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All Journal Jurnal Ilmiah Farmasi Farmasyifa PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Chindiana Khutami
Universitas Adiwangsa Jambi
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Mekanisme Kerja Obat Antihipertensi Yang Bekerja Pada GPCRs dan Tanaman Yang Berpotensi Sebagai Antihipertensi Chindiana Khutami
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 1 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35141/pharm.v2i1.773

Abstract

Hypertension is the medical term for patients with systolic blood pressure above 140 mmHg and diastolic above 100 mmHg. Hypertension is a complex multifactorial disease that contributes to the main causes of morbidity and mortality in industrialized countries: ischemic heart disease and hypertension, stroke, peripheral atherosclerosis and renal failure. Commonly used antihypertensives are usually associated with many side effects. In the last three decades, many concerted efforts have been made to research local plants with hypotensive and antihypertensive therapeutic value. The hypotensive and antihypertensive effects of some of these medicinal plants have been validated and others have not been proven. G-protein coupled-receptors or GPCRs are targets of drug action, whose signaling is mediated by G-proteins. GPCRs are receptors that reside on the cell surface and have seven transmembrane domains. For example, GPR35 is a target for furosemide and bumetanide. This is especially important in cardiovascular disease secondary to hypertension, where the degree of vessel constriction is partly due to increased levels of agonists such as catecholamines and angiotensin II.
FAKTOR PENGARUH DEGRADASI RANITIDIN MENJADI N-NITROSODIMETHYLAMINE (NDMA) Muchtaridi Muchtaridi; Hanifahzin Khatami; Chindiana Khutami
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i2.9443

Abstract

Food and Drug Administration (FDA) pada 13 September 2019 menemukan bahwa terdapat kontaminasi pada obat dengan kandungan ranitidine. Zat kontaminan yang terdapat pada obat itu adalah N-Nitrosodimethylamin, senyawa jahat yang bersifat karsinogen bagi tubuh manusia. Ranitidin dapat terkontaminasi oleh NDMA diduga karena dirinya telah terdegradasi oleh beberapa faktor seperti pH, reaksi ozonasi, dan reaksi kloraminasi. Ranitidin yang telah terdegradasi tidak dapat dikonsumsi kembali karena telah kehilangan efektifitas serta membahayakan bagi tubuh karena sifatnya yang sudah berubah. Dilain sisi, ranitidine memang telah digunakan sebagai prekursor NDMA karena reaktifitasnya yang baik dibandingkan dengan doxylamine, chlorphenamine maupun golongan H-2 bloker lainnya. Namun, kontaminasi pada senyawa ranitidine yang telah diformulasi menjadi obat tidak diharapkan terjadi karena memberikan banyak kerugian.
Co-Authors Hanifahzin Khatami Muchtaridi Muchtaridi