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All Journal Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Indonesian Journal of Health Sciences Research and Development (IJHSRD) Journal of Pharmaceutical and Sciences.
Siti Marwah Lestari
Universitas Adiwangsa Jambi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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SKRINING POTENSI EKSTRAK KULIT JANTUNG PISANG KEPOK (Musa paradisiaca Linn.) SEBAGAI ZAT ANTIBAKTERI Vindi Annisa Rahmah; Agung Kurniawan; Widya Twiny Rizki; Siti Marwah Lestari; Chindiana Khutami
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 7 No. 2 (2025): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v7i2.6086

Abstract

Abstract Indonesian Food and Drug Authority or BPOM no longer recommends the use of synthetic preservatives due to their toxic properties and potential carcinogenic risks. One of the natural ingredients that is potential as a natural preservative is the peel of kepok banana blossom (Musa paradisiaca Linn.), which is known to contain secondary metabolites with microbial activity, including steroids, terpenoids, saponins, tanning, alkaloid, flavonoids, and phenols. This study aim to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) in Staphylococcus aureus bacteria. The peel extract of kepok banana blossom (Musa paradisiaca Linn.) was obtained by maceration with a mixture of 96% ethanol: 3% Citric Acid (85:15) solvent. Concentration of extract varied from 12.5%; 25%; 50%; until 100%, it is used for antibacterial activity test in which aquadest as a negative control and Chloramphenicol as a positive control. The Minimum Inhibitory Concentration (MIC) test was conducted using the liquid macrodilution method and the Minimum Bactericidal Concentration (MBC) test was conducted using the spread method. The Minimum Inhibitory Concentration (MIC) value was obtained at a concentration of 50% and the Minimum Bactericidal Concentration (MBC) value was obtained at a concentration of 100%. The peel extract of Kepok banana blossom (Musa paradisiaca Linn.) with a concentration of 50% was able to inhibit the growth of Staphylococcus aureus bacteria and with a concentration of 100% was able to kill Staphylococcus aureus bacteria. Keywords: kepok banana blossom peel extract, natural preservatives, antibacterial acitivity test Abstrak Badan Obat dan Makanan atau BPOM telah menyarankan untuk menghindari penggunaan bahan pengawet sintesis karena cenderung toksi dan karsinogenik. Salah satu bahan alam yang berpotensi sebagai pengawet alami yaitu kulit jantung pisang kepok (Musa paradisiaca Linn.), yang diketahui mengandung metabolit sekunder yang berfungsi sebagai senyawa antimikroba diantaranya steroid, terpenoid, saponin, tanin, alkaloid, flavonoid dan fenol. Penelitian ini bertujuan untuk menentukan Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM) pada bakteri Staphylococcus aureus. Ekstrak kulit jantung pisang (Musa paradisiaca Linn.) diperoleh dengan cara maserasi dengan pelarut yang terdiri dari campuran etanol 96% : Asam Sitrat 3% (85:15). Variasi konsentrasi ekstrak dibuat untuk pengujian aktivitas antibakteri dari 12,5%; 25%; 50%; hingga 100%, aquades sebagai kontrol negatif dan Kloramfenikol sebagai kontrol positif. Uji Konsentrasi Hambat Minimum (KHM) dilakukan dengan metode makrodilusi cair dan uji Konsentrasi Bunuh Minimum (KBM) dilakukan dengan metode sebar (spread). Nilai Konsentrasi Hambat Minimum (KHM) didapatkan pada konsentrasi 50% dan nilai Konsentrasi Bunuh Minimum (KBM) didapatkan pada konsentrasi 100%. Berdasarkan hasil penelitian ini, ekstrak kulit jantung pisang (Musa paradisiaca Linn.) dengan konsentrasi 50% diketahui mampu menghambat pertumbuhan bakteri Staphylococcus aureus dan dengan konsentrasi 100% mampu membunuh bakteri Staphylococcus aureus. Keywords: ekstrak kulit jantung pisang, pengawet alami, uji aktivitas antibakteri
PROFILE OF DRUG RELATED PROBLEMS (DRPS) IN OUTPATIENT HYPERTENSION PATIENTS AT BAYUNG LENCIR PUBLIC HEALTH CENTER IN 2024: HYPERTENSION Putri Ayu; Siti Marwah Lestari
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 8 No. 1 (2026): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol8.Iss1/380

Abstract

Background; Drug-related problems (DRPs) are events associated with drug therapy, whether actual or potential, that may hinder the achievement of intended health outcomes. This study describes the profile of DRPs occurrences among outpatient hypertensive patients at Bayung Lencir Community Health Center in 2024, based on the Pharmaceutical Care Network Europe (PCNE) classification version 9.1. Methods: A non-experimental, cross-sectional design with retrospective data collection was employed, utilizing purposive sampling. The identification and evaluation of DRP incidents were conducted based on the PCNE V9.1 classification. Results: The results show that antihypertensive drug use was predominantly from the Calcium Channel Blocker (CCB) class, particularly amlodipine (86.59%). Among the 82 patients who met the inclusion criteria, 52 experienced DRPs. The primary DRP categories identified were potential suboptimal drug treatment effects (13.89%), untreated indications or symptoms (8.33%), potential adverse drug events (72.22%), and unnecessary drug therapy (4.17%). The incidence of drug-related problems (DRPs) among outpatients with hypertension at the Bayung Lencir Community Health Center remains relatively high, with the most common category being potential adverse drug events. Conclusion: The results of this study highlight the importance of comprehensive evaluation to improve treatment effectiveness and patient safety.
Ekstraksi kombinasi ultrasonik dan enzimatis untuk senyawa asam klorogenat dari Cascara Kopi Arabika Kerinci Siti Marwah Lestari; Vindi Annisa Rahmaha; Selda Vira Khairunnisa; Tiskha Salsabilla; Nur Fadillah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1220

Abstract

Arabica Coffee Cascara (CKA) has high potential as a source of bioactive compounds such as chlorogenic acid, which has antioxidant activity. The release of active compound can be optimized by combining ultrasonic and enzymatic methods, which are more efficient and environmentally friendly. The aim of this study was to examine the effectiveness of ultrasound-enzymatic-assisted extraction (UEAE) using water as a solvent for chlorogenic acid compound from CKA using Response Surface Methodology Box-Behnken Design (RSM_BBD). Three extraction parameters, such as sonication temperature (35-45°C), enzyme concentration (10-20 mg/g), and enzymolysis temperature (40-60°C), were designed to obtain optimal chlorogenic acid content. Based on the general trend data, results indicated that the highest chlorogenic acid content was 42.55 mg/g of dry extract, and was achieved under specific conditions: a sonication temperature of 40°C, an enzyme concentration of 10 mg/g, and an enzymolysis temperature of 60°C. Verification tests showed a value of 44.17 mg/g dry extract within the model’s prediction range with a 95% confidence level. The current quadratic RSM model with the existing factor design is not yet a reliable predictive tool and only serves to explore the range of operational extraction conditions.
Co-Authors Agung Kurniawan Chindiana Khutami Nur Fadillah Putri Ayu Selda Vira Khairunnisa Tiskha Salsabilla Vindi Annisa Rahmah Vindi Annisa Rahmaha Widya Twiny Rizki