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All Journal Jurnal Kedokteran Syiah Kuala Indonesian Journal of Tropical and Infectious Disease Jurnal Ilmiah Kedokteran Wijaya Kusuma Smart Medical Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Ahmar Metakarya: Jurnal Pengabdian Masyarakat Smart Society Empowerment Journal Jurnal Penyakit Dalam Indonesia
Sunggoro, Agus Jati
Staf Medik Fungsional (SMF) Ilmu Penyakit Dalam RSUD Moewardi, Surakarta - INDONESIA
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Health Professions Medicine & Pharmacology Nursing Public Health Other

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Trombosis pada corona virus disease (COVID-19) Agus Jati Sunggoro; Ibnu Purwanto; Maryatun Hasan
Jurnal Kedokteran Syiah Kuala Vol 20, No 3 (2020): Volume 20 Nomor 3 Desember 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i3.18689

Abstract

Abstrak. Coronavirus Disease 2019 (COVID-19) telah menyebabkan masalah kesehatan di seluruh dunia dengan morbiditas dan mortalitas yang terus meningkat. Pada beberapa kasus COVID-19 diketahui terjadi manifestasi trombotik. Adanya kelainan trombotik ini tentunya mempengaruhi tatalaksana dan prognosis pasien COVID-19. Oleh karena itu penting untuk mengetahui patofisiologi dan manajemen trombosis pada COVID-19. Tujuan dari artikel ini adalah mengulas literatur terbaru terkait prevalensi, patofisiologi, penilaian risiko, serta manajemen trombosis pada COVID-19.Kata kunci: COVID-19, trombosis.Abstract. Coronavirus Disease 2019 (COVID-19) has become a global health problem with ever increasing morbidity and mortality. In some cases, thrombotic manifestation has been reported in COVID-19 patients. This thrombotic manifestation certainly affects the management and prognosis of COVID-19 patients. Therefore it is crucial to understand the pathophysiology and management of thrombosis in COVID-19. The aim of this article is to review the recent literature regarding prevalence, pathophysiology, risk assessment, and management of thrombosis in COVID-19.Keywords:COVID-19, thrombosis
ASSOCIATION BETWEEN PERCEPTION OF CLINICAL LEARNING ENVIRONMENTS AND LEARNING APPROACH ON CLERKSHIP STUDENTS OF MEDICAL FACULTY Bulan Kakanita Hermasari; Erinda Kusuma Wardani; Agus Jati Sunggoro
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 8, No 1 (2019): Maret
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (47.106 KB) | DOI: 10.22146/jpki.44872

Abstract

Background: Learning environment is one parameter to evaluate the quality of learning. The learning approach reflects how a student learns in various situations that affect learning. This study aims to know the relationship between the perceptions of the learning environment and the learning approaches in the clerkship students of Medical Faculty.Methods: This research used an analytical observational method with cross-sectional technique. The sample selection technique used cluster sampling. Respondents consisted of 178 students from all clinical rotations. Each respondent was given two questionnaires to assess perceptions of the learning environment and learning approaches. Data were analyzed using contingency coefficient test.Results: Student perceptions of the learning environment show similar results between the number of clinical rotations that have the category of 'good but need improvement' (9 clinical rotations) and the 'many problems' category (9 clinical rotations). Most of the students (84.27%) used the in-depth learning approach, the remaining 10.67% used the strategic approach, and 5.06% used the surface approach. There was relationship between learning environment perception and learning approach with contingency coefficient value C = 0.312, and value p = 0,001 (p <0.05).Conclusion: There is a weak relationship between perception of clinical learning environments and learning approach on clerkship students of the medical faculty, University Sebelas Maret..   
Hubungan Rasio Neutrofil Limfosit terhadap Komplikasi Kardiovaskular pada Pasien Penyakit Ginjal Kronik Hemodialisis Akmal, Thariq Hikmatul; Susanto, Agung; Dewi, Ratih Tri Kusuma; Sunggoro, Agus Jati
Jurnal Penyakit Dalam Indonesia Vol. 11, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. The neutrophil-to-lymphocyte ratio (NLR) is a simple parameter to assess the inflammatory status, especially in chronic kidney disease (CKD) patients experiencing capillary damage due to increased glomerular capillary pressure. In a state of vascular endothelial inflammation, there is a higher tendency to form atherosclerotic plaques and calcification that can induce cardiovascular events such as heart failure, coronary heart disease, and stroke. This study aimed to determine the relationship between the NLR and cardiovascular complications in CKD patients undergoing hemodialysis. Methods. An analytical observational study with cross-sectional approach was conducted among 119 CKD patients undergoing hemodialysis at Dr Moewardi Regional Hospital who met the inclusion and exclusion criteria. The relationship between the two variables was analyzed using Fisher exact test. Results. The majority of subjects in this study were male (51.3%) and were aged over 50 years old (63.9%). Most subjects experienced complications of heart failure (54.6%), followed by coronary heart disease (19.3%), and stroke (17.7%). Analysis of complete blood count data showed a mean neutrophil count of 77.20% (SD 11.49), lymphocytes 13.64% (SD 8.23), and NLR 10.7 (SD 10.3). Notably, a majority of participants exhibited an NLR value ≥3.5, observed in 95 individuals (79.8%). Fisher exact test results indicated a significant relationship between elevated NLR and cardiovascular complications in hemodialysis CKD patients (p-value= 0.028). Conclusion. There is a significant relationship between NLR and cardiovascular complications in CKD patients undergoing hemodialysis.
Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio as Predictors of CD4 Count among People Living with HIV Hasna, Zahra Roidah Amalia; Sunggoro, Agus Jati; Sri Marwanta; Harioputro, Dhani Redhono; Yimam Getaneh Misganie; Siti Qamariyah Khairunisa
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.49929

