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All Journal Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Jurnal Kesehatan Manarang World Nutrition Journal Nusantara Science and Technology Proceedings Prosiding University Research Colloquium Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan
Harioputro, Dhani Redhono
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio as Predictors of CD4 Count among People Living with HIV Hasna, Zahra Roidah Amalia; Sunggoro, Agus Jati; Sri Marwanta; Harioputro, Dhani Redhono; Yimam Getaneh Misganie; Siti Qamariyah Khairunisa
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.49929

Abstract

Human Immunodeficiency Virus (HIV) infection remains a global health concern characterized by the reduction of CD4 lymphocyte cells and weakened immune systems. Knowing the CD4 count and the factors affecting it is crucial for assessing the immune status of HIV patients. Hematological markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been recognized as prognostic tools that were associated with CD4 Count. The goal of this study was to determine the impact of NLR and PLR on CD4 count among people living with HIV (PLHIV). This study used analytic observational method with a cross-sectional on HIV-positive individuals who were treated at Moewardi Hospital, Surakarta, Indonesia. The Chi-Square and Pearson correlation tests were performed to identify the correlation between variables and the linear regression test was done to investigate the association between NLR and PLR with CD4 count. A total of 80 PLHIV were identified for this study, with the median CD4 count of 103 cells/mm3. NLR and PLR were found to be 3.06 and 181.03, respectively. This study found that opportunistic infection, duration on ARV treatment, body mass index, total lymphocyte count, and hemoglobin were significantly associated with CD4 count. The Pearson correlation test revealed a strong correlation between NLR and PLR to CD4 count. Linear regression analyses showed that NLR and PLR could predict the CD4 count. These findings indicate that NLR and PLR could serve as alternative prognostic parameters for monitoring treatment outcomes in PLHIV, particularly in health facilities where access to CD4 count testing is limited.
The Potential of Durian Seed (Durio zibethinus Murr.) as Natural Resources with Antioxidant Activity and Total Flavonoid Content Aisyah, Siti; Harioputro, Dhani Redhono; Nurwati, Ida
Nusantara Science and Technology Proceedings The 1st International Conference of Health Institut Kesehatan Mitra Bunda 2024
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4303

Abstract

Durian is mainly distributed in Southeast Asia and is already famous among Indonesian society. In addition, the nutritional content and unique flavor of the pulp, part of durian fruit such as the seed, peel, roots, and leaves also have many benefits. Durian seeds are known as inedible parts and should disposed of as food waste. However, these are a good source of bioactive compounds. Durian seeds contain bioactive compounds that are antioxidants, including phenolics, flavonoids, and alkaloids. Flavonoids are phenolic compounds which have good benefits for human health. This research aims to analyze the potential antioxidant activity and flavonoid content of durian seed waste. The extraction used ethanol 70%, the antioxidant activity test used a scavenging test to 2,2-diphenyl-1-pycryl-hydrazil (DPPH) radical, and total flavonoid content was determined by the UV-Vis spectrophotometry method. Based on the results, durian seed extract has antioxidant activity of 99.70 µg/ml and total flavonoid content of 23,24±0,39 mgQE/g. Durian seed extract has relatively strong antioxidant activity and contains flavonoids as a bioactive compound. This information is useful for researchers to find bioactive compounds that may be new nutraceuticals for antioxidants, anti-inflammatory, anti-diabetic, and therapeutic functional foods.
The Effect of Durio Zibethinus L. Seed Extract on Fasting Blood Glucose and Insulin Resistance in Metabolic Syndrome Model Rats Aisyah, Siti; Harioputro, Dhani Redhono; Nurwati, Ida
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): December 2024
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1526

