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All Journal Jurnal Ners Jurnal Medika: Medika
Khoirista Noor Rohmah
Universitas Pembangunan Nasional Veteran Jawa Timur
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Computational Screening of Bioactive Compounds from Aglaia odorata L. Leaves as Potential Inhibitors of Matrix Metalloproteinase-1 for Premature Skin Aging Khoirista Noor Rohmah; Ilham Kurniawan; Febby Yulia Hastika; Dina Ayuning Tyas
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.57331

Abstract

Premature skin aging is driven by UV‑induced upregulation of matrix metalloproteinase‑1 (MMP‑1), which degrades dermal collagens. Natural products are explored as safer anti‑aging alternatives. This study computationally screened five bioactive compounds from Aglaia odorata leaves (β‑turmerone, phytol, methyl cinnamate, n‑hexadecanoic acid, methyl palmitate) against MMP‑1 (PDB ID: 1HFC) and predicted their drug‑likeness, skin permeability, and safety for topical use. Molecular docking was performed using AutoDock Vina; ADMET properties were predicted with SwissADME and pkCSM. All compounds complied with Lipinski’s Rule of Five (zero violations). Methyl cinnamate formed three hydrogen bonds including with the catalytic residue Glu219. β‑Turmerone showed the highest affinity (ΔG = –6.5 kcal/mol, Ki = 17.0 µM). Phytol, methyl palmitate, and n‑hexadecanoic acid exhibited weaker binding (Ki = 33.5–78.0 µM), while the positive control PLH had ΔG = –7.5 kcal/mol (Ki = 3.14 µM). ADMET predictions showed excellent skin permeability for phytol and the fatty acid derivatives (Log Kp > –3.0 cm/h). All compounds were non‑mutagenic, non‑hepatotoxic, and safe for skin sensitisation. Methyl cinnamate and β‑turmerone are the most promising A. odorata‑derived MMP‑1 inhibitors, supporting further validation as natural anti‑aging cosmeceuticals.
Food Rescue Program: Reducing Urban Household Food Waste and Strengthening Community Food Security Ilham Kurniawan; Aulia Umi Rohmatika; Fairuz Haniyah Ramadhani; Khoirista Noor Rohmah
Jurnal Medika: Medika in progres
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/kqq9n185

Abstract

Urban areas face the dual challenges of food waste and household food insecurity. This community service activity aimed to reduce food waste and strengthen food security among low-income urban communities through a food rescue program implemented in KP Gembong RT 10, Surabaya, Indonesia. The activity involved three main stages: sorting of food items to ensure edibility and safety, packaging according to household needs, and direct distribution to beneficiaries. A total of 30 beneficiary families (household heads) received over 100 food packages containing dry food, beverages, snacks, powdered milk, and bakery products. Surplus food that remains fit for consumption is identified and diverted before becoming waste through a structured redistribution mechanism. The results indicate that this program effectively channels such food to vulnerable urban households, thereby reducing short-term household food expenditure and decreasing organic waste generation. The community-based approach enabled targeted and adaptive distribution, strengthening social solidarity between volunteers and residents. In conclusion, food rescue programs serve as a viable social intervention to bridge food surplus and deficit at the community level, contributing simultaneously to food security and environmental sustainability. However, structural food insecurity requires complementary long-term strategies.
Co-Authors Aulia Umi Rohmatika Dina Ayuning Tyas Fairuz Haniyah Ramadhani Febby Yulia Hastika Ilham Kurniawan