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Enhancing Wound Repair With Carica Papaya -Based Formulation: A Pretest-Posttest Control Group Trial Mokh. Sujarwadi; Mukhammad Toha; Ida Zuhroidah; Rondhianto Rondhianto; Dimas Hadi Prayoga; Fatimah Zahra; Nadia Rohmatul Laili
An Idea Health Journal Vol 6 No 01 (2026)
Publisher : PT.Mantaya Idea Batara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53690/ihj.v6i01.652

Abstract

Background: Natural products are increasingly favored in wound care due to concerns about antibiotic resistance and side effects of synthetic drugs. Carica papaya L., a tropical plant native to Central America and widely grown in Indonesia, contains bioactive compounds with properties essential for tissue repair. This study tests whether a topical Carica papaya formulation speeds up wound healing by measuring granulation and epithelialization. Methods: Using a quasi-experimental design. A total of 50 participants were divided into a control (standard wound care) and a treatment group (standard care + C. papaya extract). Analysis used the Paired T test. Result: Paired t-tests indicated no significant changes in the control group (p = 1.00). In contrast, the treatment group demonstrated statistically significant improvements in granulation (pre: 0.44 ± 0.51; post: 1.56 ± 0.51; t = -9.35, p < 0.001) and epithelialization (pre: 0.68 ± 0.47; post: 1.72 ± 0.46; t = -10.25, p < 0.001). Independent-samples t-tests confirmed significant differences between groups after the intervention (granulation: t = -9.35, p < 0.001; epithelialization: t = -10.25, p < 0.001). These results support the incorporation of C. papaya extract into evidence-based complementary wound management protocols. Conclusion: Carica papaya extract significantly enhances wound healing, promoting granulation and epithelialization. Thus, it may serve as an effective adjunctive therapy in clinical wound management.
Alpha and theta wave activation through pure crystal vibration on reducing anxiety in post-stroke patients with sleep disorders Ida Zuhroidah; Mokh. Sujarwadi; Mukhammad Toha
Nursing and Health Sciences Journal (NHSJ) Vol. 5 No. 2 (2025): June 2025
Publisher : KHD-Production

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53713/nhsj.v5i2.505

Abstract

Post-stroke patients often experience anxiety and sleep disorders that can hinder the recovery process. Improvement in sleep quality increases with decreasing anxiety; activation of alpha and theta waves can reduce anxiety. This study evaluates the effectiveness of pure crystal vibration waves in activating alpha and theta waves in decreasing anxiety, which has implications for improving sleep quality in post-stroke patients. This study used a quasi-experimental design with a pretest-posttest control group design. The sample consisted of 30 post-stroke patients divided into two groups. Pure crystal vibration wave therapy intervention was given 30 minutes per day for 2 weeks in the treatment group; the control group was not given intervention. Anxiety was measured using the Hamilton Anxiety Rating Scale (HARS), and sleep quality was calculated using the Pittsburgh Sleep Quality Index (PSQI). Data were analyzed using paired t-tests and independent t-tests. There was a significant decrease in anxiety scores (p = 0.001) and an increase in sleep quality (p = 0.001) in the intervention group compared to the control group. The frequency of pure crystal vibration waves effectively activates alpha and theta waves to indicate decreased anxiety, which has implications for improving the sleep quality of post-stroke patients.