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All Journal Biology, Medicine, & Natural Product Chemistry Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat
Cornelia Amanda
Universitas Kadiri
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health

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The Role of the NF-kB Pathway and Oxidative Stress Markers in the Protective Effects of Peperomia pellucida in a Gastroenteritis Model Lisa Savitri; Fendy Prasetyawan; Yuneka Saristiana; Elfred Rinaldo Kasimo; Rochmad Krissanjaya; Cornelia Amanda; Konradus Klala Mebung
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.803-808

Abstract

Gastroenteritis is a common gastrointestinal disorder characterized by intestinal inflammation, epithelial damage, and oxidative stress. Activation of the nuclear factor kappa B (NF-kB) signaling pathway and excessive production of reactive oxygen species play key roles in its pathogenesis. Peperomia pellucida is a medicinal plant traditionally used for inflammatory and gastrointestinal conditions; however, its molecular mechanisms of action remain poorly understood. This study aimed to investigate the protective effects of P. pellucida extract in an experimental gastroenteritis model, with a particular focus on NF-kB pathway modulation and oxidative stress markers. Gastroenteritis was induced in experimental animals, followed by oral administration of P. pellucida extract at different doses. NF-kB p65 expression was assessed using molecular analysis, while oxidative stress was evaluated through malondialdehyde levels and antioxidant enzyme activities, including superoxide dismutase and catalase. Histopathological examination of intestinal tissue was also performed. The results demonstrated that P. pellucida treatment significantly suppressed NF-kB p65 activation, reduced lipid peroxidation, restored antioxidant enzyme activities, and improved intestinal histopathological features compared to the untreated gastroenteritis group. These findings indicate that P. pellucida confers intestinal protection by attenuating inflammation and oxidative stress, supporting its potential as a natural therapeutic agent for gastroenteritis.
Pengenalan Metode Imunodiagnostik Dasar untuk Pencegahan Penyakit Menular di Peternakan Lisa Savitri; Elfred Rinaldo Kasimo; Rochmad Krissanjaya; Fendy Prasetyawan; Yuneka Saristiana; Cornelia Amanda; Konradus Klala Mebung
Abdimas Galuh Vol 8, No 1 (2026): Maret 2026
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v8i1.23354

Abstract

Penyakit menular pada ternak masih menjadi salah satu kendala utama dalam usaha peternakan rakyat karena dapat menurunkan produktivitas dan menyebabkan kerugian ekonomi. Salah satu upaya pencegahan yang dapat dilakukan adalah deteksi dini penyakit melalui metode imunodiagnostik dasar. Namun, tingkat pemahaman peternak mengenai prinsip kerja dan pemanfaatan metode imunodiagnostik masih relatif rendah. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan pemahaman peternak mengenai pengenalan penyakit menular serta prinsip dasar metode imunodiagnostik sebagai langkah awal pencegahan penyakit di peternakan. Kegiatan dilaksanakan melalui penyuluhan interaktif, diskusi dua arah, serta demonstrasi penggunaan alat imunodiagnostik dasar berupa kit uji cepat. Sasaran kegiatan adalah peternak ternak rakyat di wilayah sasaran pengabdian. Evaluasi dilakukan melalui pengukuran tingkat pengetahuan peserta sebelum dan sesudah kegiatan serta observasi partisipasi aktif selama kegiatan berlangsung. Hasil kegiatan menunjukkan adanya peningkatan pemahaman peternak terkait jenis penyakit menular, prinsip reaksi antigen–antibodi, dan manfaat penggunaan metode imunodiagnostik dalam deteksi dini penyakit. Selain itu, peternak menunjukkan antusiasme dan partisipasi aktif selama proses penyuluhan dan demonstrasi. Kegiatan ini memberikan kontribusi positif dalam meningkatkan kesadaran peternak terhadap pentingnya pencegahan penyakit menular melalui pendekatan diagnostik sederhana yang aplikatif di tingkat peternakan rakyat.
Co-Authors Elfred Rinaldo Kasimo Fendy Prasetyawan Konradus Klala Mebung Lisa Savitri Rochmad Krissanjaya Yuneka Saristiana