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Burnout as a Predictor of Quality of Life Among the Federal Road Safety Corps Employees in Benue State Sector Command Zakariah, Danladi; Akafa, Vika Tensaba; Akafa, Tensaba Andes; Oladele, Gloria Omonefe; Iseko, Kingsley Iyoko; David, Izam Emmanuel; Ujah, Oche Williams
Kwaghe International Journal of Arts, Humanities and Religious Studies Vol 1 No 1 (2024): Kwaghe International Journal of Arts, Humanities and Religious Studies
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijahrs.v1i1.3983

Abstract

This study investigated the relationship between burnout and quality of life among the Federal Road Safety Corps Employees in Benue State Sector Command. The study employed cross sectional and expost facto design where 200 participants consisting of 161 (80.5%) males, 37 (18.5%) females and 2 (1.0%) did not indicate their sex. Their ages ranged from 21-60 years with means age of 35.55 (SD=7.21). Maslach Burnout Inventory (MBI) and quality of Life Scale (WHOQOL) were used for data collection using Multistage, Stratified random and systematic sampling techniques. Statistical analysis involved the use of multiple regressions. Findings indicated that, there was a significant negative relationship between burnout and quality of life among the Federal Road Safety Corps Employees in Benue State Sector Command. The result of the finding reviewed that there was a significant negative relationship between burnout and the overall quality of life among the Federal Road Safety Corps employees in Benue State Command [R=.562, R2=.316, F (3,178)=27.376, p<.001]. This implies that burnout accounted for 31.6% of the total variance observed in quality of life among the Federal Road Safety Corps employees in Benue State Sector Command. The result of the study also showed the individual contributions of the various dimensions of burnout to overall quality of life which indicated that emotional exhaustion made the highest significant negative contribution (β=-.414, t=-5.180, p<.001) followed by depersonalization (β=-.235, t=-3.081, p<.01) while personal accomplishment made no significant contribution to the model (β=.027, t=.355, p>.05) respectively. Based on the findings of this study, it was recommended that conscious efforts should be made to enhance quality of life among the Federal Road Safety Corps Employees through reduction of burnout stress inherent in the work place among the Federal Road Safety Corps Employees in Benue State Sector Command and Nigeria at large.
From Perception to Effect of Oil Spillage Among Fishermen in the Niger Delta Region of Bayelsa State, Nigeria Akafa, Tensaba Andes; Asare, Solomon Ossom; Dennis, Adobeni Emmanuel; Konka, Daniel; Ametsi, Smile Kobina; Tahidu, Issifu; Oladele, Gloria Omonefe
Kwaghe International Journal of Arts, Humanities and Religious Studies Vol 2 No 2 (2025): Kwaghe International Journal of Arts, Humanities and Religious Studies
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijahrs.v2i2.6064

Abstract

Oil spillage continues to pose a significant environmental threat in Nigeria’s Niger Delta, leading to ecological degradation, disruption of livelihoods, and socio-political instability. This study investigates the perceptions and impacts of oil spillage among fishermen in the Biseni community of Bayelsa State. Utilizing a descriptive cross-sectional design, data were collected from 358 respondents selected through systematic random sampling. A semi-structured, interviewer-administered questionnaire was employed, and responses were analyzed using SPSS version 16. The results show that 94.4% of respondents identified pipeline corrosion from soil-related factors as a major cause of oil spillage. Other commonly perceived causes included sabotage by surveillance contractors (86.3%), pipeline vandalism (85.2%), and unemployment (84.1%). Water pollution was identified by 98.0% of respondents as the most severe environmental consequence, particularly affecting aquatic life. Health impacts were also substantial, with 96.9% reporting adverse effects, skin rashes being the most frequently cited (32.0%). Economically, 95.5% of respondents reported reduced income due to declining fish yields. Broader socio-economic impacts included perceived links to unemployment (91.9%), increased kidnapping (79.6%), lack of compensation (80.4%), displacement (35.8%), and the need to purchase drinking water (70.4%). The study concludes that repeated oil spillage and unregulated exploitation have caused significant environmental and socio-economic harm in the Biseni community. The lack of effective compensation mechanisms intensifies local grievances and underscores the urgent need for sustainable environmental governance and enhanced corporate accountability in oil-producing areas.
Effect of Aqueous Hibiscus Sabdariffa on the Histology of the Testes of Male Albino Wistar Rats Ayara, Charles; Ujah, Williams Oche; Bafai, Favour Joel; Makanjuola, Victor; Enang, Kingsley Bassey; Williams, Queen Uyo; Akafa, Tensaba Andes; Uduak, Peter Ise; Umaru, Isaac John
African Journal of Clinical Medicine and Pharmacy Research Vol 1 No 1 (2024): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v1i1.3974

