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All Journal Klinikal Sains (Jurnal Analis Kesehatan) Media Ilmiah Kesehatan Indonesia
Maya Herliana Sasmitha
Universitas Borneo Lestari
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Jumlah Leukosit berkorelasi dengan Jumlah Trombosit pada Demam Tifoid Anak Dian Nurmansyah; Lala Foresta Valentine Gunasari; Puspawati Puspawati; Maya Herliana Sasmitha
Media Ilmiah Kesehatan Indonesia Vol. 4 No. 2 (2026): MAY
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/miki.v4i2.938

Abstract

Typhoid fever in children remains a health problem in developing countries, with hematological changes such as leukocyte and platelet abnormalities being frequently observed. This study aimed to analyze the relationship between leukocyte and platelet counts in pediatric patients with typhoid fever. A cross-sectional design was employed using secondary data from the Clinical Pathology Laboratory of RSDI Banjarbaru City. A total of 72 children aged 5–13 years who met the inclusion criteria (diagnosis of typhoid fever by Tubex TF, no prior antibiotic therapy) were analyzed. Leukocyte and platelet measurements were performed using a hematology analyzer, and data were analyzed using simple linear regression (SPSS version 24). Results showed a mean age of 8.2 years, with a higher proportion of males (59.7%). Leukocyte distribution was highly variable, ranging from severe leukopenia (1200–1248/mm³) to extremely high values. Platelet distribution was also wide, with very low values of 51,000/mm³ and high outliers up to 460,000/mm³. Regression analysis yielded the equation y = 13.74x + 118195 with a coefficient of determination (R²) of 0.4998, indicating that approximately 50% of the variability in platelet count could be explained by leukocyte count. Pathophysiologically, this relationship is mediated by proinflammatory cytokines (TNF-α, IL-1, IL-6) and leukocyte-platelet aggregation induced by Salmonella typhi endotoxin. In conclusion, there is a moderate positive correlation between leukocyte and platelet counts in children with typhoid fever. These hematological parameters have the potential to serve as adjunctive diagnostic tools and for risk stratification, particularly in settings with limited blood culture facilities.
POTENSI FILTRAT UMBI TALAS (Colocasia esculenta (L.) Schott) SEBAGAI ANTIKOAGULAN Maya Herliana Sasmitha; Shabrina Dewi Ramadhani; Muhammad Arsyad; Nafila Nafila; Dian Nurmansyah
Klinikal Sains : Jurnal Analis Kesehatan Vol. 11 No. 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3719

Abstract

A Clinical laboratory is a health laboratory that carries out clinical specimen examination services with the type of blood test material. Blood that is used as an examination material sometimes requires additional substances that can inhibit blood clotting such as anticoagulants. Natural ingredients that are thought to have anticoagulant content are taro tuber filtrate (Colocasia esculenta (L.) Schott). This study aimed to determine the potential of taro tuber filtrate (Colocasia esculenta (L.) Schott) as an alternative anticoagulant. The method used in testing anticoagulant activity is Clotting Time in Vitro. Taro tubers are grated and filtered to obtain filtrate from taro tubers. Taro tuber filtrate test samples are divided into 5 concentrations of 10%, 30%, 50%, 70%, and 90%. Each concentration was carried out 4 times with each treatment given a blood sample of 1 mL. The results of the phytochemical screening test of taro tuber filtrate contain secondary metabolite compounds of flavonoids, alkaloids, and saponins that have anticoagulant activity. Based on the results of clotting time testing that 1 mL of blood mixed with 10% taro tuber filtrate clotted after the 15th hour, while concentrations of 30%, 50%, 70%, and 90% did not occur blood clots after observation for 6 days. Based on the results of research that has been done, it can be concluded that taro tuber filtrate (Colocasia esculenta (L.) Schott) has the potential as an alternative anticoagulant
Co-Authors Dian Nurmansyah Gunasari, Lala Foresta Valentine Muhammad Arsyad Nafila, Nafila Puspawati Puspawati Shabrina Dewi Ramadhani