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Practice and Determinants of Breast Self-Examination Among Women in Chereponi District, Northern Region of Ghana Oteng, Joseph
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 2 No 1 (2025): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v2i1.4856

Breast cancer is a public health problem in Ghana and early detection is a key determinant to the survival rate of the disease. It is a preventive measure usually encouraged among women to examine their breasts by feeling them several times a month for any lumpiness or hardness. The study was conducted to find out the practice and determinants of BSE among women in the Chereponi district in the northern region of Ghana. Method: A community-based cross-sectional research design with a mixed methods approach was utilized among 384 women aged 18 - 49 years in the Chereponi district. Participants were recruited using a multistage sampling technique with a structured questionnaire and Key Informant Interviews for data collection. The descriptive and inferential data were analysed using the SPSS and NVIVO. Results: The finding reveals that the participants were abreast with Breast self-examination (BSE) techniques. The bivariate correlation study of the level of knowledge and BSE also indicated strong positive relationship between the two variables. In other words, a two-tailed Pearson correlation coefficient of 0.777 shows positive significant relationship between the two variables at 0.01 level. Conclusion: The practice of BSE was found to have a direct relationship with the knowledge. Though the practice was commendable among those who had the knowledge, there were still challenges of cultural and social norms that mitigated against the practice of breast self-examination. It is important to empower women, promote supportive relationships and maximise women’s social networks to promote BSE uptake at the community level.

Effect of Jatropha Gossypiifolia Leaves in Wistar Albino Rats Against Gentamicin-Induced Biochemical Injury Umaru, Isaac John; Akafa, Tensaba Andes; Oteng, Joseph; Akem, Ingwu Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Akam, Odok Endurance; Ekup, Ogholo Ogholo
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 2 No 2 (2025): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v2i2.5186

Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “bellyache bush,” is a medicinal plant largely used throughout Africa and America. Several human and veterinary uses in traditional medicine are described for different parts and preparations based on this plant. The protective potentials of ethanol leaf extract of Bryophyllum pinnatum against gentamicin induced biochemical injury in Wistar albino rats were evaluated using serum biochemical parameters. Twenty-five male albino rats were divided randomly into five groups A to E. Groups C and D received 100, 200 and 300 mg/kg Jatropha gossypiifolia leaves extract respectively. Groups A and B were fed with chow (normal and positive controls) while Group E received 100 mg/kg of Vitamin C. Biochemical injury was induced in rats in groups B-E with gentamicin (i.p) at the dose of 80 mg/kg body weight on the 16th day of study. The rats were then fasted for 48 h and sacrificed by cervical dislocation. Serum was collected for biochemical analysis using standard methods and analytical biochemical kits. There was a significant increase in the serum levels of AST, ALT and ALP of the rats administered with gentamicin (Group B - positive control) compared to the Group A- normal control. However, treatment of rats with 100, 200 and 300 mg/kg body weight of ethanol leaf extract of Jatropha gossypiifolia L significantly decrease these biochemical parameters compared to Group B (p < 0.05). Also, there was a significant increase in the serum levels of conjugated bilirubin and total bilirubin in Group B compared to the normal control. Rat pre-treated with 200 and 300 mg/kg body weight of extract showed significant decrease in the conjugated and total bilirubin compared to the non-treated rats in Group B (p <0.05). Serum level of urea and creatinine significantly increased in Group B compared to normal control. Rats in groups C and D pre-treated with 200 and 300 mg/kg body weight of extract showed significant decrease in the levels of urea and creatinine compared to Group B (p <0.05). There was significant decrease in the serum levels of albumin and total protein of the rats administered with gentamicin compared to the normal control. Rats pre-treated with 200 and 300 mg/kg body weight of extract showed significant increase compared rats in non-treated Group B (p <0.05). The results obtained from this study shows that the ethanolic leaf extract of Jatropha gossypiifolia L has protective functions against gentamicin-induced hepatic and nephrotic damage in Wistar albino rats.

