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Chindiana Khutami
Universitas Adiwangsa Jambi
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Mekanisme Kerja Obat Antihipertensi Yang Bekerja Pada GPCRs dan Tanaman Yang Berpotensi Sebagai Antihipertensi Chindiana Khutami
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35141/pharm.v2i1.773

Abstract

Hypertension is the medical term for patients with systolic blood pressure above 140 mmHg and diastolic above 100 mmHg. Hypertension is a complex multifactorial disease that contributes to the main causes of morbidity and mortality in industrialized countries: ischemic heart disease and hypertension, stroke, peripheral atherosclerosis and renal failure. Commonly used antihypertensives are usually associated with many side effects. In the last three decades, many concerted efforts have been made to research local plants with hypotensive and antihypertensive therapeutic value. The hypotensive and antihypertensive effects of some of these medicinal plants have been validated and others have not been proven. G-protein coupled-receptors or GPCRs are targets of drug action, whose signaling is mediated by G-proteins. GPCRs are receptors that reside on the cell surface and have seven transmembrane domains. For example, GPR35 is a target for furosemide and bumetanide. This is especially important in cardiovascular disease secondary to hypertension, where the degree of vessel constriction is partly due to increased levels of agonists such as catecholamines and angiotensin II.
FAKTOR PENGARUH DEGRADASI RANITIDIN MENJADI N-NITROSODIMETHYLAMINE (NDMA) Muchtaridi Muchtaridi; Hanifahzin Khatami; Chindiana Khutami
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i2.9443

Abstract

Food and Drug Administration (FDA) pada 13 September 2019 menemukan bahwa terdapat kontaminasi pada obat dengan kandungan ranitidine. Zat kontaminan yang terdapat pada obat itu adalah N-Nitrosodimethylamin, senyawa jahat yang bersifat karsinogen bagi tubuh manusia. Ranitidin dapat terkontaminasi oleh NDMA diduga karena dirinya telah terdegradasi oleh beberapa faktor seperti pH, reaksi ozonasi, dan reaksi kloraminasi. Ranitidin yang telah terdegradasi tidak dapat dikonsumsi kembali karena telah kehilangan efektifitas serta membahayakan bagi tubuh karena sifatnya yang sudah berubah. Dilain sisi, ranitidine memang telah digunakan sebagai prekursor NDMA karena reaktifitasnya yang baik dibandingkan dengan doxylamine, chlorphenamine maupun golongan H-2 bloker lainnya. Namun, kontaminasi pada senyawa ranitidine yang telah diformulasi menjadi obat tidak diharapkan terjadi karena memberikan banyak kerugian.
Phytochemical Analysis and Determination of MIC and MFC of Cacao Leaves Extract (Theobroma cacao L.) against Malassezia furfur Lestari, Siti Marwah; Camelia, Leonyta; Rizki, Widya Twini; Pratama, Septa; Khutami, Chindiana; Amelia, Amraini; Rahmadevi, Rahmadevi; Andriani, Yuni
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.316

Abstract

Pityriasis versicolor is a disease caused by Malassezia furfur. One of the plants that can potentially act as antifungal is cacao leaves (Theobroma cacao L.), which contain several secondary metabolite compounds, including alkaloids, flavonoids, tannins, quinones, terpenoids, and saponins. This study aims to determine the phytochemical analysis and the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of cacao leaves ethanolic extract against M. furfur. Extracts were obtained by maceration using 70% ethanol and phytochemicals analysis using Herborne’s method. Furthermore, the extracts were made into concentrations’ variations of 3.125%; 6.25%; 12.5%; 25%; 50%; and 100% for testing antifungal activity, with 10% DMSO as negative control and 2% Ketoconazole and Itraconazole as positive controls. MIC was performed with liquid macrodilution method, and MFC was performed with spread method. The results of phytochemical analysis showed that the extract contained alkaloids, flavonoids, phenols, tannins, quinones, terpenoids and saponins. MIC value was obtained at concentration of 50% and MFC value was obtained at 100%. Cacao leaves ethanolic extract with concentration of 50% can inhibit M. furfur’s growth and with 100% can eliminate M. furfur.
FORMULASI NANOKAPSUL BIJI LABU (Cucurbita moschata) SEBAGAI SUPLEMEN ZAT BESI DAN ZINK UNTUK STUNTING Rahmadevi, Rahmadevi; Khutami, Chindiana; Oktavia, Nazifa
Jurnal Kesehatan Medika Saintika Vol 15, No 2 (2024): Desember 2024
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v15i2.2950

