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All Journal Jurnal Kedokteran MNJ (Malang Neurology Journal) Jurnal Pepadu Jurnal Pendidikan dan Pengabdian Masyarakat
Lestari, Rizka Vidya
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PENGARUH EKSPRESI RESEPTOR INSULIN PANKREAS TERHADAP EKSPRESI GLUT4 NEURON HIPOKAMPUS PADA TIKUS MODEL DIABETES Sahly, Aliza Raudatin; Hunaifi, Ilsa; Lestari, Rizka Vidya; Wardani, Indah Sapta; Padauleng, Novrita; Nurhidayati; Harahap, Herpan Syafii
Jurnal Kedokteran Vol 9 No 4 (2020): Jurnal Kedokteran volume 9 no 4 2020
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i4.441

Abstract

Background: Diabetes Melitus (DM) is a degenerative diseases characterized by hyperglycemia condition. Basic Health Research data for 2018, shows an increase in prevalence of DM in Indonesia over last 5 years with 6,9% in 2013 to 8,5% in 2018. Pancreatic insulin receptor expression can be a marker for assessing presence of ? cells, production and secretion of insulin. Insulin could cause GLUT4 to be translocated to cell membrane of hippocampal neurons. In DM conditions, there may be changes in expression of pancreatic insulin receptors accompanied by changes in expression of GLUT4 hippocampal neurons. Methods: This experimental research used 16 white rats (Rattus Novergicus) which divided randomly into 4 groups, namely 2 control grups (A0 and A1) and 2 treatment groups (B0 and B1). Treatment group were induced by diabetes with a single dose of nicotinamide 110 mg/kgBB and streptozotocin 70 mg/kgBB intraperitoneally. The research data were obtained from immunohistochemical analysis of pancreatic and hippocampal tissue. Result: The mean expression of pancreatic insulin receptor in diabetic rat group was higher but not significant on the 14th day observation compared to the 0th day (p>0,05), while the mean GLUT4 expression of hippocampal neurons was significantly higher on 14th day of observation compared to the 0th day (p<0,05). The result of correlation test did not show a significant results in each group both at the 0th and 14th day observation (p>0,05). Conclusion: There was no significant effect of pancreatic insulin receptor expression on hippocampal neuron GLUT4 expression in diabetic model rats.
THE EFFECT OF GLUT4 EXPRESSION IN HIPPOCAMPAL NEURONS TO SPATIAL MEMORY OF DIABETES-INDUCED RATTUS NOVERGICUS Harahap, Herpan Syafii; Padauleng, Novrita; Lestari, Rizka Vidya; Nurhidayati, Nurhidayati; Wedayani, Anak Agung Ayu Niti; Sari, Putu Suwita; Muliyana, Hifdzil Haq; Laksmana, Ngakan Putu Proudy; Sahly, Aliza Raudatin
MNJ (Malang Neurology Journal) Vol. 7 No. 2 (2021): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.02.6

Abstract

Background: Identification of appropriate biomarker involved in the pathophysiology of diabetes-associated cognitive decline in animal model is necessary. Glucose transporter 4 (GLUT4) is the component of insulin-dependent neuronal signaling pathway needed for maintaining cognitive function. It is highly expressed in hippocampal neurons.Objective: To investigate the effect of GLUT4 expression in hippocampal neurons on the spatial memory of diabetes-induced Rattus novergicus.Methods: This experimental study used 24 male Rattus novergicus divided into control groups terminated on day-0 (C0), 14 (C1) and 28 (C2) and diabetic groups terminated on day-0 (D0), 14 (D1) and 28 (D2). Diabetes was induced using streptozotocin injections intraperitoneally. Spatial memory (travel time) of rats was assessed on day-14 and 28. Brain tissue sampling was performed for assessment of GLUT4 expression using immunohistochemical methods. Significant differences in means of GLUT4 expression and travel time between groups on day-0, 14 and 28 as well as correlation between means of GLUT4 expression and travel time in D1 and D2 were analyzed statistically.Results: The mean of GLUT4 expression in diabetic group was significantly higher compared to control on day-14, but not on day-0 and 28. The immunohistochemical examination confirmed this results. There were no significant differences in mean of travel time between control and diabetic groups on day-14 and 28. There were no significant correlation between means of GLUT4 expression and travel time in diabetic groups on day-14 and 28.Conclusion: The GLUT4 expression of hippocampal neurons did not significantly affect spatial memory of diabetes-induced Rattus novergicus.
SKRINING KANKER SERVIKS DENGAN METODE PAP SMEAR DI KOTA MATARAM Padauleng, Novrita; Djannah, Fathul; Lestari, Rizka Vidya; Zuhan, Arif; Taufik, Ahmad; Christian, Steven
Jurnal Pepadu Vol 5 No 3 (2024): Jurnal PEPADU
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v5i3.5896

