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All Journal Elkawnie Al-Kimia Pharmasipha Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education Parapemikir Jurnal Ilmiah Farmasi
Adam Mustapa, Muhammad
Universitas Negeri Gorontalo
Biochemistry, Genetics & Molecular Biology Chemistry Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Isolasi Senyawa Alkaloid dari Tumbuhan Mahoni (Switenia mahagoni Jacq) Muhammad Taupik; Endah Nurrohwinta Djuwarno; Moh Adam Mustapa
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 2 (2021): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i2.6663

Abstract

Penelitian ini bertujuan untuk mengidentifikasi senyawa Alkaloid yang terkandung didalam biji buah mahoni (Switenia mahagoni Jacq). Senyawa target hasil isolasi diidentifikasi menggunakan spektrofotometri UV-Vis. Proses pengambilan senyawa menggunakan metode refluks hingga diperoleh ekstrak kental berwarna hijau gelap sebanyak 27 gram. Identifikasi awal dilakukan dengan skrining fitokimia pada ekstrak kental methanol, meliputi skrining senyawa alakaloid, flavonoid, dan saponin. Proses fraksinasi dilakukan dengan sistem partisis cair-cair menggunakan n-heksanaa dan metanol dan selanjutnya hasil partisi dipekatkan dengan rotary evaporator. Fraksi metanol dielusi pada plat KLT (Kromatografi Lapis Tipis) guna mendapatkan formulasi eluen terbaik untuk dilanjutkan pada Kromatografi Cair Vakum (KCV) dan diperoleh formula eluen terbaik n-heksanaa:metanol (4:1). Proses pemisahan menggunakan KCV dengan silica gel 60 PF254, dengan system eluen n-heksana:metanol bergradien. Isolat dievaluasi kemurniannya menggunakan KLT. Isolat diidentifikasi menggunakan Spektrofotometri UV-Vis dan serapan diperoleh pada panjang gelombang gelombang 208, 240, 286 nm. Nilai absorbansi berturutturut 0,318; 0,852; dan 0,443 A. Hasil interpretasi data mengkonfirmasi bahwa terdapat ikatan rangkap terkonjugasi dikarenakan serapan terbentuk pada panjang gelombang 250-800 nm. Diduga terjadi transisi nπ* yang mengindikasikan gugus N-H dengan abrosbansi pada rentang ultraviolet kuarsa (200-400 nm).
Evaluasi Penggunaan Obat Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis Di Rsud Toto Kabila Periode 2017-2018 Teti Sutriyati Tuloli; Madania Madania; Moh Adam Mustapa; Evania P. Tuli
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1470

Abstract

Chronic Renal Failure (CRF) is kidney damage with a decrease in Glomerular Filtration Rate (LFG) of less than 60mL/min/1.73 m2 during (at least) 3 months. Hemodialysis therapy is the most widely used CRF therapy. Due to certain conditions, in addition to receiving hemodialysis therapy, patients with CRF alsoreceive oral drug therapy. This is intended to overcome complications both from CRF and hemodialysis therapy itself. This study aims to evaluate drugs use in patients with CRF with hemodialysis based on four aspects, namely the proper patient, the proper medication, the proper indication and the proper dose according to the standard of therapy. This research was a descriptive study using a cross sectional design with data collection done retrospectively on patients undergoing hemodialysis in Regional General Hospitalof Toto Kabila Hospital January 2017-October 2018. 43 patients were taken as samples by purposive sampling method that met the criteria. The data obtained were analyzed by univariate analysis.The results showed that the use of drugs in kidney failure patients undergoing hemodialysis in Regional General Hospitalof Toto Kabila Hospital in the period of January2017-October 2018 based on the four aspects were as follows: proper patient of 100%; proper drug of 86.05% and improper drug of 13.95%; proper indication of 83.72% and improper indication of 16.28%; proper dosage of 53.49%; and improper dosage of 46.51%.Overall, the drugs use evaluation results show that the drugs use on patients with Chronic Rena Failure undergoing hemodialysis in Regional General Hospitalof Toto Kabila Hospital in the period January 2017-October 2018 can be included in the good category.Keywords— Chronic Kidney Failure, Hemodialysis, Gorontalo
Uji Praklinik Kombinasi Obat Herbal Kopi Pinogu (Coffea canephora var Robusta) Dan Bunga Cengkeh (Syzygium aromaticum) Terhadap Penurunan Kadar Asam Urat Pada Mencit Moh Adam Mustapa; Muhammad Taupik; Friskawati Hanapi
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1468

