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All Journal VISIKES TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES (TIRES)
Hermawan, Farhan Aqil Putra
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Mathematics Physics

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Management Challenge of Culture-Negative Infective Endocarditis in an Adolescent with Uncorrected Patent Ductus Arteriosus: A Case Report Hermawan, Farhan Aqil Putra; Sari, Linda Silvana; Rahmansyah, M. Badzlul; Prabajati, Anis Wulan
TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES Vol. 5 No. 1 (2026): JANUARY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/tires.v5i1.2211

Abstract

Infective Endocarditis (IE) remains a life-threatening complication for patients with uncorrected Congenital Heart Disease (CHD). This case report illustrates the complex clinical management of a 39 kg pediatric patient presenting with a five-day history of fever and acute heart failure. Clinical examination and Transthoracic Echocardiography (TTE) confirmed the presence of a Patent Ductus Arteriosus (PDA) with associated bacterial vegetation, consistent with IE. The patient’s condition was further complicated by sepsis and hypochromic microcytic anemia. Management required a high-precision, multi-modal approach to balance competing physiological demands. To eradicate the infection, a synergistic regimen of broad-spectrum antibiotics (Ceftriaxone and Gentamicin) was initiated. Simultaneously, heart failure was addressed using a combination of diuretics (Furosemide, Spironolactone) and afterload reduction via ACE-inhibitors (Captopril). A critical component of the intervention was strict fluid restriction (1900 ml/day) to prevent pulmonary volume overload, despite the concurrent systemic sepsis. Supportive therapies included corticosteroids and gastrointestinal care. This case demonstrates that while sepsis typically necessitates fluid resuscitation, the presence of a PDA-induced shunt requires cautious fluid titration to maintain hemodynamic stability. The successful stabilization of this patient underscores the necessity of aggressive antimicrobial therapy and meticulous fluid management in complex CHD complications. Ultimately, this report emphasizes the vital importance of early PDA closure as a primary preventive measure against the development of high-morbidity Infective Endocarditis.
Knowledge and Breast Self-Examination Practice Among Health and Non-Health University Students Rahmansyah, M Badzlul; Hermawan, Farhan Aqil Putra; Nurhidayati, Nurhidayati; Lestari, Rizka Vidya; Afifah, Hanan
VISIKES Vol. 25 No. 1 (2026): VISIKES
Publisher : Dian Nuswantoro Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60074/visikes.v25i1.15950

Abstract

Breast cancer remains the most prevalent malignancy in Mataram City, with many cases diagnosed at advanced stages due to inadequate early screening. This study aims to analyze the relationship between breast cancer knowledge and Breast Self-Examination (BSE/SADARI) practice among health and non-health university students in Mataram. An observational analytic quantitative design with a cross-sectional approach was utilized. Data were collected from 256 female students across multiple universities in Mataram using a validated questionnaire distributed via Google Forms, selected through quota sampling. Data analysis included univariate descriptive statistics, Chi-Square tests, and Independent Sample T-tests. The results revealed that 41.4% of respondents had poor knowledge, while 56.3% demonstrated poor BSE practices. Bivariate analysis showed a statistically significant positive relationship between knowledge levels and BSE practice (), although the correlation strength was relatively weak. Students in the health cluster demonstrated significantly higher scores in both knowledge and practice compared to those in the non-health cluster (). This study concludes that while knowledge serves as a foundational requirement, a prominent "knowledge-practice gap" exists, likely influenced by psychological barriers such as fear and forgetfulness. Future interventions should move beyond disseminating theoretical facts and focus on digital-based technical training and self-efficacy to bridge the gap between awareness and consistent preventive behavior among university students.  
Co-Authors Afifah, Hanan Lestari, Rizka Vidya Nurhidayati Nurhidayati Prabajati, Anis Wulan Rahmansyah, M Badzlul Rahmansyah, M. Badzlul Sari, Linda Silvana