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All Journal Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Multidisciplinary Indonesian Center Journal
Sternatami Liberitera
Universitas Sriwijaya
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ASSOCIATION BETWEEN INHALED CORTICOSTEROIDS AND OSTEOPOROSIS: A REVIEW Ulfa Mustofa Nurfadilasari; Sternatami Liberitera
Multidisciplinary Indonesian Center Journal (MICJO) Vol. 2 No. 3 (2025): Vol. 2 No. 3 Edisi Juli 2025
Publisher : PT. Jurnal Center Indonesia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/micjo.v2i3.1241

Abstract

Inhaled corticosteroids (ICS) are commonly prescribed to manage asthma and chronic obstructive pulmonary disease (COPD) due to their local anti-inflammatory effects in the airways. However, prolonged or high-dose ICS use has been associated with systemic adverse effects, including decreased bone mineral density (BMD) and increased risk of osteoporosis. This review aimed to examine the association between ICS use and the risk of osteoporosis or fractures, and to identify modifying factors such as dose, duration, patient age, sex, and type of corticosteroid used. Literature review was conducted using databases including PubMed, Scopus, and Web of Science. Articles were selected using specific inclusion and exclusion criteria. The review focused on original studies published up to March 2025, resulting in 28 relevant articles, of which 6–8 high-quality studies were analyzed in depth. Most studies demonstrated that long-term or high-dose ICS use is associated with decreased BMD and increased risk of fractures, especially in elderly COPD patients. The greatest risk was linked to fluticasone and budesonide at doses ≥500 µg/day. Some studies found neutral or even protective effects in specific subgroups, indicating population-dependent variability. Meta-analyses revealed conflicting results due to heterogeneity in populations and methodologies. High-dose and long-term ICS use may increase the risk of osteoporosis. Clinicians should consider individualized risk assessments and adopt strategies such as using the lowest effective dose, monitoring BMD, and providing calcium and vitamin D supplementation in at-risk populations.
LITERATURE REVIEW OF EMBRYONIC DEVELOPMENT EPIGENETICS: CHROMATIN MODIFICATION AND CELL PROGRAMMING Kamila Alawiyah; Rizki Andini Nawawi; Meillisa Carlen Mainassy; Syarinta Adenina; Hamzah Alfarisi; Sternatami Liberitera
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 5 No. 6 (2025): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.18492220

Abstract

This study aims to comprehensively examine epigenetic mechanisms in embryonic development, focusing on the role of chromatin modification and cell programming as regulators of gene expression without changes in DNA sequence. The type of study used was qualitative , with a descriptive approach through literature review, which examined scientific literature from reputable international journals such as Nature, Trends in Genetics, and The FEBS Journal published between 2015 and 2025. Data were collected through systematic searches of scientific articles using thematic and inductive analysis techniques, including theme identification, data reduction, and concept categorization. The results of the study show that DNA methylation, acetylation, and histone methylation are key factors in regulating gene expression during the zygotic genome activation (ZGA) phase and the formation of cell lineages. This process demonstrates the complex interaction between epigenetic and transcriptional factors that determine the direction of cell differentiation. In addition, similarities in epigenetic regulation principles between mammals and plants were found, indicating the conservation of biological mechanisms across species. The implications of the study " " include the development of regenerative therapies, increased effectiveness of assisted reproductive technologies, and innovations in agricultural biotechnology. In conclusion, this study confirms that epigenetics is an important layer of regulation in developmental biology that enriches our understanding of the mechanisms of life formation from the earliest stages.
Co-Authors Alfarisi, Hamzah Kamila Alawiyah Meillisa Carlen Mainassy Rizki Andini Nawawi Syarinta Adenina Ulfa Mustofa Nurfadilasari