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All Journal Journal of Global Nutrition JOURNAL OF Pharmacy and Tropical Issues
Kiki Rizky Ananda
Sekolah Tinggi Ilmu Kesehatan Samarinda
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Nutritional Care Management of a Pediatric Patient with Stage V Chronic Kidney Disease on Hemodialysis Complicated by Hypertension and Pulmonary Edema with a Differential Diagnosis of Rheumatic Heart Disease Komang Windayani; Kiki Rizky Ananda; Wiwik Ekorinawati; Eka Rusliana; Laras Sekar Windaningrum
Journal of Global Nutrition Vol 6 No 1 (2026)
Publisher : Ikatan Sarjana Gizi Indonesia (ISAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53823/jgn.v6i1.200

Abstract

Chronic Kidney Disease (CKD) stage V in pediatric patients requires renal replacement therapy such as hemodialysis and is often accompanied by complications including hypertension and cardiovascular disorders, such as suspected rheumatic heart disease (RHD). These conditions increase the risk of fluid overload, pulmonary edema, and nutritional problems, thus requiring comprehensive nutritional management. This study used a descriptive observational case study design conducted at Dr. Moewardi General Hospital, Surakarta. The subject was selected using purposive sampling based on the risk of malnutrition using the STRONG-kids screening form. Data were collected through interviews, medical records, anthropometric measurements, biochemical and clinical assessments, and a 24-hour food recall. Nutritional care was carried out using the standardized Nutrition Care Process, including assessment, diagnosis, intervention, education, and monitoring for three days. The subject was a 13-year-old pediatric patient with CKD undergoing hemodialysis, presenting with edema, hypertension, and suspected RHD. Dietary intake was inadequate (<70%). Anthropometric assessment based on Mid-Upper Arm Circumference (MUAC) indicated normal nutritional status despite the presence of edema. Biochemical examination showed anemia and increased creatinine and urea levels. Nutritional intervention showed an increasing trend in intake over three days, although energy and carbohydrate intake remained deficient. Clinical parameters, including blood pressure and respiratory rate, showed improvement, along with decreased creatinine and urea levels. Nutritional therapy in the form of a hemodialysis diet and low-sodium diet contributed to improved intake, fluid balance, and clinical outcomes. Sodium restriction played an important role in controlling blood pressure and preventing fluid overload, including the risk of pulmonary edema. Integrated nutritional management combined with hemodialysis improved intake, clinical condition, and biochemical parameters in pediatric CKD patients with hypertension and suspected RHD.
Skrining kandungan quercetin pada ekstrak kelakai (stenochlaena palustris) menggunakan high performance liquid chromatography (HPLC) Kiki Rizky Ananda; Herviana Herviana; Saidah Saidah
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 1 (2026): May Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i1.3205

Abstract

Background: Kelakai (Stenochlaena palustris) is a plant endemic to Kalimantan that is used as a functional food and traditional medicine due to its bioactive compounds. Previous research has reported that kelakai has high total flavonoid content and strong antioxidant activity. Purpose: To conduct specific screening of quercetin compounds in kelakai extract. Methods: High-Performance Liquid Chromatography (HPLC) was used, given that quercetin is often used as an indicator of the health potential of foods. The analysis was performed using a C18 column with an isocratic mobile phase of a mixture of phosphoric acid and methanol, and detection at a wavelength of 370 nm.. Results: Quercetin was not detected in the kelakai extract. However, the validity of the method was proven through accuracy testing using a standard 10 mg/L spiking technique, which produced an average recovery value of 104.06%. The absence of the bioactive compound quercetin in the kelakai extract indicates that the flavonoid profile of this plant is likely dominated by other groups, such as kaempferol and its glycoside (astragalin), which still responded positively in the total flavonoid test. Conclusion: Quercetin was not detected in the kelakai extract using the HPLC method under the analytical conditions used.   Keywords: HPLC method; Kelakai; Quercetin; Stenochlaena palustris.   Pendahuluan: Kelakai (Stenochlaena palustris) merupakan tanaman endemik Kalimantan yang dimanfaatkan sebagai pangan fungsional dan obat tradisional karena mengandung senyawa bioaktifnya. Penelitian sebelumnya melaporkan kelakai memiliki kadar flavonoid total dan aktivitas antioksidan yang kuat. Tujuan: Untuk melakukan skrining spesifik terhadap senyawa quercetin pada ekstrak kelakai. Metode: Menggunakan metode High Performance Liquid Chromatography (HPLC), mengingat quercetin sering dijadikan indikator potensi kesehatan suatu bahan pangan. Analisis dilakukan menggunakan kolom C18 dengan fase gerak isokratik campuran asam fosfat dan metanol, serta deteksi pada panjang gelombang 370 nm. Hasil: Senyawa quercetin tidak terdeteksi dalam ekstrak kelakai. Namun, validitas metode terbukti melalui uji akurasi menggunakan teknik spiking standar 10 mg/L, yang menghasilkan nilai perolehan kembali (recovery) rata-rata sebesar 104,06%. Tidak adanya senyawa bioaktif quercetin dalam ekstrak kelakai menunjukkan bahwa profil flavonoid tanaman ini kemungkinan didominasi oleh kelompok lain, seperti kaempferol dan glikosidanya (astragalin), yang tetap memberikan respon positif pada uji total flavonoid. Simpulan: Quercetin tidak terdeteksi dalam ekstrak kelakai menggunakan metode HPLC pada kondisi analisis yang digunakan.   Kata Kunci: Kelakai; Metode HPLC; Quercetin; Stenochlaena palustris.
Co-Authors Eka Rusliana Herviana Herviana Komang Windayani Laras Sekar Windaningrum Saidah Saidah Wiwik Ekorinawati