Practice and Determinants of Breast Self-Examination Among Women in Chereponi District, Northern Region of Ghana Oteng, Joseph
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 2 No 1 (2025): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v2i1.4856

Breast cancer is a public health problem in Ghana and early detection is a key determinant to the survival rate of the disease. It is a preventive measure usually encouraged among women to examine their breasts by feeling them several times a month for any lumpiness or hardness. The study was conducted to find out the practice and determinants of BSE among women in the Chereponi district in the northern region of Ghana. Method: A community-based cross-sectional research design with a mixed methods approach was utilized among 384 women aged 18 - 49 years in the Chereponi district. Participants were recruited using a multistage sampling technique with a structured questionnaire and Key Informant Interviews for data collection. The descriptive and inferential data were analysed using the SPSS and NVIVO. Results: The finding reveals that the participants were abreast with Breast self-examination (BSE) techniques. The bivariate correlation study of the level of knowledge and BSE also indicated strong positive relationship between the two variables. In other words, a two-tailed Pearson correlation coefficient of 0.777 shows positive significant relationship between the two variables at 0.01 level. Conclusion: The practice of BSE was found to have a direct relationship with the knowledge. Though the practice was commendable among those who had the knowledge, there were still challenges of cultural and social norms that mitigated against the practice of breast self-examination. It is important to empower women, promote supportive relationships and maximise women’s social networks to promote BSE uptake at the community level.

Effect of Jatropha Gossypiifolia Leaves in Wistar Albino Rats Against Gentamicin-Induced Biochemical Injury Umaru, Isaac John; Akafa, Tensaba Andes; Oteng, Joseph; Akem, Ingwu Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Akam, Odok Endurance; Ekup, Ogholo Ogholo
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 2 No 2 (2025): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v2i2.5186

Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “bellyache bush,” is a medicinal plant largely used throughout Africa and America. Several human and veterinary uses in traditional medicine are described for different parts and preparations based on this plant. The protective potentials of ethanol leaf extract of Bryophyllum pinnatum against gentamicin induced biochemical injury in Wistar albino rats were evaluated using serum biochemical parameters. Twenty-five male albino rats were divided randomly into five groups A to E. Groups C and D received 100, 200 and 300 mg/kg Jatropha gossypiifolia leaves extract respectively. Groups A and B were fed with chow (normal and positive controls) while Group E received 100 mg/kg of Vitamin C. Biochemical injury was induced in rats in groups B-E with gentamicin (i.p) at the dose of 80 mg/kg body weight on the 16th day of study. The rats were then fasted for 48 h and sacrificed by cervical dislocation. Serum was collected for biochemical analysis using standard methods and analytical biochemical kits. There was a significant increase in the serum levels of AST, ALT and ALP of the rats administered with gentamicin (Group B - positive control) compared to the Group A- normal control. However, treatment of rats with 100, 200 and 300 mg/kg body weight of ethanol leaf extract of Jatropha gossypiifolia L significantly decrease these biochemical parameters compared to Group B (p < 0.05). Also, there was a significant increase in the serum levels of conjugated bilirubin and total bilirubin in Group B compared to the normal control. Rat pre-treated with 200 and 300 mg/kg body weight of extract showed significant decrease in the conjugated and total bilirubin compared to the non-treated rats in Group B (p <0.05). Serum level of urea and creatinine significantly increased in Group B compared to normal control. Rats in groups C and D pre-treated with 200 and 300 mg/kg body weight of extract showed significant decrease in the levels of urea and creatinine compared to Group B (p <0.05). There was significant decrease in the serum levels of albumin and total protein of the rats administered with gentamicin compared to the normal control. Rats pre-treated with 200 and 300 mg/kg body weight of extract showed significant increase compared rats in non-treated Group B (p <0.05). The results obtained from this study shows that the ethanolic leaf extract of Jatropha gossypiifolia L has protective functions against gentamicin-induced hepatic and nephrotic damage in Wistar albino rats.