Abstract

Metabolic syndrome is known as insulin resistance syndrome, characterized by chronic hyperglycemia. Management of metabolic syndrome involves several combinations, including lifestyle modifications and pharmacological interventions. Durian seeds are one source of antioxidants that have the potential to improve blood glucose homeostasis and insulin sensitivity. This study aims to analyze the effect of durian seed extract on changes in fasting blood glucose levels and insulin resistance. The extraction process utilized the maceration method with a 70% ethanol solution. This study consisted of 30 rats divided into six treatment groups: KN (normal group), K- (negative control), K+ (positive control metformin 9 mg/kgBW), P1, P2, and P3, which were given durian seed extract at doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW, respectively. Metabolic syndrome rats were induced with a high-fat, high-fructose diet for 14 days, then induced with streptozocin (STZ) and nicotinamide (NA). Fasting blood glucose levels were determined using the GOD-PAP method. The HOMA-IR index was used to measure insulin resistance. The data results were evaluated using a paired T-test and one-way ANOVA. The analysis showed a significant variance in fasting blood glucose and HOMA-IR index following a 21-day treatment (p<0.05). The highest decrease was found in the 300 mg/kgBW dose group with fasting blood glucose and HOMA-IR index of 90.00 ± 2.70 mg/dl and 3.55 ± 0.11. The P2 and P3 treatments did not show different results with metformin treatment (p>0.05). The findings of this study suggest that consumption of durian seed extract for 21 days can effectively improve the condition of mice with metabolic syndrome. In addition, the drug metformin has the same effect as the intervention of durian seed extract doses of 200 and 300 mg/kgBW.
A COMBINATION OF APPLE AND CINNAMON EXTRACTS REDUCES BLOOD GLUCOSE AND INCREASES INSULIN LEVELS OF T2DM MODEL RATS Hamka, Dwi Wulandari Aaas; Harioputro, Dhani Redhono; Febrinasari, Ratih Puspita
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 4 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i4.1772

Abstract

Prevalensi penyandang penyakit diabetes melitus (DMT2) terus meningkatan akibat kenaikan kadar glukosa darah dan resisten insulin oleh sel β pancreas. Hiperglikemia pada DMT2 dapat menyebabkan stress oksidatif. Pemberian kombinasi ekstrak apel dan kayu manis memiliki potensi untuk menurunkan kadar glukosa darah karena mengandung senyawa flavonoid dan antioksidan yang mencegah stress oksidatif. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian Kombinasi Ekstrak Apel dan Kayu manis (KEAK) terhadap kadar GDP dan insulin pada tikus DMT2. Jenis penelitian ini adalah eksperimental laboratorik dengan rancangan randomized pre-post test control group design. Penelitian ini menggunakan 36 tikus Rattus norvegicus Jantan, dibagi menjadi 6 kelompok: KN tikus dikondisikan normal, K- tikus DMT2 tanpa perlakuan, K+ tikus DMT2 yang diberikan obat metformin, kelompok KP1 (9,14+45 mg/200 gramBB), KP2 (18,36+30 mg/200 gramBB) dan KP3 (27,42+15mg/200gramBB) yaitu tikus DMT2 yang di berikan KEAK selama 21 hari. Analisis data menggunakan uji One-way Anova. Setelah 21 hari intervensi KP1 mengalami penurunan kadar GDP (Δ -177,88 ± 4,61) dan kenaikan kadar insulin tertinggi (Δ 81,83 ± 9,37) dibandingkan dengan perlakuan yang lain. KP2 mengalami penurunan kadar GDP (Δ -167,41 ± 4,13) dan kenaikan kadar insulin (Δ 62,82 ± 9,37) yang hampir sama dengan kelompok perlakuan yang diberikan obat metformin (K+) dengan penurunan kadar GDP (Δ -167,80 ± 4,96) dan kadar insulin (Δ 56,23 ± 8,54). Pemberian kombinasi ekstrak apel dan kayu manis berpengaruh dalam menurunkan kadar GDP dan meningkatkan kadar insulin. Kombinasi ekstrak apel dan kayu manis dapat dipertimbangkan untuk menurunkan GDP dan meningkatkan kadar insulin.
A scoping review : Potential nutraceutical values of bioactive compounds and antioxidant activity in durian seed – An exotic tropical plant Aisyah, Siti; Harioputro, Dhani Redhono; Nurwati, Ida
World Nutrition Journal Vol. 8 No. i2 (2025): Volume 08 Issue 2, February 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i2.0001

