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All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Philip, Shadrach
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Effect of Methanol Stem Bark Extract of Annona senegalensis on Haematological Profile in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats Umaru, Isaac John; Philemon, Panah; Akem, Ingwu Joseph; Omolara, Mosugu Ovayoza; Okang, Ogar Fonne; Tansaba, Akafa Andes; Philip, Shadrach; Frank, Otashu Kenneth
African Journal of Clinical Medicine and Pharmacy Research Vol 2 No 3 (2025): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v2i3.7364

Abstract

Liver cancer, particularly hepatocellular carcinoma (HCC), is a leading cause of mortality worldwide and is frequently associated with hematological complications such as anemia and impaired blood clotting. This study evaluated the hematoprotective effects of methanol stem-bark extract of Annona senegalensis in rats with diethylnitrosamine (DEN)-induced HCC. Fifty-four male rats were allocated into six groups: a normal control group, a DEN-induced group without treatment, a positive control group treated with silymarin, and three treatment groups administered varying doses of A. senegalensis extract. Hematological parameters assessed included red blood cells (RBC), hemoglobin (HGB), white blood cells (WBC), hematocrit (HCT), and platelets (PLT). DEN induction significantly reduced RBC, HGB, and PLT levels, indicating anemia and coagulation impairment. Treatment with A. senegalensis, particularly at 400 mg/kg, markedly improved these hematological indices, suggesting a restorative effect on blood parameters. The protective role of the extract may be attributed to its bioactive constituents, such as flavonoids, alkaloids, and tannins, known for their antioxidant and anti-inflammatory activities. These findings suggest that A. senegalensis possesses promising hematoprotective potential in the management of blood-related complications associated with liver cancer. Further research, including mechanistic studies and clinical trials, is warranted to validate its safety and therapeutic efficacy in humans.
Effect of Methanol Stem Bark Extract of Annona senegalensis as an Antibacterial Agent and on Liver Enzyme Markers in Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Rats Umaru, Isaac John; Efongwa, Emmanuel; Omolara, Mosugu Ovayoza; Okang, Ogar Fonne; Akem, Ingwu Joseph; Tansaba, Akafa Andes; Philip, Shadrach; Frank, Otashu Kenneth
African Journal of Medicine, Surgery and Public Health Research Vol 2 No 3 (2025): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v2i3.7361

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, frequently linked to exposure to chemical carcinogens such as diethylnitrosamine (DEN). Medicinal plants have emerged as promising sources of bioactive compounds with potential anticancer and antimicrobial properties. This study evaluated the therapeutic potential of methanol stem-bark extract of Annona senegalensis against DEN-induced hepatocellular carcinoma and selected bacterial pathogens. Fifty-four male albino rats were allocated into six groups, with hepatocarcinogenesis induced by DEN, followed by a 14-day treatment with varying doses of the extract. Hepatoprotective effects were assessed using liver enzyme markers and serum protein levels, while antibacterial activity was determined via disc diffusion assays against Staphylococcus aureus and Escherichia coli. Results demonstrated that the extract significantly reduced liver enzyme levels (ALT, AST, ALP) and improved serum proteins (total protein and albumin) at higher doses (400 and 600 mg/kg), indicating hepatoprotective potential. Bilirubin levels also improved, suggesting reduced liver stress. Antibacterial evaluation revealed dose-dependent activity, with strong inhibition against S. aureus comparable to tetracycline at 200 µg/mL, and moderate efficacy against E. coli. These findings highlight the dual therapeutic potential of A. senegalensis stem-bark extract as both a hepatoprotective and antibacterial agent. Future studies are recommended to isolate and characterize the bioactive compounds responsible for these effects and to expand antibacterial evaluation to a wider spectrum of pathogens.
Co-Authors Abbas, Khalid Yahuza Absalom, Augustine Adamu, Usman Lukman Adebisi, Arowora Kayode Akem, Ingwu Joseph Chinedu, Imo Efongwa, Emmanuel Ekunyi, Agbo Chibuike Frank, Otashu Kenneth Ikira, Usman Iseko, Kingsley Iyoko Ismail, Muhammad Zuhairah Istifanus, Dafup Katdel Mohammed, Rashida Ismail Mona, Etah Hope Okang, Ogar Fonne Omolara, Mosugu Ovayoza Philemon, Panah Tansaba, Akafa Andes Udoh, Mary Athanasius Umaru, Isaac John