Effect of Aqueous Extract of Achyranthes aspera Leaves on Antiretroviral Drug-Induced Hepatotoxicity in Rats Umaru, Isaac John; Udoh, Mary Athanasius; Akafa, Tensaba Andes; Oteng, Joseph; Akem, Ingwu Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Ekup, Ogholo Ogholo
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5183

Achyranthes aspera leaves are believed to reverse drug resistance and increase the efficacy of current drugs. Achyranthes aspera leaves contain many secondary metabolites needed for the redressal of diseases and ailment. Thus, the ART-induced hepatotoxicity in rats. Methodology: Thirty (30) albino rats were divided into 5 groups of 6 each and treated as follows: Group A (no antiretroviral drugs, no extract); group B (antiretroviral drugs alone); group C (extract alone); group D (antiretroviral drug plus 40 mg/kg extract); group E (antiretroviral drug plus 80 mg/kg extract). All treatment lasted for twenty-eight days. Blood samples were collescted and serum ALT and AST determined using UV-spectrophotometer. The mean (± S.E.M) of data were calculated and further analysed for statistical significance using graph Pad Prism 5.0. Results: Mean serum ALT were 36.8 ± 20.24, 56.11 ± 6.12, 54.6 ± 24.18, 90.40 ± 11.14, 88.36 ± 13.10 and that of AST were 143.8 ± 20.24, 208.4 ± 16.13, 60.0 ± 24.18, 164.40 ± 11.14, 52.36 ± 16.14 for groups A, B, C, D, and E respectively. There was a statistically significant difference between the mean values of serum AST for group B and those for group C. However, there was no statistically significant difference between the ALT values for the test and control groups of rats (p value >0.999) Also, there was no statistically significant difference between the mean values of AST for group B and those of groups A, D, E. Conclusions: This extract at a higher concentration should add to the treatment of HIV in synergy with antiviral drugs, However, the extract shown no significant reduction of serum ALT and AST in ART treated rats.

Effect of Aqueous Extract of Achyranthes aspera Leaves on Antiretroviral Drug-Induced Hepatotoxicity in Rats Umaru, Isaac John; Udoh, Mary Athanasius; Akafa, Tensaba Andes; Oteng, Joseph; Akem, Ingwu Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Ekup, Ogholo Ogholo
African Journal of Biochemistry and Molecular Biology Research Vol 2 No 2 (2025): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v2i2.5183

Achyranthes aspera leaves are believed to reverse drug resistance and increase the efficacy of current drugs. Achyranthes aspera leaves contain many secondary metabolites needed for the redressal of diseases and ailment. Thus, the ART-induced hepatotoxicity in rats. Methodology: Thirty (30) albino rats were divided into 5 groups of 6 each and treated as follows: Group A (no antiretroviral drugs, no extract); group B (antiretroviral drugs alone); group C (extract alone); group D (antiretroviral drug plus 40 mg/kg extract); group E (antiretroviral drug plus 80 mg/kg extract). All treatment lasted for twenty-eight days. Blood samples were collescted and serum ALT and AST determined using UV-spectrophotometer. The mean (± S.E.M) of data were calculated and further analysed for statistical significance using graph Pad Prism 5.0. Results: Mean serum ALT were 36.8 ± 20.24, 56.11 ± 6.12, 54.6 ± 24.18, 90.40 ± 11.14, 88.36 ± 13.10 and that of AST were 143.8 ± 20.24, 208.4 ± 16.13, 60.0 ± 24.18, 164.40 ± 11.14, 52.36 ± 16.14 for groups A, B, C, D, and E respectively. There was a statistically significant difference between the mean values of serum AST for group B and those for group C. However, there was no statistically significant difference between the ALT values for the test and control groups of rats (p value >0.999) Also, there was no statistically significant difference between the mean values of AST for group B and those of groups A, D, E. Conclusions: This extract at a higher concentration should add to the treatment of HIV in synergy with antiviral drugs, However, the extract shown no significant reduction of serum ALT and AST in ART treated rats.

