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Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio as Predictors of CD4 Count among People Living with HIV Hasna, Zahra Roidah Amalia; Sunggoro, Agus Jati; Sri Marwanta; Harioputro, Dhani Redhono; Yimam Getaneh Misganie; Siti Qamariyah Khairunisa
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.49929

Abstract

Human Immunodeficiency Virus (HIV) infection remains a global health concern characterized by the reduction of CD4 lymphocyte cells and weakened immune systems. Knowing the CD4 count and the factors affecting it is crucial for assessing the immune status of HIV patients. Hematological markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been recognized as prognostic tools that were associated with CD4 Count. The goal of this study was to determine the impact of NLR and PLR on CD4 count among people living with HIV (PLHIV). This study used analytic observational method with a cross-sectional on HIV-positive individuals who were treated at Moewardi Hospital, Surakarta, Indonesia. The Chi-Square and Pearson correlation tests were performed to identify the correlation between variables and the linear regression test was done to investigate the association between NLR and PLR with CD4 count. A total of 80 PLHIV were identified for this study, with the median CD4 count of 103 cells/mm3. NLR and PLR were found to be 3.06 and 181.03, respectively. This study found that opportunistic infection, duration on ARV treatment, body mass index, total lymphocyte count, and hemoglobin were significantly associated with CD4 count. The Pearson correlation test revealed a strong correlation between NLR and PLR to CD4 count. Linear regression analyses showed that NLR and PLR could predict the CD4 count. These findings indicate that NLR and PLR could serve as alternative prognostic parameters for monitoring treatment outcomes in PLHIV, particularly in health facilities where access to CD4 count testing is limited.
Sosialisasi Kesehatan Reproduksi Remaja sebagai Upaya Pencegahan Pernikahan Dini Munawaroh, Siti; Putra, Farras Handyra; Az Zakiya, Aisyah Shabrina; Pramuni, Anggriyani Widya; Felisha, Davina Shinta; Shalihah, Farah; Paramesti, Khansa Firyalelly; Albashiry, Muhammad Iqbal; Ajingga, Octavia Jihan; Septiana, Sativa; Hasna, Zahra Roidah Amalia
Smart Society Empowerment Journal Vol 3, No 3 (2023): November
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i3.79055

Abstract

Pendahuluan: Berdasarkan data dari Survei Sosial Ekonomi Nasional (Susenas) tahun 2018, persentase perempuan usia 20-24 tahun yang melangsungkan pernikahan pertama baik kurang dari usia 15 tahun adalah 0,56% sedangkan yang di bawah usia 18 tahun adalah sebesar 11,21%. Pernikahan dini dapat memberikan pengaruh buruk bagi remaja yang menjalaninya atau anak yang dikandungnya. Organ reproduksi belum matang di masa remaja sehingga akan berisiko apabila seorang remaja perempuan mengandung anaknya. Maka dari itu, perlu dilakukan sosialisasi kepada para remaja mengenai kesehatan reproduksi sedini mungkin. Dengan adanya pengetahuan terkait kesehatan reproduksi yang adekuat, maka remaja akan lebih paham mengenai apa yang terjadi dalam dirinya pada masa remaja, pentingnya menjaga organ reproduksi, dan dampak yang akan terjadi apabila terjadi hal-hal yang tidak diinginkan seperti kehamilan di masa remaja.Metode: Sosialisasi dilakukan di posyandu Desa Gawan, Kecamatan Tanon, Kabupaten Sragen. Sosialisasi diawali dengan pengerjaan pretest kemudian dilanjutkan edukasi terkait kesehatan reproduksi remaja. Pengerjaan posttest dilakukan setelahnya dengan harapan tercapainya output dari edukasi yaitu peningkatan nilai tes dengan rata-rata nilai di atas 80.Hasil dan pembahasan: Rata-rata nilai yang didapatkan para peserta sebesar 87,2 sehingga sudah mencapai rata-rata nilai target yang ditetapkan,Kesimpulan: Sosialisasi Kesehatan Reproduksi Remaja di Desa Gawan, Tanon, Sragen sudah terlaksana dengan baik.