Abstract

Medicinal plants contain physiological principles that over the years had been exploited in traditional medicine for the treatment of various ailments. Hibiscus Sabdariffa is not primarily a medicinal plant, but is used as alternative treatment to a wide variety of medical conditions. It is a plant of various psychoactive properties. This study investigated the histological effect of Hibiscus Sabdariffa aqueous solution on the testes of male albino rats. The research used 20 rats weighing 50-100g and were divided into Group A, Group B, Group C, Group D and Group E. Group A was the control group; unexposed to any form of Hibiscus Sabdariffa. Group B were exposed to the extract in a dosage of 0.5ml only in the morning. Group C were exposed to the extract in a dosage of 0.5ml in the morning and afternoon after (6) six hours. Group D were exposed to the extract in a dosage of 0.5ml in the morning, afternoon and by evening after six-hour intervals. Group E were exposed to the extract in an alternating administrative routine. In the end, the rats were sacrificed and the testes were removed and fixed in 10% formal saline solution. The testes were stained with hematoxylin and eosin. Results on the histology show changes to the histology of the testes of the group administered high doses. The results obtained from hormonal profiling shows a series of reduction in the levels of the evaluated hormones at the given dosage. Therefore, Hibiscus Sabdariffa can damage the histology of the testes at given dosage.
Histological Assessment of Aqueous Solution of Hibiscus sabariffa calyx (Zobo drink) on the Frontal Cortex and Hippocampus of Albino Wistar Rats Ujah, Williams Oche; Acha, Ozzioma Praise; Ayara, Charles; Makanjuola, Victor; Agaba, Eric Agim; Williams, Queen Uyo; Akafa, Tensaba Andes; Umaru, Isaac John
African Journal of Clinical Medicine and Pharmacy Research Vol 1 No 1 (2024): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v1i1.3975

Abstract

Zobo drink which is consumed by many Nigerians, is a non-alcoholic beverage with phytoactive properties. This study investigated the histological outcome of Hibiscus sabdariffa calyx aqueous solution (Zobo drink) on the frontal cortex and hippocampus of albino wistar rats. Twenty (20) albino wistar rats were used, and grouped into a control group A, B, C, D and E. Group A was the control group. 0.5ml of Zobo drink was administered at different time interval to the experimental groups for 21 days. Zobo drink was administered to group B once a day, two times a day to group C, three times a day to group D and throughout the duration of administration to group E. In the end, the rats were sacrificed and the brain was removed and fixed in 10% formal saline solution. The frontal cortex and hippocampus were stained with Haematoxylin and eosin. Results show that no adverse effect on the frontal cortex of group B, C, D and E but shows effect on group E which is the high dose.
In-vitro Cytotoxic and Anti-vibro Cholerae Activities of Methanol Roots Extracts of Morinda citrifolia L (Noni) Umaru, Isaac John; Konka, Daniel; Kingsly, Iseko Iyoko; Asare, Solomon Ossom; Hassan, Okrah George; Oteng, Joseph; Akafa, Tensaba Andes; Umaru, Kerenhappuch Isaac
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 1 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i1.4720

