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All Journal Vitek : Bidang Kedokteran Hewan
Ragil Angga Prastiya
Department of Health, Medicine and Life Sciences, Universitas Airlangga, Banyuwangi, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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PROTECTIVE EFFECTS OF COMBINED VITAMIN E AND ZINC SULFATE ON OVARIAN AND UTERUS WEIGHT OF ALBINO RATS (Rattus norvegicus) EXPOSED TO LEAD ACETATE Fitriani Sultan; Tri Wahyu Suprayogi; Rimayanti; Ragil Angga Prastiya; Bodhi Agustono; Amung Logam Saputro
VITEK : Bidang Kedokteran Hewan Vol. 16 No. 1 (2026): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/594dbr52

Abstract

Lead exposure exerts toxic effects on the female reproductive system, particularly on the ovaries and uterus, resulting in hypofunction and organ atrophy. Oxidative stress induced by lead accumulation may be attenuated by antioxidants such as vitamin E and zinc sulfate. This study aimed to evaluate the protective effects of vitamin E, zinc sulfate, and their combination on ovarian and uterus weights in albino rats (Rattus norvegicus) exposed to lead acetate. Twenty-five female rats were randomly divided into five groups (K, T0, T1, T2, and T3) and treated orally for 21 days. On day 22, the rats were euthanized, and the ovaries and uterus were collected and weighed. The average ovarian weights for K, T0, T1, T2, and T3 were 25.80 ± 2.49; 18.62 ± 4.36; 28.40 ± 5.67; 33.78 ± 6.09; and 36.84 ± 5.15 mg, respectively. The average uterus weights for K, T0, T1, T2, and T3 were 292.48 ± 36.81; 249.96 ± 25.97; 315.86 ± 26.56; 325.54 ± 31.53; and 375.00 ± 36.55 mg, respectively. In conclusion, vitamin E and zinc sulfate demonstrated protective effects against lead-induced reproductive toxicity, with the combined treatment showing the greatest improvement in ovarian and uterus weights.
Co-Authors Amung Logam Saputro Bodhi Agustono Fitriani Sultan Rimayanti Tri Wahyu Suprayogi