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All Journal Vitek : Bidang Kedokteran Hewan journal of Basic Medical Veterinary
Rimayanti
Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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PROTECTIVE EFFECTS OF COMBINED VITAMIN E AND ZINC SULFATE ON OVARIAN AND UTERUS WEIGHT OF ALBINO RATS (Rattus norvegicus) EXPOSED TO LEAD ACETATE Fitriani Sultan; Tri Wahyu Suprayogi; Rimayanti; Ragil Angga Prastiya; Bodhi Agustono; Amung Logam Saputro
VITEK : Bidang Kedokteran Hewan Vol. 16 No. 1 (2026): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/594dbr52

Abstract

Lead exposure exerts toxic effects on the female reproductive system, particularly on the ovaries and uterus, resulting in hypofunction and organ atrophy. Oxidative stress induced by lead accumulation may be attenuated by antioxidants such as vitamin E and zinc sulfate. This study aimed to evaluate the protective effects of vitamin E, zinc sulfate, and their combination on ovarian and uterus weights in albino rats (Rattus norvegicus) exposed to lead acetate. Twenty-five female rats were randomly divided into five groups (K, T0, T1, T2, and T3) and treated orally for 21 days. On day 22, the rats were euthanized, and the ovaries and uterus were collected and weighed. The average ovarian weights for K, T0, T1, T2, and T3 were 25.80 ± 2.49; 18.62 ± 4.36; 28.40 ± 5.67; 33.78 ± 6.09; and 36.84 ± 5.15 mg, respectively. The average uterus weights for K, T0, T1, T2, and T3 were 292.48 ± 36.81; 249.96 ± 25.97; 315.86 ± 26.56; 325.54 ± 31.53; and 375.00 ± 36.55 mg, respectively. In conclusion, vitamin E and zinc sulfate demonstrated protective effects against lead-induced reproductive toxicity, with the combined treatment showing the greatest improvement in ovarian and uterus weights.
The Effect of Red Ginger (Zingiber officinale var. rubrum) Extract Administration on the Number of Spermatogenic Cells and Leydig Cells in White Rats (Rattus norvegicus) Exposed to Monosodium Glutamate Ahmad Fahrisa Sidharta; Kadek Rachmawati; Rimayanti; Budi Utomo; Nove Hidajati; Kuncoro Puguh Santoso; Rahmi Sugihartuti; Rochmah Kurnijasanti
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.82732

Abstract

The purpose of this study was to examine the effect of red ginger extract (Zingiber officinale var. rubrum) on the number of spermatogenic cells and Leydig cells in white rats (Rattus norvegicus) exposed to monosodium glutamate (MSG). This study used 25 male white rats divided into five treatment groups. The K− group received 1% CMC-Na, the K+ group received MSG at a dose of 5 g/kg body weight (BW), and the P1 to P3 groups received MSG at 5 g/kg BW along with red ginger extract at doses of 50 mg/kg BW, 100 mg/kg BW, and 200 mg/kg BW, respectively, for 42 days. The rats’ testes were collected, processed into histopathological preparations, and observed under a microscope at 400× magnification. Data were analyzed using one-way ANOVA followed by Duncan’s test. The results showed significant differences (p < 0.05) in the number of spermatogenic cells and Leydig cells among the K−, K+, P1, and P2 groups, but no significant differences (p > 0.05) were observed between the K− group (57.60ᵈ ± 1.490 and 14.92ᵈ ± 1.487) and the P3 group (57.20ᵈ ± 1.208 and 14.84ᵈ ± 1.459). The optimal dose of red ginger extract was 200 mg/kg BW (P3). In conclusion, administration of red ginger extract can maintain the number of spermatogenic cells and Leydig cells in white rats (Rattus norvegicus) exposed to MSG.
Co-Authors Ahmad Fahrisa Sidharta Amung Logam Saputro Bodhi Agustono Budi Utomo Fitriani Sultan Kadek Rachmawati Kuncoro Puguh Santoso Nove Hidajati Ragil Angga Prastiya Rahmi Sugihartuti Rochmah Kurnijasanti Tri Wahyu Suprayogi