Abstract

Decreasing uric acid levels can be given with coffee plants Pinogu (Coffea canephora var robusta) which is combined with clove flowers (Syzygium aromaticum) as a hyperuricemia drug. This study aims to measure the effect of the combination of Pinogu coffee herbal medicine and clove flower seen from the decrease in uric acid levels of male white mice made hyperuricemia by chicken liver juice. This study uses a pure experimental design with pre and post test design. Where animals are grouped into seven groups, each group consisting of 5 male white mice. Each group was induced 1 mL / 20 g BB chicken liver juice and left for 24 hours then blood was taken after 2 hours, 3 hours and 4 hours of treatment. Group I as a negative control was given Na-CMC, group II was given allopurinol suspension 0.0538 g / kg BB, group III was given a combination of Pinogu coffee and clove flowers 0.209 g / kg BB, group IV was given a combination of Pinogu coffee and clove flower 0.39936 g / kg BB, group V was given a combination of Pinogu coffee and clove flower 0.404 g / kg BB, group VI was given a single Pinogu coffee extract 0.195 g / kg BB, and group VII was given clove flower extract 0.0140 g / kg BW. The results showed that the combination of Pinogu coffee herbal medicine (Coffea canephora var robusta) and clove flower (Syzygium romaticum) can reduce uric acid levels in male white mice (Mus musculus). The combination of Pinogu coffee and clove flower 0.209 g / kg BW gives the optimal effect of reducing blood uric acid levels in mice by 64.93%. Keywords— Gout, Pinogu Coffee, Clove Flowers
The Type Fragmentation Patterns Confirmed Acetaminophen By Using Liquid Chromatography-Mass Spectroscopy (LCMS) From Herbal Medicine (Jamu) Muhammad Taupik; Endah Nurrohwinta Djuwarno; Moh Adam Mustapa; Wiwin R Kunusa; Jafar La Kilo; Muhamad Handoyo Sahumena
Elkawnie Vol. 7 No. 2 (2021)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v7i2.7492

Abstract

Abstract: The Jamu or herbal medicine were adulterated with chemical drugs in the last twenty years. One of the chemical drugs that are commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered an analgesic-antipyretic drug. The research aims to identify the content of paracetamol and its amount added to the jamu. This study consisted of 6 jamu or herbal medicine samples with different brands. The TLC method conducted the qualitative analysis using the mobile phase n-hexane: ethyl acetate (1:1). Three positive samples containing acetaminophen were obtained: D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 µL, it was obtained the levels of acetaminophen in sample D as much as  0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and sample F of 0.56 g/7 g of sample. Although the acetaminophen content in herbal medicine is relatively small, according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals.Abstrak: Dalam dua puluh tahun terakhir, banyak jamu yang dipalsukan dengan obat-obatan kimia. Salah satu obat kimia yang biasa ditambahkan pada jamu adalah asetaminofen. Acetaminophen umumnya dianggap sebagai obat analgesik-antipiretik. Penelitian ini bertujuan untuk mengetahui kandungan parasetamol dan jumlah yang ditambahkan pada jamu. Sampel penelitian ini terdiri dari 6 sampel jamu dengan merek yang berbeda. Analisis kualitatif dilakukan dengan metode KLT menggunakan fase gerak n-heksana: etil asetat (1:1). Diperoleh tiga sampel positif mengandung asetaminofen, yaitu sampel D, E, dan F. Tiga sampel positif mengandung asetaminofen dihitung menggunakan metode LCMS. Analisis kuantitatif dilakukan dengan LCMS menggunakan fase terbalik dengan fase gerak asetonitril: air (15%>:85%> v/v) pada laju alir 0,2 mL/menit dan volume injeksi 5 µL. Diperoleh kadar asetaminofen pada sampel D sebanyak 0,16 g/2 g sampel, pada sampel E sebesar 0,63 g/7 g sampel, dan pada sampel F sebesar 0,56 g/7 g sampel. Meskipun kandungan asetaminofen dalam jamu relatif sedikit, namun menurut Peraturan Menteri Kesehatan RI No. 007 Tahun 2012, obat tradisional atau jamu tidak boleh mengandung bahan kimia sintetik.
Co-Authors A. Mu’thi Andy Suryadi Endah Nurrohwinta Djuwarno Evania P. Tuli Friskawati Hanapi Jafar La Kilo Madania, Madania Muhamad Handoyo Sahumena Muhammad Taupik Nur Khofifah Zahrah Ramadhan L, Aditya Selvi Marcellia Sintiya Basiru Teti Sutriyati Tuloli Wiwin Rewini Kunusa