Abstract

 Kasus stunting di Indonesia sampai tahun 2022 masih terbilang tinggi menurut riskesdas yaitu 21,6% dari seluruh populasi penduduk Indonesia. Salah satu faktor yang menyebabkan kasus ini adalah kurangnya asupan mineral untuk pertumbuhan terutama zink dan Fe (zat besi). Zink bertanggung jawab terhadap pembelahan sel pada manusia, sedangkan Fe (zat besi) sangat berperan dalam pembentukan sel darah merah. Masalh ini dapat diatasi dengan cepat jika ada produk atau suplemen yang mengandung zink dan Fe. Suplemen ini telah beredar dipasaran, namun yang berasal dari alam masih sangat sedikit didapat. Kelangkaan ini dapat diatasi dengan melakukan eksplorasi produk dari alam yang mengandung banyak mineral terutama zink dan Fe. Salah tumbuhan yang memiliki kandungan mineral yang cukup banyak terutama zink adalah labu kuning. Penelitian ini bertujuan untuk membuat suplemen berbentuk nanokapsul dengan teknik freeze drying. Sampel merupakan campuran antara serbuk biji labu kuning dengan maltodekstrin yang dilarutkan dalam aquadest dengan perbandingan (0,5:5; 1,5:5 dan 3:5). Dan dibekukan dengan freeze drying. Sampel dikarakterisasi dengan AAS, FTIR, PSA dan SEM. Hasil yang diperoleh Formulasi terbaik adalah sampel 3 dengan persentase maltodekstrin 90,9%, ukuran partikel nanokapsul (214,6 nm) dengan indeks polidipersitas terendah yaitu 0,47, nilai rendemen 95,64%, dan bentuk morfologi cenderung bulat, permukaan sedikit cekungan (hampir sempurna). Serbuk biji labu kuning dan maltodekstrin dengan Teknik freeze drying merupakan suplemen yang menjanjikan sebagai suplemen untuk penanganan stunting. Kata kunci : Stunting; Zink; Biji labu kuning
Uji Efektivitas Analgesik Esktrak Daun Senduduk (Melastoma malabathricum L.) terhadap Mencit Jantan anggriani, Adelia; Khutami, Chindiana; Andriani, Yuni; Pratama, Septa
Pharmaceutical Science and Clinical Pharmacy Vol 3 No 1 (2025)
Publisher : Akademi Farmasi Bumi Siliwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61329/pscp.v3i1.36

Abstract

Nyeri adalah pengalaman yang terakait dengan kerusakan jaringan aktaual atau potensial yang bersifat subyektif. Penggunaan OAINS dalam mengatasi nyeri dalam jangka panjang memiliki efek samping seperti gangguan lambung dan usus, kerusakan pada ginjal. Secara empiris daun senduduk ungu (Melastoma malabathricum L.) mengandung senyawa metabolit sekunder yang mempunyai kemampuan sebagai analgesik. Tujuan penelitian mengetahui efektivitas analgesik dan dosis yang tepat ekstrak etanol daun senduduk (Melastoma malabathricum L.) terhadap mencit jantan yang diuji menggunakan metode tail flick.  Hewan uji yang digunakan dalam penelitian ini sebanyak 25 ekor. Uji analgesik terdiri dari kelompok kontrol positif, negatif dan variasi dosis 400 mg/kgBB, 600 mg/kgBB dan 800 mg/ kgBB. Hasil pengamatan menujukan bahwa ekstrak daun senduduk (Melastoma malabthricum L.) memiliki efektivitas analgesik yang ditunjukan dengan perpanjangan waktu respon penjetikan ekor. Pada dosis ekstrak 600 mg/kgBB dan 800mg/kgBB merupakan dosis yang paling efektif sebagai analgesik dengan persentase hambatan yaitu 82,3% dan 93,5%.
Uji Aktivitas Ekstrak Etanol Biji Pinang (Areca catechu L.) Sebagai Antidiabetes Pada Mencit Putih Jantan (Mus musculus) Jamilah, Siti; Pratama, Septa; Andriani, Yuni; Khutami, Chindiana
Pharmaceutical Science and Clinical Pharmacy Vol 3 No 1 (2025)
Publisher : Akademi Farmasi Bumi Siliwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61329/pscp.v3i1.37

