.60911

Abstract

Sargassum cristaefolium is one of 782 types of seaweed/macroalgae that grows in Indonesia and is known as one of the macroalgae with bioactive compounds having an important role in the development of nutraceuticals for disease prevention and health maintenance. Sargassum cristaefolium extract (SCE) is known for its various beneficial activities such as antimigraine by reducing levels of CGRP and inhibitor of tyrosinase activity in anti-melanogenetics. Nevertheless, due to its hygroscopic viscous extract consistency and fishy odor, a suitable formulation is required to prepare a powder form of SCE and thus could be applied in a suitable dosage form. Our current study aims to develop the extract into suitable powder raw material by applying a solid dispersion technique.  The solid dispersion of SCE was initially prepared by selecting suitable carrier agents such as Aerosil, Microcrystalline cellulose (MCC) PH 101, maltodextrin, and PVP K30 with the extract in a ratio of 1:1, and continued by the combination of the carrier agents. The best powder formula was characterized by its powder characteristic, solubility and powder flow was assessed by its angle of repose, Carr’s index and Hausner ratio.  The experiment results that the optimum formulation for solid dispersion of SCE was obtained by the combination of SCE:PVP: MCC at a ratio of 1:1:3 with a less fishy smell, and excellent powder properties. The composite mixture was estimated due to the formation of hydrogen bonds between the carbonyl group of PVP and the hydroxyl group of SCE’s compound and MCC. In conclusion, solid dispersion of SCE by employing a combination of PVP and MCC can be an alternative to prepared SCE powder with optimum humidity protection and good flowability thus suitable to proceed as solid dosage form.  Keywords: Sargassum cristaefolium, solid dispersion, PVP K30, Microcrystalline                      cellulose PH101 
 A Comparative Study on The Therapeutic Effect of pH, Temperature Triggered, and Ion Activated In Situ Gelling System For Ocular Delivery Kurniawansyah, Insan Sunan; Farisa Desy Arya, Insi; Budiman, Arif; Zubaidah, and
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.52695

Abstract

One of the most popular pharmaceutical preparations for the eyes today is in situ gel. The in situ gel system is a system that is liquid at room temperature but will form a gel when it comes into contact with the body or undergoes a change in pH. The form of the drug delivery system is in-situ is a type of mucoadhesive drug delivery system. Gel formation depends on several factors such as temperature modulation, pH changes, the presence of ions, ultra-violet irradiation, electrical sensitivity, and the enzyme by which the active substance is released. The purpose of this study is to compare the therapeutic efficacy of in situ gel medicines on pH, temperature triggered, and ion activated gelling systems. A drug in situ gel is a drug delivery device that transforms into a gel after being applied to the body. The findings revealed that the pH, temperature triggered, and ion activated gelling system factors had a substantial influence on the extended release medicines that affect the therapeutic effect of in situ gel medications. This comparative investigation demonstrates that the pH, temperature triggered, and ion activated gelling system factors have significant implications on the therapeutic benefits of in situ gelled medicines. A deeper knowledge of the relationships between these variables and in situ gel drug delivery methods can lead to the development of more effective and dependable medication compositions. These findings could aid in the development of improved gel in situ drug delivery systems to improve therapeutic benefits in the treatment of a variety of medical disorders.  Keywords: in situ gel, pH triggered, temperature triggered, ion activated, therapeutic effect.
Topical Formulation of Herbal Nanocosmetics for Anti-Aging Husni, Patihul; Eryani, Mikhania Christiningtyas
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.56857

Abstract

Skin aging is a biological process that involves a decline in skin function. Regarding prevention and inhibition of skin aging, use of cosmetic products is an option to avoid skin aging because it can improve texture and function of skin. Recently, development of a topical formulation of herbal nanocosmetics for anti-aging has grown increasingly popular. This review is aimed to summarize and describe topical formulation of herbal nanocosmetics for anti-aging application. In addition, this review also shows several studies performed by researchers in development of topical formulation of herbal nanocosmetics for anti-aging. The data were collected from published journals in the range of 2011-2023. Study result showed that nanoemulsion, nanostructured lipid carriers (NLC), solid lipid nanoparticles (SLN), niosomes, liposomes, ethosomes, and transfersomes are nanotechnology methods used to prepare herbal nanocosmetics for anti-aging in the cream or gel dosage form. In conclusion, herbal nanocosmetics combine the benefits of herbal extracts with nanotechnology which can be used to enhance the effectiveness of natural ingredients for anti-aging effect. Keywords: topical, herbal, nanocosmetics, anti-aging
Increasing Solubility of Simvastatin Via Salting Form Using Isonicotinamide As Co-Formers Sopyan, Iyan; Puspa, Inge; Salsabila Hapsari, Raira
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.60538

Abstract

Simvastatin is a drugs used to lower plasma cholesterol. Simvastatin is a class II BCS drug that has low solubility and high permeability. One of the efforts made to increase the solubility of simvastatin is the formation of multicomponent crystals (co-crystals and salts). The purpose of this study was to determine the solubility and dissolution profile of multicomponent crystal simvastatin with the best co-former candidate from the in silico test. Simvastatin-co-former multicomponent crystal were prepared using solvent drop grinding method with a mol ratio of 1:1 ; 1:2 and 2:1. Based on the result of value of binding affinity and ability to form hydrogen bonds, isonicotinamide was chosen as the co-former in this research. Evaluation of multicomponent crystals was carried out by solubility and dissolution tests. The evaluation results showed an increase in the solubility and dissolution of the simvastatin-isocotinamide multicomponent crystal with the highest increase occurring in the simvastatin-isocotinamide multicomponent crystal with a mol ratio of 1:2. Multicomponent crystal characterization was carried out to determine physicochemical characteristics. The results of characterization using infrared spectrophotometry showed a spectrum shift. The results of the Differential Scanning Calorimetry (DSC) analysis show a decrease in the melting point. The results of Powder X-ray diffraction analysis showed that there were differences in the shape of the crystals indicated by the formation of new peaks on the diffractogram. So, it can be concluded that simvastatin-isocotinamide multicomponent crystals are able to increase solubility and dissolution compared to pure simvastatin.

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