Abstract

Human Immunodeficiency Virus (HIV) infection remains a global health concern characterized by the reduction of CD4 lymphocyte cells and weakened immune systems. Knowing the CD4 count and the factors affecting it is crucial for assessing the immune status of HIV patients. Hematological markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been recognized as prognostic tools that were associated with CD4 Count. The goal of this study was to determine the impact of NLR and PLR on CD4 count among people living with HIV (PLHIV). This study used analytic observational method with a cross-sectional on HIV-positive individuals who were treated at Moewardi Hospital, Surakarta, Indonesia. The Chi-Square and Pearson correlation tests were performed to identify the correlation between variables and the linear regression test was done to investigate the association between NLR and PLR with CD4 count. A total of 80 PLHIV were identified for this study, with the median CD4 count of 103 cells/mm3. NLR and PLR were found to be 3.06 and 181.03, respectively. This study found that opportunistic infection, duration on ARV treatment, body mass index, total lymphocyte count, and hemoglobin were significantly associated with CD4 count. The Pearson correlation test revealed a strong correlation between NLR and PLR to CD4 count. Linear regression analyses showed that NLR and PLR could predict the CD4 count. These findings indicate that NLR and PLR could serve as alternative prognostic parameters for monitoring treatment outcomes in PLHIV, particularly in health facilities where access to CD4 count testing is limited.
Peningkatan Kapasitas Dokter Layanan Primer dalam Deteksi Dini Kanker Sunggoro, Agus Jati; Nurwati, Ida; Subandono, Jarot; Hermawan, Danus; Budiani, Dyah Ratna; Hakim, Fikar Arsyad; Handayani, Selfi; Pakha, Dyonisa Nasirochmi; Muthmainah, Muthmainah
Ahmar Metakarya: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2026): Ahmar Metakarya: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Ahmad Mansyur Nasirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/amjpm.v5i2.672

Abstract

Kanker merupakan salah satu beban penyakit tidak menular terbesar di Indonesia dengan tingkat mortalitas yang tinggi akibat keterlambatan diagnosis. Sebagai kontak pertama dalam sistem kesehatan, dokter di fasilitas kesehatan tingkat pertama (FKTP) memiliki peran krusial dalam deteksi dini untuk menurunkan risiko stadium lanjut, namun kapasitas klinis mereka saat ini masih perlu ditingkatkan. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan klinis dokter layanan primer di Kabupaten Sukoharjo dalam deteksi dini kanker payudara, serviks, paru, dan kolorektal, serta mendorong kesiapan implementasi dan perubahan praktik skrining di FKTP. Kegiatan dilakukan melalui seminar interaktif secara hibrid yang diikuti oleh 243 dokter layanan primer. Evaluasi pengetahuan dilakukan menggunakan pre-test dan post-test, di mana 117 peserta menyelesaikan kedua tes tersebut secara lengkap dan datanya dianalisis lebih lanjut. Hasil analisis statistik menggunakan uji Wilcoxon menunjukkan adanya peningkatan pengetahuan yang signifikan (p < 0,001), dengan nilai rata-rata pre-test sebesar 67,95 ± 15,22 dan post-test sebesar 90,43 ± 18,53. Hasil ini menunjukkan bahwa kegiatan seminar efektif dalam meningkatkan pemahaman dokter layanan primer mengenai deteksi dini kanker. Diharapkan kegiatan serupa dapat dilakukan secara rutin untuk memperluas jangkauan dan memperbarui pengetahuan dokter mengenai skrining kanker.
Correlation of Serum 25(OH) Vitamin D Levels With TNF-α and Caspase Levels in Sjögren`s Syndrome Patients Susanto, Agus Joko; Sunggoro, Agus Jati; Wati, Fatna Andika
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 1 (2025): MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4136