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan dosis ekstrak Biji Pinang (Areca catechu L.). Sebanyak 25 ekor mencit dibagi menjadi lima kelompok meliputi kontrol negatif (KN), kontrol positif (KP), dosis I (6,3 mg/kg BB), dosis II (12,6 mg/kg BB), dosis III (25,2 mg/kg BB), dengan lima kali pengecekan kadar gula darah. Mencit pada setiap kelompok diinduksi streptozotocin 100 mg/kg BB. Analisis data berat badan, kadar gula darah dan persentase penurunan kadar gula darah menggunakan uji Analysis of Variance (ANOVA), dan dilanjutkan dengan Uji Duncan. Ekstrak biji pinang berpengaruh signifikan terhadap berat badan pada mencit (p<0,05). Ekstrak biji pinang berpengaruh signifikan terhadap kadar gula darah dan selisih pada mencit (p<0,05). Pemberian ekstrak juga berpengaruh signifikan terhadap persentase penurunan kadar gula darah (p<0,05), hal ini disebabkan biji pinang mengandung senyawa alkaloid dan flavonoid. Pengaruh paling optimal terhadap penurunan kadar gula darah mencit diabetes ditunjukkan oleh pemberian ekstrak daun Biji Pinang dosis III (25,2 mg/kg BB). Dengan demikian, Biji Pinang berpotensi sebagai bahan obat tradisional untuk diabetes melitus.
Program Pendampingan Berbasis Herbal untuk Pencegahan Anemia pada Remaja Putri di SMAN 4 Muaro Jambi Amraini Amelia; Chindiana Khutami; Yesi Mustika Sari
PaKMas: Jurnal Pengabdian Kepada Masyarakat Vol 5 No 1 (2025): Mei 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/pakmas.v5i1.3319

Abstract

Anemia is a health problem that requires special attention, especially among adolescents, due to its high prevalence and harmful impact on future generations. Data from Riskesdas 2018 shows that the prevalence of anemia in Indonesia is 26.8% in children aged 5-14 years and 32% in those aged 15-24 years. This community service program aims to prevent anemia and improve food security among adolescents at SMAN 4 Muaro Jambi through preparation, socialization, training, technology implementation, mentoring, and evaluation phases. The methods used include counseling, cadre training, and herbal product creation. Mandatory outputs include activity videos, media publications, and increased partner knowledge, along with additional outputs such as a guidebook and scientific articles. Significant results from this program include increased adolescent knowledge about anemia prevention and food security, cadre training for simple Hb level checks, and training on making simple herbal products for anemia prevention, such as lemongrass butterfly pea flower tea, roselle tea, and turmeric tamarind herbal drink. This program is expected to serve as a model for other schools and help reduce the prevalence of anemia in Jambi Province.
Phytochemical Analysis and Determination of MIC and MFC of Cacao Leaves Extract (Theobroma cacao L.) against Malassezia furfur Lestari, Siti Marwah; Camelia, Leonyta; Rizki, Widya Twini; Pratama, Septa; Khutami, Chindiana; Amelia, Amraini; Rahmadevi, Rahmadevi; Andriani, Yuni
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.316

