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All Journal Jurnal Farmasi Higea Jurnal Kefarmasian Indonesia
Ifora, Ifora
STIFARM Padang
Chemistry Medicine & Pharmacology

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Efek Antikolesterol Ekstrak Etanol Buah Kundua (Benincasa Hispida (Thunb.) Cogn.) pada Mencit Putih Jantan Ifora, Ifora; Eriadi, Aried; Kardela, Widya; Mandala, Yoga Febrian
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.585 KB)

Abstract

Hiperkolesterolemia merupakan suatu keadaan saat kadar kolesterol tinggi didalam darah. Penelitian ini bertujuan untuk melihat pengaruh ekstrak etanol buah kundua (Benincasa hispida (Thunb.) Cogn.) terhadap kadar kolesterol total, LDL, trigliserida, VLDL dan HDL pada mencit putih jantan. Penginduksi peningkat kolesterol yang digunakan berupa makanan lemak tinggi dan prophlythiourassil secara peroral selama 14 hari. Kemudian dilanjutkan penambahan pemberian ekstrak secara peroral satu kali sehari selama 14 hari dengan dosis 150 mg/kg BB; 300 mg/kg BB dan 600 mg/kg BB. Parameter yang diamati adalah kadar kolesterol total, LDL, trigliserida, VLDL dan HDL. Pengukuran dilakukan pada hari ke-29 menggunakan fotometer v5­+ 5010. Data hasil penelitian ini dianalisis dengan ANOVA satu arah. Dari hasilpenelitian dapat disimpulkan bahwa, pemberian ekstrak etanol buah kundua (Benincasa hispida (Thunb.) Cogn.) tidak dapat mempengaruhi secara signifikan penurunan kadar kolesterol total, LDL, trigliserida, VLDL  dan peningkatan kadar HDL pada mencit putih jantan hiperkolesterolemia.Kata Kunci : Ekstrak etanol; Benincasa hispida (Thunb.) Cogn.; Hiperkolesterolemia; Prophylthiourassil
Uji Efek Teratogen Ekstrak Etanol Daun Sirsak (Annona muricata L) Terhadap Fetus Mencit Putih Ifora, Ifora; Suhatri, Suhatri; Yolandha, Suzie
Jurnal Farmasi Higea Vol 8, No 1 (2016)
Publisher : STIFARM Padang

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Research on test teratogenic effects of ethanol  extract of leaves of the soursop (Annona muricata L.) have been conducted on white mice fetus. Animal experiments are grouped into  4 group consisting of Group I as a negative control only granted suspension of Na CMC 0.5%, Group II, Group III and Group IV granted soursop leaf ethanol extract at a dose of 250 mg / kg, 500 mg / kg, and 1000 mg / kg once daily from day 6 to day 15 of pregnancy. The 18th day of pregnancy mice were dissected. Results of the study at a dose of 250 mg / kg, a dose of 500 mg / kg, a dose of 1000 mg / kg give teratogen effects. A dose of 250 mg / kg, a dose of 500 mg / kg give teratogen effect with the discovery of skeletal abnormalities. A dose of 1000 mg / kg give teratogen effect with the discovery of late growth. Results showed that the ethanol extract of the leaves of the soursop affect weight loss parent mice were significantly (p <0.05) when compared to the negative control. The quantity of fetuses decreased significantly (p <0.05) when compared to the negative control. Fetal body weight showed a significant effect (p <0.05) when compared to the negative control.
Pengaruh Penghambatan Enzim Siklooksigenase-2 dan Aktivitas Antiinflamasi dari Ekstrak Daun Ketumbar (Coriandrum sativum L.) Ifora, Ifora; Sintia, Bella; Srangenge, Yoneta
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3487

Abstract

Inflammation is a normal protective response to tissue damage that mediated by Cyclooxygenase-2 (COX-2) enzyme. The enhancement incidence and impact of inflammatory diseases have encouraged the search for new pharmacological strategies to overcome the problem. Ketumbar (Coriandrumsativum L.) has been traditionally used as an anti-inflammatory and antioxidant, thus giving chance for anti-inflammatory studies. This study aims to determine the ethanol extract of Ketumbar (Coriandrumsativum L.) leaves anti-inflammatory activity and inhibitory effect on COX-2 enzyme. This study uses male wistar rats with 180–220 g body weights. The rats is divided into six groups by the dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW; positive control (Carrageenan 1%); negative control (Na. CMC 0,5%); and comparative group (Celecoxib 9 mg/kg BW). Determining the anti-inflammatory activity, the oedema formation is measured using a plethysmometer and the inhibition activity is determined by ELISA methods. The results showed that the ethanol extract of Ketumbar leaves by the dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW was significantly inhibitted COX-2 valued 65,61%, 76,83%, and 62,93%. The anti-inflammatory activity was shown by inhibiting oedema valued of 62.26%, 70.59%, and 54.90% respectively. These findings suggested that the ethanol extract of Ketumbar leaves had anti-inflammatory activity, that was possibly mediated through inhibition of COX-2 enzymes
Co-Authors Eriadi, Aried Mandala, Yoga Febrian Sintia, Bella Srangenge, Yoneta Suhatri Suhatri Widya Kardela Yolandha, Suzie