Potential of Aqueous Leaves Extract of Jatropha Gossypiifolia Seed Against Highly Active Antiretroviral Therapy Induced Hepatotoxicity in Rats Umaru, Isaac John; Akafa, Tensaba Andes; Akem3, Ingwu Joseph; Oteng, Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Akam, Odok Endurance; Ekup, Ogholo Ogholo
African Journal of Sciences and Traditional Medicine Vol 2 No 2 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i2.5182

While many methods exist for measuring the impact of AIDS, treatment remedy the human development approach focuses on people rather than medical or economic indicators. Human Development Index captures three basic dimensions of human development: a long and healthy life—measured by life expectancy at birth; knowledge—measured by adult literacy and school enrolment; and standard of living—measured by per capita gross domestic product. Thus, investigate the hepatoprotective activity of aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy administered rats. Liver is a metabolically active organ responsible for many vital life functions. It performs many activities that are critical for survival. Due to its important activities, the liver is exposed to a number of insults and is one of the body's organs most subject to injury. In spite of tremendous advances in modern medicine, there are hardly any reliable drugs that protect the liver from damage and/or help in regeneration of hepatic cell. It is, therefore, necessary to search for effective and safe herbal drugs for the treatment of liver disease to replace currently used drugs of doubtful efficacy and safety. Hence, the need to evaluate the aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy (Lamivudine, Zidovudine and Efavirenz) administered rats. Sixty rats weighed between 150-200g were randomly divided into six groups and each group comprised of ten rats. Rats in group I were administered with distilled water. Rats in group II were administered with highly active antiretroviral therapy only. Rats in groups III - VI were administered 100, 200, 400 and 600 mg/kg Jatropha gossypiifolia seed plus highly active antiretroviral therapy respectively. The treatments were given orally for 28 consecutive days. On the 29th day, all rats were sacrificed under light diethyl ether anaesthesia; blood samples were collected for the assessment of biochemical parameters, while Serum levels of liver enzymes ALT, AST, ALP, and GGT were significantly (p<0.05) increased and albumin concentration was significantly decreased in animals treated with highly active antiretroviral therapy as compared to the normal control. Treatment of highly active antiretroviral therapy exposed animals with Jatropha gossypiifolia seed showed marked improvement in biochemical findings. Rise in liver enzymes was almost restored to normal in animals treated with Jatropha gossypiifolia seed. Jatropha gossypiifolia seed through its antioxidant activity effectively protects highly active antiretroviral therapy induced liver toxicity.

Potential of Aqueous Leaves Extract of Jatropha Gossypiifolia Seed Against Highly Active Antiretroviral Therapy Induced Hepatotoxicity in Rats Umaru, Isaac John; Akafa, Tensaba Andes; Akem3, Ingwu Joseph; Oteng, Joseph; Ngbede, Ocheifa Mathew; Utioukpan, Ashaka Fidelis; Mijinyawa, Aboki Nwunuji; Akam, Odok Endurance; Ekup, Ogholo Ogholo
African Journal of Sciences and Traditional Medicine Vol 2 No 2 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i2.5182