Abstract

Pityriasis versicolor is a disease caused by Malassezia furfur. One of the plants that can potentially act as antifungal is cacao leaves (Theobroma cacao L.), which contain several secondary metabolite compounds, including alkaloids, flavonoids, tannins, quinones, terpenoids, and saponins. This study aims to determine the phytochemical analysis and the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of cacao leaves ethanolic extract against M. furfur. Extracts were obtained by maceration using 70% ethanol and phytochemicals analysis using Herborne’s method. Furthermore, the extracts were made into concentrations’ variations of 3.125%; 6.25%; 12.5%; 25%; 50%; and 100% for testing antifungal activity, with 10% DMSO as negative control and 2% Ketoconazole and Itraconazole as positive controls. MIC was performed with liquid macrodilution method, and MFC was performed with spread method. The results of phytochemical analysis showed that the extract contained alkaloids, flavonoids, phenols, tannins, quinones, terpenoids and saponins. MIC value was obtained at concentration of 50% and MFC value was obtained at 100%. Cacao leaves ethanolic extract with concentration of 50% can inhibit M. furfur’s growth and with 100% can eliminate M. furfur.
Mekanisme Kerja Obat Antihipertensi Yang Bekerja Pada GPCRs dan Tanaman Yang Berpotensi Sebagai Antihipertensi Khutami, Chindiana
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension is the medical term for patients with systolic blood pressure above 140 mmHg and diastolic above 100 mmHg. Hypertension is a complex multifactorial disease that contributes to the main causes of morbidity and mortality in industrialized countries: ischemic heart disease and hypertension, stroke, peripheral atherosclerosis and renal failure. Commonly used antihypertensives are usually associated with many side effects. In the last three decades, many concerted efforts have been made to research local plants with hypotensive and antihypertensive therapeutic value. The hypotensive and antihypertensive effects of some of these medicinal plants have been validated and others have not been proven. G-protein coupled-receptors or GPCRs are targets of drug action, whose signaling is mediated by G-proteins. GPCRs are receptors that reside on the cell surface and have seven transmembrane domains. For example, GPR35 is a target for furosemide and bumetanide. This is especially important in cardiovascular disease secondary to hypertension, where the degree of vessel constriction is partly due to increased levels of agonists such as catecholamines and angiotensin II.
Penguatan Eduwisata Hidroponik Barokah dan Inovasi Produk Sayur Amraini Amelia; Chindiana Khutami; Adria Wuri Lastari
Jurnal Medika: Medika Vol. 5 No. 1 (2026)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/5dvs2s42

Abstract

This community service program was conducted at the Barokah Hydroponic Group in Kenali Asam Atas Subdistrict, Jambi City, which operates an active hydroponic system but has not yet optimally utilized it as educational tourism or a source of value-added product development. The main challenges faced by the partner included the absence of durable processed vegetable products and the lack of standardized educational tourism management. This program aimed to strengthen hydroponic educational tourism and develop innovative vegetable-based processed products in the form of vegetable powder (simplisia) to enhance community capacity and economic potential. The implementation methods included preparation, socialization, training, application of simple technology, mentoring, and evaluation. Activities focused on producing vegetable powder from Brazilian spinach and common spinach, developing Standard Operating Procedures (SOP) for educational tourism, and providing initial mentoring for educational tourism implementation. The results indicated an improvement in partners’ knowledge and skills, as reflected by an increase in average pre-test scores from 60% to 82% in the post-test. In addition, the partners successfully produced value-added products and established structured guidelines for managing educational tourism activities. This program is important as a sustainable model for strengthening hydroponic-based educational tourism and local product innovation
Co-Authors Adria Wuri Lastari Agung Kurniawan Amraini Amelia Anggraini, Putri Dewi anggriani, Adelia armayanti, dini Azzahra, Talitha Salshabilla Camelia, Leonyta DWI RAHMAWATI Fitrianto, Rahmad Hanifahzin Khatami Karimah, Sa'adatul Kristy Mellya Putri Menrisal Monica, Egis Muchtaridi Muchtaridi Oktavia, Nazifa Rahmadevi Rahmat Hidayat Rizki, Widya Twini Siti Jamilah Siti Marwah Lestari Siti Marwah Lestari Vindi Annisa Rahmah Widya Twiny Rizki Yesi Mustika Sari Yuni Andriani