Abstract

Background: Durian is a tropical fruit with a unique flavour and intense aroma. All parts of durian are reported to have many health benefits, especially the seeds. The seeds are known to have higher antioxidant activity and phytochemical compound than the pulp. Durian seeds are food waste that has the potential to be reused in the food and health industry. Objective: This article provides information on the presence of bioactive compounds, antioxidant activity, and the potential use of durian seeds as therapeutic agents. Methods: The study used a scoping review with four databases: Google Scholar, PubMed, DOAJ, and ScienceDirect. Scoping is needed to complete the article, summarize scientific data, and as a future reference regarding the nutraceutical potential of durian seeds. Results: A total of 6 articles were reviewed based on the screening results. The bioactive compounds found in these articles are phenolics, flavonoids, α-tocopherol, terpenoids, saponins, anthraquinones, and several flavonoid classes such as catechin, rutin, isoquercitrin, quercitrin. Total phenolic content (TPC) and antioxidant activity were highest in the Chanee durian seed cultivar compared to the Monthong type and various other cultivars from several countries. Conclusion: Durian seeds as food waste seem to have potential as a nutraceutical. Known as food waste that is rarely utilized, based on several studies, durian seeds have several benefits, one of which is to overcome various diseases. Further research needs to be done to prove that durian seeds can be helpful in the food industry as well as in pharmaceutical and cosmetic applications.
SCABIES RISK FACTORS IN PATIENTS WITH MENTAL DISORDERS AND THE LONG-TERM TREATMENT OPTIONS IN INDONESIA Astiyani, Roro Flaviana Bayu; Harioputro, Dhani Redhono; Susilo, R. Satriyo Budhi; Sumandjar, Tatar
Prosiding University Research Colloquium Proceeding of The 19th University Research Colloquium 2024: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Scabies is still common in Indonesia, although the national prevalence of scabies cannot yet be explained. This study was conducted to assess the prevalence of scabies and risk factors in patients with mental disorders. The patients in this study were patients who received treatment at a mental hospital for scabies infection (n=94) from January 2022 to August 2023. There were 53 male patients (56.38%). There were 41 female patients (43.61%). The patients consisted of 35 patients who had previously been treated at a rehabilitation center (37.23%) and 59 patients who had previously been treated at home (62.76%). A cross-sectional analytical study showed that male patients previously treated at home were more likely to experience scabies attacks. The hospital develops scabies infection control guidelines, provides patient therapy with scabicides, and performs skin examinations on inpatients upon admission. Infection control teams should be aware that scabies can cause outbreaks. Insufficient screening is a risk factor for scabies infection entry to hospital. So preventive action against scabies, such as examining patients when they enter the hospital and treating all suspicious patients, are effective in preventing the infection of scabies.
Beetroot (Beta vulgaris L.) Extract Gives Superior Effect than Beetroot Juice on Increasing HDL and Decreasing LDL and IL-6 in Dyslipidemic Rats Model Riri, Miftahul Jannah; Harioputro, Dhani Redhono; Wardhani, Lusi Oka
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.2890

Abstract

BACKGROUND: Dyslipidemia derives from disturbances in lipid metabolism as an interaction between genetic and environmental factors, characterized by increased levels of cholesterol, triglycerides, low-density lipoprotein (LDL) and decreased levels of high-density lipoprotein (HDL). Continuous dyslipidemia will increase the risk of atherosclerosis. In dyslipidemia, macrophages release inflammatory cytokines such as interleukin (IL)-1, IL-6, IL-12, IL-15, IL-18, and then induce T-cell infiltration formed atherosclerotic plaques. Beet (Beta vulgaris L.) which contains active compounds and antioxidant, such as flavonoids and betacyanin, has the ability to reduce dyslipidemia. This study evaluated effect of beetroot juice and beetroot extract on dyslipidemic rat models by evaluating the level of HDL, LDL and IL-6.METHODS: Fourty-two male Sprague Dawley rats were divided into seven groups. Rats were fed either with standard food or high fat diet (HFD) for 28 days, then different interventions using either single combination of simvastatin, beetroot juice, or beetroot extract were given alongside the standard food or HFD diet for another 28 days. LDL and HDL were measured pre- and post-intervention, while IL-6 was measured only post-treatment.RESULTS: Daily administration of a single beetroot juice or beetroot extract or in combination with simvastatin reduced LDL significantly compared to pre-intervention. The interventions also increased HDL significantly and lower IL-6 concentrations compared to group that received no intervention.CONCLUSION: Administration of beetroot juice and beetroot extract can lower LDL, increase HDL, and decrease IL-6 either alone or in combination treatment with simvastatin, it is indicated beetroot have a potential benefit for prevention and therapeutic in dyslipidemia.KEYWORDS: beetroot juice, beetroot extract, LDL, HDL, IL-6
The Effect of Durio Zibethinus L. Seed Extract on Fasting Blood Glucose and Insulin Resistance in Metabolic Syndrome Model Rats Aisyah, Siti; Harioputro, Dhani Redhono; Nurwati, Ida
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): Bahasa Inggris
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1526