Abstract

Background: Vitamin D deficiency is known to cause changes in disease pathogenesis in primary Sjögren's syndrome related to its immunological effects. Objective: This study aims to determine the correlation between serum 25(OH) vitamin D levels and TNF-α and caspase levels in Sjögren's syndrome patients. Methods: This study was a cross-sectional study involving 34 Sjögren's syndrome patients aged 18-59 years with vitamin D deficiency/insufficiency and measured levels of TNF-α and caspase. Result: The correlation between 25(OH) vitamin D levels and caspase levels obtained a value of r=-0.581, which means that there is a negative correlation in the moderate category (r=0.400-0.599) between 25(OH) vitamin D levels and caspase levels, and the p-value =<0.001 (p-value<0.05). The correlation between 25(OH) vitamin D levels and TNF-α levels obtained a value of r=-0.436, which means that there is a negative correlation in the moderate category (r=0.400-0.599) between 25(OH) vitamin D levels and a decrease in TNF-α, and p-value =<0.001 (p-value<0.05). Conclusion: There was a significant negative relationship between 25(OH) vitamin D levels and TNF-α and caspase levels.
The Increase of HDL-C Levels using Ethanol Extract of Vernonia amygdalina Leaves in Wistar Rats Models of Metabolic Syndrome Pakha, Dyonisa Nasirochmi; Nurwati, Ida; Sunggoro, Agus Jati; Muthmainah, Muthmainah; Handayani, Selfi
Smart Medical Journal Vol 6, No 3 (2023): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i3.80480

Abstract

Introduction: Metabolic syndrome (MetS) is a cluster of metabolic factors, including low high-density lipoprotein cholesterol (HDL-C) levels. Vernonia amygdalina (VA) leaves have been documented for their anti-cholesterol properties. The purpose of this study to evaluate ethanol extract of VA leaves in rising HDL-C levels in the MetS model.Methods: An experimental study using pre-and post-test design was conducted using 30 male Wistar rats divided into five groups randomly. KN group served as the control group. KP group was the MetS model without ethanol extract administration. Meanwhile, P1, P2, and P3 were MetS models and were administered ethanol extract of VA leaves administration (50mg/kg, 100mg/kg, and 150 mg/kg) for 28 days. The data were analysed using paired t-test and one-way ANOVA (α=0,05).Results: This study discovered that administering the extract in P1, P2, and P3 significantly improved HDL levels. Furthermore, increasing the dose resulted in significantly greater HDL levels. VA leaves contain phytochemicals that have impacts on cholesterol levels in the blood. Flavonoids and tannin inhibit ester cholesterol formation. Terpenoid and flavonoid hinder HMG-CoA. Saponin contributes to free cholesterol transporter, reducing oxidative stress and increasing LDL receptors. Lastly, vitamin C raises catabolism levels and clearance LDL.Conclusion: There are increases in HDL levels in the MetS model group receiving ethanol extract VA leaves. 
Edukasi dan Aplikasi Loci pada Guru SD di Wilayah Kecamatan Kerjo Karanganyar Muthmainah, Muthmainah; Nurwati, Ida; Subandono, Jarot; Hermawan, Danus; Budiani, Dyah Ratna; Hakim, Fikar Arsyad; Handayani, Selfi; Pakha, Dyonisa Nasirochmi; Sunggoro, Agus Jati
Smart Society Empowerment Journal Vol 3, No 3 (2023): November
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i3.79482