While many methods exist for measuring the impact of AIDS, treatment remedy the human development approach focuses on people rather than medical or economic indicators. Human Development Index captures three basic dimensions of human development: a long and healthy life—measured by life expectancy at birth; knowledge—measured by adult literacy and school enrolment; and standard of living—measured by per capita gross domestic product. Thus, investigate the hepatoprotective activity of aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy administered rats. Liver is a metabolically active organ responsible for many vital life functions. It performs many activities that are critical for survival. Due to its important activities, the liver is exposed to a number of insults and is one of the body's organs most subject to injury. In spite of tremendous advances in modern medicine, there are hardly any reliable drugs that protect the liver from damage and/or help in regeneration of hepatic cell. It is, therefore, necessary to search for effective and safe herbal drugs for the treatment of liver disease to replace currently used drugs of doubtful efficacy and safety. Hence, the need to evaluate the aqueous extract of Jatropha gossypiifolia seed in highly active antiretroviral therapy (Lamivudine, Zidovudine and Efavirenz) administered rats. Sixty rats weighed between 150-200g were randomly divided into six groups and each group comprised of ten rats. Rats in group I were administered with distilled water. Rats in group II were administered with highly active antiretroviral therapy only. Rats in groups III - VI were administered 100, 200, 400 and 600 mg/kg Jatropha gossypiifolia seed plus highly active antiretroviral therapy respectively. The treatments were given orally for 28 consecutive days. On the 29th day, all rats were sacrificed under light diethyl ether anaesthesia; blood samples were collected for the assessment of biochemical parameters, while Serum levels of liver enzymes ALT, AST, ALP, and GGT were significantly (p<0.05) increased and albumin concentration was significantly decreased in animals treated with highly active antiretroviral therapy as compared to the normal control. Treatment of highly active antiretroviral therapy exposed animals with Jatropha gossypiifolia seed showed marked improvement in biochemical findings. Rise in liver enzymes was almost restored to normal in animals treated with Jatropha gossypiifolia seed. Jatropha gossypiifolia seed through its antioxidant activity effectively protects highly active antiretroviral therapy induced liver toxicity.

Descriptive Knowledge About Breast Cancer and the Importance of Breast Self-Examination Among Women Oteng, Joseph
Kwaghe International Journal of Sciences and Technology Vol 2 No 1 (2025): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v2i1.4855

Numerous studies regarding the efficacy of publicly advocated breast self-examination in the literature have suggested that it could contribute to an early diagnosis of breast anomalies and increased survival rates. Method: A community-based cross-sectional research design with a mixed methods approach was utilized among 384 women aged 18 - 49 years in the Chereponi district. Multistage sampling technique with a structured questionnaire and Key Informant Interviews for data collection. data were analysed using the SPSS and NVIVO. Results: The research work showed that the participants were abreast with Breast self-examination (BSE) techniques. And that majority of our respondents have a significantly positive impression of BSE. This tallies with the outcome of a study on affected perception of BSE among female secondary school teachers with high perception of BSE (95.5% in the study) by 95.6% of the respondents. Thus, it was also observed that the respondents gave a mean response of 4.04 (SD 0.884), indicating an average but strong sense of knowledge pertaining to where they could seek additional support. Conclusion: It is evident that the majority of the respondents view breast self-examination (BSE) as a significant component of the entire health care regime and also believe the regular practice of BSE can aid greatly in the early detection of breast cancer thereby increase the chances of early cure and furthermore have good confidence in their ability to examine themselves properly.

Descriptive Knowledge About Breast Cancer and the Importance of Breast Self-Examination Among Women Oteng, Joseph
Kwaghe International Journal of Sciences and Technology Vol 2 No 1 (2025): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v2i1.4855

Numerous studies regarding the efficacy of publicly advocated breast self-examination in the literature have suggested that it could contribute to an early diagnosis of breast anomalies and increased survival rates. Method: A community-based cross-sectional research design with a mixed methods approach was utilized among 384 women aged 18 - 49 years in the Chereponi district. Multistage sampling technique with a structured questionnaire and Key Informant Interviews for data collection. data were analysed using the SPSS and NVIVO. Results: The research work showed that the participants were abreast with Breast self-examination (BSE) techniques. And that majority of our respondents have a significantly positive impression of BSE. This tallies with the outcome of a study on affected perception of BSE among female secondary school teachers with high perception of BSE (95.5% in the study) by 95.6% of the respondents. Thus, it was also observed that the respondents gave a mean response of 4.04 (SD 0.884), indicating an average but strong sense of knowledge pertaining to where they could seek additional support. Conclusion: It is evident that the majority of the respondents view breast self-examination (BSE) as a significant component of the entire health care regime and also believe the regular practice of BSE can aid greatly in the early detection of breast cancer thereby increase the chances of early cure and furthermore have good confidence in their ability to examine themselves properly.

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