Abstract

Upaya eliminasi kanker serviks dapat dilakukan dengan pendekatan komprehensif yang meliputi pencegahan primer dan sekunder. Pencegahan sekunder ini dilakukan dengan deteksi dini atau skrining adanya lesi prekanker, dan terapi lesi pada fase asimtomatis (tahap preklinis). Kegiatan pengabdian ini bertujuan untuk mendeteksi adanya lesi prekanker pada wanita berusia 21-65 tahun yang berdomisili di Kota Mataram. Sebanyak 50 partisipan ikut serta dalam kegiatan yang diadakan di RS Universitas Mataram. Rerata usia partisipan yaitu 42,8 tahun dengan persentase terbesar pada kelompok usia 26-45 tahun (54%). Partisipan terbanyak berasal dari kecamatan Mataram (32%). Papsmear digunakan sebagai metode pemeriksaan untuk menemukan perubahan abnormal sel servikal. Skrining kanker serviks pada kegiatan ini didapatkan hasil negative atau tidak dijumpai lesi prekanker ataupun kanker pada seluruh partisipan. Pemeriksaan papsmear pada 10 partisipan didapatkan keputihan, dan 1 partisipan dengan massa polip. Berdasarkan hasil pemeriksaan papsmear pada seluruh partisipan, perlu dilakukan evaluasi ulang 3 tahun setelah pemeriksaan. Kegiatan pengabdian ini dilaksanakan sebagai implementasi dukungan FKIK Universitas Mataram bekerjasama dengan Dharma Wanita Persatuan Kota Mataram, dalam rencana aksi nasional eliminasi kanker serviks di Indonesia tahun 2023-2030. Upaya eliminasi ini berfokus pada pelaksanaan prioritas kedua dari pilar pertama (pemberian layanan), yaitu skrining kanker serviks.
SOSIALISASI GAYA HIDUP SEHAT SEBAGAI UPAYA MENINGKATKAN KUALITAS HIDUP JAMAAH MASJID RIYADUSSHALIHIN CAKRANEGARA BARAT - MATARAM Musanip, Musanip; Pahmi, Khairil; Lestari, Rizka Vidya; Feftyanto, Hangga Rizky
Jurnal Pendidikan dan Pengabdian Masyarakat Vol. 6 No. 4 (2023): November
Publisher : FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppm.v6i4.6100

Abstract

Gaya hidup sehat menjadi perhatian utama dalam upaya meningkatkan kualitas hidup jamaah Masjid Riyadusshalihin Cakranegara Barat-Mataram. Kegiatan pengabdian ini bertujuan untuk meningkatkan kesadaran dan pemahaman jamaah tentang pentingnya gaya hidup sehat. Metode pelaksanaan mencakup ceramah dan diskusi. Media visual seperti slide presentasi dan video juga digunakan untuk mendukung penyampaian materi. Adapun materi sosialisasi yang disampaikan mencakup berbagai aspek gaya hidup sehat, seperti pola makan sehat, aktivitas fisik, manajemen stres, tidur yang cukup, dan perubahan kebiasaan buruk. Materi tersebut disusun agar sesuai dengan kebutuhan peserta. Peningkatan pemahaman dan motivasi dalam perubahan perilaku menunjukkan perubahan signifikan masing-masing sebesar 62,5% dan 65%. Sosialisasi gaya hidup sehat di Masjid Riyadusshalihin Cakranegara Barat-Mataram memberikan dampak positif dalam peningkatan kesadaran dan tindakan sehat di antara jamaah masjid. Peserta menyadari tentang pentingnya menjaga kesehatan dan memiliki niat yang kuat untuk mengubah perilaku buruk, seperti mengurangi konsumsi makanan tidak sehat, berhenti merokok, dan lebih aktif secara fisik. Dengan demikian, kegiatan ini merupakan langkah awal yang baik dalam upaya meningkatkan kualitas hidup dan kesejahteraan komunitas masjid Riyadusshalihin Cakranegara Barat-Mataram.
Co-Authors Ahmad Taufik Anak Agung Ayu Niti Wedayani Fathul Djannah Feftyanto, Hangga Rizky Herpan Syafii Harahap Ilsa Hunaifi Indah Sapta Wardani Laksmana, Ngakan Putu Proudy Muliyana, Hifdzil Haq Musanip, Musanip Nurhidayati Nurhidayati Nurhidayati Padauleng, Novrita Padauleng, Novrita Pahmi, Khairil Sahly, Aliza Raudatin Sari, Putu Suwita Steven Christian Zuhan, Arif