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All Journal African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset African Journal of Clinical Medicine and Pharmacy Research
Habibu, Bilyaminu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Open Access DRIVERset

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Effects of AlCl3 on the Enzymatic Antioxidants of Wister Rats Treated with Moringa oleifera Seed Extracts Yusufu, Dawoye; Zinas, Simon Teza; Habibu, Bilyaminu; Amen, Ananias; Umaru, Isaac John; Ejeh, Yakubu Ojochenemi; Grace, Onwubiko N.; Henry, Onwubiko A.; Audu, Anthony Mishara; Umaru, Kerenhappuch Isaac
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3693

Abstract

Determination of Malondialdehyde, MDA in blood plasma or tissue homogenates is one of the useful methods to predict the oxidative stress levels. The current study investigates the ameliorative effects of the seed extracts of Moringa oleifera on 35 albino rats induced with AlCl3 toxicity. Biomarkers of oxidative stress (Superoxide Dismutase, SOD; Catalase, CAT; Glutathione Peroxidase, GPx and Malondialdehyde, MDA were assayed. The plant seed extracts were shown to reduce the levels of MDA increased by AlCl3. AlCl3 caused decrease in (glutathione peroxidase) GPx levels as it causes MDA to significantly get elevated. The results showed that GPx decreased from 9.48 ± 0.86 to 6.68 ± 1.73 but upon treatments with 100 mg/kg bw of M. oleifera, GPx levels increased to 8.84 ± 0.86 (ethanol) and 8.96 ± 0.86 (aqueous). Increasing the concentrations of the extracts further increased the GPx levels while MDA were reduced.
Co-Authors Adeseye, Abdullahi Sa’adu Aisami, Abubakar Akafa, Tensaba Andes Aliyu, Sulaiman Abubakar Amen, Ananias Audu, Anthony Mishara Dauda, Mai-anguwa Abdulrashid Dauda, Maianguwa Abdulrashid Dauda, Maianguwa Abdulrsashid Ejeh, Yakubu Ojochenemi Ezeonu, Chukuma Stephen Goje, Lazaru Joseph Grace, Onwubiko N. Gyasi, Prince Kwadwo Henry, Onwubiko A. Iseko, Kingsley Iyoko Istifanus, Dafup Katdel Jabir, Abdulmumin Joel, Emmanuel Askeb-nde Kingsly, Iseko Iyoko Malantso, Jackson Soyinka Muhammad, Muhammad Bashir Odufa, Egbeadumah Maryanne Ogochukwu, Edom Favour Oko, John Odiba Oladele, Gloria Omonefe Olawale, Otitoju Oluwabunmi, Adeseye Helen Oluwabunmi, Helen Siddan, Ahmad Alhassan Umaru, Isaac John Umaru, Kerenhappuch Isaac Yusufu, Dawoye Zinas, Simon Teza