Abstract

Metabolic syndrome is known as insulin resistance syndrome, characterized by chronic hyperglycemia. Management of metabolic syndrome involves several combinations, including lifestyle modifications and pharmacological interventions. Durian seeds are one source of antioxidants that have the potential to improve blood glucose homeostasis and insulin sensitivity. This study aims to analyze the effect of durian seed extract on changes in fasting blood glucose levels and insulin resistance. The extraction process utilized the maceration method with a 70% ethanol solution. This study consisted of 30 rats divided into six treatment groups: KN (normal group), K- (negative control), K+ (positive control metformin 9 mg/kgBW), P1, P2, and P3, which were given durian seed extract at doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW, respectively. Metabolic syndrome rats were induced with a high-fat, high-fructose diet for 14 days, then induced with streptozocin (STZ) and nicotinamide (NA). Fasting blood glucose levels were determined using the GOD-PAP method. The HOMA-IR index was used to measure insulin resistance. The data results were evaluated using a paired T-test and one-way ANOVA. The analysis showed a significant variance in fasting blood glucose and HOMA-IR index following a 21-day treatment (p<0.05). The highest decrease was found in the 300 mg/kgBW dose group with fasting blood glucose and HOMA-IR index of 90.00 ± 2.70 mg/dl and 3.55 ± 0.11. The P2 and P3 treatments did not show different results with metformin treatment (p>0.05). The findings of this study suggest that consumption of durian seed extract for 21 days can effectively improve the condition of mice with metabolic syndrome. In addition, the drug metformin has the same effect as the intervention of durian seed extract doses of 200 and 300 mg/kgBW.
Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio as Early Sign Plasma Leakage Process in Dengue Infection Ashma, Aisya Nailatul; Susilo, Satrio Budi; Marwanta, Sri; Harioputro, Dhani Redhono
JURNAL INFO KESEHATAN Vol 21 No 4 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss4.1382

Abstract

Dengue hemorrhagic fever remains a global health concern, especially in tropical and subtropical regions, such as Indonesia. Plasma leakage is the main symptom of Dengue infection which be seen through a hemoconcentration. NLR and PLR are cost-effective and easily measurable indexes that help to predict signs of infection. This study aims to analyze the correlation of NLR and PLR as early sign on hemoconcentration in Dengue infection. This study was an analytical observational method with a cross-sectional design. The study was conducted at the inpatient infectious disease wards of Dr. Moewardi General Hospital and Sebelas Maret University Hospital. The data was statistically analyzed using bivariate and multivariate analysis. There were seventy subject which of male was more than female. The result of bivariate analysis showed a statistically significant correlation for NLR (p = 0,008; r = 0,314) and non-significant for PLR (p = 0,150; r = 0,174). Both NLR and PLR were positively correlated with hemoconcentration. The effect of NLR on hemoconcentration was significant. There was a positive correlation significant between NLR and hemoconcentration in Dengue infection.
Co-Authors Ashma, Aisya Nailatul Astiyani, Roro Flaviana Bayu Hamka, Dwi Wulandari Aaas Hasna, Zahra Roidah Amalia Ida Nurwati Marwanta, Sri Ratih Puspita Febrinasari Riri, Miftahul Jannah Siti Aisyah Siti Qamariyah Khairunisa, Siti Qamariyah Sri Marwanta Sumandjar, Tatar Sunggoro, Agus Jati Susilo, R. Satriyo Budhi Susilo, Satrio Budi Wardhani, Lusi Oka Yimam Getaneh Misganie