Abstract

Pendahuluan: Fakta di lapangan menunjukkan sebagian besar guru SD di Kecamatan Kerjo, Karanganyar belum pernah mendengar atau mengetahui metode Loci. Metode Loci merupakan salah satu cara untuk meningkatkan daya ingat dengan mengoptimalkan keseimbangan fungsi otak kiri dan kanan. Tujuan pengabdian masyarakat ini adalah melakukan edukasi dan aplikasi metode Loci melalui penyuluhan kepada para guru SD tersebut untuk meningkatkan daya ingat.Metode: Penyuluhan dilakukan pada Selasa, 23 Mei 2023 jam 08.00-12.30, di aula kantor Korwilcam Bidang Pendidikan Kecamatan Kerjo, Karanganyar. Peserta penyuluhan adalah para guru SD dalam wilayah Kecamatan Kerjo, Karanganyar sebanyak 50 orang. Di Kecamatan Kerjo terdapat 29 SD, dari tiap-tiap SD mewakilkan 1-2 orang guru. Tahap-tahap kegiatan pengabdian masyarakat meliputi persiapan, pelaksanaan, dan pelaporan kegiatan. Penyuluhan diberikan melalui ceramah interaktif dan mempraktekkan cara menghafal dengan metode Loci. Peserta menjalani pretes sebelum dan postes sesudah penyuluhan. Nilai pretes dan postes dibandingkan menggunakan uji statistik Wilcoxon (α=0,05). Hasil dan pembahasan: Kegiatan pengabdian masyarakat yang berupa penyuluhan metode Loci telah dilaksanakan sesuai rencana dan diikuti oleh 50 orang guru SD dari 29 SD yang ada di wilayah Kecamatan Kerjo, Karanganyar. Rerata nilai pretes peserta 42,56±21,04 dan nilai postes 62,56±28,11 dengan nilai signifikansi p<0,001. Hal ini berarti bahwa penyuluhan yang berupa ceramah interaktif dan praktek aplikasi metode Loci, selain dapat memberikan pemahaman mengenai pengetahuan metode Loci, juga berpengaruh dalam meningkatkan daya ingat peserta.Kesimpulan: Edukasi dan aplikasi metode Loci yang diberikan melalui penyuluhan dapat memberikan pemahaman mengenai metode Loci dan dapat meningkatkan daya ingat pada para guru SD di Kecamatan Kerjo, Karanganyar.
Pelatihan Kader Kesehatan dalam Pemberdayaan Poskestren di Pondok Pesantren Al Amaanah Karanganyar Handayani, Selfi; Nurwati, Ida; Subandono, Jarot; Muthmainah, Muthmainah; Hermawan, Danus; Budiani, Dyah Ratna; Hakim, Fikar Arsyad; Pakha, Dyonisa Nasirochmi; Sunggoro, Agus Jati
Smart Society Empowerment Journal Vol 5, No 2 (2025): Juli
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v5i2.94068

Abstract

Pendahuluan: Pos Kesehatan Pesantren (Poskestren) adalah suatu bentuk upaya untuk meningkatkan kesehatan warga pesantren. Para kader poskestren, yang meliputi para santri, perlu memiliki pengetahuan dan keterampilan dalam pemeriksaan vital sign (VS), antropometri, serta perilaku hidup bersih dan sehat (PHBS). Tujuan dari kegiatan pengabdian ini adalah memberikan pengetahuan, pemahaman dan keterampilan pelatihan VS, antropometri, dan PHBS kepada kader kesehatan di pos kesehatan pesantren.Metode: Sosialisasi dan pelatihan keterampilan pemeriksaan VS, antropometri, dan PHBS dilaksanakan pada bulan Juli 2024. Terdapat 30 orang kader kesehatan poskestren beserta 10 pamong yang mengikuti acara ini. Pemateri dan instruktur memberikan materi menggunakan media presentasi, pamflet, dan tanya-jawab. Kemudian kegiatan dilanjutkan dengan melatih keterampilan kader secara langsung. Sebelum dilakukan sosialisasi dan pelatihan, peserta melaksanakan pre-test, dan kemudian diikuti dengan post-test setelah mendapatkan pelatihan.Hasil dan pembahasan: Hasil evaluasi terhadap pengetahuan tentang PHBS pada kader Kesehatan memperlihatkan bahwa 80% (24 kader) telah mengalami peningkatan pengetahuan dari yang awalnya hanya 24% (7 kader). Nilai pretest dan post-test keterampilan VS dan antropometri memperlihatkan perbedaan, yaitu terjadi peningkatan pengetahuan tentang vital sign dan antropometri. Setelah dilakukan pelatihan pemeriksaan vital sign dan antropometri, semua kader sudah dapat melakukan pemeriksaan dengan baik.Kesimpulan: Sosialisasi dan pelatihan keterampilan dapat meningkatkan pengetahuan tentang PHBS, pemeriksaan VS, dan antropometri. Semua kader kesehatan yang dilatih sudah dapat melaksanakan pemeriksaan VS dan antropometri dengan baik.
Co-Authors Agus Joko Susanto, Agus Joko Akmal, Thariq Hikmatul Bulan Kakanita Hermasari Dyah Ratna Budiani Dyonisa Nasirochmi Pakha Erinda Kusuma Wardani Hakim, Fikar Arsyad Harioputro, Dhani Redhono Hasna, Zahra Roidah Amalia Hermawan, Danus Ibnu Purwanto Ida Nurwati Jarot Subandono Maryatun Hasan Muthmainah Muthmainah Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Selfi Handayani Siti Qamariyah Khairunisa, Siti Qamariyah Sri Marwanta Susanto, Agung Wati, Fatna Andika Yimam Getaneh Misganie