Abstract

Knowledge on medicinal properties of plants has extensively been applied all over the World to cure or ameliorate suffering of mankind. The use of remedies from plant origin covers a wide variety of maladies and constitutes an alternative way to antibiotics, which is otherwise no longer promising due to the generalized antibiotic resistance among pathogenic microorganisms. The majority of epidemic Vibrio cholerae strains have become resistant to multiple antimicrobial agents for many reasons, including mutations, horizontal gene transfers, etc. Therefore, secondary means of treatment are needed to overcome this impediment in combating cholera. Morinda citrifolia roots extensively used in traditional medicine. Therefore, the present study aims to evaluate the In-vitro Cytotoxic and Anti-vibro Cholerae Activities of Methanol Roots Extracts of Morinda citrifolia against V. cholerae isolates. Methods: Initially, different concentration of the extracts materials was subjected to qualitative phytochemical screening. Anti-V.cholerae activities were assessed by performing MIC (minimum inhibitory concentration) test using disc diffusion method with different concentrations (1.25, 2.25, 5.00, 8.00, 10.00mg/ml) where standard discs of gentamycin and meropenem (10 μg/disc) were used. Further, Brine shrimp lethality bioassay was done to evaluate the extracts’ cytotoxic activities using different concentrations (5,10, 20, 50, 100, 200, 400, 800μg/ml) against vincristine sulphate. Results: The preliminary screening confirms the presence of convenient phytochemical constituents like flavonoids, alkaloids, glycosides, tannins, etc., and are liable for the emergence of the antibacterial activities in different strains. The minimum inhibitory concentrations of methanolic Morinda citrifolia roots was found to be (a) 1.25, (b) 2.25, (c) 5, (d) 8, and (f) 10 mg/ml, respectively. Moreover, 100% mortality was observed only at the highest concentration (800 μg/ml). In comparison, the rest of the test concentration showed less than 90% mortality at the highest concentration (400 μg/ml). Conclusions: The Morinda citrifolia roots possess significant phytochemicals and showed potential anti-V. cholerae activities with mild toxicity. Hence, Morinda citrifolia (L.) roots may be recommended as potential phytotherapy against cholera disease.
Anticancer effect of Copper Activated Plasma Water on MCF7 Breast Cancer Cells Umaru, Isaac John; Kingsly, Iseko Iyoko; Ogochukwu, Edom Favour; Akafa, Tensaba Andes; Malantso, Jackson Soyinka; Habibu, Bilyaminu; Umaru, Kerenhappuch Isaac
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 1 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i1.4721

Abstract

Broad biological activities of “plasma-activated water” (PAW) have drawn great attentions recently. Treatment of water using gas discharge plasma led to acidic solutions with excellent and broad antibacterial activity. Because PAW caused severe membrane damages in bacteria and diffused freely in extracellular matrix, PAW also demonstrated good anti-biofilm activity. However, further studies revealed that trace amounts of metal ions (mainly copper) in PAW brought by plasma treatment played key roles in bacteria inactivation. The contribution of metal ions to the antibacterial activity varied among PAWs from different working gases. However, solution acidification caused by reactive species in plasma was essential. The experimental results demonstrated that potential artifacts in reported biological activities of PAWs should be considered. Therefore, Copper has important redox activity and can participate in various biochemical reactions by accepting and donating electrons. As a trace element, thus, Anticancer effect of Copper Activated Plasma Water on MCF7 Breast Cancer Cells. Materials and method, used are a non-thermal micro-hollow cathode discharge (MHCD) was used to generate plasma-activated waters (CU-PAWs), The MCF-7 human breast adenocarcinoma cell line (IBRC C10082), and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was acquired. Cell Viability Measurements; After 48 h of incubation 0.5 mg/ml MTT (20 μl) was added to the control and experimental cells and the cells were incubated for 3 h in a CO2 incubator at 37 °C, Measurement of Reactive Oxygen Species (ROS) and Flow Cytometry was conducted. Results: The 3- and 4-min CU-PAW reduced MCF-7 cells viability to approximately 62% and 56% of control (p< 0.01), respectively. However, in the cases of 1- and 2-min CU-PAW cell proliferation did not diminish significantly as compared with the control group (p> 0.05). This observation is consistent with earlier studies, which illustrated that plasma irradiation reduced cell viability in a time-dependent manner. Thus, in this research, DOX (0.45 µM) combined with 3- or 4-min CU-PAW killed MCF-7 cell efficiently (44% and 39% cell viability, respectively; p< 0.01) than DOX (54% cell viability) or 3- or 4-min CU-PAW alone (63% and 56% cell viability, respectively). These was in line with a that PAW plus cisplatin at low doses reduced viability of human endometrial carcinoma more effectively than cisplatin or PAW alone. Conclusion: Although further investigations are crucial, CU-PAW combined with DOX could be a promising cancer treatment strategy, contributing to a more positive therapeutic agent.
Efficacy and Safety of Triple Synergy Therapy Containing Annona Senegalese, Ciprofloxacin, and Omeprazole for Helicobacter Pylori Initial Treatment Umaru, Isaac John; Akafa, Tensaba Andes; Ngbede, Ocheifa Matthew; John, Artu Ishishen; Umaru, Kerenhappuch Isaac
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 2 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i2.4970

