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All Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Multidisciplinary Indonesian Center Journal
Ulfa Mustofa Nurfadilasari
Sekolah Tinggi Ilmu Farmasi Bhakti Pertiwi
Religion Humanities Earth & Planetary Sciences Education Health Professions Nursing Public Health Other

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ASSOCIATION BETWEEN INHALED CORTICOSTEROIDS AND OSTEOPOROSIS: A REVIEW Ulfa Mustofa Nurfadilasari; Sternatami Liberitera
Multidisciplinary Indonesian Center Journal (MICJO) Vol. 2 No. 3 (2025): Vol. 2 No. 3 Edisi Juli 2025
Publisher : PT. Jurnal Center Indonesia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/micjo.v2i3.1241

Abstract

Inhaled corticosteroids (ICS) are commonly prescribed to manage asthma and chronic obstructive pulmonary disease (COPD) due to their local anti-inflammatory effects in the airways. However, prolonged or high-dose ICS use has been associated with systemic adverse effects, including decreased bone mineral density (BMD) and increased risk of osteoporosis. This review aimed to examine the association between ICS use and the risk of osteoporosis or fractures, and to identify modifying factors such as dose, duration, patient age, sex, and type of corticosteroid used. Literature review was conducted using databases including PubMed, Scopus, and Web of Science. Articles were selected using specific inclusion and exclusion criteria. The review focused on original studies published up to March 2025, resulting in 28 relevant articles, of which 6–8 high-quality studies were analyzed in depth. Most studies demonstrated that long-term or high-dose ICS use is associated with decreased BMD and increased risk of fractures, especially in elderly COPD patients. The greatest risk was linked to fluticasone and budesonide at doses ≥500 µg/day. Some studies found neutral or even protective effects in specific subgroups, indicating population-dependent variability. Meta-analyses revealed conflicting results due to heterogeneity in populations and methodologies. High-dose and long-term ICS use may increase the risk of osteoporosis. Clinicians should consider individualized risk assessments and adopt strategies such as using the lowest effective dose, monitoring BMD, and providing calcium and vitamin D supplementation in at-risk populations.
Perubahan Tingkat Kepatuhan Pengobatan setelah Konseling Apoteker pada Pasien Hipertensi di Apotek Nusantara Kota Palembang Riskayanti Ramadhani; Elin Yulinah Sukandar; Suryani Suryani; Ulfa Mustofa Nurfadilasari
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 4 (2026): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i4.2409

Abstract

Hypertension is a chronic disease requiring long-term treatment, making adherence to antihypertensive medication essential for blood pressure control and the prevention of complications. Pharmacist counseling, as part of clinical pharmacy services, is one approach that may support patients' adherence to medication therapy. This study aimed to analyze changes in medication adherence among patients with hypertension following pharmacist counseling at Apotek Nusantara, Palembang, Indonesia. A quasi-experimental study using a one-group pretest–posttest design was conducted from April to June 2025. A total of 73 patients with hypertension who met the inclusion criteria were enrolled. Medication adherence was assessed before and after pharmacist counseling using an educational booklet and the Morisky Medication Adherence Scale-4 (MMAS-4). Data were analyzed using the Wilcoxon Signed-Rank test with a 95% confidence level. At baseline, all participants (100%) demonstrated low medication adherence. Following pharmacist counseling, 45 participants (62%) achieved moderate medication adherence, while 28 participants (38%) remained in the low-adherence category. The Wilcoxon Signed-Rank test demonstrated a statistically significant difference in medication adherence before and after counseling (p < 0.001). These findings indicate a change in medication adherence following pharmacist counseling among patients with hypertension. Further studies employing controlled study designs are needed to provide stronger evidence regarding the effect of pharmacist counseling on medication adherence.
Co-Authors Elin Yulinah Sukandar Riskayanti Ramadhani Sternatami Liberitera Suryani Suryani