Abstract

Annona senegalensis is a complex plant, with several active compounds contributing to its medicinal properties. The presence of alkaloids such as annonaine and corossolin, which have been shown to possess anti-inflammatory and analgesic effects, is particularly noteworthy. Flavonoids like quercetin and kaempferol are potent antioxidants that help to reduce oxidative stress, while tannins contribute to the plant’s antimicrobial and anti-inflammatory properties. These compounds, working synergistically, may explain the plant’s potential. Material and methods: This study was conducted in accordance with the Declaration of Helsinki with little modification, The rats were completely randomized, numbered according to the sequence, and randomly enrolled in a ratio of 1:1:1 to receive the triple therapy (A group, Annona senegalensis, ciprofloxacin quadruple therapy (B group as Omeprazole quadruple therapy. Results: Annona Senegalese scheme for initial and rescue treatment of H. pylori infection are not inferior to the guideline-recommended therapy. A study compared the eradication efficacy of the Annona Senegalese quadruple therapy (300 mg, 3 times/day) with that of bismuth quadruple therapy. The eradication rates of H.pylori were 87.5% and 87.1% in PP analysis, with no statistical significance (P >0.05), It was observed that, the eradication rates of H. pylori in response to the new triple therapy consisting of Annona Senegalese’s triple therapy (A. Senegalese 500 mg, Ciprofloxacin 1000 mg, Omeprazole 20 mg, A group), were 70.0% and 81.4% by ITT and PP analyses, respectively. Conclusion: The efficacy of Annona Senegalese triple therapy for the initial eradication of H. pylori is commendable thus be used as a combination in clinical therapy.
Potential of Aqueous Leaves Extract of Jatropha Gossypiifolia Seed Against Highly Active Antiretroviral Therapy Induced Hepatotoxicity in Rats Umaru, Isaac John; Akafa, Tensaba Andes; Akem, Ingwu Joseph; Oteng, Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Akam, Odok Endurance; Ekup, Ogholo Ogholo
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 2 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i2.5185

Abstract

While many methods exist for measuring the impact of AIDS, treatment remedy the human development approach focuses on people rather than medical or economic indicators. Human Development Index captures three basic dimensions of human development: a long and healthy life—measured by life expectancy at birth; knowledge—measured by adult literacy and school enrolment; and standard of living—measured by per capita gross domestic product. Thus, investigate the hepatoprotective activity of aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy administered rats. Liver is a metabolically active organ responsible for many vital life functions. It performs many activities that are critical for survival. Due to its important activities, the liver is exposed to a number of insults and is one of the body's organs most subject to injury. In spite of tremendous advances in modern medicine, there are hardly any reliable drugs that protect the liver from damage and/or help in regeneration of hepatic cell. It is, therefore, necessary to search for effective and safe herbal drugs for the treatment of liver disease to replace currently used drugs of doubtful efficacy and safety. Hence, the need to evaluate the aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy (Lamivudine, Zidovudine and Efavirenz) administered rats. Sixty rats weighed between 150-200g were randomly divided into six groups and each group comprised of ten rats. Rats in group I were administered with distilled water. Rats in group II were administered with highly active antiretroviral therapy only. Rats in groups III - VI were administered 100, 200, 400 and 600 mg/kg Jatropha gossypiifolia seed plus highly active antiretroviral therapy respectively. The treatments were given orally for 28 consecutive days. On the 29th day, all rats were sacrificed under light diethyl ether anaesthesia; blood samples were collected for the assessment of biochemical parameters, while Serum levels of liver enzymes ALT, AST, ALP, and GGT were significantly (p<0.05) increased and albumin concentration was significantly decreased in animals treated with highly active antiretroviral therapy as compared to the normal control. Treatment of highly active antiretroviral therapy exposed animals with Jatropha gossypiifolia seed showed marked improvement in biochemical findings. Rise in liver enzymes was almost restored to normal in animals treated with Jatropha gossypiifolia seed. Jatropha gossypiifolia seed through its antioxidant activity effectively protects highly active antiretroviral therapy induced liver toxicity.
In Vitro Anti-HIV Activity of Rosa centifolia, (Leaves and Roots) Extract on HIV-1UG070 and HIV-1VB59 in TZM-bl and PM1 Cell Lines Umaru, Isaac John; Akem, Ingwu Joseph; Akafa, Tensaba Andes; Ngbede, Ocheifa Mathew; Oteng, Joseph; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Akam, Odok Endurance; Ekup, Ogholo Ogholo
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 2 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i2.5223

Abstract

Human immunodeficiency virus (HIV) infection is still contributing significantly in morbidities and mortalities in the world today, more especially in developing countries. The drugs normally use to reat the infection is costly, toxic, and less effective due to resistance by HIV. In view of that an assessment of In Vitro Anti-HIV Activity of Rosa centifolia, (Leaves and Roots) Extract on HIV-1UG070 and HIV-1VB59 in TZM-bl and PM1 Cell Lines. Thus, the present therapy also has limitations of development of multidrug resistance, with a need for the discovery of novel anti-HIV compounds from plants as a potential alternative in combating HIV disease. Methods: The medicinal plant was tested for entry and replication inhibition against laboratory adapted strains HIV-1IIIB, HIV-1Ada5 and primary isolates HIV-1UG070, HIV-1VB59 in TZM-bl cell lines and primary isolates HIV-1UG070, HIV-1VB59 in PM1 cell lines. The plant extracts were further evaluated for toxicity in HEC-1A epithelial cell lines by trans well epithelial model. Results: The methanolic extracts of Rosa centifolia inhibited laboratory adapted HIV-1 strains (IC80 29.17-78.43μg/ml) and primary isolates (IC80 30.4-118μg/ml) in TZM-bl cells. Conclusion: These active methanolic extracts of Rosa centifolia, (leaves and roots) could be further subjected to chemical analysis to investigate the active moiety responsible for the anti-HIV activity. Methanolic extract of Rosa centifolia was found to be well tolerated maintaining the epithelial integrity of HEC-1A cells in vitro and thus has potential for investigating it further the phytochemical responsible for these activities.
Public Knowledge, Attitude And Acceptability of COVID-19 Vaccine among Traders in Wuse Market Abuja: A Cross-Sectional Study Akafa, Tensaba Andes; Oladele, Gloria Omonefe; Iseko, Kingsley Iyoko; Akafa, Vika Tensaba; David, Izam Emmanuel; Ujah, Oche Williams; John, Tongle Nanle; Nanmar, Chakfa; Tyem, Lawal Danjuma; Umaru, Isaac John
African Journal of Medicine, Surgery and Public Health Research Vol 1 No 1 (2024): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v1i1.3976

Abstract

The effect of the COVID-19 pandemic on public health has been unpleasant. Vaccination is a critical measure to decrease COVID-19 economic loss and public health burden. This is very helpful to control the COVID-19 pandemic. The process of halting COVID-19 solely depends on population uptake of the vaccination process and the adoption of non-pharmacological measures. This in turn relies on the public willingness to get vaccinated. The public acceptability of this vaccination is further determined by the level of knowledge and trust in currently available COVID-19 vaccines. Therefore, this paper aims to discuss the findings of public knowledge, attitude, and acceptability of COVID-19 vaccines among traders in Wuse Market Abuja. A cross-sectional study was conducted among different traders in the Abuja Wuse Market to assess their knowledge, attitude and level of acceptability toward COVID-19 vaccinations using a self-administered survey questionnaire with the following four sections; socio-demographic characteristics, knowledge assessment questions, attitude assessment, and acceptability questions. A total of 166 participants completed the questionnaire. The knowledge of the COVID-19 vaccinations among the study participants was high with 143(86%) respondents stating that they knew about COVID-19 vaccinations. Among the traders that participated, 74(44.36%) believed that vaccines are safe and 109 (66.02%) agreed that vaccines are critical to protect the public from COVID-19 infection. But only, 45 (27.4%) accept to receive the vaccine. Participants’ attitudes, knowledge, and level of acceptability were significantly affected by age, gender, education level, and marital status (P <0.001). Our findings suggest that there is good knowledge and attitude toward the vaccination process against COVID-19 among study participants in spite of low acceptability. Awareness campaigns are therefore necessary to disseminate reliable knowledge about COVID-19 vaccines and demystify the COVID-19 conspiracy theory in order to raise the level of vaccination acceptance.